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1. 发明申请

WO2002070706A2 INTERLEUKIN-8 HOMOLOGOUS POLYPEPTIDES AND THERAPEUTIC USES THEREOF 审中-公开
标题翻译：白细胞介素-8同源多肽及其治疗方法
公开(公告)号：WO2002070706A2
公开(公告)日：2002-09-12
申请号：PCT/US2001/048060
申请日：2001-12-07
申请人： GENENTECH, INC. , FRENCH, Dorothy , GRIMALDI, J. Christopher , HILIAN, Kenneth, J. , PISABARRO, Maria, Teresa , SCHMIDT, Kerstin, N. , SMITH, Victoria , TUMAS, Daniel , VANDLEN, Richard, L. , WATANABE, Colin, K. , WILLIAMS, P. Mickey , WOOD, William, I.
发明人： FRENCH, Dorothy , GRIMALDI, J. Christopher , HILIAN, Kenneth, J. , PISABARRO, Maria, Teresa , SCHMIDT, Kerstin, N. , SMITH, Victoria , TUMAS, Daniel , VANDLEN, Richard, L. , WATANABE, Colin, K. , WILLIAMS, P. Mickey , WOOD, William, I.
IPC分类号： C12N15/12
CPC分类号： G01N33/567 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , C07K14/47 , C12N15/8509 , G01N33/57484 , G01N2800/52
摘要： The present invention is directed to novel polypeptides having structural homology to IL-8 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treatment and diagnosis of inflammatory diseases.
摘要翻译：本发明涉及与IL-8和编码那些多肽的核酸分子具有结构同源性的新型多肽。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。本文进一步提供了治疗和诊断炎性疾病的方法。

2. 发明申请

WO2006014505A9 INTERLEUKIN-8 HOMOLOGOUS POLYPEPTIDES AND THERAPEUTIC USES THEREOF 审中-公开
标题翻译：白细胞介素-8同源多肽及其治疗方法
公开(公告)号：WO2006014505A9
公开(公告)日：2010-01-14
申请号：PCT/US2005024019
申请日：2005-07-07
申请人： GENENTECH INC , EATON DAN L , PISABARRO MARIA TERESA , SCHMIDT KERSTIN N , VANDLEN RICHARD , CHIANG NANCY , DIEHL LAURI
发明人： EATON DAN L , PISABARRO MARIA TERESA , SCHMIDT KERSTIN N , VANDLEN RICHARD , CHIANG NANCY , DIEHL LAURI
IPC分类号： A61K39/395 , A61K38/00 , C07K16/00 , C07K16/18 , C07K16/44 , C12N5/06 , C12P21/08 , C12Q1/68 , G01N33/53
CPC分类号： G01N33/57449 , C07K14/5421 , C07K16/24 , C07K2317/76 , G01N33/57415 , G01N33/57442 , G01N33/57496 , G01N33/576 , G01N33/6869 , G01N2333/715 , G01N2800/08 , G01N2800/085 , G01N2800/24

3. 发明申请

WO2006014505A2 INTERLEUKIN-8 HOMOLOGOUS POLYPEPTIDES AND THERAPEUTIC USES THEREOF 审中-公开
标题翻译：白细胞介素-8同源多肽及其治疗方法
公开(公告)号：WO2006014505A2
公开(公告)日：2006-02-09
申请号：PCT/US2005/024019
申请日：2005-07-07
申请人： GENENTECH, INC. , EATON, Dan, L. , PISABARRO, Maria, Teresa , SCHMIDT, Kerstin, N. , VANDLEN, Richard , CHIANG, Nancy , DIEHL, Lauri
发明人： EATON, Dan, L. , PISABARRO, Maria, Teresa , SCHMIDT, Kerstin, N. , VANDLEN, Richard , CHIANG, Nancy , DIEHL, Lauri
IPC分类号： G01N33/53 , A61K39/395 , C12N5/06 , C07K16/44 , C07K16/18
CPC分类号： G01N33/57449 , C07K14/5421 , C07K16/24 , C07K2317/76 , G01N33/57415 , G01N33/57442 , G01N33/57496 , G01N33/576 , G01N33/6869 , G01N2333/715 , G01N2800/08 , G01N2800/085 , G01N2800/24
摘要： The present invention is directed to novel polypeptides having structural homology to IL-8 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treatment and diagnosis of inflammatory diseases.
摘要翻译：本发明涉及与IL-8和编码那些多肽的核酸分子具有结构同源性的新型多肽。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。本文进一步提供了治疗和诊断炎性疾病的方法。

4. 发明申请

WO2011107456A1 NOVEL PROTEIN WITH STRUCTURAL HOMOLOGY TO PROTEINS WITH IL-8-LIKE CHEMOKINE FOLD AND USES THEREOF 审中-公开
标题翻译：具有结构性同源异型蛋白质的蛋白质与IL-8样化合物的折叠及其用途
公开(公告)号：WO2011107456A1
公开(公告)日：2011-09-09
申请号：PCT/EP2011/052984
申请日：2011-03-01
申请人： TECHNISCHE UNIVERSITÄT DRESDEN , PISABARRO, Maria Teresa , TOMCZAK, Aurelie
发明人： PISABARRO, Maria Teresa , TOMCZAK, Aurelie
IPC分类号： C07K14/54 , C07K16/24
CPC分类号： C07K14/5421
摘要： The present invention relates to a protein having structural homology to proteins with IL-8-like chemokine fold and uses thereof. The invention has various industrial applications in medical, pharmaceutical and biotechnological applications, such as pharmaceuticals, diagnostics, biosensors and bioreactors. The object of the invention is to provide and use novel secreted proteins with a structural homology to proteins with an IL-8-like chemokine fold which are involved in immune-mediated and inflammatory diseases or neoplastic malignancies. The invention relates to an isolated protein having at least 80% amino acid sequence identity to an amino acid sequence of the protein shown in SEQ ID No.1. The protein according to the invention has structural similarity to proteins of the IL-8-like chemokine fold. The invention also relates to an isolated protein having at least 80% amino acid sequence identity to an amino acid sequence of the protein shown in SEQ ID No. 9. The invention further relates to an isolated protein having at least 80% amino acid sequence identity to an amino acid sequence of the protein shown in SEQ ID No.16, with cysteine residues at positions 20 and 47 and with at least one disulfide bridge formed between two cysteine residues.
摘要翻译：本发明涉及与具有IL-8样趋化因子折叠的蛋白质具有结构同源性的蛋白质及其应用。本发明在药物，诊断，生物传感器和生物反应器等医疗，制药和生物技术应用中具有各种工业应用。本发明的目的是提供和使用具有IL-8样趋化因子折叠蛋白的结构同源性的新型分泌蛋白，其涉及免疫介导的炎性疾病或肿瘤性恶性肿瘤。本发明涉及与SEQ ID No.1所示的蛋白质的氨基酸序列具有至少80％氨基酸序列同一性的分离蛋白质。根据本发明的蛋白质具有与IL-8样趋化因子折叠蛋白的结构相似性。本发明还涉及与SEQ ID No.9所示的蛋白质的氨基酸序列具有至少80％氨基酸序列同一性的分离蛋白质。本发明还涉及具有至少80％氨基酸序列同一性的分离蛋白质涉及SEQ ID No.16所示的蛋白质的氨基酸序列，其中位置20和47处的半胱氨酸残基和在两个半胱氨酸残基之间形成的至少一个二硫键。

5. 发明申请

WO02070706A3 INTERLEUKIN-8 HOMOLOGOUS POLYPEPTIDES AND THERAPEUTIC USES THEREOF 审中-公开
标题翻译：白细胞介素-8同源多肽及其治疗方法
公开(公告)号：WO02070706A3
公开(公告)日：2003-04-17
申请号：PCT/US0148060
申请日：2001-12-07
申请人： GENENTECH INC , FRENCH DOROTHY , GRIMALDI J CHRISTOPHER , HILIAN KENNETH J , PISABARRO MARIA TERESA , SCHMIDT KERSTIN N , SMITH VICTORIA , TUMAS DANIEL , VANDLEN RICHARD L , WATANABE COLIN K , WILLIAMS P MICKEY , WOOD WILLIAM I
发明人： FRENCH DOROTHY , GRIMALDI J CHRISTOPHER , HILIAN KENNETH J , PISABARRO MARIA TERESA , SCHMIDT KERSTIN N , SMITH VICTORIA , TUMAS DANIEL , VANDLEN RICHARD L , WATANABE COLIN K , WILLIAMS P MICKEY , WOOD WILLIAM I
IPC分类号： G01N33/50 , A01K67/027 , A61K38/00 , A61K38/17 , A61K39/00 , A61K39/395 , A61K45/00 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/00 , A61P7/06 , A61P9/00 , A61P11/02 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P37/02 , A61P37/06 , A61P37/08 , C07H21/04 , C07K14/435 , C07K14/47 , C07K14/54 , C07K16/18 , C07K16/24 , C07K16/40 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/85 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/567 , G01N33/574
CPC分类号： G01N33/567 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , C07K14/47 , C12N15/8509 , G01N33/57484 , G01N2800/52
摘要： The present invention is directed to novel polypeptides having structural homology to IL-8 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treatment and diagnosis of inflammatory diseases.
摘要翻译：本发明涉及与IL-8和编码那些多肽的核酸分子具有结构同源性的新型多肽。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。本文进一步提供了治疗和诊断炎性疾病的方法。

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