专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1996037232A1 STABILIZATION OF COLLOIDAL SYSTEMS BY THE FORMATION OF IONIC LIPID-POLYSACCHARIDE COMPLEXES 审中-公开
标题翻译：通过形成离子脂质 - 多糖复合物的胶体系统的稳定化
公开(公告)号：WO1996037232A1
公开(公告)日：1996-11-28
申请号：PCT/ES1996000116
申请日：1996-05-24
申请人： UNIVERSIDADE DE SANTIAGO DE COMPOSTELA , ALONSO FERNANDEZ, María José , CALVO SALVE, Pilar , REMUÑAN LOPEZ, Carmen , VILA JATO, José Luis
发明人： UNIVERSIDADE DE SANTIAGO DE COMPOSTELA
IPC分类号： A61K47/24
CPC分类号： A61K9/5153 , A61K9/10 , A61K9/1075 , A61K9/5161 , A61K9/5192 , Y10S514/937 , Y10S514/963 , Y10S977/797 , Y10S977/801 , Y10S977/906 , Y10S977/907 , Y10S977/915 , Y10S977/926
摘要： Stabilization of colloidals systems through the formation of ionic lipid-polisaccharide complexes. There is disclosed a process for the preparation of colloidal systems which includes the incorporation of a water soluble and positively charged amino polysaccharide and a negatively charged phospholipid. The colloidal systems (which comprise polymer nanoparticles, nanocapsules and nano-emulsions) are stabilized through the formation of a ionic complex, at the interface, comprised of the aminopolysaccharide and the phospholipid. The colloidal systems are characterized in that they have a particle size lower than 1 mu m, an electric positive charge and an exeptional stability during storage. They are lyophilizable so that they can be dry stored and redispersed subsequently while maintaining the original characteristics of the system. They are useful as pharmaceutical forms for the oral, transdermic, topical, ocular, nasal and vaginal administration of medicaments. They are also useful as forms for cosmetic use.
摘要翻译：通过形成离子脂质 - 糖配合物稳定胶体体系。公开了一种制备胶体体系的方法，其包括掺入水溶性和带正电荷的氨基多糖和带负电荷的磷脂。包含聚合物纳米颗粒，纳米胶囊和纳米乳液的胶体体系通过在由氨基多糖和磷脂组成的界面处形成离子络合物来稳定。胶体体系的特征在于它们具有小于1μm的粒度，电积极性和储存期间的外部稳定性。它们是可冻干的，以便随后可以将其干燥储存并重新分散，同时保持系统的原始特性。它们可用作口服，经皮，局部，眼，鼻和阴道给药药物的药物形式。它们也可用作化妆品使用的形式。

2. 发明申请

WO2004009060A1 NANOPARTÍCULAS PARA LA ADMINISTRACIÓN DE INGREDIENTES ACTIVOS, PROCEDIMIENTO PARA LA ELABORACIÓN DE DICHAS PARTÍCULAS Y COMPOSICIÓN QUE LAS CONTIENEN. 审中-公开
标题翻译：用于管理活性成分的纳米颗粒，生产所述颗粒的方法和包含其的组合物
公开(公告)号：WO2004009060A1
公开(公告)日：2004-01-29
申请号：PCT/ES2003/000372
申请日：2003-07-16
申请人： UNIVERSIDADE DE SANTIAGO DE COMPOSTELA , ALONSO FERNÁNDEZ, María, José , REMUÑÁN LÓPEZ, Carmen , CUÑA VILÁN, Margarita, María , ALONSO SANDE, María , VILA JATO, José, Luis
发明人： ALONSO FERNÁNDEZ, María, José , REMUÑÁN LÓPEZ, Carmen , CUÑA VILÁN, Margarita, María , ALONSO SANDE, María , VILA JATO, José, Luis
IPC分类号： A61K9/51
CPC分类号： A61K47/36 , A61K9/5161 , A61K9/5192
摘要： Nanopartículas para la administración de ingredientes activos, procedimiento para la elaboración de dichas nanopartículas y composiciones que las contienen, comprendiendo dichas nanopartículas quitosano, glucomanano, al menos un ingrediente activo, y, en caso dado, una sal aniónica, de forma preferida tripolifosfato sódico, las cuales pueden ser utilizadas para administrar ingredientes activos al cuerpo humano o animal.
摘要翻译：本发明涉及用于施用活性成分的纳米颗粒，所述纳米颗粒的制备方法和含有其的组合物。本发明的纳米颗粒包含壳聚糖，葡甘露聚糖，至少一种活性成分，如果需要，可以使用阴离子盐，优选三聚磷酸钠形式。所述纳米颗粒可用于向人或动物体施用活性成分。

3. 发明申请

WO1998004244A1 APPLICATION OF NANOPARTICLES BASED ON HYDROPHILIC POLYMERS AS PHARMACEUTICAL FORMS 审中-公开
标题翻译：基于水解聚合物作为药物形态的纳米颗粒的应用
公开(公告)号：WO1998004244A1
公开(公告)日：1998-02-05
申请号：PCT/ES1996000186
申请日：1996-10-22
申请人： UNIVERSIDADE DE SANTIAGO DE COMPOSTELA , ALONSO FERNANDEZ, María José , CALVO SALVE, Pilar , REMUÑAN LOPES, Carmen , VILA JATO, José Luis
发明人： UNIVERSIDADE DE SANTIAGO DE COMPOSTELA
IPC分类号： A61K09/51
CPC分类号： A61K9/5161
摘要： Application of nanoparticles based on hydrophilic polymers as, pharmaceutical forms for the administration of active macromolecules. The nanoparticles (having a nanometric size and a hydrophilic character), also called nanospheres or latex, are colloidal systems comprised of the combination of hydrophilic polymers and an active ingredient having a high molecular weight (active macromolecule, molecular weight higher than 1000 daltons). The hydrophilic polymers are the chitosane (an aminopolysaccharide) or its derivatives and the polyoxyethylene or its derivatives. The association of the active macromolecule to said nanoparticles takes place in an aqueous phase without having to use organic solvents or auxiliary toxic substances. The active ingredient charge capacity of the nanoparticles is extremely high and additionally said charge is released in a controlled and time extended way. Additionally, said nanoparticles have a positive surface electric charge which the intensity may vary in relation to its composition.
摘要翻译：基于亲水性聚合物的纳米颗粒的应用，作为用于施用活性大分子的药物形式。纳米颗粒（具有纳米尺寸和亲水特性）也称为纳米球或胶乳，是由亲水聚合物和具有高分子量（活性大分子，分子量高于1000道尔顿）的活性成分的组合组成的胶体体系。亲水性聚合物是二甲硅烷（氨基多糖）或其衍生物和聚氧乙烯或其衍生物。活性大分子与所述纳米颗粒的结合在水相中进行，而不必使用有机溶剂或辅助有毒物质。纳米颗粒的活性成分电荷容量非常高，另外所述电荷以受控和时间延长的方式释放。另外，所述纳米颗粒具有正的表面电荷，强度可以相对于其组成而变化。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式