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1. 发明申请

WO2009153139A2 MEANS AND METHODS FOR ASSESSING INCREASED PEROXISOMAL PROLIFERATION 审中-公开
标题翻译：评估增加的过度增殖的手段和方法
公开(公告)号：WO2009153139A2
公开(公告)日：2009-12-23
申请号：PCT/EP2009/056386
申请日：2009-05-26
申请人： BASF SE , VAN RAVENZWAAY, Bennard , MELLERT, Werner , FABIAN, Eric , STRAUSS, Volker , WALK, Tilmann, B. , LOOSER, Ralf , LEIBOLD, Edgar , KAMP, Hennicke , COELHO PALERMO CUNHA, Georgia , HEROLD, Michael, Manfred , WIEMER, Jan, C. , PROKOUDINE, Alexandre
发明人： VAN RAVENZWAAY, Bennard , MELLERT, Werner , FABIAN, Eric , STRAUSS, Volker , WALK, Tilmann, B. , LOOSER, Ralf , LEIBOLD, Edgar , KAMP, Hennicke , COELHO PALERMO CUNHA, Georgia , HEROLD, Michael, Manfred , WIEMER, Jan, C. , PROKOUDINE, Alexandre
IPC分类号： G01N33/68 , G01N33/82 , G01N33/92 , G01N33/84
CPC分类号： G01N33/487 , G01N33/50 , G01N33/68 , G01N33/6812 , G01N33/82 , G01N33/92 , G01N2405/00 , G01N2500/00 , G01N2800/046 , G01N2800/10 , G01N2800/24 , G01N2800/60 , H01J49/0036 , Y10T436/200833 , Y10T436/24
摘要： The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing increased peroxisomal proliferation. It also relates to a method of determining whether a compound is capable of inducing such peroxisomal proliferation in a subject and to a method of identifying a drug for treating increased peroxisomal proliferation. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing increased peroxisomal proliferation. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing increased peroxisomal proliferation in a subject.
摘要翻译：本发明涉及化学化合物危险分层的毒理学评估领域。具体而言，涉及诊断增加的过氧化物酶体增殖的方法。它还涉及确定化合物是否能够诱导受试者中这种过氧化物酶体增殖的方法以及鉴定用于治疗增加的过氧化物酶体增殖的药物的方法。此外，本发明涉及包含至少五种代谢物的特征值的数据收集，包括所述数据收集的数据存储介质，以及用于诊断增加的过氧化物酶体增殖的系统和装置。最后，本发明涉及一组代谢物或方法用于制备用于诊断受试者中增加的过氧化物酶体增殖的诊断装置或组合物的用途。

2. 发明申请

WO2009153139A3 MEANS AND METHODS FOR ASSESSING INCREASED PEROXISOMAL PROLIFERATION 审中-公开
标题翻译：评估增加的过度增殖的手段和方法
公开(公告)号：WO2009153139A3
公开(公告)日：2010-02-18
申请号：PCT/EP2009056386
申请日：2009-05-26
申请人： BASF SE , VAN RAVENZWAAY BENNARD , MELLERT WERNER , FABIAN ERIC , STRAUSS VOLKER , WALK TILMANN B , LOOSER RALF , LEIBOLD EDGAR , KAMP HENNICKE , COELHO PALERMO CUNHA GEORGIA , HEROLD MICHAEL MANFRED , WIEMER JAN C , PROKOUDINE ALEXANDRE
发明人： VAN RAVENZWAAY BENNARD , MELLERT WERNER , FABIAN ERIC , STRAUSS VOLKER , WALK TILMANN B , LOOSER RALF , LEIBOLD EDGAR , KAMP HENNICKE , COELHO PALERMO CUNHA GEORGIA , HEROLD MICHAEL MANFRED , WIEMER JAN C , PROKOUDINE ALEXANDRE
IPC分类号： G01N33/92 , G01N33/68 , G01N33/82 , G01N33/84
CPC分类号： G01N33/487 , G01N33/50 , G01N33/68 , G01N33/6812 , G01N33/82 , G01N33/92 , G01N2405/00 , G01N2500/00 , G01N2800/046 , G01N2800/10 , G01N2800/24 , G01N2800/60 , H01J49/0036 , Y10T436/200833 , Y10T436/24
摘要： The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to methods for (i) diagnosing, (ii) determining whether a compound is capable of inducing, (iii) identifying a drug for treating increased peroxisomal proliferation. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosis. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of diagnostic devices or compositions. The metabolite markers of the metabolome are selected from: Coenzyme Q10, 16-Methylheptadecanoic acid, 17-Methyloctadecanoic acid, Eicosatrienoic acid (C20:3), Threonine, Proline, Tyrosine, trans-4-Hydroxyprolme, Pantothenic acid, Coenzyme Q9, Glycerol, Palmitic acid (C16:0), Lmoleic acid (C18 :cis (9, 12) 2), 14-Methylhexadecanoic acid, gamma-Linoleic acid (C18 : cis (6, 9, 12) 3), Threonic acid, Cytosine, Phosphatidylcholine (C18 : 0/C22 : 6). Different multimarker sets are proposed for male and female subjects.
摘要翻译：本发明涉及化学化合物危险分层的毒理学评估领域。具体而言，涉及用于（i）诊断，（ii）确定化合物是否能够诱导，（iii）鉴定用于治疗增加的过氧化物酶体增殖的药物的方法。此外，本发明涉及包含至少五种代谢物的特征值的数据收集，包括所述数据收集的数据存储介质，以及用于诊断的系统和装置。最后，本发明涉及一组代谢物或装置用于制造诊断装置或组合物的用途。代谢组胺的代谢物标记选自：辅酶Q10,16-甲基十七烷酸，17-甲基十八烷酸，二十碳三烯酸（C20：3），苏氨酸，脯氨酸，酪氨酸，反式-4-羟基丙酸，泛酸，辅酶Q9，甘油，棕榈酸（C16：0），Lmoleic acid（C18：顺式（9,12）2），14-甲基十六烷酸，γ-亚油酸（C18：顺式（6,9,12）3），苏氨酸，，磷脂酰胆碱（C18：0 / C22：6）。男性和女性受试者提出了不同的多标记组合。

3. 发明申请

WO2011048007A9 METHOD FOR GENERATING BIOMARKER REFERENCE PATTERNS 审中-公开
标题翻译：用于生产生物标志物参考模式
公开(公告)号：WO2011048007A9
公开(公告)日：2011-07-07
申请号：PCT/EP2010065450
申请日：2010-10-14
申请人： BASF PLANT SCIENCE CO GMBH , PROKOUDINE ALEXANDRE , WALK TILMANN B , WIEMER JAN C , LOOSER RALF , HEROLD MICHAEL MANFRED , VAN RAVENZWAAY BENNARD , MELLERT WERNER , FABIAN ERIC , STRAUSS VOLKER , KAMP HENNICKE
发明人： PROKOUDINE ALEXANDRE , WALK TILMANN B , WIEMER JAN C , LOOSER RALF , HEROLD MICHAEL MANFRED , VAN RAVENZWAAY BENNARD , MELLERT WERNER , FABIAN ERIC , STRAUSS VOLKER , KAMP HENNICKE
IPC分类号： G06F19/18
CPC分类号： G06F19/18

4. 发明申请

WO2011018288A1 MEANS AND METHODS FOR DIAGNOSINGTHYROID DISORDERS 审中-公开
标题翻译：诊断乙型肝炎病毒的方法和方法
公开(公告)号：WO2011018288A1
公开(公告)日：2011-02-17
申请号：PCT/EP2010/060086
申请日：2010-07-13
申请人： BASF SE , STRAUSS, Volker , KAMP, Hennicke , FABIAN, Eric , COELHO PALERMO CUNHA, Georgia , MELLERT, Werner , VAN RAVENZWAAY, Bennard , WALK, Tilmann , LOOSER, Ralf , HEROLD, Michael Manfred , WIEMER, Jan, C. , PROKOUDINE, Alexandre , LEIBOLD, Edgar
发明人： STRAUSS, Volker , KAMP, Hennicke , FABIAN, Eric , COELHO PALERMO CUNHA, Georgia , MELLERT, Werner , VAN RAVENZWAAY, Bennard , WALK, Tilmann , LOOSER, Ralf , HEROLD, Michael Manfred , WIEMER, Jan, C. , PROKOUDINE, Alexandre , LEIBOLD, Edgar
IPC分类号： G01N33/50
CPC分类号： G01N33/6893 , G01N2800/046
摘要： The present invention relates to a method for diagnosing thyroid disorders. It also relates to a method of determining whether a compound is capable of inducing a thyroid disorder in a subject and to a method of identifying a drug for treating a thyroid disorder. Furthermore, the present invention relates a device for diagnosing a thyroid disorder and diagnostic uses.
摘要翻译：本发明涉及一种诊断甲状腺疾病的方法。它还涉及确定化合物是否能够诱导受试者中的甲状腺疾病的方法以及鉴定用于治疗甲状腺疾病的药物的方法。此外，本发明涉及用于诊断甲状腺疾病和诊断用途的装置。

5. 发明申请

WO2009153136A3 MEANS AND METHODS FOR ASSESSING LIVER TOXICITY 审中-公开
标题翻译：用于评估肝脏毒性的方法和方法
公开(公告)号：WO2009153136A3
公开(公告)日：2010-03-18
申请号：PCT/EP2009056367
申请日：2009-05-26
申请人： BASF SE , VAN RAVENZWAAY BENNARD , MELLERT WERNER , COELHO PALERMO CUNHA GEORGIA , FABIAN ERIC , STRAUSS VOLKER , KAMP HENNICKE , WALK TILMANN B , LOOSER RALF , HEROLD MICHAEL MANFRED , WIEMER JAN C , PROKOUDINE ALEXANDRE , LEIBOLD EDGAR
发明人： VAN RAVENZWAAY BENNARD , MELLERT WERNER , COELHO PALERMO CUNHA GEORGIA , FABIAN ERIC , STRAUSS VOLKER , KAMP HENNICKE , WALK TILMANN B , LOOSER RALF , HEROLD MICHAEL MANFRED , WIEMER JAN C , PROKOUDINE ALEXANDRE , LEIBOLD EDGAR
IPC分类号： G01N33/66 , G01N33/82 , G01N33/84 , G01N33/92
CPC分类号： G01N33/92 , G01N2500/00 , G01N2560/00 , G01N2800/085 , G01N2800/60 , Y02A90/26
摘要： The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing liver toxicity. It also relates to a method of determining whether a compound is capable of inducing such liver toxicity in a subject and to a method of identifying a drug for treating liver toxicity. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing liver toxicity. Finally, the present invention- pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing liver toxicity in a subject. For each sex, a different metabolome pattern, i.e. a different set of analytes is disclosed. The liver toxicity markers are mainly selected from free fatty acids, but also include various phosphatidylcholines, Hydroxyphenylpyruvic acid, alpha-Tocopherol, Cholesterol,myo-Inositol-2-monophosphate, 4-Hydroxysphinganine, Ceramide (dl8:1, C24:1), Ceramide (dl8:2, C24:0), Sphingomyelin (dl8:1, C16:0), 1, 2-Dioleoyl-sn-glycero-3-phosphatidyl-L-serine, 18:1 Lyso Phosphatidylcholine, CoenzymeQ9, Glucose, Glycerol, Glycerophosphates, Phosphate, 5-Methoxysphingosine, erythrosphingosine, Threonine, Diacylglycerides and Triacylglycerides.
摘要翻译：本发明涉及化学化合物危险分层的毒理学评估领域。具体地说，涉及一种诊断肝毒性的方法。它还涉及确定化合物是否能够在受试者中诱导这种肝毒性的方法以及鉴定用于治疗肝毒性的药物的方法。此外，本发明涉及包含至少五种代谢物的特征值的数据收集，包括所述数据收集的数据存储介质，以及用于诊断肝脏毒性的系统和装置。最后，本发明涉及一组代谢物或方法用于制备用于诊断受试者的肝脏毒性的诊断装置或组合物的用途。对于每个性别，公开了不同的代谢组织模式，即不同的分析物组。肝毒性标志物主要选自游离脂肪酸，还包括各种磷脂酰胆碱，羟基苯基丙酮酸，α-生育酚，胆固醇，肌醇-2-单磷酸，4-羟基鞘氨醇，神经酰胺（dl8：1，C24：1）神经酰胺（dl8：2，C24：0），鞘磷脂（dl8：1，C16：0），1,2-二油酰-sn-甘油-3-磷脂酰-L-丝氨酸，18:1溶血磷脂酰胆碱，辅酶Q9，葡萄糖，甘油，磷酸甘油酯，磷酸酯，5-甲氧基肌氨酸，红细胞素，苏氨酸，二酰基甘油酯和三酰基甘油酯。

6. 发明申请

WO2007113170A1 VERWENDUNG VON STROBILURINEN ZUR BEHANDLUNG VON STÖRUNGEN DES EISEN-STOFFWECHSELS 审中-公开
标题翻译：甲氧基丙烯酸酯，用于治疗铁代谢紊乱USE
公开(公告)号：WO2007113170A1
公开(公告)日：2007-10-11
申请号：PCT/EP2007/052917
申请日：2007-03-27
申请人： BASF AKTIENGESELLSCHAFT , VAN RAVENZWAAY, Bennard , MELLERT, Werner , COELHO PALERMO CUNHA, Georgia , DECKARDT, Klaus , KIECZKA, Heinz
发明人： VAN RAVENZWAAY, Bennard , MELLERT, Werner , COELHO PALERMO CUNHA, Georgia , DECKARDT, Klaus , KIECZKA, Heinz
IPC分类号： A61P7/06 , A61K31/165 , A61K31/216 , A61K31/415 , A61K31/44 , A61K31/505 , A61K31/5355
CPC分类号： A61K31/165 , A61K31/216 , A61K31/415 , A61K31/44 , A61K31/505 , A61K31/5355
摘要： Strobilurin-Derivate können zur Behandlung und/oder Prävention von Störungen des Eisen-Stoffwechsels bei Säugern eingesetzt werden.
摘要翻译：嗜球果伞素衍生物可用于在哺乳动物中铁代谢的疾病的治疗和/或预防。

7. 发明申请

WO2011048007A2 VERFAHREN ZUR ERZEUGUNG VON BIOMARKER-REFERENZPATTERN 审中-公开
标题翻译：用于生产生物标志物参考模式
公开(公告)号：WO2011048007A2
公开(公告)日：2011-04-28
申请号：PCT/EP2010/065450
申请日：2010-10-14
申请人： BASF PLANT SCIENCE COMPANY GMBH , PROKOUDINE, Alexandre , WALK, Tilmann, B. , WIEMER, Jan, C. , LOOSER, Ralf , HEROLD, Michael, Manfred , VAN RAVENZWAAY, Bennard , MELLERT, Werner , FABIAN, Eric , STRAUSS, Volker , KAMP, Hennicke
发明人： PROKOUDINE, Alexandre , WALK, Tilmann, B. , WIEMER, Jan, C. , LOOSER, Ralf , HEROLD, Michael, Manfred , VAN RAVENZWAAY, Bennard , MELLERT, Werner , FABIAN, Eric , STRAUSS, Volker , KAMP, Hennicke
IPC分类号： G06F19/18
CPC分类号： G06F19/18
摘要： Die vorliegende Erfindung betrifft Verfahren zur Auswertung von Biomarkern. Insbesondere betrifft die Erfindung ein Verfahren zur Erstellung mindestens eines Patterns für mindestens einen vorgegebenen Effektor mit mindestens einer bestimmbaren Wirkung auf ein biologisches System, ein Verfahren zur Erstellung einer Effektorenklasse zu einer vorgegebenen Wirkung oder Gruppe von Wirkungen, ein Verfahren zur Erstellung einer Effektorenklasse zu einer vorgegebenen Wirkung oder Gruppe von Wirkungen und ein Verfahren zur Identifikation mindestens einer Wirkung eines vorgegebenen Effektors sowie ein Computerprogramm und einen Computer, die zur Durchführung dieser Verfahren eingerichtet sind.
摘要翻译：本发明涉及一种用于生物标志物的分析方法。特别地，本发明涉及一种用于至少与生物系统，用于创建Effektorenklasse到预定动作的方法在至少一个可确定的效果的预定执行创建至少一个图案或一组操作，用于创建Effektorenklasse到预定的方法效果或效果集和用于识别一个给定执行器的至少一个效果和一种计算机程序和其适合用于执行这些方法的计算机的方法。

8. 发明申请

WO2009153285A3 1,2-BENZISOTHIAZOLE COMPOUNDS USEFUL FOR COMBATING ANIMAL PESTS 审中-公开
公开(公告)号：WO2009153285A3
公开(公告)日：2009-12-23
申请号：PCT/EP2009/057531
申请日：2009-06-17
申请人： BASF SE , VON DEYN, Wolfgang , PUHL, Michael , POHLMAN, Matthias , RACK, Michael , PARRA RAPADO, Liliana , LANGEWALD, Jürgen , ANSPAUGH, Douglas D. , OLOUMI-SADEGHI, Hassan , CULBERTSON, Deborah L. , RANKL, Nancy B. , KAMP, Hennicke , VAN RAVENZWAAY, Bennard
发明人： VON DEYN, Wolfgang , PUHL, Michael , POHLMAN, Matthias , RACK, Michael , PARRA RAPADO, Liliana , LANGEWALD, Jürgen , ANSPAUGH, Douglas D. , OLOUMI-SADEGHI, Hassan , CULBERTSON, Deborah L. , RANKL, Nancy B. , KAMP, Hennicke , VAN RAVENZWAAY, Bennard
IPC分类号： C07D417/06 , C07D417/14 , A01N43/80
摘要： The present invention relates to sulfonamide compounds of formula (I) according to claim 1, as well as to the N-oxides and salts thereof. These compounds are useful for combating animal pests. The invention also relates to a process for the preparation of these compounds and to intermediate compounds used in said process. The invention further relates to a method for controlling animal pests by using the compounds of formula (I), the N-oxides or the salts thereof, to plant propagation material and to an agricultural and veterinary composition comprising said compounds, the N-oxides or the salts thereof.

9. 发明申请

WO2009153285A2 SULFONAMIDE COMPOUNDS 审中-公开
标题翻译：磺酰胺化合物
公开(公告)号：WO2009153285A2
公开(公告)日：2009-12-23
申请号：PCT/EP2009057531
申请日：2009-06-17
申请人： BASF SE , DEYN WOLFGANG VON , PUHL MICHAEL , POHLMAN MATTHIAS , RACK MICHAEL , PARRA RAPADO LILIANA , LANGEWALD JUERGEN , ANSPAUGH DOUGLAS D , OLOUMI-SADEGHI HASSAN , CULBERTSON DEBORAH L , RANKL NANCY B , KAMP HENNICKE , VAN RAVENZWAAY BENNARD
发明人： VON DEYN WOLFGANG , PUHL MICHAEL , POHLMAN MATTHIAS , RACK MICHAEL , PARRA RAPADO LILIANA , LANGEWALD JUERGEN , ANSPAUGH DOUGLAS D , OLOUMI-SADEGHI HASSAN , CULBERTSON DEBORAH L , RANKL NANCY B , KAMP HENNICKE , VAN RAVENZWAAY BENNARD
IPC分类号： C07D417/06 , A01N43/80 , C07D417/14
CPC分类号： C07D417/06 , A01N43/80 , C02F1/001 , C02F2209/03 , C02F2303/16 , C07D417/14
摘要： The present invention relates to sulfonamide compounds of formula (I) wherein R1 is H, halogen, CN, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C4-alkyl, C1-C6-alkoxy, C2-C6-alkenyloxy, C2-C6-alkynyloxy, C1-C6-alkylthio, C2-C6-alkenylthio, C2-C6-alkynylthio, C1-C6-haloalkyl or C1-C6-haloalkoxy; R2 and R3 are H, halogen, CN, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C7-cycloalkyl, C3-C7-cycloalkyl-C1-C4-alkyl, C1-C6-alkoxy, C2-C6-alkenyloxy, C2-C6-alkynyloxy, C1-C6-alkylthio, C2-C6-alkenylthio, C2-C6-alkynylthio, C1-C6-haloalkyl or C1-C6-haloalkoxy; or R2 together with R3 form a fused 5 or 6-membered carbocycle or heterocycle; R4 is halogen, CN, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-alkoxy, C1-C6-alkylthio, C1-C6-alkylsulfinyl, C1-C6-alkylsulfonyl, C1-C6-haloalkyl, C1-C6-haloalkoxy, C1-C6-haloalkylthio, C1-C6-haloalkylsulfinyl or C1-C6-haloalksulfonyl; n is 0, 1, 2 or 3; R5 is phenyl or a 5- or 6-membered heterocycle; X is O or NRx, wherein Rx is H, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C7-cycloalkyl, C1-C6-alkoxy, C2-C6-alkenyloxy, C2-C6-alkynyloxy, C1-C6-alkylcarbonyl or C1-C6-alkylcarbonyloxy; Y is N or C(Ry), wherein Ry is H, halogen, CN, C1-C6-alkyl,C2-C6-alkenyl, C2-C6-alkynyl, C3-C7-cycloalkyl, C3-7-cycloalkyl- C1-C4-alkyl, C1-C6-alkoxy, C2-C6-alkenyloxy, C2-C6-alkynyloxy, C1-C6-alkylthio, C2-C6-alkenylthio, C2-C6-alkynylthio, C1-C6-haloalkyl and C1-C6-haloalkoxy; and Z is a chemical bond, O or N(Rz), wherein Rz is C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C7-cycloalkyl, C1-C6-alkoxy, C2-C6-alkenyloxy, C1-C6-alkylcarbonyl or C1-C6-alkylcarbonyloxy; as well as to the N-oxides and salts thereof. These compounds are useful for combating animal pests. The invention also relates to a process for the preparation of these compounds and to intermediate compounds used in said process. The invention further relates to a method for controlling animal pests by using the compounds of formula (I), the N-oxides or the salts thereof, to plant propagation material and to an agricultural and veterinary composition comprising said compounds, the N-oxides or the salts thereof.
摘要翻译：本发明涉及式（I）的磺酰胺化合物，其中R1是H，卤素，CN，C1-C6-烷基，C2-C6-烯基，C2-C6-炔基，C3-C7-环烷基，C3-C7-环烷基 C 1 -C 4 - 烷基，C 1 -C 6 - 烷氧基，C 2 -C 6 - 烯氧基，C 2 -C 6 - 炔氧基，C 1 -C 6 - 烷硫基，C 2 -C 6 - 烯硫基，C 2 -C 6 - 炔硫基，C 1 -C 6 - 卤代烷基或C 1 1 -C 6 - 卤代烷氧基; R2和R3是H，卤素，CN，C1-C6-烷基，C2-C6-烯基，C2-C6-炔基，C3-C7-环烷基，C3-C7-环烷基-C1-C4-烷基，C1-C6- 烷氧基，C 2 -C 6 - 烯氧基，C 2 -C 6 - 炔氧基，C 1 -C 6 - 烷硫基，C 2 -C 6 - 烯硫基，C 2 -C 6炔硫基，C 1 -C 6卤代烷基或C 1 -C 6卤代烷氧基; 或R 2与R 3一起形成稠合的5或6元碳环或杂环; R4是卤素，CN，C1-C6-烷基，C2-C6-烯基，C2-C6-炔基，C1-C6-烷氧基，C1-C6-烷硫基，C1-C6-烷基亚磺酰基，C1-C6-烷基磺酰基，C1- C 1 -C 6卤代烷基，C 1 -C 6卤代烷硫基，C 1 -C 6卤代烷基亚磺酰基或C 1 -C 6卤代磺酰基; n为0,1,2或3; R5是苯基或5-或6-元杂环; X是O或NR x，其中Rx是H，C 1 -C 6烷基，C 2 -C 6 - 烯基，C 2 -C 6 - 炔基，C 3 -C 7 - 环烷基，C 1 -C 6 - 烷氧基，C 2 -C 6 - 烯氧基，C 2 -C 6 - 炔基氧基，C 1 -C 6 - 烷基羰基或C 1 -C 6烷基羰基氧基; Y是N或C（Ry），其中R y是H，卤素，CN，C 1 -C 6烷基，C 2 -C 6 - 烯基，C 2 -C 6炔基，C 3 -C 7 - 环烷基，C 3-7 - C 1 -C 6烷基，C 1 -C 6 - 烷氧基，C 2 -C 6 - 烯氧基，C 2 -C 6 - 炔氧基，C 1 -C 6 - 烷硫基，C 2 -C 6 - 烯硫基，C 2 -C 6 - 炔硫基，卤代烷氧基; Z为化学键，O或N（Rz），其中Rz为C1-C6-烷基，C2-C6-烯基，C2-C6-炔基，C3-C7-环烷基，C1-C6-烷氧基，C2-C6 - 烯氧基，C1-C6-烷基羰基或C1-C6-烷基羰基氧基; 以及N-氧化物及其盐。这些化合物可用于对抗动物害虫。本发明还涉及制备这些化合物的方法和用于所述方法的中间体化合物。本发明还涉及通过使用式（I）化合物，其N-氧化物或其盐来植物繁殖材料以及包含所述化合物，N-氧化物或其盐的农业和兽医组合物来控制动物害虫的方法其盐。

10. 发明申请

WO2009153136A2 MEANS AND METHODS FOR ASSESSING LIVER TOXICITY 审中-公开
标题翻译：用于评估肝脏毒性的方法和方法
公开(公告)号：WO2009153136A2
公开(公告)日：2009-12-23
申请号：PCT/EP2009/056367
申请日：2009-05-26
申请人： BASF SE , VAN RAVENZWAAY, Bennard , MELLERT, Werner , COELHO PALERMO CUNHA, Georgia , FABIAN, Eric , STRAUSS, Volker , KAMP, Hennicke , WALK, Tilmann B. , LOOSER, Ralf , HEROLD, Michael Manfred , WIEMER, Jan C. , PROKOUDINE, Alexandre , LEIBOLD, Edgar
发明人： VAN RAVENZWAAY, Bennard , MELLERT, Werner , COELHO PALERMO CUNHA, Georgia , FABIAN, Eric , STRAUSS, Volker , KAMP, Hennicke , WALK, Tilmann B. , LOOSER, Ralf , HEROLD, Michael Manfred , WIEMER, Jan C. , PROKOUDINE, Alexandre , LEIBOLD, Edgar
IPC分类号： G01N33/66 , G01N33/68 , G01N33/82 , G01N33/84 , G01N33/92
CPC分类号： G01N33/92 , G01N2500/00 , G01N2560/00 , G01N2800/085 , G01N2800/60 , Y02A90/26
摘要： The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing liver toxicity. It also relates to a method of determining whether a compound is capable of inducing such liver toxicity in a subject and to a method of identifying a drug for treating liver toxicity. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing liver toxicity. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing liver toxicity in a subject.
摘要翻译：本发明涉及化学化合物危险分层的毒理学评估领域。具体地说，涉及一种诊断肝毒性的方法。它还涉及确定化合物是否能够在受试者中诱导这种肝毒性的方法以及鉴定用于治疗肝毒性的药物的方法。此外，本发明涉及包含至少五种代谢物的特征值的数据收集，包括所述数据收集的数据存储介质，以及用于诊断肝毒性的系统和装置。最后，本发明涉及一组代谢物或方法用于制备用于诊断受试者的肝脏毒性的诊断装置或组合物的用途。

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