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1. 发明授权

EP0475160B1 Präparat zur Wirkstoffapplikation in Kleinsttröpfchenform 有权转让
标题翻译：对于在微液滴的形式的药物递送制剂
公开(公告)号：EP0475160B1
公开(公告)日：1996-02-14
申请号：EP91114163.8
申请日：1991-08-23
申请人： Cevc, Gregor, Prof. Dr.
发明人： Cevc, Gregor, Prof. Dr.
IPC分类号： A61K9/127
CPC分类号： A61K9/127 , A61K9/0019 , A61K9/1272

2. 发明专利

DE4447287C1 Droplet-in-fluid composition to transport agent e.g. through skin 未知
公开(公告)号：DE4447287C1
公开(公告)日：1996-11-07
申请号：DE4447287
申请日：1994-12-30
申请人： CEVC GREGOR
发明人： CEVC GREGOR PROF DR
IPC分类号： A61K9/127 , A61K20060101 , A61K31/192 , A61K31/195 , A61K31/196 , A61K45/00 , A61K45/08 , B65G47/00
摘要： A composition (A) comprises liquid droplets suspended in a fluid (A) for the transport of at least one active agent, especially for medicinal or biological use, into and through barriers and constrictions such as the skin. The droplets are surrounded by a membrane-type shell made of one or a few layers of amphiphilic carrier substances (I). There are at least two, (Ia) and (Ib), carrier substances with different physico-chemical properties. (Ia) and (Ib) have solubilities in the suspension medium (usually water) that differ by a factor of at least 10. The content of solubilising components is less than 0.1 mol.%, based on the content of (I), so that the solubilising point of the droplets with shells is reached or the solubilising point cannot be reached. Also claimed is a process for the preparation of (A), where the content of amphiphilic components is chosen so that the permeability of (A) through constrictions is at least 10 of the permeability of small molecules, such as water.

3. 发明申请

WO0110413A3 PERIODIC STRUCTURES COMPRISING LIPIDS, POLYELECTROLYTES, AND STRUCTURES-INDUCING SOLUBLE OLIGOVALENT LINKERS 审中-公开
标题翻译：包含脂肪，聚电解质和结构的定期结构诱导可溶性寡糖连接体
公开(公告)号：WO0110413A3
公开(公告)日：2001-08-16
申请号：PCT/EP0007546
申请日：2000-08-03
申请人： IDEA AG , CEVC GREGOR , HUEBNER STEFAN
发明人： CEVC GREGOR , HUEBNER STEFAN
IPC分类号： C12N15/09 , A61K9/127 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K47/14 , A61K47/18 , A61K47/20 , A61K47/22 , A61K47/24 , A61K47/26 , A61K47/28 , A61K47/48 , A61K48/00 , A61P1/04 , A61P1/16 , A61P1/18 , A61P3/12 , A61P5/18 , A61P5/38 , A61P7/00 , A61P7/06 , A61P7/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/06 , A61P19/00 , A61P19/02 , A61P21/00 , A61P25/00 , A61P25/08 , A61P27/02 , A61P29/00 , A61P31/00 , A61P31/22
CPC分类号： A61K9/1272 , A61K47/183
摘要： This invention describes a method for preparing pharmaceutically usable compositions comprising periodic structures consisting of polyelectrolytes sandwiched between lipid aggregates having at least one charged component which is characterised in that a suspension of non-periodic, preferably mono- or bilayer like, lipid aggregates, a solution of polyelectrolyte molecules, and a solution of oligovalent linkers are separately made and then mixed to form said periodic structures, the simultaneous presence of said components catalysing the formation of controlling the rate of formation of said periodic structures comprising at least one layer of lipid component associated with a layer of polyelectrolyte molecules.
摘要翻译：本发明描述了一种用于制备药学上可用的组合物的方法，其包含由夹在具有至少一个带电组分的脂质聚集体之间的聚电解质组成的周期性结构，其特征在于，非周期性，优选单层或双层样脂质聚集体的悬浮液，溶液分离制备寡聚物接头的溶液，然后混合形成所述周期性结构，所述组分的同时存在催化形成控制所述周期性结构形成的速率，其包括至少一层脂质组分相关联与一层聚电解质分子。

4. 发明专利

ES2085936T3 未知
公开(公告)号：ES2085936T3
公开(公告)日：1996-06-16
申请号：ES91114163
申请日：1991-08-23
申请人： CEVC GREGOR
发明人： CEVC GREGOR
IPC分类号： A01N25/04 , A01N25/28 , A61K9/107 , A61K9/127 , A61K47/44
摘要： The invention relates to a preparation for the administration of drugs in the form of minute liquid droplets which are provided, in particular, with a membrane-like covering of one or more layers of amphiphilic molecules or with an amphiphilic carrier substance, in particular for transporting the drug in and through natural barriers and constrictions such as membranes and the like. The preparation contains a boundary-active substance in an amount corresponding to up to 99 mol% of the content of this substance by which the solubilisation point of the droplets is reached. The preparation is suitable for the non-invasive administration of antidiabetics, in particular of insulin. The invention also relates to a process for the production of such preparations.

5. 发明专利

AT134133T 未知
公开(公告)号：AT134133T
公开(公告)日：1996-02-15
申请号：AT91114163
申请日：1991-08-23
申请人： CEVC GREGOR
发明人： CEVC GREGOR
IPC分类号： A01N25/04 , A01N25/28 , A61K9/107 , A61K9/127 , A61K47/44
摘要： The invention relates to a preparation for the administration of drugs in the form of minute liquid droplets which are provided, in particular, with a membrane-like covering of one or more layers of amphiphilic molecules or with an amphiphilic carrier substance, in particular for transporting the drug in and through natural barriers and constrictions such as membranes and the like. The preparation contains a boundary-active substance in an amount corresponding to up to 99 mol% of the content of this substance by which the solubilisation point of the droplets is reached. The preparation is suitable for the non-invasive administration of antidiabetics, in particular of insulin. The invention also relates to a process for the production of such preparations.

6. 发明申请

WO2012126966A2 OPTIMISED PREPARATIONS OF HIGHLY ADAPTABLE AGGREGATES 审中-公开
标题翻译：优选的高度适应性聚合物的制备
公开(公告)号：WO2012126966A2
公开(公告)日：2012-09-27
申请号：PCT/EP2012/055040
申请日：2012-03-21
申请人： CEVC, Gregor
发明人： CEVC, Gregor
IPC分类号： A61K9/127
CPC分类号： A61K9/127 , A61K9/0014 , A61K9/1272
摘要： The present invention describes improved compositions comprising aggregates having a higher adaptability, or deformability, owing to the inclusion of certain hydrophilic additives, including suitable organic ionic compounds. The disclosed compositions demonstrate superior adaptability and stability over otherwise similar compositions lacking the disclosed additives. The invention furthermore provides methods for manufacturing said aggregate preparations, wherein the resulting preparations are useful for applications such as receiving an aggregate payload with active ingredients, for biological agent delivery, and for a non¬ invasive targeted treatment of localised body regions at or below the application site of said aggregates.
摘要翻译：本发明描述了由于包括某些亲水性添加剂（包括合适的有机离子化合物）而包含具有较高适应性或可变形性的聚集体的改进的组合物。所公开的组合物相对于缺乏所公开的添加剂的相似组合物表现出优异的适应性和稳定性。本发明还提供了用于制造所述聚集制剂的方法，其中所得制剂可用于例如接收具有活性成分的聚集体有效载荷，用于生物试剂递送的应用，以及用于非侵入性靶向治疗局部或下方所述聚集体的应用场所。

7. 发明申请

WO2004032900A1 AGGREGATE WITH INCREASED DEFORMABILITY, COMPRISING AT LEAST THREE AMPHIPATS, FOR IMPROVED TRANSPORT THROUGH SEMI-PERMEABLE BARRIERS AND FOR THE NON-INVASIVE DRUG APPLICATION IN VIVO, ESPECIALLY THROUGH THE SKIN 审中-公开
标题翻译：累积增加的可变性，包括至少三种药物，通过半渗透性障碍物进行改进的运输，以及通过皮肤特别是非侵入性药物应用
公开(公告)号：WO2004032900A1
公开(公告)日：2004-04-22
申请号：PCT/EP2003/011202
申请日：2003-10-09
申请人： IDEA AG , CEVC, Gregor , VIERL, Ulrich
发明人： CEVC, Gregor , VIERL, Ulrich
IPC分类号： A61K9/127
CPC分类号： A61K9/127 , A61K9/0014 , A61K9/1272 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/5415
摘要： The application describes combinations of at least three amphipatic substances forming aggregate suspensions in a polar liquid. Judicious choice of system components, which differ at least 2-times to 10-times in solubility, ensures said aggregates to have extended, unusually adaptable surfaces. This is probably due to simultaneous action on said aggregates of at least two more soluble substances amongst said three system components, at least one of which is an active ingredient and preferably a drug; the third component, alternatively, can take the role of a drug. The application further deals with the use of said combinations in pharmaceutical preparations capable of transporting drugs into the body of warm blood creatures. This is made possible by the drug loading capability of said aggregates with the highly flexible and deformable coating, which renders the resulting drug carriers highly adaptable. The application finally reveals suitable methods and favourable conditions for carrier manufacturing and application. The application also describes novel formulations of nonsteroidal anti-inflammatory drugs (NSAIDs) based on complex aggregates with at least three amphipatic components suspended in a suitable, e.g. pharmaceutically acceptable, polar liquid medium.
摘要翻译：本申请描述了在极性液体中形成聚集体悬浮液的至少三种两亲物质的组合。系统组件的可靠选择，其溶解度至少是2倍至10倍，确保所述聚集体具有延伸的，异常适应性的表面。这可能是由于所述三种体系组分中至少两种可溶性物质对所述聚集体的同时作用，其中至少一种是活性成分，优选药物; 替代地，第三组分可以起到药物的作用。本申请进一步涉及能够将药物输送到温血生物体内的药物制剂中所述组合的用途。这可以通过所述聚集体与高度柔性和可变形的涂层的药物加载能力而实现，这使得所得到的药物载体高度适应。该应用终于揭示了载体制造和应用的合适方法和有利条件。本申请还描述了基于复合聚集体的非甾体抗炎药（NSAID）的新型制剂，其中至少三种两亲成分悬浮在合适的例如，药学上可接受的极性液体培养基。

8. 发明公开

EP2712314A1 DRUG-FREE COMPOSITIONS AND METHODS FOR DIMINISHING PERIPHERAL INFLAMMATION AND PAIN 审中-公开
标题翻译：无毒组合物和降低外周炎症和疼痛方法
公开(公告)号：EP2712314A1
公开(公告)日：2014-04-02
申请号：EP12710718.3
申请日：2012-03-21
申请人： Cevc, Gregor
发明人： Cevc, Gregor
IPC分类号： A61K9/127 , A61K45/06 , A61P29/00
CPC分类号： A61K9/1272 , A61K9/0014 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/24 , A61K47/26
摘要： The present invention provides drug-free adaptable aggregate compositions, typically having a form of bilayer vesicles suspended in a polar, optionally thickened, fluid comprising different pharmaceutically acceptable excipients for use in or on a mammal for any medical indication, specifically for non-invasive treatment of local inflammation and the associated pain, in particular for use on the skin and underlying tissues, including muscles and/or superficial joints. Accompanying guidelines for selecting components to thereby optimizing the formulations are also provided.

9. 发明公开

EP2688554A2 OPTIMISED PREPARATIONS OF HIGHLY ADAPTABLE AGGREGATES 审中-公开
标题翻译：最佳ZUBEREITUNGEN VON HOCHADAPTIBBENEN AGGREGATEN
公开(公告)号：EP2688554A2
公开(公告)日：2014-01-29
申请号：EP12710719.1
申请日：2012-03-21
申请人： Cevc, Gregor
发明人： Cevc, Gregor
IPC分类号： A61K9/127
CPC分类号： A61K9/127 , A61K9/0014 , A61K9/1272
摘要： The present invention describes improved compositions comprising aggregates having a higher adaptability, or deformability, owing to the inclusion of certain hydrophilic additives, including suitable organic ionic compounds. The disclosed compositions demonstrate superior adaptability and stability over otherwise similar compositions lacking the disclosed additives. The invention furthermore provides methods for manufacturing said aggregate preparations, wherein the resulting preparations are useful for applications such as receiving an aggregate payload with active ingredients, for biological agent delivery, and for a noninvasive targeted treatment of localised body regions at or below the application site of said aggregates.
摘要翻译：本发明描述了由于包括某些亲水性添加剂（包括合适的有机离子化合物）而包含具有较高适应性或可变形性的聚集体的改进的组合物。所公开的组合物相对于缺乏所公开的添加剂的相似组合物表现出优异的适应性和稳定性。本发明还提供了用于制造所述聚集制剂的方法，其中所得制剂可用于例如接收具有活性成分的聚集体有效载荷，用于生物试剂递送的应用，以及用于在施用部位处或下方的非侵入性靶向治疗局部体区的所述聚集体。

10. 发明公开

EP0475160A1 Präparat zur Wirkstoffapplikation in Kleinsttröpfchenform 有权转让
标题翻译： Kleinsttröpfchenform的Präparatzur Wirkstoffapplikation。
公开(公告)号：EP0475160A1
公开(公告)日：1992-03-18
申请号：EP91114163.8
申请日：1991-08-23
申请人： Cevc, Gregor, Prof. Dr.
发明人： Cevc, Gregor, Prof. Dr.
IPC分类号： A61K9/127
CPC分类号： A61K9/127 , A61K9/0019 , A61K9/1272
摘要： Die Erfindung betrifft ein Präparat zur Applikation von Wirkstoffen in Form kleinster, insbesondere mit einer membranartigen Hülle aus einer oder wenigen Lagen amphiphiler Moleküle bzw. mit einer amphiphilen Trägersubstanz versehenen Flüssigkeitströpfchen, insbesondere zum Transport des Wirkstoffes in und durch natürliche Barrieren und Konstriktionen wie Häute und dergleichen. Das Präparat weist einen Gehalt einer randaktiven Substanz auf, der bis zu 99 Mol.-% des Gehaltes dieser Substanz entspricht, durch den der Solubilisierungspunkt der Tröpfchen erreicht wird. Das Präparat eignet sich zur nichtinvasiven Verabreichung von Antidiabetica, insbesondere von Insulin. Die Erfindung betrifft außerdem ein Verfahren zur Herstellung solcher Präparate.
摘要翻译：本发明涉及一种以微小液滴形式给药的制剂，特别是提供了一种或多种两亲性分子或两亲性载体物质的膜状覆盖物，特别是用于运输药物通过天然屏障和收缩膜如膜等。该制剂含有相当于该物质含量达99mol％的边界活性物质，通过该物质达到液滴的溶解点。该制剂适用于非侵入性给予抗糖尿病药，特别是胰岛素。本发明还涉及制备这种制剂的方法。

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