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1. 发明申请

WO2010010187A1 NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES 审中-公开
标题翻译：用于治疗变应性和炎症性疾病的新型化合物
公开(公告)号：WO2010010187A1
公开(公告)日：2010-01-28
申请号：PCT/EP2009/059599
申请日：2009-07-24
申请人： GALAPAGOS NV , MENET, Christel Jeanne Marie , VAN ROMPAEY, Luc Juliaan Corina , FLETCHER, Stephen Robert
发明人： MENET, Christel Jeanne Marie , VAN ROMPAEY, Luc Juliaan Corina , FLETCHER, Stephen Robert
IPC分类号： C07D471/04 , A61K31/437 , A61P19/00 , A61P29/00
CPC分类号： C07D471/04
摘要： [1,2,4]Triazolo[1,5-a]pyridine compounds are disclosed that have a Formula (I), represented by the following: These compounds may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, diseases involving cartilage degradation, bone and/or joint degradation, for example osteoarthritis; and/or conditions involving inflammation or immune responses, such as Crohn's disease, rheumatoid arthritis, psoriasis, allergic airways disease (e.g. asthma, rhinitis), juvenile idiopathic arthritis, colitis, inflammatory bowel diseases, endotoxin-driven disease states (e.g. complications after bypass surgery or chronic endotoxin states contributing to e.g. chronic cardiac failure), diseases involving impairment of cartilage turnover (e.g. diseases involving the anabolic stimulation of chondrocytes), congenital cartilage malformations, diseases associated with hypersecretion of IL6 and transplantation rejection (e.g. organ transplant rejection) and proliferative diseases.
摘要翻译： [1,2,4]具有式（I）的三唑并[1,5-a]吡啶化合物，由以下表示：这些化合物可以制备为药物组合物，并且可以用于预防和治疗包括人在内的哺乳动物中的各种病症，包括通过非限制性实例，涉及软骨降解，骨和/或关节降解的疾病，例如骨关节炎; 和/或涉及炎症或免疫反应的疾病，例如克罗恩病，类风湿性关节炎，牛皮癣，过敏性气道疾病（例如哮喘，鼻炎），幼年特发性关节炎，结肠炎，炎性肠病，内毒素驱动的疾病状态（例如旁路并发症手术或慢性内毒素状态，例如慢性心脏衰竭），涉及软骨周转损伤的疾病（例如涉及软骨细胞的合成代谢刺激的疾病），先天性软骨畸形，与IL6分泌过高有关的疾病和移植排斥反应（例如器官移植排斥），以及增殖性疾病

2. 发明申请

WO2010010189A1 NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES 审中-公开
标题翻译：用于治疗变应性和炎症性疾病的新型化合物
公开(公告)号：WO2010010189A1
公开(公告)日：2010-01-28
申请号：PCT/EP2009/059603
申请日：2009-07-24
申请人： GALAPAGOS NV , MENET, Christel Jeanne Marie , BLANC, Javier , JOUANNIGOT, Nolwenn , HODGES, Alastair James , VAN ROMPAEY, Luc Juliaan Corina , FLETCHER, Stephen Robert
发明人： MENET, Christel Jeanne Marie , BLANC, Javier , JOUANNIGOT, Nolwenn , HODGES, Alastair James , VAN ROMPAEY, Luc Juliaan Corina , FLETCHER, Stephen Robert
IPC分类号： C07D471/04 , A61K31/437 , A61P19/00 , A61P29/00
CPC分类号： C07D471/04
摘要： Novel [1,2,4]triazolo[1,5-a]pyridine compounds are disclosed that have a Formula represented by the Formula (I). These compounds may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, diseases involving cartilage degradation, bone and/or joint degradation, for example osteoarthritis; and/or conditions involving inflammation or immune responses, such as Crohn's disease, rheumatoid arthritis, psoriasis, allergic airways disease (e.g. asthma, rhinitis), juvenile idiopathic arthritis, colitis, inflammatory bowel diseases, endotoxin-driven disease states (e.g. complications after bypass surgery or chronic endotox in states contributing to e.g. chronic cardiac failure), diseases involving impairment of cartilage turnover (e.g. diseases involving the anabolic stimulation of chondrocytes), congenital cartilage malformations, diseases associated with hypersecretion of IL6 and transplantation rejection (e.g. organ transplant rejection) and proliferative diseases.
摘要翻译：公开了具有由式（I）表示的式的新型[1,2,4]三唑并[1,5-a]吡啶化合物。这些化合物可以作为药物组合物制备，并且可以用于预防和治疗哺乳动物包括人的各种病症，包括作为非限制性实例，涉及软骨退化，骨和/或关节降解的疾病，例如骨关节炎; 和/或涉及炎症或免疫反应的疾病，例如克罗恩病，类风湿性关节炎，牛皮癣，过敏性气道疾病（例如哮喘，鼻炎），幼年特发性关节炎，结肠炎，炎性肠病，内毒素驱动的疾病状态（例如旁路并发症涉及软骨周转的疾病（例如涉及软骨细胞的合成代谢刺激的疾病），先天性软骨畸形，与IL6分泌过高有关的疾病和移植排斥反应（例如器官移植排斥）的疾病，和增殖性疾病。

3. 发明申请

WO2005103716A3 METHODS, AGENTS, AND COMPOUND SCREENING ASSAYS FOR INDUCING DIFFERENTIATION OF UNDIFFERENTIATED MAMMALIAN CELLS INTO OSTEOBLASTS 审中-公开
标题翻译：用于诱导不稳定的哺乳动物细胞分化成OSTEOBLASTS的方法，试剂和化合物筛选测定
公开(公告)号：WO2005103716A3
公开(公告)日：2006-08-10
申请号：PCT/EP2005051914
申请日：2005-04-27
申请人： GALAPAGOS NV , VAN ROMPAEY LUC JULIAAN CORINA , TOMME PETER HERWIG MARIA , BROWN ROBIN JOHN
发明人： VAN ROMPAEY LUC JULIAAN CORINA , TOMME PETER HERWIG MARIA , BROWN ROBIN JOHN
IPC分类号： G01N33/566 , A61K48/00 , A61P19/10 , C12N15/11 , G01N33/50
CPC分类号： G01N33/566 , C12N15/111 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/11 , C12N2320/12 , G01N33/5026 , G01N2333/51 , G01N2500/04 , G01N2800/108
摘要： The present invention relates to methods, agents and compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts. The invention thus provides a method, comprising contacting a compound with a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID No: 194-309; and measuring a compound-polypeptide property related to the differentiation of said cells. The invention further relates to a bone formation enhancing pharmaceutical composition, and the use thereof in treating and/or preventing a disease involving a systemic or local decrease in mean bone density in a subject. Furthermore, the invention relates to a method for thein vitro production of bone tissue.
摘要翻译：本发明涉及用于诱导未分化哺乳动物细胞分化成成骨细胞的方法，试剂和化合物筛选试验。因此，本发明提供了一种方法，包括使化合物与包含选自SEQ ID No：194-309的氨基酸序列的多肽接触; 并测量与所述细胞的分化相关的化合物 - 多肽性质。本发明进一步涉及增强骨形成的药物组合物，以及其在治疗和/或预防受试者的全身或局部平均骨密度降低的疾病中的用途。此外，本发明涉及骨组织的体外生产方法。

4. 发明申请

WO2010010188A1 NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES. 审中-公开
标题翻译：用于治疗变应性和炎症性疾病的新型化合物。
公开(公告)号：WO2010010188A1
公开(公告)日：2010-01-28
申请号：PCT/EP2009/059600
申请日：2009-07-24
申请人： GALAPAGOS NV , MENET, Christel Jeanne Marie , BLANC, Javier , JOUANNIGOT, Nolwenn , HODGES, Alastair James , VAN ROMPAEY, Luc Juliaan Corina , FLETCHER, Stephen Robert
发明人： MENET, Christel Jeanne Marie , BLANC, Javier , JOUANNIGOT, Nolwenn , HODGES, Alastair James , VAN ROMPAEY, Luc Juliaan Corina , FLETCHER, Stephen Robert
IPC分类号： C07D471/04 , A61K31/437 , A61P19/02
CPC分类号： C07D471/04
摘要： Novel [l,2,4]triazolo[l,5-a]pyridine compounds are disclosed that have a formula represented by the Formula I. The compounds may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non- limiting example, diseases involving cartilage degradation, bone and/or joint degradation, for example osteoarthritis; and/or conditions involving inflammation or immune responses, such as Crohn's disease, rheumatoid arthritis, psoriasis, allergic airways disease (e.g. asthma, rhinitis), juvenile idiopathic arthritis, colitis, inflammatory bowel diseases, endotoxin-driven disease states (e.g. complications after bypass surgery or chronic endotoxin states contributing to e.g. chronic cardiac failure), diseases involving impairment of cartilage turnover (e.g. diseases involving the anabolic stimulation of chondrocytes), congenital cartilage malformations, diseases associated with hypersecretion of IL6 and transplantation rejection (e.g. organ transplant rejection) and proliferative diseases.
摘要翻译：公开了具有由式I表示的式的新型[1,2,4]三唑并[1,5-a]吡啶化合物。该化合物可以制备为药物组合物，并且可用于预防和治疗哺乳动物包括人的各种条件，包括非限制性实例，涉及软骨退化，骨和/或关节降解的疾病，例如骨关节炎; 和/或涉及炎症或免疫反应的疾病，例如克罗恩病，类风湿性关节炎，牛皮癣，过敏性气道疾病（例如哮喘，鼻炎），幼年特发性关节炎，结肠炎，炎性肠病，内毒素驱动的疾病状态（例如旁路并发症手术或慢性内毒素状态，例如慢性心脏衰竭），涉及软骨周转损伤的疾病（例如涉及软骨细胞的合成代谢刺激的疾病），先天性软骨畸形，与IL6分泌过高相关的疾病和移植排斥反应（例如器官移植排斥）以及增殖性疾病

5. 发明申请

WO2005063976A3 METHODS FOR INDUCING DIFFERENTIATION OF UNDIFFERENTIATED MAMMALIAN CELLS INTO OSTEOBLASTS 审中-公开
标题翻译：诱导不育MAMMALIAN细胞分化为OSTEOBLASTS的方法
公开(公告)号：WO2005063976A3
公开(公告)日：2005-12-15
申请号：PCT/EP2004014885
申请日：2004-12-29
申请人： GALAGAPOS N V , VAN ROMPAEY LUC JULIAAN CORINA , TOMME PETER HERWIG MARIA , BROWN ROBIN JOHN
发明人： VAN ROMPAEY LUC JULIAAN CORINA , TOMME PETER HERWIG MARIA , BROWN ROBIN JOHN
IPC分类号： C12N5/077 , C12N15/113 , G01N33/68 , C12N15/11 , A61K31/713 , A61P19/08 , A61P19/10 , C07K16/00 , C12N5/10 , C12Q1/68 , G01N33/50
CPC分类号： C12N15/1137 , C12N5/0654 , C12N2310/11 , C12N2310/111 , C12N2310/14 , C12N2310/315 , C12N2310/53 , C12N2510/00 , C12N2799/021 , C12Y207/11001 , G01N33/6893
摘要： The present invention provides methods for inducing differentiation of undifferentiated mammalian cells into osteoblasts, and methods for identifying a compound that induces differentiation of undifferentiated mammalian cells into osteoblasts. In addition, the present invention provides polynucleotides and vectors, and the use thereof as a medicament for the treatment of a disease involving a systemic or local decrease in mean bone density. Moreover, the present invention provides methods for in vitro production of bone tissue, osteoblast cells and methods for diagnosing a pathological condition involving a systemic or local decrease in mean bone density or a susceptibility to the condition.
摘要翻译：本发明提供了诱导未分化哺乳动物细胞分化为成骨细胞的方法，以及用于鉴定诱导未分化哺乳动物细胞分化成成骨细胞的化合物的方法。此外，本发明提供多核苷酸和载体，以及其用作治疗涉及全身或局部平均骨密度降低的疾病的药物的用途。此外，本发明提供了用于体外生产骨组织，成骨细胞的方法和用于诊断涉及全身或局部平均骨密度降低或对该病症易感性的病理状况的方法。

6. 发明申请

WO2005103716A2 METHODS, AGENTS, AND COMPOUND SCREENING ASSAYS FOR INDUCING DIFFERENTIATION OF UNDIFFERENTIATED MAMMALIAN CELLS INTO OSTEOBLASTS 审中-公开
标题翻译：用于诱导不稳定的哺乳动物细胞分化成OSTEOBLASTS的方法，试剂和化合物筛选测定
公开(公告)号：WO2005103716A2
公开(公告)日：2005-11-03
申请号：PCT/EP2005/051914
申请日：2005-04-27
申请人： GALAPAGOS GENOMICS N.V. , VAN ROMPAEY, Luc, Juliaan, Corina , TOMME, Peter, Herwig, Maria , BROWN, Robin, John
发明人： VAN ROMPAEY, Luc, Juliaan, Corina , TOMME, Peter, Herwig, Maria , BROWN, Robin, John
IPC分类号： G01N33/68
CPC分类号： G01N33/566 , C12N15/111 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/11 , C12N2320/12 , G01N33/5026 , G01N2333/51 , G01N2500/04 , G01N2800/108
摘要： The present invention relates to methods, agents and compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts. The invention thus provides a method, comprising contacting a compound with a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID No: 194-309; and measuring a compound-polypeptide property related to the differentiation of said cells. The invention further relates to a bone formation enhancing pharmaceutical composition, and the use thereof in treating and/or preventing a disease involving a systemic or local decrease in mean bone density in a subject. Furthermore, the invention relates to a method for the in vitro production of bone tissue.
摘要翻译：本发明涉及用于诱导未分化哺乳动物细胞分化成成骨细胞的方法，试剂和化合物筛选试验。因此，本发明提供了一种方法，包括使化合物与包含选自SEQ ID No：194-309的氨基酸序列的多肽接触; 并测量与所述细胞的分化相关的化合物 - 多肽性质。本发明进一步涉及增强骨形成的药物组合物，以及其在治疗和/或预防受试者的全身或局部平均骨密度降低的疾病中的用途。此外，本发明涉及体外生产骨组织的方法。

7. 发明申请

WO2010010190A1 NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES 审中-公开
标题翻译：用于治疗衰老和炎症疾病的新型化合物
公开(公告)号：WO2010010190A1
公开(公告)日：2010-01-28
申请号：PCT/EP2009/059604
申请日：2009-07-24
申请人： GALAPAGOS NV , MENET, Christel Jeanne Marie , VAN ROMPAEY, Luc Juliaan Corina , FLETCHER, Stephen Robert , BLANC, Javier , JOUANNIGOT, Nolwenn , HODGES, Alastair James , SMITS, Koen Kurt
发明人： MENET, Christel Jeanne Marie , VAN ROMPAEY, Luc Juliaan Corina , FLETCHER, Stephen Robert , BLANC, Javier , JOUANNIGOT, Nolwenn , HODGES, Alastair James , SMITS, Koen Kurt
IPC分类号： C07D471/04 , A61K31/437 , A61P19/02
CPC分类号： A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/4995 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/5386 , A61K31/541 , A61K31/551 , C07D471/04
摘要： [1,2,4]Triazolo[1,5- a ]pyridine compounds are disclosed that have a formula represented by the formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non- limiting example, diseases involving cartilage degradation, bone and/or joint degradation, for example osteoarthritis; and/or conditions involving inflammation or immune responses, such as Crohn's disease, rheumatoid arthritis, psoriasis, allergic airways disease (e.g. asthma, rhinitis), juvenile idiopathic arthritis, colitis, inflammatory bowel diseases, endotoxin-driven disease states (e.g. complications after bypass surgery or chronic endotoxin states contributing to e.g. chronic cardiac failure), diseases involving impairment of cartilage turnover (e.g diseases involving the anabolic stimulation of chondrocytes), congenital cartilage malformations, diseases associated with hypersecretion of IL6, transplantation rejection (e.g. organ transplant rejection) and proliferative diseases.
摘要翻译： [1,2,4]三唑并[1,5-a]吡啶化合物，其具有由式（I）表示的式。化合物可以制备成药物组合物，并且可以用于预防和治疗包括人在内的哺乳动物中的各种病症，包括通过非限制性实例，涉及软骨降解，骨和/或关节降解的疾病，用于例如骨关节炎; 和/或涉及炎症或免疫反应的疾病，例如克罗恩病，类风湿性关节炎，银屑病，过敏性气道疾病（例如哮喘，鼻炎），幼年特发性关节炎，结肠炎，炎性肠病，内毒素驱动的疾病状态（例如旁路并发症手术或慢性内毒素状态，例如慢性心脏衰竭），涉及软骨周转损伤的疾病（例如涉及软骨细胞的合成代谢刺激的疾病），先天性软骨畸形，与IL6分泌过高相关的疾病，移植排斥反应（例如器官移植排斥）和增殖性疾病

8. 发明申请

WO2010010186A1 NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES 审中-公开
标题翻译：用于治疗变应性和炎症性疾病的新型化合物
公开(公告)号：WO2010010186A1
公开(公告)日：2010-01-28
申请号：PCT/EP2009/059598
申请日：2009-07-24
申请人： GALAPAGOS NV , MENET, Christel Jeanne Marie , JOUANNIGOT, Nolwenn , BLANC, Javier , VAN ROMPAEY, Luc Juliaan Corina , FLETCHER, Stephen Robert
发明人： MENET, Christel Jeanne Marie , JOUANNIGOT, Nolwenn , BLANC, Javier , VAN ROMPAEY, Luc Juliaan Corina , FLETCHER, Stephen Robert
IPC分类号： C07D471/04 , A61K31/437 , A61P19/02
CPC分类号： C07D471/04
摘要： [1,2,4]Triazolo[1,5-a]pyridine compounds are disclosed that have a formula represented by the following: (I) These compound may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, diseases involving cartilage degradation, bone and/or joint degradation, for example osteoarthritis; and/or conditions involving inflammation or immune responses, such as Crohn's disease, rheumatoid arthritis, psoriasis, allergic airways disease (e.g. asthma, rhinitis), juvenile idiopathic arthritis, colitis, inflammatory bowel diseases, endotoxin-driven disease states (e.g. complications after bypass surgery or chronic endotoxin states contributing to e.g. chronic cardiac failure), diseases involving impairment of cartilage turnover (e.g. diseases involving the anabolic stimulation of chondrocytes), congenital cartilage malformations, diseases associated with hypersecretion of IL6 and transplantation rejection (e.g. organ transplant rejection) and proliferative diseases.
摘要翻译： [1,2,4]三唑并[1,5-a]吡啶化合物，其具有由下式表示的式：（I）这些化合物可以制备为药物组合物，并且可用于预防和治疗包括通过非限制性实例的包括软骨降解，骨和/或关节降解的疾病，例如骨关节炎的疾病; 和/或涉及炎症或免疫反应的疾病，例如克罗恩病，类风湿性关节炎，牛皮癣，过敏性气道疾病（例如哮喘，鼻炎），幼年特发性关节炎，结肠炎，炎性肠病，内毒素驱动的疾病状态（例如旁路并发症手术或慢性内毒素状态，例如慢性心脏衰竭），涉及软骨周转损伤的疾病（例如涉及软骨细胞的合成代谢刺激的疾病），先天性软骨畸形，与IL6分泌过高有关的疾病和移植排斥反应（例如器官移植排斥），以及增殖性疾病

9. 发明申请

WO2010010184A1 [1, 2, 4] TRIAZOLO [1, 5-A] PYRIDINES AS JAK INHIBITORS 审中-公开
标题翻译： [1,2,4]三唑并[1,5-A]吡啶作为JAK抑制剂
公开(公告)号：WO2010010184A1
公开(公告)日：2010-01-28
申请号：PCT/EP2009/059595
申请日：2009-07-24
申请人： GALAPAGOS NV , MENET, Christel, Jeanne, Marie , BLANC, Javier , HODGES, Alastair, James , BURLI, Roland, Werner , BRECCIA, Perla , BLACKABY, Wesley, Peter , VAN ROMPAEY, Luc, Juliaan, Corina , FLETCHER, Stephen, Robert
发明人： MENET, Christel, Jeanne, Marie , BLANC, Javier , HODGES, Alastair, James , BURLI, Roland, Werner , BRECCIA, Perla , BLACKABY, Wesley, Peter , VAN ROMPAEY, Luc, Juliaan, Corina , FLETCHER, Stephen, Robert
IPC分类号： C07D471/04 , A61K31/437 , A61P19/02 , A61P29/00
CPC分类号： C07D471/04
摘要： Novel [1,2,4]triazolo[1,5-a]pyridine compounds are disclosed that have a Formula represented by the following: (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, joint disease, inflammation, and others.
摘要翻译：公开了具有下列表示的式（I）的新型[1,2,4]三唑并[1,5-a]吡啶化合物。化合物可以制备成药物组合物，并且可以用于预防和治疗包括人在内的哺乳动物中的各种病症，包括作为非限制性实例，关节疾病，炎症等。

10. 发明申请

WO2005063983A1 MODULATORS OF BONE HOMEOSTASIS IDENTIFIED IN A HIGH-THROUGHPUT SCREEN 审中-公开
标题翻译：在高通量屏幕中识别的骨质疏松症的调节剂
公开(公告)号：WO2005063983A1
公开(公告)日：2005-07-14
申请号：PCT/EP2003/014994
申请日：2003-12-29
申请人： GALAPAGOS GENOMICS N.V. , VAN ROMPAEY, Luc, Juliaan, Corina , TOMME, Peter, Herwig, Maria , BROWN, Robin, John
发明人： VAN ROMPAEY, Luc, Juliaan, Corina , TOMME, Peter, Herwig, Maria , BROWN, Robin, John
IPC分类号： C12N15/11
CPC分类号： C12N15/1137 , C12N5/0654 , C12N2310/11 , C12N2310/111 , C12N2310/14 , C12N2310/315 , C12N2310/53 , C12N2510/00 , C12N2799/021 , C12Y207/11001 , G01N33/6893
摘要： The present invention provides a method for inducing differentiation of undifferentiated mammalian cells into osteoblasts, and a method for identifying a compound that induces differentiation of undifferentiated mammalian cells into osteoblasts. In addition, the present invention provides polynucleotide sequences and vectors for use as a medicament for the treatment of a disease involving a systemic or local decrease in mean bone density. Moreover, the present invention provides a method for in vitro production of bone tissue, osteoblast cells and use of the osteoblast cells for in vitro production of bone tissue. In addition, a method for diagnosing a pathological condition involving a systemic or local decrease in mean bone density or a susceptibility to the condition in a subject is provided.
摘要翻译：本发明提供了诱导未分化哺乳动物细胞分化为成骨细胞的方法，以及鉴定诱导未分化哺乳动物细胞分化成成骨细胞的化合物的方法。此外，本发明提供用作治疗涉及全身或局部平均骨密度降低的疾病的药物的多核苷酸序列和载体。此外，本发明提供了体外生产骨组织，成骨细胞和成骨细胞用于体外产生骨组织的方法。此外，提供了诊断涉及全身或局部平均骨密度降低或对受试者的状况易感性的病理状况的方法。

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