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1. 发明专利

AU2010255391B2 Formulations for the treatment of deep tissue pain 未知
公开(公告)号：AU2010255391B2
公开(公告)日：2016-06-02
申请号：AU2010255391
申请日：2010-06-03
申请人： ROTHER MATTHIAS , VIERL ULRICH , MAYO JOHN , ILIFFE GEORGE
发明人： MAYO JOHN CHARLES , ILIFFE GEORGE LANGTON , VIERL ULRICH , ROTHER MATTHIAS
IPC分类号： A61K9/127 , A61P19/02
摘要： Disclosed herein are vesicular formulations comprising one or more phospholipids and one or more nonionic surfactants that are effective in the treatment of pain or inflammation or osteoarthritis, more specifically in the treatment of deep tissue pain, for example osteoarthritis and other joint or muscle pain, as well as methods of treating pain or inflammation or osteoarthritis, more specifically in the treatment of deep tissue pain, for example osteoarthritis and other joint or muscle pain using same.

2. 发明专利

IL216737D0 FORMULATIONS FOR THE TREATMENT OF DEEP TISSUE PAIN 未知
公开(公告)号：IL216737D0
公开(公告)日：2012-02-29
申请号：IL21673711
申请日：2011-12-01
申请人： MAYO JOHN CHARLES , ILIFFE GEORGE LANGTON , VIERL ULRICH , ROTHER MATTHIAS
IPC分类号： A61K20060101
摘要： Disclosed herein are vesicular formulations comprising one or more phospholipids and one or more nonionic surfactants that are effective in the treatment of pain or inflammation or osteoarthritis, more specifically in the treatment of deep tissue pain, for example osteoarthritis and other joint or muscle pain, as well as methods of treating pain or inflammation or osteoarthritis, more specifically in the treatment of deep tissue pain, for example osteoarthritis and other joint or muscle pain using same.

3. 发明专利

GB201122433D0 Formulations for the treatment of deep tissue pain 未知
公开(公告)号：GB201122433D0
公开(公告)日：2012-02-08
申请号：GB201122433
申请日：2010-06-03
申请人： MAYO JOHN C , ROTHER MATTHIAS , VIERL ULRICH , ILIFFE GEORGE L
摘要： Disclosed herein are vesicular formulations comprising one or more phospholipids and one or more nonionic surfactants that are effective in the treatment of pain or inflammation or osteoarthritis, more specifically in the treatment of deep tissue pain, for example osteoarthritis and other joint or muscle pain, as well as methods of treating pain or inflammation or osteoarthritis, more specifically in the treatment of deep tissue pain, for example osteoarthritis and other joint or muscle pain using same.

4. 发明申请

WO2010010470A2 METHODS OF ADMINISTERING TOPICAL ANTIFUNGAL FORMULATIONS FOR THE TREATMENT OF FUNGAL INFECTIONS 审中-公开
标题翻译：管理用于治疗真菌感染的局部抗菌配方的方法
公开(公告)号：WO2010010470A2
公开(公告)日：2010-01-28
申请号：PCT/IB2009/006742
申请日：2009-07-23
申请人： TDT, LTD , CEVC, Gregor , VIERL, Ulrich
发明人： CEVC, Gregor , VIERL, Ulrich
IPC分类号： A61K31/137 , A61K9/107 , A61K47/24 , A61K47/44 , A61K9/00
CPC分类号： A61K31/137 , A61K9/0014 , A61K9/06 , A61K47/24 , A61K47/26
摘要： The present invention relates to topical antifungal formulations comprising one or more antifungal (e.g., terbinafme), a lipid and a surfactant, and uses thereof for the treatment of skin and nail fungal infections.
摘要翻译：本发明涉及包含一种或多种抗真菌剂（例如特比萘芬），脂质和表面活性剂的局部抗真菌制剂及其用于治疗皮肤和指甲真菌感染的用途。

5. 发明申请

WO2004032900A1 AGGREGATE WITH INCREASED DEFORMABILITY, COMPRISING AT LEAST THREE AMPHIPATS, FOR IMPROVED TRANSPORT THROUGH SEMI-PERMEABLE BARRIERS AND FOR THE NON-INVASIVE DRUG APPLICATION IN VIVO, ESPECIALLY THROUGH THE SKIN 审中-公开
标题翻译：累积增加的可变性，包括至少三种药物，通过半渗透性障碍物进行改进的运输，以及通过皮肤特别是非侵入性药物应用
公开(公告)号：WO2004032900A1
公开(公告)日：2004-04-22
申请号：PCT/EP2003/011202
申请日：2003-10-09
申请人： IDEA AG , CEVC, Gregor , VIERL, Ulrich
发明人： CEVC, Gregor , VIERL, Ulrich
IPC分类号： A61K9/127
CPC分类号： A61K9/127 , A61K9/0014 , A61K9/1272 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/5415
摘要： The application describes combinations of at least three amphipatic substances forming aggregate suspensions in a polar liquid. Judicious choice of system components, which differ at least 2-times to 10-times in solubility, ensures said aggregates to have extended, unusually adaptable surfaces. This is probably due to simultaneous action on said aggregates of at least two more soluble substances amongst said three system components, at least one of which is an active ingredient and preferably a drug; the third component, alternatively, can take the role of a drug. The application further deals with the use of said combinations in pharmaceutical preparations capable of transporting drugs into the body of warm blood creatures. This is made possible by the drug loading capability of said aggregates with the highly flexible and deformable coating, which renders the resulting drug carriers highly adaptable. The application finally reveals suitable methods and favourable conditions for carrier manufacturing and application. The application also describes novel formulations of nonsteroidal anti-inflammatory drugs (NSAIDs) based on complex aggregates with at least three amphipatic components suspended in a suitable, e.g. pharmaceutically acceptable, polar liquid medium.
摘要翻译：本申请描述了在极性液体中形成聚集体悬浮液的至少三种两亲物质的组合。系统组件的可靠选择，其溶解度至少是2倍至10倍，确保所述聚集体具有延伸的，异常适应性的表面。这可能是由于所述三种体系组分中至少两种可溶性物质对所述聚集体的同时作用，其中至少一种是活性成分，优选药物; 替代地，第三组分可以起到药物的作用。本申请进一步涉及能够将药物输送到温血生物体内的药物制剂中所述组合的用途。这可以通过所述聚集体与高度柔性和可变形的涂层的药物加载能力而实现，这使得所得到的药物载体高度适应。该应用终于揭示了载体制造和应用的合适方法和有利条件。本申请还描述了基于复合聚集体的非甾体抗炎药（NSAID）的新型制剂，其中至少三种两亲成分悬浮在合适的例如，药学上可接受的极性液体培养基。

6. 发明专利

CA2764227C FORMULATIONS FOR THE TREATMENT OF DEEP TISSUE PAIN 未知
公开(公告)号：CA2764227C
公开(公告)日：2016-12-06
申请号：CA2764227
申请日：2010-06-03
申请人： MAYO JOHN CHARLES , ILIFFE GEORGE LANGTON , VIERL ULRICH , ROTHER MATTHIAS
发明人： MAYO JOHN CHARLES , ILIFFE GEORGE LANGTON , VIERL ULRICH , ROTHER MATTHIAS
IPC分类号： A61K9/127 , A61P19/02
摘要： Disclosed herein are vesicular formulations comprising one or more phospholipids and one or more nonionic surfactants that are effective in the treatment of pain or inflammation or osteoarthritis, more specifically in the treatment of deep tissue pain, for example osteoarthritis and other joint or muscle pain, as well as methods of treating pain or inflammation or osteoarthritis, more specifically in the treatment of deep tissue pain, for example osteoarthritis and other joint or muscle pain using same.

7. 发明专利

GB2483419A Formulations for the treatment of deep tissue pain 未知
公开(公告)号：GB2483419A
公开(公告)日：2012-03-07
申请号：GB201122433
申请日：2010-06-03
申请人： MAYO JOHN CHARLES , ILIFFE GEORGE LANGTON , VIERL ULRICH , ROTHER MATTHIAS
发明人： MAYO JOHN CHARLES , ILIFFE GEORGE LANGTON , VIERL ULRICH , ROTHER MATTHIAS
IPC分类号： A61K9/00 , A61K9/127
摘要： Disclosed herein are vesicular formulations comprising one or more phospholipids and one or more nonionic surfactants that are effective in the treatment of pain or inflammation or osteoarthritis, more specifically in the treatment of deep tissue pain, for example osteoarthritis and other joint or muscle pain, as well as methods of treating pain or inflammation or osteoarthritis, more specifically in the treatment of deep tissue pain, for example osteoarthritis and other joint or muscle pain using same.

8. 发明公开

EP2437726A2 FORMULATIONS FOR THE TREATMENT OF DEEP TISSUE PAIN 有权转让
标题翻译：配方深部组织疼痛的治疗
公开(公告)号：EP2437726A2
公开(公告)日：2012-04-11
申请号：EP10742250.3
申请日：2010-06-03
申请人： Mayo, John Charles , Iliffe, George Langton , Vierl, Ulrich , Rother, Matthias
发明人： Mayo, John Charles , Iliffe, George Langton , Vierl, Ulrich , Rother, Matthias
IPC分类号： A61K9/127
CPC分类号： A61K47/24 , A61K9/0014 , A61K9/06 , A61K9/10 , A61K9/107 , A61K9/12 , A61K9/127 , A61K47/10 , A61K47/12 , A61K47/26 , A61K47/34
摘要： Disclosed herein are vesicular formulations comprising one or more phospholipids and one or more nonionic surfactants that are effective in the treatment of pain or inflammation or osteoarthritis, more specifically in the treatment of deep tissue pain, for example osteoarthritis and other joint or muscle pain, as well as methods of treating pain or inflammation or osteoarthritis, more specifically in the treatment of deep tissue pain, for example osteoarthritis and other joint or muscle pain using same.

9. 发明申请

WO2010140061A2 FORMULATIONS FOR THE TREATMENT OF DEEP TISSUE PAIN 审中-公开
标题翻译：治疗深层组织疼痛的配方
公开(公告)号：WO2010140061A2
公开(公告)日：2010-12-09
申请号：PCT/IB2010001557
申请日：2010-06-03
申请人： MAYO JOHN CHARLES , ILIFFE GEORGE LANGTON , VIERL ULRICH , ROTHER MATTHIAS
发明人： MAYO JOHN CHARLES , ILIFFE GEORGE LANGTON , VIERL ULRICH , ROTHER MATTHIAS
IPC分类号： A61K9/127
CPC分类号： A61K47/24 , A61K9/0014 , A61K9/06 , A61K9/10 , A61K9/107 , A61K9/12 , A61K9/127 , A61K47/10 , A61K47/12 , A61K47/26 , A61K47/34
摘要： Disclosed herein are vesicular formulations comprising one or more phospholipids and one or more nonionic surfactants that are effective in the treatment of pain or inflammation or osteoarthritis, more specifically in the treatment of deep tissue pain, for example osteoarthritis and other joint or muscle pain, as well as methods of treating pain or inflammation or osteoarthritis, more specifically in the treatment of deep tissue pain, for example osteoarthritis and other joint or muscle pain using same.
摘要翻译：本文公开了包含一种或多种磷脂和一种或多种在治疗疼痛或炎症或骨关节炎中有效的非离子表面活性剂的泡囊制剂，更具体地涉及治疗深部组织疼痛，例如骨关节炎和其他关节或肌肉疼痛，如以及治疗疼痛或炎症或骨关节炎的方法，更具体地涉及治疗深部组织疼痛，例如骨关节炎和使用其的其他关节或肌肉疼痛。

10. 发明申请

WO2004032900A8 AGGREGATE WITH INCREASED DEFORMABILITY, COMPRISING AT LEAST THREE AMPHIPATS, FOR IMPROVED TRANSPORT THROUGH SEMI-PERMEABLE BARRIERS AND FOR THE NON-INVASIVE DRUG APPLICATION IN VIVO, ESPECIALLY THROUGH THE SKIN 审中-公开
标题翻译：累积增加的可变性，包括至少三种药物，通过半渗透性障碍物进行改进的运输，以及通过皮肤特别是非侵入性药物应用
公开(公告)号：WO2004032900A8
公开(公告)日：2005-03-31
申请号：PCT/EP0311202
申请日：2003-10-09
申请人： IDEA AG , CEVC GREGOR , VIERL ULRICH
发明人： CEVC GREGOR , VIERL ULRICH
IPC分类号： A61K9/107 , A61K9/00 , A61K9/127 , A61K31/192 , A61K31/195 , A61K31/196 , A61K31/405 , A61K31/5415 , A61K47/10 , A61K47/16 , A61K47/24 , A61K47/26 , A61K47/34 , A61K47/44 , A61P29/00 , H04B7/005
CPC分类号： A61K9/127 , A61K9/0014 , A61K9/1272 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/5415
摘要： The application describes combinations of at least three amphipatic substances forming aggregate suspensions in a polar liquid. Judicious choice of system components, which differ at least 2-times to 10-times in solubility, ensures said aggregates to have extended, unusually adaptable surfaces. This is probably due to simultaneous action on said aggregates of at least two more soluble substances amongst said three system components, at least one of which is an active ingredient and preferably a drug; the third component, alternatively, can take the role of a drug. The application further deals with the use of said combinations in pharmaceutical preparations capable of transporting drugs into the body of warm blood creatures. This is made possible by the drug loading capability of said aggregates with the highly flexible and deformable coating, which renders the resulting drug carriers highly adaptable. The application finally reveals suitable methods and favourable conditions for carrier manufacturing and application. The application also describes novel formulations of nonsteroidal anti-inflammatory drugs (NSAIDs) based on complex aggregates with at least three amphipatic components suspended in a suitable, e.g. pharmaceutically acceptable, polar liquid medium.
摘要翻译：本申请描述了在极性液体中形成聚集体悬浮液的至少三种两亲物质的组合。系统组件的可靠选择，其溶解度至少是2倍至10倍，确保所述聚集体具有延伸的，异常适应性的表面。这可能是由于所述三种体系组分中至少两种可溶性物质对所述聚集体的同时作用，其中至少一种是活性成分，优选药物; 替代地，第三组分可以起到药物的作用。本申请进一步涉及能够将药物输送到温血生物体内的药物制剂中所述组合的用途。这可以通过所述聚集体与高度柔性和可变形的涂层的药物加载能力而实现，这使得所得到的药物载体高度适应。该应用终于揭示了载体制造和应用的合适方法和有利条件。本申请还描述了基于复合聚集体的非甾体抗炎药（NSAID）的新型制剂，其中至少三种两亲成分悬浮在合适的例如，药学上可接受的极性液体培养基。

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