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1. 发明申请

WO2010149771A1 NOVEL COMPOUND USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES 审中-公开
标题翻译：用于治疗衰老和炎症疾病的新型化合物
公开(公告)号：WO2010149771A1
公开(公告)日：2010-12-29
申请号：PCT/EP2010/059067
申请日：2010-06-25
申请人： GALAPAGOS NV , MENET, Christel Jeanne Marie , BLANC, Javier
发明人： BLANC, Javier
IPC分类号： C07D471/04 , A61K31/437 , A61P29/00 , A61P35/00 , A61P37/00
CPC分类号： C07D471/04 , A61K31/437 , A61K45/06
摘要： A compound is disclosed that has a formula represented by the following: (I). This compound may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non- limiting example, inflammatory conditions, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6.
摘要翻译：公开了具有由下式表示的式的化合物：（I）。该化合物可以制备为药物组合物，并且可以用于预防和治疗包括人在内的哺乳动物中的各种病症，包括作为非限制性实例，炎性病症，自身免疫性疾病，增殖性疾病，移植排斥反应，涉及软骨周转损害，先天性软骨畸形和/或与IL6分泌过多相关的疾病的疾病。

2. 发明申请

WO2010010189A1 NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES 审中-公开
标题翻译：用于治疗变应性和炎症性疾病的新型化合物
公开(公告)号：WO2010010189A1
公开(公告)日：2010-01-28
申请号：PCT/EP2009/059603
申请日：2009-07-24
申请人： GALAPAGOS NV , MENET, Christel Jeanne Marie , BLANC, Javier , JOUANNIGOT, Nolwenn , HODGES, Alastair James , VAN ROMPAEY, Luc Juliaan Corina , FLETCHER, Stephen Robert
发明人： MENET, Christel Jeanne Marie , BLANC, Javier , JOUANNIGOT, Nolwenn , HODGES, Alastair James , VAN ROMPAEY, Luc Juliaan Corina , FLETCHER, Stephen Robert
IPC分类号： C07D471/04 , A61K31/437 , A61P19/00 , A61P29/00
CPC分类号： C07D471/04
摘要： Novel [1,2,4]triazolo[1,5-a]pyridine compounds are disclosed that have a Formula represented by the Formula (I). These compounds may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, diseases involving cartilage degradation, bone and/or joint degradation, for example osteoarthritis; and/or conditions involving inflammation or immune responses, such as Crohn's disease, rheumatoid arthritis, psoriasis, allergic airways disease (e.g. asthma, rhinitis), juvenile idiopathic arthritis, colitis, inflammatory bowel diseases, endotoxin-driven disease states (e.g. complications after bypass surgery or chronic endotox in states contributing to e.g. chronic cardiac failure), diseases involving impairment of cartilage turnover (e.g. diseases involving the anabolic stimulation of chondrocytes), congenital cartilage malformations, diseases associated with hypersecretion of IL6 and transplantation rejection (e.g. organ transplant rejection) and proliferative diseases.
摘要翻译：公开了具有由式（I）表示的式的新型[1,2,4]三唑并[1,5-a]吡啶化合物。这些化合物可以作为药物组合物制备，并且可以用于预防和治疗哺乳动物包括人的各种病症，包括作为非限制性实例，涉及软骨退化，骨和/或关节降解的疾病，例如骨关节炎; 和/或涉及炎症或免疫反应的疾病，例如克罗恩病，类风湿性关节炎，牛皮癣，过敏性气道疾病（例如哮喘，鼻炎），幼年特发性关节炎，结肠炎，炎性肠病，内毒素驱动的疾病状态（例如旁路并发症涉及软骨周转的疾病（例如涉及软骨细胞的合成代谢刺激的疾病），先天性软骨畸形，与IL6分泌过高有关的疾病和移植排斥反应（例如器官移植排斥）的疾病，和增殖性疾病。

3. 发明申请

WO2010010188A1 NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES. 审中-公开
标题翻译：用于治疗变应性和炎症性疾病的新型化合物。
公开(公告)号：WO2010010188A1
公开(公告)日：2010-01-28
申请号：PCT/EP2009/059600
申请日：2009-07-24
申请人： GALAPAGOS NV , MENET, Christel Jeanne Marie , BLANC, Javier , JOUANNIGOT, Nolwenn , HODGES, Alastair James , VAN ROMPAEY, Luc Juliaan Corina , FLETCHER, Stephen Robert
发明人： MENET, Christel Jeanne Marie , BLANC, Javier , JOUANNIGOT, Nolwenn , HODGES, Alastair James , VAN ROMPAEY, Luc Juliaan Corina , FLETCHER, Stephen Robert
IPC分类号： C07D471/04 , A61K31/437 , A61P19/02
CPC分类号： C07D471/04
摘要： Novel [l,2,4]triazolo[l,5-a]pyridine compounds are disclosed that have a formula represented by the Formula I. The compounds may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non- limiting example, diseases involving cartilage degradation, bone and/or joint degradation, for example osteoarthritis; and/or conditions involving inflammation or immune responses, such as Crohn's disease, rheumatoid arthritis, psoriasis, allergic airways disease (e.g. asthma, rhinitis), juvenile idiopathic arthritis, colitis, inflammatory bowel diseases, endotoxin-driven disease states (e.g. complications after bypass surgery or chronic endotoxin states contributing to e.g. chronic cardiac failure), diseases involving impairment of cartilage turnover (e.g. diseases involving the anabolic stimulation of chondrocytes), congenital cartilage malformations, diseases associated with hypersecretion of IL6 and transplantation rejection (e.g. organ transplant rejection) and proliferative diseases.
摘要翻译：公开了具有由式I表示的式的新型[1,2,4]三唑并[1,5-a]吡啶化合物。该化合物可以制备为药物组合物，并且可用于预防和治疗哺乳动物包括人的各种条件，包括非限制性实例，涉及软骨退化，骨和/或关节降解的疾病，例如骨关节炎; 和/或涉及炎症或免疫反应的疾病，例如克罗恩病，类风湿性关节炎，牛皮癣，过敏性气道疾病（例如哮喘，鼻炎），幼年特发性关节炎，结肠炎，炎性肠病，内毒素驱动的疾病状态（例如旁路并发症手术或慢性内毒素状态，例如慢性心脏衰竭），涉及软骨周转损伤的疾病（例如涉及软骨细胞的合成代谢刺激的疾病），先天性软骨畸形，与IL6分泌过高相关的疾病和移植排斥反应（例如器官移植排斥）以及增殖性疾病

4. 发明申请

WO2010010190A1 NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES 审中-公开
标题翻译：用于治疗衰老和炎症疾病的新型化合物
公开(公告)号：WO2010010190A1
公开(公告)日：2010-01-28
申请号：PCT/EP2009/059604
申请日：2009-07-24
申请人： GALAPAGOS NV , MENET, Christel Jeanne Marie , VAN ROMPAEY, Luc Juliaan Corina , FLETCHER, Stephen Robert , BLANC, Javier , JOUANNIGOT, Nolwenn , HODGES, Alastair James , SMITS, Koen Kurt
发明人： MENET, Christel Jeanne Marie , VAN ROMPAEY, Luc Juliaan Corina , FLETCHER, Stephen Robert , BLANC, Javier , JOUANNIGOT, Nolwenn , HODGES, Alastair James , SMITS, Koen Kurt
IPC分类号： C07D471/04 , A61K31/437 , A61P19/02
CPC分类号： A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/4995 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/5386 , A61K31/541 , A61K31/551 , C07D471/04
摘要： [1,2,4]Triazolo[1,5- a ]pyridine compounds are disclosed that have a formula represented by the formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non- limiting example, diseases involving cartilage degradation, bone and/or joint degradation, for example osteoarthritis; and/or conditions involving inflammation or immune responses, such as Crohn's disease, rheumatoid arthritis, psoriasis, allergic airways disease (e.g. asthma, rhinitis), juvenile idiopathic arthritis, colitis, inflammatory bowel diseases, endotoxin-driven disease states (e.g. complications after bypass surgery or chronic endotoxin states contributing to e.g. chronic cardiac failure), diseases involving impairment of cartilage turnover (e.g diseases involving the anabolic stimulation of chondrocytes), congenital cartilage malformations, diseases associated with hypersecretion of IL6, transplantation rejection (e.g. organ transplant rejection) and proliferative diseases.
摘要翻译： [1,2,4]三唑并[1,5-a]吡啶化合物，其具有由式（I）表示的式。化合物可以制备成药物组合物，并且可以用于预防和治疗包括人在内的哺乳动物中的各种病症，包括通过非限制性实例，涉及软骨降解，骨和/或关节降解的疾病，用于例如骨关节炎; 和/或涉及炎症或免疫反应的疾病，例如克罗恩病，类风湿性关节炎，银屑病，过敏性气道疾病（例如哮喘，鼻炎），幼年特发性关节炎，结肠炎，炎性肠病，内毒素驱动的疾病状态（例如旁路并发症手术或慢性内毒素状态，例如慢性心脏衰竭），涉及软骨周转损伤的疾病（例如涉及软骨细胞的合成代谢刺激的疾病），先天性软骨畸形，与IL6分泌过高相关的疾病，移植排斥反应（例如器官移植排斥）和增殖性疾病

5. 发明申请

WO2010010191A1 NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES. 审中-公开
标题翻译：用于治疗变应性和炎症性疾病的新型化合物。
公开(公告)号：WO2010010191A1
公开(公告)日：2010-01-28
申请号：PCT/EP2009/059605
申请日：2009-07-24
申请人： GALAPAGOS NV , MENET, Christel Jeanne Marie , BLANC, Javier
发明人： MENET, Christel Jeanne Marie , BLANC, Javier
IPC分类号： C07D471/04 , A61K31/437 , A61P19/02
CPC分类号： A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/4995 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/5386 , A61K31/541 , A61K31/551 , C07D471/04
摘要： A novel [1,2,4]triazolo[1,5-a]pyridine compound is disclosed that has a formula represented by the formula (I). This compound may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, diseases involving cartilage degradation, bone and/or joint degradation, for example osteoarthritis; and/or conditions involving inflammation or immune responses, such as Crohn's disease, rheumatoid arthritis, psoriasis, allergic airways disease (e.g. asthma, rhinitis), juvenile idiopathic arthritis, colitis, inflammatory bowel diseases, endotoxin-driven disease states (e.g. complications after bypass surgery or chronic endotoxin states contributing to e.g. chronic cardiac failure), diseases involving impairment of cartilage turnover (e.g. diseases involving the anabolic stimulation of chondrocytes), congenital cartilage malformations, diseases associated with hypersecretion of IL6and transplantation rejection (e.g. organ transplant rejection) and proliferative diseases.
摘要翻译：公开了具有由式（I）表示的式的新型[1,2,4]三唑并[1,5-a]吡啶化合物。该化合物可以制备为药物组合物，并且可以用于预防和治疗包括人的哺乳动物中的各种病症，包括作为非限制性实例的涉及软骨降解，骨和/或关节降解的疾病，例如骨关节炎; 和/或涉及炎症或免疫反应的疾病，例如克罗恩病，类风湿性关节炎，牛皮癣，过敏性气道疾病（例如哮喘，鼻炎），幼年特发性关节炎，结肠炎，炎性肠病，内毒素驱动的疾病状态（例如旁路并发症手术或慢性内毒素状态，例如慢性心脏衰竭），涉及软骨周转损伤的疾病（例如涉及软骨细胞的合成代谢刺激的疾病），先天性软骨畸形，与IL6分泌过多相关的疾病和移植排斥反应（例如器官移植排斥）和增殖疾病。

6. 发明申请

WO2010010186A1 NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES 审中-公开
标题翻译：用于治疗变应性和炎症性疾病的新型化合物
公开(公告)号：WO2010010186A1
公开(公告)日：2010-01-28
申请号：PCT/EP2009/059598
申请日：2009-07-24
申请人： GALAPAGOS NV , MENET, Christel Jeanne Marie , JOUANNIGOT, Nolwenn , BLANC, Javier , VAN ROMPAEY, Luc Juliaan Corina , FLETCHER, Stephen Robert
发明人： MENET, Christel Jeanne Marie , JOUANNIGOT, Nolwenn , BLANC, Javier , VAN ROMPAEY, Luc Juliaan Corina , FLETCHER, Stephen Robert
IPC分类号： C07D471/04 , A61K31/437 , A61P19/02
CPC分类号： C07D471/04
摘要： [1,2,4]Triazolo[1,5-a]pyridine compounds are disclosed that have a formula represented by the following: (I) These compound may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, diseases involving cartilage degradation, bone and/or joint degradation, for example osteoarthritis; and/or conditions involving inflammation or immune responses, such as Crohn's disease, rheumatoid arthritis, psoriasis, allergic airways disease (e.g. asthma, rhinitis), juvenile idiopathic arthritis, colitis, inflammatory bowel diseases, endotoxin-driven disease states (e.g. complications after bypass surgery or chronic endotoxin states contributing to e.g. chronic cardiac failure), diseases involving impairment of cartilage turnover (e.g. diseases involving the anabolic stimulation of chondrocytes), congenital cartilage malformations, diseases associated with hypersecretion of IL6 and transplantation rejection (e.g. organ transplant rejection) and proliferative diseases.
摘要翻译： [1,2,4]三唑并[1,5-a]吡啶化合物，其具有由下式表示的式：（I）这些化合物可以制备为药物组合物，并且可用于预防和治疗包括通过非限制性实例的包括软骨降解，骨和/或关节降解的疾病，例如骨关节炎的疾病; 和/或涉及炎症或免疫反应的疾病，例如克罗恩病，类风湿性关节炎，牛皮癣，过敏性气道疾病（例如哮喘，鼻炎），幼年特发性关节炎，结肠炎，炎性肠病，内毒素驱动的疾病状态（例如旁路并发症手术或慢性内毒素状态，例如慢性心脏衰竭），涉及软骨周转损伤的疾病（例如涉及软骨细胞的合成代谢刺激的疾病），先天性软骨畸形，与IL6分泌过高有关的疾病和移植排斥反应（例如器官移植排斥），以及增殖性疾病

7. 发明申请

WO2010010184A1 [1, 2, 4] TRIAZOLO [1, 5-A] PYRIDINES AS JAK INHIBITORS 审中-公开
标题翻译： [1,2,4]三唑并[1,5-A]吡啶作为JAK抑制剂
公开(公告)号：WO2010010184A1
公开(公告)日：2010-01-28
申请号：PCT/EP2009/059595
申请日：2009-07-24
申请人： GALAPAGOS NV , MENET, Christel, Jeanne, Marie , BLANC, Javier , HODGES, Alastair, James , BURLI, Roland, Werner , BRECCIA, Perla , BLACKABY, Wesley, Peter , VAN ROMPAEY, Luc, Juliaan, Corina , FLETCHER, Stephen, Robert
发明人： MENET, Christel, Jeanne, Marie , BLANC, Javier , HODGES, Alastair, James , BURLI, Roland, Werner , BRECCIA, Perla , BLACKABY, Wesley, Peter , VAN ROMPAEY, Luc, Juliaan, Corina , FLETCHER, Stephen, Robert
IPC分类号： C07D471/04 , A61K31/437 , A61P19/02 , A61P29/00
CPC分类号： C07D471/04
摘要： Novel [1,2,4]triazolo[1,5-a]pyridine compounds are disclosed that have a Formula represented by the following: (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, joint disease, inflammation, and others.
摘要翻译：公开了具有下列表示的式（I）的新型[1,2,4]三唑并[1,5-a]吡啶化合物。化合物可以制备成药物组合物，并且可以用于预防和治疗包括人在内的哺乳动物中的各种病症，包括作为非限制性实例，关节疾病，炎症等。

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