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1. 发明申请

WO2010071844A1 SUBSTANCE DELIVERING PUNCTUM IMPLANTS AND METHODS 审中-公开
标题翻译：物质输送冲压件和方法
公开(公告)号：WO2010071844A1
公开(公告)日：2010-06-24
申请号：PCT/US2009/068848
申请日：2009-12-18
申请人： QLT PLUG DELIVERY, INC , UTKHEDE, Deepank , MONK, Wendy
发明人： UTKHEDE, Deepank , MONK, Wendy
IPC分类号： A61F2/00
CPC分类号： A61F9/00772 , A61F9/0017
摘要： Substance delivering punctum plug devices and related methods for treating disorders and diseases of the eye. Some embodiments of the device maximize dissolution of the substance in tears and/or other fluid(s) that distribute to the anterior surface of the eye so as to maximize delivery of the substance to or through the cornea or anterior surface of the eye ball while minimizing loss of substance through other routes.
摘要翻译：物质输送泪点塞装置和相关方法，用于治疗眼睛疾病和疾病。该装置的一些实施方案使分散于眼前表面的泪液和/或其它流体中物质的溶解最大化，以便最大限度地将物质递送至眼球或角膜的前表面或通过眼球的前表面，同时通过其他路线减少物质的损失。

2. 发明专利

IN9713DEN2014A DRUG DELIVERY SYSTEM AND METHODS OF TREATING OPEN ANGLE GLAUCOMA AND OCULAR HYPERTENSION 未知
公开(公告)号：IN9713DEN2014A
公开(公告)日：2015-07-31
申请号：IN9713DEN2014
申请日：2014-11-18
申请人： QUADRA LOGIC TECH INC , UTKHEDE DEEPANK , CADDEN SUZANNE , HAO YONG
发明人： UTKHEDE DEEPANK , CADDEN SUZANNE , HAO YONG
IPC分类号： A61K9/00 , A61F9/00 , A61K31/557
摘要： A method of decreasing intraocular pressure (IOP) in an eye of a patient in need thereof includes implanting a first lacrimal implant through an upper punctum and into an upper lacrimal canaliculus of the eye of the patient. The method may further comprise implanting a second lacrimal implant through a lower punctum and into a lower lacrimal canaliculus of the eye of the patient and releasing on a sustained basis a therapeutically effective amount of an intraocular pressure reducing therapeutic agent.

3. 发明申请

WO2013030679A3 SUSTAINED RELEASE DELIVERY OF ACTIVE AGENTS TO TREAT GLAUCOMA AND OCULAR HYPERTENSION 审中-公开
标题翻译：持续释放活性药剂以治疗玻尿酸和高血压
公开(公告)号：WO2013030679A3
公开(公告)日：2013-05-02
申请号：PCT/IB2012002210
申请日：2012-08-29
申请人： QUADRA LOGIC TECH INC , CADDEN SUZANNE , HAO YONG , UTKHEDE DEEPANK , RUBINCHIK VALERY , KJELLBOTN CHARLES RICHARD
发明人： CADDEN SUZANNE , HAO YONG , UTKHEDE DEEPANK , RUBINCHIK VALERY , KJELLBOTN CHARLES RICHARD
IPC分类号： A61K9/00 , A61F2/02 , A61K31/5575 , A61L31/06 , A61L31/16 , A61M31/00
CPC分类号： A61K31/5575 , A61F9/0017 , A61F9/00772 , A61F9/00781 , A61K9/0051 , A61K9/0092 , A61K31/216
摘要： A method of decreasing intraocular pressure (IOP) in an eye of a patient in need thereof includes implanting a first lacrimal implant through a firsts punctum and into a first lacrimal canaliculus of the eye of the patient. The method may further comprise implanting a second lacrimal implant through a second punctum and into a second lacrimal canaliculus of the eye of the patient, and releasing, on a sustained basis a therapeutically effective amount of an intraocular pressure-reducing therapeutic agent.
摘要翻译：在有需要的患者的眼睛中减少眼内压（IOP）的方法包括将第一泪液植入物通过第一泪点植入，并进入患者眼睛的第一泪小管。该方法还可以包括将第二泪液植入物植入穿过第二泪点并进入患者眼睛的第二泪小管，并持续释放治疗有效量的眼内压降治疗剂。

4. 发明申请

WO2013030679A2 SUSTAINED RELEASE DELIVERY OF ACTIVE AGENTS TO TREAT GLAUCOMA AND OCULAR HYPERTENSION 审中-公开
标题翻译：持续释放活性药物治疗青光眼和高眼压症
公开(公告)号：WO2013030679A2
公开(公告)日：2013-03-07
申请号：PCT/IB2012/002210
申请日：2012-08-29
申请人： QLT INC. , CADDEN, Suzanne , HAO, Yong , UTKHEDE, Deepank , RUBINCHIK, Valery , KJELLBOTN, Charles, Richard
发明人： CADDEN, Suzanne , HAO, Yong , UTKHEDE, Deepank , RUBINCHIK, Valery , KJELLBOTN, Charles, Richard
CPC分类号： A61K31/5575 , A61F9/0017 , A61F9/00772 , A61F9/00781 , A61K9/0051 , A61K9/0092 , A61K31/216
摘要： A method of decreasing intraocular pressure (IOP) in an eye of a patient in need thereof includes implanting a first lacrimal implant through a firsts punctum and into a first lacrimal canaliculus of the eye of the patient. The method may further comprise implanting a second lacrimal implant through a second punctum and into a second lacrimal canaliculus of the eye of the patient, and releasing, on a sustained basis a therapeutically effective amount of an intraocular pressure-reducing therapeutic agent.
摘要翻译：降低有此需要的患者眼中的眼内压（IOP）的方法包括将第一泪腺植入物通过第一泪点植入患者眼睛的第一泪小管中。该方法可进一步包括将第二泪腺植入物通过第二泪点植入患者眼睛的第二泪小管中，并持续释放治疗有效量的眼内压降低治疗剂。 >

5. 发明申请

WO2012097264A2 PHARMACEUTICAL COMPOSITIONS FOR TOPICAL DELIVERY OF PHOTOSENSITIZERS AND USES THEREOF 审中-公开
标题翻译：用于光敏剂局部输送的药物组合物及其用途
公开(公告)号：WO2012097264A2
公开(公告)日：2012-07-19
申请号：PCT/US2012/021263
申请日：2012-01-13
申请人： QLT INC. , MORRIS, Jerome A. , UTKHEDE, Deepank , HUNT, David W. C.
发明人： MORRIS, Jerome A. , UTKHEDE, Deepank , HUNT, David W. C.
IPC分类号： A61K47/00
CPC分类号： A61K41/0071 , A61K9/0014 , A61K9/08 , A61K31/409 , A61K47/10
摘要： The invention includes and provides compositions comprising photosensitizing agents and their use in photodynamic therapy for the treatment of dermatological conditions.
摘要翻译：本发明包括并提供包含光敏剂的组合物及其在光动力疗法中用于治疗皮肤病学条件的用途。

6. 发明申请

WO2009035562A2 DRUG CORES FOR SUSTAINED RELEASE OF THERAPEUTIC AGENTS 审中-公开
标题翻译：用于持续释放治疗药物的药物
公开(公告)号：WO2009035562A2
公开(公告)日：2009-03-19
申请号：PCT/US2008/010487
申请日：2008-09-05
申请人： QLT PLUG DELIVERY, INC , UTKHEDE, Deepank , SHIMIZU, Robert W. , JAIN, Rachna , BOYD, Stephen , GIFFORD, Hanson S. , DE JUAN JR., Eugene , REICH, Cary J.
发明人： UTKHEDE, Deepank , SHIMIZU, Robert W. , JAIN, Rachna , BOYD, Stephen , GIFFORD, Hanson S. , DE JUAN JR., Eugene , REICH, Cary J.
IPC分类号： A61K9/00 , A61M5/14 , A61F2/02 , A61F9/00
CPC分类号： A61K9/0051 , A61F9/0017 , A61F9/00772 , A61F2230/0069 , A61F2250/0067 , A61K31/5575 , A61K47/34 , A61L27/54 , A61L2300/41 , A61L2300/602 , A61L2300/802 , Y02A50/395
摘要： A solid drug core insert can be manufactured by injecting a liquid mixture comprising a therapeutic agent and a matrix precursor into a sheath body. The injection can be conducted at subambient temperatures. The mixture is cured to form a solid drug-matrix core. The therapeutic agent can be a liquid at about room temperature that forms a dispersion of droplets in the matrix material. A surface of the solid drug core is exposed, for example by cutting the tube, and the exposed surface of the solid drug core releases therapeutic quantities of the therapeutic agent when implanted into the patient. In some embodiments, the insert body inhibits release of the therapeutic agent, for example with a material substantially impermeable to the therapeutic agent, such that the therapeutic quantities are released through the exposed surface, thereby avoiding release of the therapeutic agent to non-target tissues.
摘要翻译：可以通过将包含治疗剂和基质前体的液体混合物注入鞘体来制造固体药物核心插入物。注射可以在低于环境温度下进行。将混合物固化以形成固体药物基质核心。治疗剂可以是在约室温下的液体，其形成液滴在基质材料中的分散体。固体药物核心的表面例如通过切割管而暴露，并且固体药物核心的暴露表面在植入患者体内释放治疗剂量。在一些实施方案中，插入体抑制治疗剂的释放，例如具有对治疗剂基本上不可渗透的材料，使得治疗量通过暴露表面释放，从而避免将治疗剂释放到非靶组织。

7. 发明申请

WO2018064648A1 OPHTHALMIC DRUG SUSTAINED RELEASE FORMULATION AND USES THEREOF 审中-公开
标题翻译：眼药水持续释放制剂及其用途
公开(公告)号：WO2018064648A1
公开(公告)日：2018-04-05
申请号：PCT/US2017/054654
申请日：2017-09-30
申请人： MATI THERAPEUTICS INC. , UTKHEDE, Deepank , JONES, Catherine , WISEMAN, David
发明人： UTKHEDE, Deepank , JONES, Catherine , WISEMAN, David
IPC分类号： A61K9/00
摘要： A solid matrix sustained release ophthalmic formulation for topical delivery of a solid ophthalmic drug to the eye, medical devices, drug cores, drug inserts and drug delivery systems comprising the formulation, methods of manufacturing the formulation, medical devices and their methods thereof for delivering the ophthalmic drug for a treatment period provided herein. The formulation disclosed herein is an admixture of an ophthalmic drug, and a combination of a hydrophobic polymer, a hydrophilic polymer and a surfactant, wherein the drug is eluted daily over an extended period of time at therapeutic dose of drug.
摘要翻译：用于将固体眼科药物局部递送至眼睛的固体基质缓释眼用制剂，包含该制剂的医疗装置，药物核心，药物插入物和药物递送系统，制造该制剂的方法，医疗装置及其用于在此提供治疗期间递送眼科药物的方法。本文公开的制剂是眼科药物与疏水性聚合物，亲水性聚合物和表面活性剂的组合的混合物，其中所述药物在治疗剂量的药物中在延长的时间内每天洗脱。

8. 发明申请

WO2013164671A1 DRUG DELIVERY SYSTEM AND METHODS OF TREATING OPEN ANGLE GLAUCOMA AND OCULAR HYPERTENSION 审中-公开
标题翻译：药物输送系统及治疗开放性角膜囊肿和眼压高血压的方法
公开(公告)号：WO2013164671A1
公开(公告)日：2013-11-07
申请号：PCT/IB2013/000694
申请日：2013-02-27
申请人： QLT INC. , UTKHEDE, Deepank , CADDEN, Suzanne , HAO, Yong
发明人： UTKHEDE, Deepank , CADDEN, Suzanne , HAO, Yong
IPC分类号： A61K9/00 , A61F9/00 , A61K31/5575 , A61L31/04 , A61L31/16 , A61P27/06
CPC分类号： A61F9/00781 , A61K9/0051 , A61K9/7007 , A61K31/5575
摘要： A method of decreasing intraocular pressure (IOP) in an eye of a patient in need thereof includes implanting a first lacrimal implant through an upper punctum and into an upper lacrimal canaliculus of the eye of the patient. The method may further comprise implanting a second lacrimal implant through a lower punctum and into a lower lacrimal canaliculus of the eye of the patient, and releasing, on a sustained basis a therapeutically effective amount of an intraocular pressure -reducing therapeutic agent.
摘要翻译：在有需要的患者的眼睛中降低眼内压（IOP）的方法包括将第一泪液植入物通过上眼泪植入患者眼睛的上泪小管。该方法还可以包括将第二泪液植入物植入穿过下泪点并进入患者眼睛的下泪小管，并持续释放治疗有效量的眼内压降治疗剂。

9. 发明申请

WO2010085696A9 SUSTAINED RELEASED DELIVERY OF ONE OR MORE AGENTS 审中-公开
公开(公告)号：WO2010085696A9
公开(公告)日：2010-07-29
申请号：PCT/US2010/021868
申请日：2010-01-22
申请人： QLT PLUG DELIVERY INC. , BUTUNER, Zuhal , UTKHEDE, Deepank , SIM, Sylvie , WISEMAN, David, J.
发明人： BUTUNER, Zuhal , UTKHEDE, Deepank , SIM, Sylvie , WISEMAN, David, J.
IPC分类号： A61M37/00 , A61F9/00 , A61K9/00
摘要： The lacrimal implant delivery systems and methods described herein provide for controlled release of a therapeutic agent for the treatment of disease, including the treatment of glaucoma, ocular hypertension, or elevated intraocular pressure with latanoprost or other anti- glaucoma agents. Treatment of disease, including glaucoma, ocular hypertension, or elevated intraocular pressure with latanoprost or other anti-glaucoma agent in conjunction with penetration enhancer, such as benzalkonium chloride, and/or artificial tears is also provided. Also provided are implants containing a drug core emplacable in a punctum adjacent to an eye of a patient for controlled release of a therapeutic agent such as latanoprost for the treatment of glaucoma, the drug core containing a polymer such as cross-linked silicone, a therapeutic agent, and an excipient, wherein the excipient can increase the rate of release of the agent from the drug core, or can increase the drug loading in the core without loss of desirable homogeneity of the agent within the core, or can improve retention of the agent in the eye or in tear fluid, or can increase corneal penetration of the agent into the eye.

10. 发明申请

WO2018013869A1 STATIC PIN INSERTION TOOL FOR LACRIMAL IMPLANT 审中-公开
标题翻译：用于LACRIMAL植入物的静脉插入工具
公开(公告)号：WO2018013869A1
公开(公告)日：2018-01-18
申请号：PCT/US2017/042020
申请日：2017-07-13
申请人： MATI THERAPEUTICS INC. , UTKHEDE, Deepank , WALLACE, Jon , WILLIAMS, Robert
发明人： UTKHEDE, Deepank , WALLACE, Jon , WILLIAMS, Robert
IPC分类号： A61F9/007 , A61F9/00 , A61F2/14
摘要： An insertion tool, systems, and methods for use with lacrimal implants are herein provided. An insertion tool is disclosed that includes an inserter tip with a static pin at a distal end configured to be placed in a bore of a lacrimal implant and a mechanical coupling to receive a handle at a proximal end of the inserter tip; and, a handle coupled to the inserter tip at a distal end of the handle and a plunger at a proximal end of the handle, wherein the plunger is configured to release the inserter tip from the handle. The static pin of the inserter tip is de-coupled from the lacrimal implant after placement in a lacrimal canaliculus without mechanical force from the insertion tool.
摘要翻译：本文提供了用于泪管植入物的插入工具，系统和方法。公开了一种插入工具，该插入工具包括：插入器尖端，该插入器尖端在远端处具有静态销，该静止销被构造成放置在泪管植入物的孔中;以及机械联接器，以在插入器尖端的近端处接收手柄; 以及手柄，所述手柄在所述手柄的远端处连接至所述插入器尖端，并且在所述手柄的近端处连接至柱塞，其中所述柱塞构造成从所述手柄释放所述插入器尖端。插入器尖端的静止针在置入泪小管之后与泪管植入物分离，而没有来自插入工具的机械力。

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