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1. 发明申请

US20190080043A1 METHOD AND DEVICE FOR MODELLING HUMAN OR ANIMAL TISSUE 审中-公开
公开(公告)号：US20190080043A1
公开(公告)日：2019-03-14
申请号：US15773602
申请日：2016-10-25
申请人： Optimo Medical AG , Universität Bern Verwaltungsdirektion
发明人： Philippe Büchler , Elena Businaro , Harald P. Studer
IPC分类号： G16H50/50 , G16H20/40 , A61B3/00
摘要： Disclosed is a computer-implemented method for modelling human or animal patient tissue. The method includes: acquiring a stressed patient topography data set, the stressed patient topography data set describing a topography of at least one patient tissue surface under mechanical stress; determining an input data set; evaluating a statistic model for the input data set, thereby obtaining an output data set; determining, from the output data set, a relaxed patient topography data set. The statistic model includes a set of Gaussian Processes and is defined by a pre-determined model parameter set, the model parameter set including at least one Gaussian Process parameter for each Gaussian Process, and wherein the statistic model is independent from the patient tissue to be modelled. Disclosed is further a computerized device for carrying out such method. Disclosed are further a computer-implemented method and a computerized device for determining a parameter set.

2. 发明申请

WO2014033186A1 ELECTROSPRAY DEVICE 审中-公开
标题翻译：电子设备
公开(公告)号：WO2014033186A1
公开(公告)日：2014-03-06
申请号：PCT/EP2013/067849
申请日：2013-08-28
申请人： UNIVERSITÄT BERN VERWALTUNGSDIREKTION , FACHHOCHSCHULE NORDWESTSCHWEIZ FHNW
发明人： HRADETZKY, David , SCHKOMMODAU, Erik , BÖHRINGER, Stephan , GAZDHAR, Amiq , GEISER, Thomas
IPC分类号： A61M15/02 , A61M11/00 , A61M16/04 , B05B5/025 , A61M35/00 , A61M25/00
CPC分类号： B05B5/0533 , A61M11/00 , A61M15/02 , A61M35/003 , A61M2202/04 , A61M2210/1039 , B05B5/0255 , B05B5/087 , B05B5/1691
摘要： The invention related to a device (1) for spraying charged droplets of a liquid towards a target along a spraying direction, comprising: a reservoir (10) for storing the liquid (L), a first electrode (100) being arranged at an outlet (11) of said reservoir (10), a second electrode (200) forming a counter electrode to the first electrode (100) for accelerating said droplets (D) along the spraying direction (S), and a housing (30) holding the reservoir (10) as well as said electrodes (100, 200).
摘要翻译：本发明涉及一种用于沿着喷射方向朝向靶喷射液体的带电液滴的装置（1），包括：储存器（10），用于储存液体（L）;第一电极（100）布置在出口（10）的第一电极（11），形成与第一电极（100）对置的反电极的第二电极（200），用于沿着喷射方向（S）加速所述液滴（D）;以及壳体（30）储存器（10）以及所述电极（100,200）。

3. 发明专利

ES2526292T3 Antagonistas de la somatostatina selectivos para receptor (SSTR2) 未知
公开(公告)号：ES2526292T3
公开(公告)日：2015-01-09
申请号：ES11173287
申请日：2007-10-15
申请人： SALK INST FOR BIOLOGICAL STUDI , UNIVERSITÄT BERN VERWALTUNGSDIREKTION , UNIV HOSPITAL BASEL
发明人： RIVIER JEAN E F , ERCHEGYI JUDIT , REUBI JEAN CLAUDE , MAECKE HELMUT R
IPC分类号： A61K38/00 , C07K14/655
摘要： Un péptido análogo de somatostatina (SRIF) cíclico que se une selectivamente al receptor de SRIF SSTR2 sin desencadenar la internalización en una célula, péptido que tiene una de las siguientes secuencias de aminoácidos en las que el extremo C está amidado:**Fórmula** en las que Cpa se refiere a cloro-Phe, Aph (Cbm) se refiere a 4-ureido-fenilalanina y 2 Nal se refiere al isómero de alanina que está sustituido con naftilo sobre el átomo de carbono ß, siendo la unión al naftaleno en la posición 2 sobre el anillo; y sales no tóxicas del mismo.

4. 发明申请

WO2022013110A1 MEDICAL DEVICE AND METHOD OF FABRICATION THEREOF 审中-公开
公开(公告)号：WO2022013110A1
公开(公告)日：2022-01-20
申请号：PCT/EP2021/069219
申请日：2021-07-09
申请人： CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA - RECHERCHE ET DÉVELOPPEMENT , UNIVERSITÄT BERN VERWALTUNGSDIREKTION
发明人： LUU-DINH, Angélique , ZUBAK, Irena
IPC分类号： A61L27/36 , A61L27/22 , A61L27/50 , A61L27/52 , A61B17/08 , A61F13/00 , A61F13/62 , A44B18/00 , A61L27/18 , A61B17/00
摘要： The invention relates to a medical device (1) for use in surgery comprising at least one structured substrate (2) comprising a plurality of structures (10), at least a portion of the plurality of structures (12) being a plurality of ridges (101-106, 121-127) having each a length (L) that is at least 5 times greater than their width (W). The ridges (101-106, 121-127) have at least two different cross-sections (C1-C19) and have swellable properties, for example in presence of water. The medical device (1) comprises at least a second substrate (4),comprising a second plurality of structures (12), said first and second plurality of structures (10, 12) being arranged to interlock when said first substrate (2) is pressed against said second substrate (4) in presence of water. The invention is also achieved by a method to realize the medical device.

5. 发明申请

WO2013034687A1 AVIBACTERIUM PARAGALLINARUM RTX TOXIN 审中-公开
标题翻译： AVARACTERIUM PARAGALLINARUM RTX TOXIN
公开(公告)号：WO2013034687A1
公开(公告)日：2013-03-14
申请号：PCT/EP2012/067506
申请日：2012-09-07
申请人： UNIVERSITÄT BERN VERWALTUNGSDIREKTION , FREY, Joachim , KÜNG, Eliane
发明人： FREY, Joachim , KÜNG, Eliane
IPC分类号： A61K39/102 , C07K14/285 , C12Q1/68 , G01N33/569
CPC分类号： A61K39/102 , A61K2039/505 , A61K2039/552 , C07K14/285 , C07K16/1242 , C07K2317/76 , G01N33/56911
摘要： The present invention provides the polypeptide sequences of Avibacterium paragallinarum toxin, its coding nucleic acid sequence, as well as the use of the inventive sequences as a vaccine, antibodies and their use.
摘要翻译：本发明提供了副杆菌属杆菌毒素的多肽序列，其编码核酸序列以及本发明序列作为疫苗，抗体及其用途的用途。

6. 发明申请

WO2017076698A1 METHOD AND DEVICE FOR MODELLING HUMAN OR ANIMAL TISSUE 审中-公开
标题翻译：用于模拟人类或动物组织的方法和设备
公开(公告)号：WO2017076698A1
公开(公告)日：2017-05-11
申请号：PCT/EP2016/075676
申请日：2016-10-25
申请人： OPTIMO MEDICAL AG , UNIVERSITÄT BERN VERWALTUNGSDIREKTION
发明人： BÜCHLER, Philipp , BUSINARO, Elena , STUDER, Harald
IPC分类号： G06F19/00 , G06T17/00 , A61B3/00
CPC分类号： G06F19/3481 , A61B3/00 , A61B3/0025 , G06F19/00 , G16H50/50
摘要： Disclosed is a computer-implemented method for modelling human or animal patient tissue. The method includes: acquiring a stressed patient topography data set, the stressed patient topography data set describing a topography of at least one patient tissue surface under mechanical stress; determining an input data set; evaluating a statistic model for the input data set, thereby obtaining an output data set; determining, from the output data set, a relaxed patient topography data set. The statistic model includes a set of Gaussian Processes and is defined by a pre-determined model parameter set, the model parameter set including at least one Gaussian Process parameter for each Gaussian Process, and wherein the statistic model is independent from the patient tissue to be modelled. Disclosed is further a computerized device for carrying out such method. Disclosed are further a computer-implemented method and a computerized device for determining a parameter set.
摘要翻译：公开了一种用于对人或动物患者组织进行建模的计算机实现的方法。该方法包括：获取紧张的患者形貌数据集，所述紧张的患者形貌数据集描述了机械应力下至少一个患者组织表面的形貌; 确定输入数据集; 评估输入数据集的统计模型，从而获得输出数据集; 从输出数据集中确定放松的患者形貌数据集。该统计模型包括一组高斯过程并且由预定模型参数集定义，该模型参数集包括用于每个高斯过程的至少一个高斯过程参数，并且其中该统计模型独立于将被病人组织建模。进一步公开了用于执行这种方法的计算机化设备。还公开了一种用于确定参数集的计算机实现的方法和计算机化的设备。

7. 发明申请

WO2012069592A1 SUCTION AND IRRIGATION DEVICE 审中-公开
标题翻译：抽吸和灌溉装置
公开(公告)号：WO2012069592A1
公开(公告)日：2012-05-31
申请号：PCT/EP2011/070952
申请日：2011-11-24
申请人： UNIVERSITÄT BERN VERWALTUNGSDIREKTION , STIEGLITZ, Lennart Henning , SPIEGELBERG, Andreas
发明人： STIEGLITZ, Lennart Henning , SPIEGELBERG, Andreas
IPC分类号： A61M1/00
CPC分类号： A61M3/0283 , A61M1/0045 , A61M1/0047 , A61M1/0062
摘要： A suction and irrigation device for medical use comprises a valve body with an irrigation passage (7) and a suction passage (8). At least one irrigation pipe and at least one suction pipe are connectable to the irrigation passage and the suction passage by connections at a proximal side of the valve body. A suction/irrigation tube (5) is connectable to the irrigation passage (7) and the suction passage (8) at a distal side of the valve body (2) by at least one further connection. A valve assembly (15, 17, 18) is provided within the valve body, which in a first position opens the suction passage (8) and closes the irrigation passage (7) and in a second position closes the suction passage (8) and opens the irrigation passage (7). The device comprises at least one push element which interacts with at least one movable element (15, 17, 18) of the valve assembly, whereas the movable element (15, 17, 18) is movable by mechanical force acted upon the push element such, that the push element activates the valve assembly (15, 17, 18) from one position to the other position.
摘要翻译：用于医疗用途的吸入和冲洗装置包括具有冲洗通道（7）和吸入通道（8）的阀体。至少一个冲洗管和至少一个吸入管可通过在阀体的近侧的连接连接到冲洗通道和吸入通道。吸入/冲洗管（5）可通过至少一个另外的连接件连接到冲洗通道（7）和在阀体（2）的远侧侧的吸入通道（8）。一个阀组件（15,17,18）设置在阀体内，其在第一位置打开吸入通道（8）并关闭冲洗通道（7），并且在第二位置关闭吸入通道（8）和打开灌溉通道（7）。该装置包括与阀组件的至少一个可移动元件（15,17,18）相互作用的至少一个推动元件，而可移动元件（15,17,18）可通过作用在推动元件上的机械力而移动，推动元件将阀组件（15,17,18）从一个位置激活到另一个位置。

8. 发明申请

WO2013135900A1 TRICYCLIC NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM 审中-公开
标题翻译：三核核苷酸和低分子化合物
公开(公告)号：WO2013135900A1
公开(公告)日：2013-09-19
申请号：PCT/EP2013/055498
申请日：2013-03-15
申请人： UNIVERSITÄT BERN VERWALTUNGSDIREKTION
发明人： LEUMANN, Christian , DUGOVICH, Branislav , LIÉTARD, Jory
IPC分类号： C07H19/06 , C07H21/00
CPC分类号： C07F9/65517 , C07H19/02 , C07H19/04 , C07H19/06 , C07H19/16 , C07H21/00 , C12N15/113 , C12N2310/11
摘要： The present invention provides novel tricyclic nucleosides and oligomeric compounds prepared therefrom. Incorporation of one or more of the tricyclic nucleosides into an oligomeric compound is expected to enhance one or more properties of the oligomeric compound. Such oligomeric compounds can also be included in double stranded compositions. In certain embodiments, the oligomeric compounds provided herein are expected to hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.
摘要翻译：本发明提供由其制备的新型三环核苷和寡聚化合物。预期将一种或多种三环核苷掺入低聚化合物可增强寡聚化合物的一种或多种性质。这种低聚化合物也可以包括在双链组合物中。在某些实施方案中，预期本文提供的寡聚化合物与靶RNA的一部分杂交，导致靶RNA的正常功能丧失。

9. 发明申请

WO2011064152A1 INHIBITORS OF TOPOISOMERASE I FOR THE TREATMENT OF AUTOIMMUNE DISEASES 审中-公开
标题翻译： TOPOISOMERASE I的抑制剂治疗自身免疫性疾病
公开(公告)号：WO2011064152A1
公开(公告)日：2011-06-03
申请号：PCT/EP2010/067871
申请日：2010-11-21
申请人： UNIVERSITÄT BERN VERWALTUNGSDIREKTION , FRESE, Steffen
发明人： FRESE, Steffen
IPC分类号： A61K31/00 , A61K31/4745 , A61P29/00
CPC分类号： A61K31/4745 , A61K31/00
摘要： The invention relates to topoisomerase I inhibitors, in particular camptothecin and camptothecin derivatives, for use in the prevention and treatment of autoimmune diseases, for example systemic lupus erythematosus. In particular, it was found that the topoisomerase I inhibitor irinotecan, a camptothecin derivative, prevents and cures a spontaneous systemic lupus erythematosus disease in mice.
摘要翻译：本发明涉及拓扑异构酶I抑制剂，特别是喜树碱和喜树碱衍生物，用于预防和治疗自身免疫性疾病，例如系统性红斑狼疮。特别地，发现拓扑异构酶I抑制剂伊立替康，喜树碱衍生物预防和治疗小鼠中自发性系统性红斑狼疮病。

10. 发明公开

EP3917610A1 URINARY PUMPING DEVICE WITH AN IMPLANTABLE ACTIVATION ARRANGEMENT 无效
公开(公告)号：EP3917610A1
公开(公告)日：2021-12-08
申请号：EP20702463.9
申请日：2020-01-29
申请人： Universität Bern Verwaltungsdirektion
发明人： OBRIST, Dominik , CLAVICA, Francesco , BURKHARD, Fiona , SCHNEIDER, Marc
IPC分类号： A61N1/05 , A61F2/04 , A61N1/36 , A61F2/00 , A61N1/372 , A61N1/378

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