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1. 发明申请

WO2009099719A2 COMPOSITIONS AND METHODS FOR THE TREATMENT OF TUMOR OF HEMATOPOIETIC ORIGIN 审中-公开
标题翻译：用于治疗HEMATOPOIETIC ORIGIN肿瘤的组合物和方法
公开(公告)号：WO2009099719A2
公开(公告)日：2009-08-13
申请号：PCT/US2009/030851
申请日：2009-01-13
申请人： GENENTECH, INC. , CROWLEY, Craig , DESAUVAGE, Frederic, J. , EATON, Dan, L. , EBENS, Allen, Jr. , ELKINS, Kristi , HONGO, Jo-Anne, S. , JUNUTULA, Jagath, Reddy , POLSON, Andrew , ROSS, Sarajane , SMITH, Victoria , VANDLEN, Richard, L. , ZHENG, Bing
发明人： CROWLEY, Craig , DESAUVAGE, Frederic, J. , EATON, Dan, L. , EBENS, Allen, Jr. , ELKINS, Kristi , HONGO, Jo-Anne, S. , JUNUTULA, Jagath, Reddy , POLSON, Andrew , ROSS, Sarajane , SMITH, Victoria , VANDLEN, Richard, L. , ZHENG, Bing
IPC分类号： A61K47/48 , C07K16/28 , C07K16/46 , A61P35/00 , C12N5/20
CPC分类号： C07K16/2803 , A61K38/00 , A61K47/6817 , A61K47/6851 , A61K2039/505 , C07K14/705 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/624 , C07K2317/73 , C07K2317/77 , C07K2317/92 , G01N33/574
摘要： The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.
摘要翻译：本发明涉及可用于治疗哺乳动物造血肿瘤的物质组合物，以及使用这些物质组合物的方法。

2. 发明申请

WO02070706A3 INTERLEUKIN-8 HOMOLOGOUS POLYPEPTIDES AND THERAPEUTIC USES THEREOF 审中-公开
标题翻译：白细胞介素-8同源多肽及其治疗方法
公开(公告)号：WO02070706A3
公开(公告)日：2003-04-17
申请号：PCT/US0148060
申请日：2001-12-07
申请人： GENENTECH INC , FRENCH DOROTHY , GRIMALDI J CHRISTOPHER , HILIAN KENNETH J , PISABARRO MARIA TERESA , SCHMIDT KERSTIN N , SMITH VICTORIA , TUMAS DANIEL , VANDLEN RICHARD L , WATANABE COLIN K , WILLIAMS P MICKEY , WOOD WILLIAM I
发明人： FRENCH DOROTHY , GRIMALDI J CHRISTOPHER , HILIAN KENNETH J , PISABARRO MARIA TERESA , SCHMIDT KERSTIN N , SMITH VICTORIA , TUMAS DANIEL , VANDLEN RICHARD L , WATANABE COLIN K , WILLIAMS P MICKEY , WOOD WILLIAM I
IPC分类号： G01N33/50 , A01K67/027 , A61K38/00 , A61K38/17 , A61K39/00 , A61K39/395 , A61K45/00 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/00 , A61P7/06 , A61P9/00 , A61P11/02 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P37/02 , A61P37/06 , A61P37/08 , C07H21/04 , C07K14/435 , C07K14/47 , C07K14/54 , C07K16/18 , C07K16/24 , C07K16/40 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/85 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/567 , G01N33/574
CPC分类号： G01N33/567 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , C07K14/47 , C12N15/8509 , G01N33/57484 , G01N2800/52
摘要： The present invention is directed to novel polypeptides having structural homology to IL-8 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treatment and diagnosis of inflammatory diseases.
摘要翻译：本发明涉及与IL-8和编码那些多肽的核酸分子具有结构同源性的新型多肽。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。本文进一步提供了治疗和诊断炎性疾病的方法。

3. 发明申请

WO2011069104A2 MULTISPECIFIC ANTIBODIES, ANTIBODY ANALOGS, COMPOSITIONS, AND METHODS 审中-公开
标题翻译：多特异性抗体，抗体类似物，组合物和方法
公开(公告)号：WO2011069104A2
公开(公告)日：2011-06-09
申请号：PCT/US2010/058958
申请日：2010-12-03
申请人： GENENTECH, INC. , F. HOFFMANN-LA ROCHE AG , SCHEER, Justin , VANDLEN, Richard L.
发明人： SCHEER, Justin , VANDLEN, Richard L.
IPC分类号： A61K39/395 , C12P21/06
CPC分类号： C07K16/468 , A61K2039/505 , C07K16/283 , C07K16/2863 , C07K16/32 , C07K2317/31 , C07K2317/55 , C07K2317/73 , C07K2317/75 , C07K2317/76 , C07K2317/90
摘要： Multispecific antibodies that specifically bind at least two different epitopes are provided. Structural variants of native antibodies (antibody analogs) are also provided. Also provided are multispecific antibodies and antibody analogs having a range of biological activities. Agonist and antagonist multispecific antibodies and agonist and antagonist antibody analogs are provided. Multispecific antibodies and antibody analogs conjugated with therapeutic and/or diagnostic agents are also provided, as are multispecific antibodies and antibody analogs conjugated with agents to increase in vivo half-life compared to multispecific antibodies and antibody analogs lacking such agents. In addition, methods of making multispecific antibodies and antibody analogs and compositions comprising multispecific antibodies and antibody analogs are provided. Therapeutic, research, and diagnostic uses of multispecific antibodies and antibody analogs are also provided.
摘要翻译：提供了特异性结合至少两个不同表位的多特异性抗体。还提供了天然抗体的结构变体（抗体类似物）。还提供了具有一系列生物学活性的多特异性抗体和抗体类似物。提供了激动剂和拮抗剂多特异性抗体和激动剂和拮抗剂抗体类似物。还提供了与治疗剂和/或诊断剂缀合的多特异性抗体和抗体类似物，多特异性抗体和与试剂缀合的抗体类似物与增加体内半衰期的多特异性抗体和缺乏这些试剂的抗体类似物相比。另外，提供了制备包含多特异性抗体和抗体类似物的多特异性抗体和抗体类似物和组合物的方法。还提供了多特异性抗体和抗体类似物的治疗，研究和诊断用途。

4. 发明申请

WO2009099719A3 COMPOSITIONS AND METHODS FOR THE TREATMENT OF TUMOR OF HEMATOPOIETIC ORIGIN 审中-公开
标题翻译：用于治疗HEMATOPOIETIC ORIGIN肿瘤的组合物和方法
公开(公告)号：WO2009099719A3
公开(公告)日：2009-10-29
申请号：PCT/US2009030851
申请日：2009-01-13
申请人： GENENTECH INC , CROWLEY CRAIG , DESAUVAGE FREDERIC J , EATON DAN L , EBENS ALLEN JR , ELKINS KRISTI , HONGO JO-ANNE S , JUNUTULA JAGATH REDDY , POLSON ANDREW , ROSS SARAJANE , SMITH VICTORIA , VANDLEN RICHARD L , ZHENG BING
发明人： CROWLEY CRAIG , DESAUVAGE FREDERIC J , EATON DAN L , EBENS ALLEN JR , ELKINS KRISTI , HONGO JO-ANNE S , JUNUTULA JAGATH REDDY , POLSON ANDREW , ROSS SARAJANE , SMITH VICTORIA , VANDLEN RICHARD L , ZHENG BING
IPC分类号： A61K47/48 , A61P35/00 , C07K16/28 , C07K16/46 , C12N5/20
CPC分类号： C07K16/2803 , A61K38/00 , A61K47/6817 , A61K47/6851 , A61K2039/505 , C07K14/705 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/624 , C07K2317/73 , C07K2317/77 , C07K2317/92 , G01N33/574
摘要： Compositions of matter useful for the treatment of hematopoietic tumor in mammals and methods of using those compositions of matter for the same.
摘要翻译：用于治疗哺乳动物造血肿瘤的物质组合物和使用这些物质组合物的方法。

5. 发明申请

WO2004004662A3 COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF TUMOR 审中-公开
标题翻译：用于诊断和治疗肿瘤的组合物和方法
公开(公告)号：WO2004004662A3
公开(公告)日：2005-08-11
申请号：PCT/US0321606
申请日：2003-07-08
申请人： GENENTECH INC , PHILLIPS HEIDI S , MENG YU-JU G , VANDLEN RICHARD L
发明人： PHILLIPS HEIDI S , MENG YU-JU G , VANDLEN RICHARD L
IPC分类号： A61K38/00 , C07K14/705 , C07K16/30 , G01N33/574 , C07H21/02 , C12N15/85 , C12P21/06
CPC分类号： C07K16/30 , A61K38/00 , C07K14/705 , G01N33/574
摘要： An embeddable corrosion rate meter (ECRM) for detecting and measuring corrosion in metal and concrete structures comprises an electrochemical cell with an ECRM sensor circuit (20). Circuit (20) includes at least one working electrode (10) evenly spaced from counter/reference electrode (12) with the separation distance between the electrodes determining an electrolyte medium resistance. Circuit (20) also includes a current source generated by power source (28) connected through different resistances RI (26) to Rn (24). A first selector is used in applying current through each or the plurality of resistances to working electrode (10) and a second selector (16) selects a duration of the current pulse. Current is applied between the electrodes through galvanostat (22) and polarization of working electrode (10) is measured by voltmeter/A-D converter (18) connected via link (34). The voltmeter has an input impedance greater than a billion ohms. An external reader-head with power link (32) powers circuit (20) and reads and transfers corrosion measurement data via data link (36) to computer (30).
摘要翻译：用于检测和测量金属和混凝土结构腐蚀的嵌入式腐蚀速率计（ECRM）包括具有ECRM传感器电路（20）的电化学电池。电路（20）包括与计数器/参比电极（12）均匀间隔开的至少一个工作电极（10），电极间的距离决定电解质介质电阻。电路（20）还包括通过不同电阻RI（26）至Rn（24）连接的电源（28）产生的电流源。第一选择器用于将电流通过每个或多个电阻施加到工作电极（10），而第二选择器（16）选择电流脉冲的持续时间。通过恒电流器（22）在电极之间施加电流，并且通过连接（34）连接的电压表/ A-D转换器（18）测量工作电极（10）的极化。电压表的输入阻抗大于十亿欧姆。具有电力链路（32）的外部读取器头对电路（20）供电，并且经由数据链路（36）读取并传送腐蚀测量数据到计算机（30）。

6. 发明申请

WO2007130875A2 MICROWAVE ASSISTED DEGLYCOSYLATION OF PROTEINS FOR MOLECULAR WEIGHT DETERMINATION BY MASS SPECTROMETRY 审中-公开
标题翻译：微波辅助蛋白质分解质谱法测定分子量
公开(公告)号：WO2007130875A2
公开(公告)日：2007-11-15
申请号：PCT/US2007/067714
申请日：2007-04-27
申请人： GENENTECH, INC. , ARNOTT, David P. , LILL, Jennie , SANDOVAL, Wendy N. , VANDLEN, Richard L.
发明人： ARNOTT, David P. , LILL, Jennie , SANDOVAL, Wendy N. , VANDLEN, Richard L.
IPC分类号： C12S3/00
CPC分类号： C12P21/00 , G01N33/6842 , G01N33/6848 , G01N2333/924 , G01N2400/00
摘要： Methods are presented for microwave assisted, enzymatic deglycosylation of proteins. The rate at which deglycosylation is achieved and without protein degradation facilitates rapid and accurate molecular weight determination by mass spectrometry.
摘要翻译：介绍了微波辅助，蛋白质酶解脱糖基化的方法。去糖基化达到并且没有蛋白质降解的速率有助于通过质谱法快速准确的分子量测定。

7. 发明申请

WO2002070706A2 INTERLEUKIN-8 HOMOLOGOUS POLYPEPTIDES AND THERAPEUTIC USES THEREOF 审中-公开
标题翻译：白细胞介素-8同源多肽及其治疗方法
公开(公告)号：WO2002070706A2
公开(公告)日：2002-09-12
申请号：PCT/US2001/048060
申请日：2001-12-07
申请人： GENENTECH, INC. , FRENCH, Dorothy , GRIMALDI, J. Christopher , HILIAN, Kenneth, J. , PISABARRO, Maria, Teresa , SCHMIDT, Kerstin, N. , SMITH, Victoria , TUMAS, Daniel , VANDLEN, Richard, L. , WATANABE, Colin, K. , WILLIAMS, P. Mickey , WOOD, William, I.
发明人： FRENCH, Dorothy , GRIMALDI, J. Christopher , HILIAN, Kenneth, J. , PISABARRO, Maria, Teresa , SCHMIDT, Kerstin, N. , SMITH, Victoria , TUMAS, Daniel , VANDLEN, Richard, L. , WATANABE, Colin, K. , WILLIAMS, P. Mickey , WOOD, William, I.
IPC分类号： C12N15/12
CPC分类号： G01N33/567 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , C07K14/47 , C12N15/8509 , G01N33/57484 , G01N2800/52
摘要： The present invention is directed to novel polypeptides having structural homology to IL-8 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treatment and diagnosis of inflammatory diseases.
摘要翻译：本发明涉及与IL-8和编码那些多肽的核酸分子具有结构同源性的新型多肽。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。本文进一步提供了治疗和诊断炎性疾病的方法。

8. 发明申请

WO1997024440A1 OB PROTEIN DERIVATIVES HAVING PROLONGED HALF-LIFE 审中-公开
标题翻译：具有延长半衰期的OB蛋白衍生物
公开(公告)号：WO1997024440A1
公开(公告)日：1997-07-10
申请号：PCT/US1996020718
申请日：1996-12-19
申请人： GENENTECH, INC. , DE SAUVAGE, Frederic, J. , LEVIN, Nancy , VANDLEN, Richard, L.
发明人： GENENTECH, INC.
IPC分类号： C12N15/16
CPC分类号： C07K14/5759 , A61K38/00 , C07K2319/00
摘要： The present invention concerns long half-life derivative of the obesity protein OB. The invention specifically concerns OB protein-immunoglobulin chimeras and polyethylene glycol (PEG)-OB derivatives, which have extended half-life as compared to the corresponding native OB proteins. The invention further relates to methods for appetite and/or weight reduction and for treating other physiological conditions by using the long half-life derivatives of OB.
摘要翻译：本发明涉及肥胖蛋白质OB的长半衰期衍生物。本发明特别涉及与相应的天然OB蛋白相比延长半衰期的OB蛋白 - 免疫球蛋白嵌合体和聚乙二醇（PEG）-OB衍生物。本发明还涉及通过使用OB的长半衰期衍生物来控制食欲和/或体重减轻的方法和用于治疗其它生理状况的方法。

9. 发明申请

WO2011069104A3 MULTISPECIFIC ANTIBODIES, ANTIBODY ANALOGS, COMPOSITIONS, AND METHODS 审中-公开
标题翻译：多重抗体，抗体模拟物，组合物和方法
公开(公告)号：WO2011069104A3
公开(公告)日：2011-08-04
申请号：PCT/US2010058958
申请日：2010-12-03
申请人： GENENTECH INC , HOFFMANN LA ROCHE , SCHEER JUSTIN , VANDLEN RICHARD L
发明人： SCHEER JUSTIN , VANDLEN RICHARD L
IPC分类号： C12P21/08
CPC分类号： C07K16/468 , A61K2039/505 , C07K16/283 , C07K16/2863 , C07K16/32 , C07K2317/31 , C07K2317/55 , C07K2317/73 , C07K2317/75 , C07K2317/76 , C07K2317/90
摘要： Multispecific antibodies that specifically bind at least two different epitopes are provided. Structural variants of native antibodies (antibody analogs) are also provided. Also provided are multispecific antibodies and antibody analogs having a range of biological activities. Agonist and antagonist multispecific antibodies and agonist and antagonist antibody analogs are provided. Multispecific antibodies and antibody analogs conjugated with therapeutic and/or diagnostic agents are also provided, as are multispecific antibodies and antibody analogs conjugated with agents to increase in vivo half-life compared to multispecific antibodies and antibody analogs lacking such agents. In addition, methods of making multispecific antibodies and antibody analogs and compositions comprising multispecific antibodies and antibody analogs are provided. Therapeutic, research, and diagnostic uses of multispecific antibodies and antibody analogs are also provided.
摘要翻译：提供特异性结合至少两个不同表位的多特异性抗体。还提供天然抗体（抗体类似物）的结构变体。还提供具有一系列生物活性的多特异性抗体和抗体类似物。提供激动剂和拮抗剂多特异性抗体和激动剂和拮抗剂抗体类似物。还提供了与治疗和/或诊断剂缀合的多特异性抗体和抗体类似物，与多种特异性抗体和抗体类似物缀合的多特异性抗体和抗体类似物与体内半衰期相比，与缺少此类试剂的多特异性抗体和抗体类似物相比。此外，提供了制备多特异性抗体和抗体类似物的方法以及包含多特异性抗体和抗体类似物的组合物。还提供了多特异性抗体和抗体类似物的治疗，研究和诊断用途。

10. 发明申请

WO2007130875A3 MICROWAVE ASSISTED DEGLYCOSYLATION OF PROTEINS FOR MOLECULAR WEIGHT DETERMINATION BY MASS SPECTROMETRY 审中-公开
标题翻译：微波辅助蛋白质分解质谱法测定分子量
公开(公告)号：WO2007130875A3
公开(公告)日：2008-01-17
申请号：PCT/US2007067714
申请日：2007-04-27
申请人： GENENTECH INC , ARNOTT DAVID P , LILL JENNIE , SANDOVAL WENDY N , VANDLEN RICHARD L
发明人： ARNOTT DAVID P , LILL JENNIE , SANDOVAL WENDY N , VANDLEN RICHARD L
IPC分类号： C12P21/00 , G01N33/68
CPC分类号： C12P21/00 , G01N33/6842 , G01N33/6848 , G01N2333/924 , G01N2400/00
摘要： Methods are presented for microwave assisted, enzymatic deglycosylation of proteins. The rate at which deglycosylation is achieved and without protein degradation facilitates rapid and accurate molecular weight determination by mass spectrometry.
摘要翻译：介绍了微波辅助，蛋白质酶解脱糖基化的方法。去糖基化达到并没有蛋白质降解的速率有助于通过质谱快速准确的分子量测定。

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