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1. 发明申请

WO0228345A3 ALDEHYDE-RELEASING COMPOUNDS 审中-公开
标题翻译：甲醛释放化合物
公开(公告)号：WO0228345A3
公开(公告)日：2007-11-29
申请号：PCT/AU0101254
申请日：2001-10-05
申请人： UNIV TROBE , UNIV BAR ILAN , UNIV TEL AVIV , PHILLIPS DONALD RALPH , CUTTS SUZANNE MARGARET , REPHAELI ADA , NUDELMAN ABRAHAM
发明人： PHILLIPS DONALD RALPH , CUTTS SUZANNE MARGARET , REPHAELI ADA , NUDELMAN ABRAHAM
IPC分类号： A61K31/19 , A61K31/203 , A61K31/21 , A61K31/53 , A61K45/06 , A61P35/00 , C07C59/125 , C07C59/305 , C07C69/003 , C07C69/28 , C07C69/36 , C07C69/40 , C07F9/09 , C12N15/12
CPC分类号： A61K45/06 , C07C69/003 , C07C69/28 , C07C69/36 , C07C69/40
摘要： A method of treating cancer, comprising the step of administering to a subject in need thereof an effective amount of a compound or compounds which increase or supplement the intracellular levels of endogenous aldehyde, prior to, together with, or subsequent to the administration of a therapeutically-effective amount of a chemotherapeutic agent such as anthracyclines and anthracenediones, wherein the efficacy of the chemotherapeutic agent is enhanced relative to the efficacy of the chemotherapeutic agent alone. The compound may be an aldehyde-releasing compound (preferably formaldehyde), including known aldehyde-releasing compounds and two new classes of aldehyde-releasing compounds. One new class of aldehyde-releasing compounds of formula (II) release more than one equivalent of aldehyde Z-(L-M 1 -CHR-M 2 ) x (II) wherein x is an integer of 2 or more Z is a direct bond or a linking group of valency x; L is either a direct bond or a spacer group R is H or C1-4 alkyl, alkenyl or alkynyl; M 1 is a decomposable or hydrolysable group; and M 2 is a second decomposable or hydrolysable group. Another new class of aldehyde-releasing compounds include a radical based on an inhibitor of an aldehyde detoxifying agent, such as buthionine sulphoximine or crotonaldehyde.
摘要翻译：一种治疗癌症的方法，包括以下步骤：在有需要的受试者之前，在施用治疗性疾病之前，之后或之后施用有效量的增加或补充内源性醛的细胞内水平的化合物或化合物 - 化学治疗剂如蒽环类和蒽环类化合物的有效量，其中化疗剂的功效相对于单独的化学治疗剂的功效增强。化合物可以是释放醛的化合物（优选甲醛），包括已知的释放醛的化合物和两种新类型的释放醛的化合物。一类新的醛释放式（II）的化合物释放出多于一当量的醛Z-（LM 1 - ）-CHR-M 2 O 2，（II）其中x是2或更大的整数Z是直接键或价数x的连接基团; L是直接键或间隔基R是H或C 1-4烷基，烯基或炔基; M 1是可分解的或可水解的基团; 和M 2是第二个可分解或可水解的基团。另一种新的醛释放化合物包括基于醛解毒剂抑制剂的基团，例如丁硫氨酸亚磺酰亚胺或巴豆醛。

2. 发明公开

EP1620553A4 INSECT CHYMOTRYPSIN AND INHIBITORS THEREOF 审中-公开
标题翻译：昆虫胰凝乳蛋白酶及其抑制剂
公开(公告)号：EP1620553A4
公开(公告)日：2007-01-03
申请号：EP04729014
申请日：2004-04-23
申请人： HEXIMA LTD , UNIV TROBE
发明人： DUNSE KERRY MICHELLE , HEATH ROBYN LOUISE , ANDERSON MARILYN ANNE
IPC分类号： C12N9/76 , A01H5/00 , A01N37/46 , A01N61/00 , A01N63/00 , A01N63/02 , C12N15/12 , C12N15/57 , C12N15/82
CPC分类号： C12N15/8286 , A01N37/46 , A01N61/00 , A01N63/02 , C07K16/40 , C12N9/6427 , Y02A40/162
摘要： The present invention relates generally to a novel chymotrypsin that exhibits resistance to a plant serine proteinase inhibitor. More particularly, the present invention provides a chymotrypsin which is up-regulated in the gut of Helicoverpa armigera and Helicoverpa punctigera insect larvae when fed the serine proteinase inhibitors of Nicotiana alata. The novel chymotrypsin represents, therefore, a target for the identification of antagonists including inhibitors which are proposed to be useful in the control of Helicoverpa spp. populations that have become resistant to serine proteinase inhibitors produced in plants. The antagonists of the chymotrypsin may be topically applied to the plants or, when in proteinaceous form, may be produced by genetic means in plant cells. The antagonists may act at the level of gene expression or protein activity.

3. 发明公开

EP1385379A4 INSECTICIDE AND METHOD OF CONTROLLING INSECTS 有权
标题翻译： INSEKTIZID SOWIE VERFAHREN ZURBEKÄMPFUNGVON INSEKTEN
公开(公告)号：EP1385379A4
公开(公告)日：2004-06-23
申请号：EP02712624
申请日：2002-03-28
申请人： NUFARM AUSTRALIA LTD , UNIV TROBE
发明人： SANDEMAN RICHARD MARK , CHANDLER DAVID SPENCER , DUNCAN ANN MAREE , HAY PHILLIP MAXWELL
IPC分类号： C07D263/18 , A01N25/30 , A01N37/44 , A01N37/46 , A01N43/24 , A01N43/36 , A01N43/76 , A01N43/80 , A01N47/22 , A01N57/16 , A01N57/20 , A01N57/22 , A01N57/24 , A01N57/28 , A01N63/02 , C07F9/38 , C07F9/40
CPC分类号： C07F9/3808 , A01N37/44 , A01N37/46 , A01N43/36 , A01N43/80 , A01N57/20 , A01N57/24 , A01N57/28 , C07F9/4006 , A01N47/22 , A01N43/90 , A01N43/24 , A01N57/16 , A01N2300/00
摘要： An insecticide of formula (1) and the agriculturally acceptable salts thereof, wherein: R1 is selected from the group consisting of: the group OR5 wherein R5 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, substituted cycloalkyl, heterocyclic and substituted heterocyclic; the group -NR¿6?OH wherein R?6¿ is selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, carbocyclic and substituted carbocyclic; the group NR7R8 wherein R?7 and R8¿ are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl, substituted aryl and carbocyclic; and the group wherein R1 is linked to R2 to form a diradical bridging group; R?2 and R3¿ are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, carbocyclic, substituted carbocyclic, aryl, substituted aryl, acyl and substituted acyl; and A is a diradical linking group which has a molecular weight of preferably less than 200 and more preferably less than 100.
摘要翻译：通式（1）的杀虫剂及其农业上可接受的盐，其中：R1选自：OR5，其中R5选自氢，烷基，取代的烷基，芳基，取代的芳基，环烷基，取代的环烷基，杂环和取代的杂环; 基团-NR 6 OH其中R 6选自氢，烷基，取代的烷基，芳基，取代的芳基，碳环和取代的碳环; 基团NR 7 R 8，其中R 7和R 8独立地选自氢，烷基，取代的烷基，芳基，取代的芳基和碳环; 和其中R1连接于R2以形成双自由基桥连基团的基团; R 2和R 3独立地选自氢，烷基，取代的烷基，碳环，取代的碳环，芳基，取代的芳基，酰基和取代的酰基; A是分子量优选小于200，更优选小于100的双自由基连接基团。

4. 发明申请

WO2011029137A3 METHOD AND SYSTEM FOR ENERGY MANAGEMENT 审中-公开
标题翻译：用于能量管理的方法和系统
公开(公告)号：WO2011029137A3
公开(公告)日：2011-07-07
申请号：PCT/AU2010001160
申请日：2010-09-09
申请人： UNIV TROBE , DESAI ANIRUDDHA ANIL , SINGH JUGDUTT
发明人： DESAI ANIRUDDHA ANIL , SINGH JUGDUTT
IPC分类号： G06Q10/00 , G06Q50/00
CPC分类号： G06Q10/06 , G06Q50/06 , H02J3/00 , H02J2003/003 , H02J2003/007
摘要： A method (300) of managing energy consumption associated with premises includes firstly generating (302) and storing an initial energy profile (304) of the premises. The profile (304) includes information characterising the premises, such as occupancy patterns, function of the premises, geographical location, installed appliances (108), and so forth. An expected energy usage (308) associated with the premises is computed over a predetermined time period based upon the information in the initial energy profile (304). Actual energy usage (312) associated with the premises is then recorded over the predetermined time period and the energy profile (304) is adaptively updated based upon the recorded energy usage (312). The energy profile (304) and the actual energy usage (312) are used to manage energy consumption associated with the premises. An installable system (100) and apparatus (102) for implementing the method at premises are also provided.
摘要翻译：管理与房屋相关联的能量消耗的方法（300）包括首先生成（302）并存储房屋的初始能量简档（304）。简档（304）包括表征房屋的信息，诸如占用模式，房屋的功能，地理位置，安装的电器（108）等等。基于初始能量分布图（304）中的信息在预定时间段上计算与房屋相关联的预期能量使用量（308）。然后在预定时间段内记录与房屋相关联的实际能量使用（312），并且基于记录的能量使用（312）适应性地更新能量分布（304）。能量简档（304）和实际能量使用（312）被用于管理与房屋相关的能量消耗。还提供了用于在房屋中实施该方法的可安装系统（100）和设备（102）。

5. 发明申请

WO0230906B1 ANTI-TUMOUR COMPOUNDS 审中-公开
标题翻译：抗肿瘤化合物
公开(公告)号：WO0230906B1
公开(公告)日：2002-06-13
申请号：PCT/AU0101265
申请日：2001-10-09
申请人： UNIV TROBE , AUCKLAND UNISERVICES LIMTED , DEADY LESLIE WILLIAM , DENNY WILLIAM ALEXANDER , BU XIANYONG
发明人： DEADY LESLIE WILLIAM , DENNY WILLIAM ALEXANDER , BU XIANYONG
IPC分类号： A61K31/166 , A61K31/4184 , A61K45/06 , A61P35/00 , C07C235/84 , C07D221/08 , C07D221/18 , C07D231/54 , C07D239/70 , C07D471/06 , C07C229/12
CPC分类号： C07D471/06 , A61K31/166 , A61K31/4184 , A61K45/06 , C07C235/84 , C07C2603/42 , C07D221/08 , C07D221/18 , C07D231/54 , C07D239/70 , A61K2300/00
摘要： A compound of formula (II) in which positional numbering, where mentioned, refers to the system illustrated above, and one or more W and one or more U are attached to a ring carbon or carbons at any of positions 1-11 or to a ring nitrogen at position 7 if present, and in which: W is C(=Q)NRCHJ(CH2)nR where Q is O or S, R is hydrogen or a C1-4 alkyl group which is optionally substituted with one or more OH or NH2 groups, J is H or a C1-C6 alkyl group optionally substituted with OH, OMe, NH2, NHMe or NMe2 functions, R is C(=NR )NH2, NHC(=NR )NH2 or NR R , where each of R and R are independently hydrogen or a C1-4 alkyl group which is optionally substituted with one or more OH or NH2 groups, and R and R are independently hydrogen or a C1-4 alkyl group which is optionally substituted with one or more OH or NH2 groups, or R and R together with the nitrogen atom to which they are attached form an optionally substituted saturated or unsaturated heterocyclic group; and n is an integer from 0 to 5; X, Y, V are independently CH or N; Z is CH2, CH-C1-4 alkyl, CO, O, S, SO, SO2, N-C1-4 alkyl or NH; and U is H, halo, OH, CO2H, NR R , nitro, cyano, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 aminoalkyl or C1-6 aminoalkoxy in which R and R have the same definitions as R and R above; or a pharmaceutically-acceptable salt, N-oxide, hydrate, solvate, pharmaceutically acceptable derivative, pro-drug, tautomer or isomer thereof, with the proviso that W at position 4 cannot be CONH(CH2)2NMe2, CONH(CH2)2NEt2, CONH(CH2)3NMe2, CONH(CH2)3NEt2, CONH(CH2)2Npiperidyl, or CONH(CH2)2Nmorpholinyl, when X and Y are N, V is CH, U is H and Z is CO. "Bis" compounds and carboxylic acid precursors are also claimed. The compounds are useful in the treatment of neoplastic conditions such as cancer.
摘要翻译：其中位置编号（其中提及的是上述系统）和一个或多个W和一个或多个U的位置编号的式（II）化合物与位于1-11任何位置的环碳或碳键连接至其中：W为C（= Q）NRCHJ（CH2）nR 1其中Q为O或S，R为氢或任选被一个取代基取代的C 1-4烷基或更多的OH或NH 2基团，J为H或任选被OH，OMe，NH 2，NHMe或NMe 2取代的C 1 -C 6烷基，R 1为C（= NR 2）NH 2，NHC（= NR NH 2或NR 4 R 5，其中R 2和R 3各自独立地为氢或任选被一个或多个OH或NH 2基团取代的C 1-4烷基， R 4和R 5独立地是氢或任选被一个或多个OH或NH 2基团取代的C 1-4烷基，或者R 4和R 5与氮原子一起被它们连接形成任选取代的饱和或不饱和杂环向上; n为0〜5的整数。 X，Y，V独立地为CH或N; Z是CH 2，CH-C 1-4烷基，CO，O，S，SO，SO 2，N-C 1-4烷基或NH; 并且U是H，卤素，OH，CO 2 H，NR 6 R 7，硝基，氰基，C 1-6烷基，C 1-6卤代烷基，C 1-6烷氧基，C 1-6卤代烷氧基，C 1-6氨基烷基或C 1 -6氨基烷氧基，其中R 6和R 7具有与上述R 4和R 5相同的定义; 或其药学上可接受的盐，N-氧化物，水合物，溶剂合物，药学上可接受的衍生物，前药物，互变异构体或异构体，条件是位置4处的W不能是CONH（CH2）2NMe2，CONH（CH2）2NEt2， CONH（CH2）3NMe2，CONH（CH2）3NEt2，CONH（CH2）2N哌啶基或CONH（CH2）2N吗啉基，当X和Y为N时，V为CH，U为H，Z为CO，“双” 酸性前体也被要求保护。这些化合物可用于治疗肿瘤性疾病如癌症。

6. 发明公开

EP0204775A4 AMINO ACID AND PEPTIDE INHIBITORS OF HUMAN LEUCOCYTIC ELASTASE. 失效
标题翻译：氨基酸和肽抑制剂人类白细胞弹性蛋白酶。
公开(公告)号：EP0204775A4
公开(公告)日：1989-10-04
申请号：EP86900028
申请日：1985-12-13
申请人： UNIV TROBE
发明人： TERNAI BELA
IPC分类号： C12N9/99 , A61K38/00 , C07C67/00 , C07C239/00 , C07C271/22 , C07K1/113 , C07K5/06 , C07K5/08 , C07K5/083 , C07K5/10 , C07K5/103 , C07K7/06 , C07K14/81
CPC分类号： C07K5/0808 , A61K38/00 , C07K5/06026 , C07K5/06052 , C07K5/0806 , C07K5/1008 , Y02P20/55

7. 发明公开

EP2874647A4 METHOD OF DIAGNOSIS AND TREATMENT 审中-公开
标题翻译： VERFAHREN ZUR DIAGNOSE UND BEHANDLUNG
公开(公告)号：EP2874647A4
公开(公告)日：2016-04-13
申请号：EP13819559
申请日：2013-07-19
申请人： UNIV TROBE
发明人： PARKER BELINDA SHEREE , HERTZOG PAUL JOHN
IPC分类号： A61K38/21 , A61K31/4745 , A61P35/04 , C12Q1/68 , G01N33/574
CPC分类号： A61K38/21 , A61K31/4745 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16 , G01N33/57484 , G01N2333/4706 , G01N2333/56 , G01N2333/7156
摘要： The present invention relates generally to a method of diagnosing, prognosing or monitoring the development or progress of metastatic cancer, more particularly bone metastatic cancer. The method of the present invention more particularly provides a method for detecting metastatic cancer, or a predisposition thereto, by screening for the differential expression of a panel of genes which comprise an IRF7 binding site. In a related aspect, the present invention provides a method of therapeutically or prophylactically treating metastatic cancer, in particular bone metastatic cancer. More particularly, the present invention provides a means of therapeutically or prophylactically treating metastatic cancer by upregulating type I IFN levels.
摘要翻译：本发明一般涉及诊断，预后或监测转移性癌症，特别是骨转移癌的发展或进展的方法。本发明的方法更具体地提供了通过筛选包含IRF7结合位点的一组基因的差异表达来检测转移性癌症或其倾向的方法。在相关方面，本发明提供治疗或预防性治疗转移性癌症，特别是骨转移癌症的方法。更具体地，本发明提供了通过上调I型IFN水平治疗或预防性治疗转移性癌症的方法。

8. 发明公开

EP1507778A4 ANTI-TUMOUR POLYCYCLIC CARBOXAMIDES 有权
标题翻译：具有抗肿瘤作用POLZCYCLISCHE甲酰胺
公开(公告)号：EP1507778A4
公开(公告)日：2006-05-31
申请号：EP03717051
申请日：2003-05-12
申请人： UNIV TROBE , AUCKLAND UNISERVICES LTD
发明人： BAGULEY BRUCE CHARLES , DEADY LESLIE WILLIAM , DENNY WILLIAM ALEXANDER , RODEMANN THOMAS , ROGERS MICHAEL LESLIE
IPC分类号： C07D471/04 , A61K31/4745 , A61P35/00 , A61P43/00 , C07D491/04 , C07D519/00
CPC分类号： C07D471/04 , A61K31/4745 , C07D491/04

9. 发明公开

EP1366168A4 PLANT-DERIVED MOLECULES AND GENETIC SEQUENCES ENCODING SAME AND USES THEREFOR 有权
标题翻译：来自植物的分子和该编码基因序列及其用途
公开(公告)号：EP1366168A4
公开(公告)日：2005-05-11
申请号：EP02710687
申请日：2002-02-08
申请人： HEXIMA LTD , UNIV TROBE
发明人： ANDERSON MARILYN ANNE , LAY FUNG TSO , HEATH ROBYN LOUISE
IPC分类号： A01N37/46 , C07K14/415 , C12N15/29 , C12N15/82
CPC分类号： C12N15/8286 , A01N37/46 , A01N65/20 , A01N65/38 , C07K14/415 , C12N15/8279 , C12N15/8281 , C12N15/8282 , C12N15/8283 , Y02A40/162
摘要： The present invention provides amino acid molecules derived from Nicotiana alata. The present invention contemplates the use of nucleic acids encoding such amino acid molecules in the generation of transgenic plants having resistance or at least reduced sensitivity to plant pests including insects, microorganisms, fungi and/or viruses. The transgenic plants provided by the present invention include monocotyledonous and dicotyledonous plants, and particularly include crop plants and ornamental flowering plants.

10. 发明公开

EP1322756A4 MANIPULATION OF PLANT SENESCENCE USING AN i MYB /i GENE PROMOTER AND CYTOKININ BIOSYNTHESIS GENES 有权
标题翻译：老化过程在使用我MYB植物MANIPULATION / I GEN启动子及细胞分裂素生物合成基因
公开(公告)号：EP1322756A4
公开(公告)日：2005-05-11
申请号：EP01962486
申请日：2001-08-30
申请人： AGRICULTURE VICTORIA SERV PTY , UNIV TROBE
发明人： SPANGENBERG GERMAN , LIN YI HAN , PARISH ROGER W , LI SONG FENG , HEAZLEWOOD JOSHUA , PALLAGHY CHARLES K
IPC分类号： C12N15/09 , A01H1/00 , A01H3/00 , A01H5/00 , C12N5/10 , C12N15/11 , C12N15/63 , C12N15/82
CPC分类号： C12N15/8249 , C12N15/8271
摘要： The present invention relates to methods of manipulating senescence in plants. The invention also relates to vectors useful in such methods, transformed plants with modified senescence characteristics and plant cells, seeds and other parts of such plants. Specifically the present invention provides a method of manipulating senescence in a plant, said method including introducing into said plant a genetic construct including a myb gene promoter, or functionally active fragment or variant thereof, operably linked to a gene encoding an enzyme involved in biosynthesis of a cytokinin, or a functionally active fragment or variant thereof.

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