专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2009153139A2 MEANS AND METHODS FOR ASSESSING INCREASED PEROXISOMAL PROLIFERATION 审中-公开
标题翻译：评估增加的过度增殖的手段和方法
公开(公告)号：WO2009153139A2
公开(公告)日：2009-12-23
申请号：PCT/EP2009/056386
申请日：2009-05-26
申请人： BASF SE , VAN RAVENZWAAY, Bennard , MELLERT, Werner , FABIAN, Eric , STRAUSS, Volker , WALK, Tilmann, B. , LOOSER, Ralf , LEIBOLD, Edgar , KAMP, Hennicke , COELHO PALERMO CUNHA, Georgia , HEROLD, Michael, Manfred , WIEMER, Jan, C. , PROKOUDINE, Alexandre
发明人： VAN RAVENZWAAY, Bennard , MELLERT, Werner , FABIAN, Eric , STRAUSS, Volker , WALK, Tilmann, B. , LOOSER, Ralf , LEIBOLD, Edgar , KAMP, Hennicke , COELHO PALERMO CUNHA, Georgia , HEROLD, Michael, Manfred , WIEMER, Jan, C. , PROKOUDINE, Alexandre
IPC分类号： G01N33/68 , G01N33/82 , G01N33/92 , G01N33/84
CPC分类号： G01N33/487 , G01N33/50 , G01N33/68 , G01N33/6812 , G01N33/82 , G01N33/92 , G01N2405/00 , G01N2500/00 , G01N2800/046 , G01N2800/10 , G01N2800/24 , G01N2800/60 , H01J49/0036 , Y10T436/200833 , Y10T436/24
摘要： The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing increased peroxisomal proliferation. It also relates to a method of determining whether a compound is capable of inducing such peroxisomal proliferation in a subject and to a method of identifying a drug for treating increased peroxisomal proliferation. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing increased peroxisomal proliferation. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing increased peroxisomal proliferation in a subject.
摘要翻译：本发明涉及化学化合物危险分层的毒理学评估领域。具体而言，涉及诊断增加的过氧化物酶体增殖的方法。它还涉及确定化合物是否能够诱导受试者中这种过氧化物酶体增殖的方法以及鉴定用于治疗增加的过氧化物酶体增殖的药物的方法。此外，本发明涉及包含至少五种代谢物的特征值的数据收集，包括所述数据收集的数据存储介质，以及用于诊断增加的过氧化物酶体增殖的系统和装置。最后，本发明涉及一组代谢物或方法用于制备用于诊断受试者中增加的过氧化物酶体增殖的诊断装置或组合物的用途。

2. 发明申请

WO2009153139A3 MEANS AND METHODS FOR ASSESSING INCREASED PEROXISOMAL PROLIFERATION 审中-公开
标题翻译：评估增加的过度增殖的手段和方法
公开(公告)号：WO2009153139A3
公开(公告)日：2010-02-18
申请号：PCT/EP2009056386
申请日：2009-05-26
申请人： BASF SE , VAN RAVENZWAAY BENNARD , MELLERT WERNER , FABIAN ERIC , STRAUSS VOLKER , WALK TILMANN B , LOOSER RALF , LEIBOLD EDGAR , KAMP HENNICKE , COELHO PALERMO CUNHA GEORGIA , HEROLD MICHAEL MANFRED , WIEMER JAN C , PROKOUDINE ALEXANDRE
发明人： VAN RAVENZWAAY BENNARD , MELLERT WERNER , FABIAN ERIC , STRAUSS VOLKER , WALK TILMANN B , LOOSER RALF , LEIBOLD EDGAR , KAMP HENNICKE , COELHO PALERMO CUNHA GEORGIA , HEROLD MICHAEL MANFRED , WIEMER JAN C , PROKOUDINE ALEXANDRE
IPC分类号： G01N33/92 , G01N33/68 , G01N33/82 , G01N33/84
CPC分类号： G01N33/487 , G01N33/50 , G01N33/68 , G01N33/6812 , G01N33/82 , G01N33/92 , G01N2405/00 , G01N2500/00 , G01N2800/046 , G01N2800/10 , G01N2800/24 , G01N2800/60 , H01J49/0036 , Y10T436/200833 , Y10T436/24
摘要： The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to methods for (i) diagnosing, (ii) determining whether a compound is capable of inducing, (iii) identifying a drug for treating increased peroxisomal proliferation. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosis. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of diagnostic devices or compositions. The metabolite markers of the metabolome are selected from: Coenzyme Q10, 16-Methylheptadecanoic acid, 17-Methyloctadecanoic acid, Eicosatrienoic acid (C20:3), Threonine, Proline, Tyrosine, trans-4-Hydroxyprolme, Pantothenic acid, Coenzyme Q9, Glycerol, Palmitic acid (C16:0), Lmoleic acid (C18 :cis (9, 12) 2), 14-Methylhexadecanoic acid, gamma-Linoleic acid (C18 : cis (6, 9, 12) 3), Threonic acid, Cytosine, Phosphatidylcholine (C18 : 0/C22 : 6). Different multimarker sets are proposed for male and female subjects.
摘要翻译：本发明涉及化学化合物危险分层的毒理学评估领域。具体而言，涉及用于（i）诊断，（ii）确定化合物是否能够诱导，（iii）鉴定用于治疗增加的过氧化物酶体增殖的药物的方法。此外，本发明涉及包含至少五种代谢物的特征值的数据收集，包括所述数据收集的数据存储介质，以及用于诊断的系统和装置。最后，本发明涉及一组代谢物或装置用于制造诊断装置或组合物的用途。代谢组胺的代谢物标记选自：辅酶Q10,16-甲基十七烷酸，17-甲基十八烷酸，二十碳三烯酸（C20：3），苏氨酸，脯氨酸，酪氨酸，反式-4-羟基丙酸，泛酸，辅酶Q9，甘油，棕榈酸（C16：0），Lmoleic acid（C18：顺式（9,12）2），14-甲基十六烷酸，γ-亚油酸（C18：顺式（6,9,12）3），苏氨酸，，磷脂酰胆碱（C18：0 / C22：6）。男性和女性受试者提出了不同的多标记组合。

3. 发明申请

WO2011018288A1 MEANS AND METHODS FOR DIAGNOSINGTHYROID DISORDERS 审中-公开
标题翻译：诊断乙型肝炎病毒的方法和方法
公开(公告)号：WO2011018288A1
公开(公告)日：2011-02-17
申请号：PCT/EP2010/060086
申请日：2010-07-13
申请人： BASF SE , STRAUSS, Volker , KAMP, Hennicke , FABIAN, Eric , COELHO PALERMO CUNHA, Georgia , MELLERT, Werner , VAN RAVENZWAAY, Bennard , WALK, Tilmann , LOOSER, Ralf , HEROLD, Michael Manfred , WIEMER, Jan, C. , PROKOUDINE, Alexandre , LEIBOLD, Edgar
发明人： STRAUSS, Volker , KAMP, Hennicke , FABIAN, Eric , COELHO PALERMO CUNHA, Georgia , MELLERT, Werner , VAN RAVENZWAAY, Bennard , WALK, Tilmann , LOOSER, Ralf , HEROLD, Michael Manfred , WIEMER, Jan, C. , PROKOUDINE, Alexandre , LEIBOLD, Edgar
IPC分类号： G01N33/50
CPC分类号： G01N33/6893 , G01N2800/046
摘要： The present invention relates to a method for diagnosing thyroid disorders. It also relates to a method of determining whether a compound is capable of inducing a thyroid disorder in a subject and to a method of identifying a drug for treating a thyroid disorder. Furthermore, the present invention relates a device for diagnosing a thyroid disorder and diagnostic uses.
摘要翻译：本发明涉及一种诊断甲状腺疾病的方法。它还涉及确定化合物是否能够诱导受试者中的甲状腺疾病的方法以及鉴定用于治疗甲状腺疾病的药物的方法。此外，本发明涉及用于诊断甲状腺疾病和诊断用途的装置。

4. 发明申请

WO2009153136A3 MEANS AND METHODS FOR ASSESSING LIVER TOXICITY 审中-公开
标题翻译：用于评估肝脏毒性的方法和方法
公开(公告)号：WO2009153136A3
公开(公告)日：2010-03-18
申请号：PCT/EP2009056367
申请日：2009-05-26
申请人： BASF SE , VAN RAVENZWAAY BENNARD , MELLERT WERNER , COELHO PALERMO CUNHA GEORGIA , FABIAN ERIC , STRAUSS VOLKER , KAMP HENNICKE , WALK TILMANN B , LOOSER RALF , HEROLD MICHAEL MANFRED , WIEMER JAN C , PROKOUDINE ALEXANDRE , LEIBOLD EDGAR
发明人： VAN RAVENZWAAY BENNARD , MELLERT WERNER , COELHO PALERMO CUNHA GEORGIA , FABIAN ERIC , STRAUSS VOLKER , KAMP HENNICKE , WALK TILMANN B , LOOSER RALF , HEROLD MICHAEL MANFRED , WIEMER JAN C , PROKOUDINE ALEXANDRE , LEIBOLD EDGAR
IPC分类号： G01N33/66 , G01N33/82 , G01N33/84 , G01N33/92
CPC分类号： G01N33/92 , G01N2500/00 , G01N2560/00 , G01N2800/085 , G01N2800/60 , Y02A90/26
摘要： The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing liver toxicity. It also relates to a method of determining whether a compound is capable of inducing such liver toxicity in a subject and to a method of identifying a drug for treating liver toxicity. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing liver toxicity. Finally, the present invention- pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing liver toxicity in a subject. For each sex, a different metabolome pattern, i.e. a different set of analytes is disclosed. The liver toxicity markers are mainly selected from free fatty acids, but also include various phosphatidylcholines, Hydroxyphenylpyruvic acid, alpha-Tocopherol, Cholesterol,myo-Inositol-2-monophosphate, 4-Hydroxysphinganine, Ceramide (dl8:1, C24:1), Ceramide (dl8:2, C24:0), Sphingomyelin (dl8:1, C16:0), 1, 2-Dioleoyl-sn-glycero-3-phosphatidyl-L-serine, 18:1 Lyso Phosphatidylcholine, CoenzymeQ9, Glucose, Glycerol, Glycerophosphates, Phosphate, 5-Methoxysphingosine, erythrosphingosine, Threonine, Diacylglycerides and Triacylglycerides.
摘要翻译：本发明涉及化学化合物危险分层的毒理学评估领域。具体地说，涉及一种诊断肝毒性的方法。它还涉及确定化合物是否能够在受试者中诱导这种肝毒性的方法以及鉴定用于治疗肝毒性的药物的方法。此外，本发明涉及包含至少五种代谢物的特征值的数据收集，包括所述数据收集的数据存储介质，以及用于诊断肝脏毒性的系统和装置。最后，本发明涉及一组代谢物或方法用于制备用于诊断受试者的肝脏毒性的诊断装置或组合物的用途。对于每个性别，公开了不同的代谢组织模式，即不同的分析物组。肝毒性标志物主要选自游离脂肪酸，还包括各种磷脂酰胆碱，羟基苯基丙酮酸，α-生育酚，胆固醇，肌醇-2-单磷酸，4-羟基鞘氨醇，神经酰胺（dl8：1，C24：1）神经酰胺（dl8：2，C24：0），鞘磷脂（dl8：1，C16：0），1,2-二油酰-sn-甘油-3-磷脂酰-L-丝氨酸，18:1溶血磷脂酰胆碱，辅酶Q9，葡萄糖，甘油，磷酸甘油酯，磷酸酯，5-甲氧基肌氨酸，红细胞素，苏氨酸，二酰基甘油酯和三酰基甘油酯。

5. 发明申请

WO2007113170A1 VERWENDUNG VON STROBILURINEN ZUR BEHANDLUNG VON STÖRUNGEN DES EISEN-STOFFWECHSELS 审中-公开
标题翻译：甲氧基丙烯酸酯，用于治疗铁代谢紊乱USE
公开(公告)号：WO2007113170A1
公开(公告)日：2007-10-11
申请号：PCT/EP2007/052917
申请日：2007-03-27
申请人： BASF AKTIENGESELLSCHAFT , VAN RAVENZWAAY, Bennard , MELLERT, Werner , COELHO PALERMO CUNHA, Georgia , DECKARDT, Klaus , KIECZKA, Heinz
发明人： VAN RAVENZWAAY, Bennard , MELLERT, Werner , COELHO PALERMO CUNHA, Georgia , DECKARDT, Klaus , KIECZKA, Heinz
IPC分类号： A61P7/06 , A61K31/165 , A61K31/216 , A61K31/415 , A61K31/44 , A61K31/505 , A61K31/5355
CPC分类号： A61K31/165 , A61K31/216 , A61K31/415 , A61K31/44 , A61K31/505 , A61K31/5355
摘要： Strobilurin-Derivate können zur Behandlung und/oder Prävention von Störungen des Eisen-Stoffwechsels bei Säugern eingesetzt werden.
摘要翻译：嗜球果伞素衍生物可用于在哺乳动物中铁代谢的疾病的治疗和/或预防。

6. 发明申请

WO2007014825A1 A METHOD FOR PROVIDING AND ANALYZING AN ANIMAL POPULATION HAVING AN ESSENTIALLY IDENTICAL METABOLOME 审中-公开
标题翻译：一种提供和分析具有基本代谢代谢物的动物群体的方法
公开(公告)号：WO2007014825A1
公开(公告)日：2007-02-08
申请号：PCT/EP2006/064053
申请日：2006-07-10
申请人： BASF AKTIENGESELLSCHAFT , RAVENZWAAY, Bennard van , COELHO PALERMO CUNHA, Georgia , MELLERT, Werner , LOOSER, Ralf , WALK, Tilmann B. , WIEMER, Jan C. , HAAKE, Volker
发明人： RAVENZWAAY, Bennard van , COELHO PALERMO CUNHA, Georgia , MELLERT, Werner , LOOSER, Ralf , WALK, Tilmann B. , WIEMER, Jan C. , HAAKE, Volker
IPC分类号： A01K29/00 , A01K1/03 , A01K67/02
CPC分类号： A01K1/031 , A01K29/00 , A01K67/02
摘要： The present invention relates to a method for providing an animal population having an essentially identical metabolome comprising compiling an animal population being of essentially the same age, keeping said animal population for a time period sufficient for acclimatization under the following housing conditions: (i) constant temperature, (ii) constant humidity, (iii) physical separation of the animals of the animal population, (iv) feeding ad libitum, wherein the food to be fed is essentially free of chemical or micro- bial contaminance, (v) drinking libitum, wherein the drinking liquid is essentially free of chemical or microbial contaminance, (vi) constant illumination period, and providing the animal population after said time period. Further, the present invention relates to methods for the identification of a compound which effects the metabolome of an animal, or methods for the identification of a marker for such compounds. Moreover, the present invention encompasses methods for the identification of such compounds or markers thereof comprising metabolically analyzing a sample from at least one animal of an animal population.
摘要翻译：本发明涉及一种用于提供具有基本相同的代谢组的动物群体的方法，其包括编译基本相同年龄的动物群体，在下列住房条件下将所述动物群体保持足够的时间以适应适应环境：（i）恒定温度，（ii）恒定湿度，（iii）动物群体的动物的物理分离，（iv）随意喂食，其中待进食的食物基本上没有化学或微生物污染，（v）自由饮用，其中所述饮用液体基本上不含化学或微生物污染物，（vi）恒定的照射期，并且在所述时间段之后提供所述动物群体。此外，本发明涉及用于鉴定影响动物代谢组合物的化合物的方法，或用于鉴定这些化合物的标记物的方法。此外，本发明包括用于鉴定这样的化合物或其标志物的方法，其包括代谢分析来自动物群体的至少一种动物的样品。

7. 发明申请

WO2009153136A2 MEANS AND METHODS FOR ASSESSING LIVER TOXICITY 审中-公开
标题翻译：用于评估肝脏毒性的方法和方法
公开(公告)号：WO2009153136A2
公开(公告)日：2009-12-23
申请号：PCT/EP2009/056367
申请日：2009-05-26
申请人： BASF SE , VAN RAVENZWAAY, Bennard , MELLERT, Werner , COELHO PALERMO CUNHA, Georgia , FABIAN, Eric , STRAUSS, Volker , KAMP, Hennicke , WALK, Tilmann B. , LOOSER, Ralf , HEROLD, Michael Manfred , WIEMER, Jan C. , PROKOUDINE, Alexandre , LEIBOLD, Edgar
发明人： VAN RAVENZWAAY, Bennard , MELLERT, Werner , COELHO PALERMO CUNHA, Georgia , FABIAN, Eric , STRAUSS, Volker , KAMP, Hennicke , WALK, Tilmann B. , LOOSER, Ralf , HEROLD, Michael Manfred , WIEMER, Jan C. , PROKOUDINE, Alexandre , LEIBOLD, Edgar
IPC分类号： G01N33/66 , G01N33/68 , G01N33/82 , G01N33/84 , G01N33/92
CPC分类号： G01N33/92 , G01N2500/00 , G01N2560/00 , G01N2800/085 , G01N2800/60 , Y02A90/26
摘要： The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing liver toxicity. It also relates to a method of determining whether a compound is capable of inducing such liver toxicity in a subject and to a method of identifying a drug for treating liver toxicity. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing liver toxicity. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing liver toxicity in a subject.
摘要翻译：本发明涉及化学化合物危险分层的毒理学评估领域。具体地说，涉及一种诊断肝毒性的方法。它还涉及确定化合物是否能够在受试者中诱导这种肝毒性的方法以及鉴定用于治疗肝毒性的药物的方法。此外，本发明涉及包含至少五种代谢物的特征值的数据收集，包括所述数据收集的数据存储介质，以及用于诊断肝毒性的系统和装置。最后，本发明涉及一组代谢物或方法用于制备用于诊断受试者的肝脏毒性的诊断装置或组合物的用途。

8. 发明申请

WO2009153131A1 MEANS AND METHODS FOR ASSESSING LIVER ENZYME INDUCTION 审中-公开
标题翻译：用于评估肝脏酶诱导的方法和方法
公开(公告)号：WO2009153131A1
公开(公告)日：2009-12-23
申请号：PCT/EP2009/056312
申请日：2009-05-25
申请人： BASF SE , RAVENZWAAY, Bennard van , MELLERT, Werner , COELHO PALERMO CUNHA, Georgia , FABIAN, Eric , STRAUSS, Volker , KAMP, Hennicke , WALK, Tilmann, B. , LOOSER, Ralf , HEROLD, Michael, Manfred , WIEMER, Jan, C. , PROKOUDINE, Alexandre , LEIBOLD, Edgar
发明人： RAVENZWAAY, Bennard van , MELLERT, Werner , COELHO PALERMO CUNHA, Georgia , FABIAN, Eric , STRAUSS, Volker , KAMP, Hennicke , WALK, Tilmann, B. , HEROLD, Michael, Manfred , WIEMER, Jan, C. , PROKOUDINE, Alexandre , LEIBOLD, Edgar
IPC分类号： G01N33/66 , G01N33/92 , G01N33/84
CPC分类号： G01N33/66 , G01N33/84 , G01N33/92 , G01N2405/00 , G01N2500/00 , G01N2800/085 , G01N2800/50 , G01N2800/60
摘要： The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing the pro-pathological effect of compounds which are inducing liver enzymes. It also relates to a method of determining whether a compound is capable of exhibiting pro-pathological effects on the liver by enzyme induction in a subject and to a method of identifying a drug for treating the pro-pathological effect of liver enzyme induction. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five analytes, a data storage medium comprising said data collection, and a system and a device for diagnosing the pro-pathological effect of liver enzyme induction. Finally, the present invention pertains to the use of a group of analytes or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing the pro-pathological effect of liver enzyme induction in a subject. For each sex, a different metabolome pattern, i.e. a different set of analytes is disclosed. The liver enzyme induction markers are mainly selected from free fatty acids, but also include various phosphatidylcholines, galactose, 3- and 5-Methoxysphingosine, Cholesterol, Threonic acid, 1, 2-Dioleoyl-sn-glycero-3-phosphatidyl-L-serine, Glycerol, Glycerophosphate, Dodecanol, myo-Inositol-2-monophosphate.
摘要翻译：本发明涉及化学化合物危险分层的毒理学评估领域。具体地说，涉及一种用于诊断诱导肝酶的化合物的前病理作用的方法。本发明还涉及确定化合物能否通过受试者的酶诱导对肝脏表现出前病理作用的方法以及鉴定用于治疗肝酶诱导的病理学作用的药物的方法。此外，本发明涉及包含至少五种分析物的特征值的数据收集，包括所述数据收集的数据存储介质，以及用于诊断肝脏酶诱导的原病毒作用的系统和装置。最后，本发明涉及一组分析物或方法用于制备诊断装置或组合物用于诊断受试者中肝酶诱导的原病毒作用的用途。对于每个性别，公开了不同的代谢组织模式，即不同的分析物组。肝酶诱导标记主要选自游离脂肪酸，还包括各种磷脂酰胆碱，半乳糖，3-和5-甲氧基鞘氨醇，胆固醇，苏氨酸，1,2-二油酰-sn-甘油-3-磷脂酰-L-丝氨酸甘油，甘油磷酸酯，十二烷醇，肌醇-2-单磷酸酯。

9. 发明申请

WO2008025579A1 MEANS AND METHOD FOR DIAGNOSING HEMOLYTIC ANEMIA 审中-公开
标题翻译：用于诊断HEMOLYTIC ANEMIA的手段和方法
公开(公告)号：WO2008025579A1
公开(公告)日：2008-03-06
申请号：PCT/EP2007/055472
申请日：2007-06-04
申请人： Metanomics GmbH , WALK, Tilmann B. , LOOSER, Ralf , HEROLD, Michael Manfred , WIEMER, Jan C. , PROKOUDINE, Alexandre , LEIBOLD, Edgar , VAN RAVENZWAAY, Bennard , MELLERT, Werner , COELHO PALERMO CUNHA, Georgia , FABIAN, Eric , STRAUSS, Volker
发明人： WALK, Tilmann B. , LOOSER, Ralf , HEROLD, Michael Manfred , WIEMER, Jan C. , PROKOUDINE, Alexandre , LEIBOLD, Edgar , VAN RAVENZWAAY, Bennard , MELLERT, Werner , COELHO PALERMO CUNHA, Georgia , FABIAN, Eric , STRAUSS, Volker
IPC分类号： G01N33/53
CPC分类号： G01N33/5308 , G01N2500/04 , G01N2800/22 , Y10T436/14 , Y10T436/145555
摘要： The present invention relates to a method for diagnosing hemolytic anemia or a predis- position thereof. It also relates to a method of determining whether a compound is capable of inducing hemolytic anemia in a subject and to a method of identifying a drug for treating hemolytic anemia. Furthermore, the present invention relates to a data collection comprising characteristic values of metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing hemolytic anemia. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing hemolytic anemia in a subject.
摘要翻译：本发明涉及诊断溶血性贫血的方法或其前提。它还涉及确定化合物是否能够诱导受试者的溶血性贫血的方法以及鉴定用于治疗溶血性贫血的药物的方法。此外，本发明涉及包含代谢物的特征值，包含所述数据收集的数据存储介质的数据收集以及用于诊断溶血性贫血的系统和装置。最后，本发明涉及一组代谢物或方法用于制备用于诊断受试者中的溶血性贫血的诊断装置或组合物的用途。

10. 发明申请

WO2007012643A1 MEANS AND METHODS FOR ANALYZING A SAMPLE BY MEANS OF CHROMATOGRAPHY-MASS SPECTROMETRY 审中-公开
标题翻译：用于通过色谱质谱法分析样品的方法和方法
公开(公告)号：WO2007012643A1
公开(公告)日：2007-02-01
申请号：PCT/EP2006/064628
申请日：2006-07-25
申请人： METANOMICS GMBH , WALK, Tilmann B. , LOOSER, Ralf , BETHAN, Bianca , HEROLD, Michael Manfred , KAMLAGE, Beate , SCHMITZ, Oliver , RAVENZWAAY, Bennard van , MELLERT, Werner , COELHO PALERMO CUNHA, Georgia , EHRHARDT, Thomas , WIEMER, Jan , PROKOUDINE, Alexandre , KRENNRICH, Gerhard
发明人： WALK, Tilmann B. , LOOSER, Ralf , BETHAN, Bianca , HEROLD, Michael Manfred , KAMLAGE, Beate , SCHMITZ, Oliver , RAVENZWAAY, Bennard van , MELLERT, Werner , COELHO PALERMO CUNHA, Georgia , EHRHARDT, Thomas , WIEMER, Jan , PROKOUDINE, Alexandre , KRENNRICH, Gerhard
IPC分类号： G06F19/00
CPC分类号： G01N30/8675 , G01N30/8668 , G01N2030/8813 , G01N2030/8818 , G01N2030/8822 , G06F19/703 , G06F19/707
摘要： The present invention relates to a method for analyzing at least one test sample, wherein said test sample comprises at least one compound, said method comprising the steps of: a) providing at least one test sample comprising at least one compound; b) determining said at least one compound in said test sample whereby raw results are generated; and c) analyzing the raw results obtained in step b), wherein the analysis of said at least one test sample is accompanied by an analysis of at least one reference sample; and wherein the test sample and the reference sample are analyzed in an identical sequence in each step of the method. Moreover, the present invention further encompasses a system for carrying out said method comprising operatively linked to each other: (a) means for determining a compound; (b) means for monitoring process parameters, (c) means for analyzing raw results obtained from the means according to (a), wherein said means for analyzing raw results comprise: (i) a first database comprising raw results received from the means according to (a); (ii) a second database comprising monitored process parameters received from the means according to (b); (iii) a third database comprising rules for evaluating the raw results; and (iv) a fourth database comprising allocated results of identified compounds; wherein at least the second, third and fourth database are operatively linked to the first database.
摘要翻译：本发明涉及用于分析至少一种测试样品的方法，其中所述测试样品包含至少一种化合物，所述方法包括以下步骤：a）提供至少一种包含至少一种化合物的测试样品; b）确定所述测试样品中的所述至少一种化合物，从而产生原始结果; 以及c）分析在步骤b）中获得的原始结果，其中所述至少一个测试样品的分析伴随着至少一个参考样品的分析; 并且其中在该方法的每个步骤中以相同的顺序分析测试样品和参考样品。此外，本发明还包括用于执行所述方法的系统，其包括彼此可操作地连接：（a）用于确定化合物的装置; （b）用于监视过程参数的装置，（c）用于分析根据（a）的装置获得的原始结果的装置，其中所述用于分析原始结果的装置包括：（i）第一数据库，包括从根据至（a）; （ii）第二数据库，包括从根据（b）的装置接收的监测过程参数; （iii）包含用于评估原始结果的规则的第三数据库; 和（iv）第四个数据库，其中包括所鉴别化合物的分配结果; 其中至少所述第二，第三和第四数据库可操作地链接到所述第一数据库。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式