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1. 发明授权

US3827115A Method of manufacturing a catheter 失效
标题翻译：制造导管的方法
公开(公告)号：US3827115A
公开(公告)日：1974-08-06
申请号：US33430073
申请日：1973-02-21
申请人： UNIV ERASMUS
发明人： BOM N
IPC分类号： A61B8/00 , A61B8/12 , A61B8/14 , A61M25/00 , B06B1/06 , G10K11/34 , B01J17/00
CPC分类号： A61B8/12 , A61B8/445 , A61B8/4483 , A61B8/4488 , A61M25/0009 , A61M25/0069 , B06B1/0633 , G10K11/345 , Y10T29/42
摘要： A device for examining the heart is provided with a catheter adapted to be placed within the heart and including at one end thereof, circumferentially arranged, equidistantly distributed elements, serving for the transmission and reception of ultrasonic waves. The catheter has an axis and the elements have no directivity in a plane perpendicular to this axis. The elements are so dimensioned in axial direction that in a plane through the axis they do show directivity. An excitation device is provided which successively excites groups of adjacently arranged elements and time delays are provided for delaying the transmitted and received pulses for the elements of a group that the differences in travel times are compensated. An adder is provided for the summation of echo pulses and a device is provided for visually displaying the part of the examined heart surrounding the catheter. A method is provided whereby the elements are provided on the catheter by positioning a piezoelectric cylinder on a core and thereafter sawing through the cylinder along a plurality of radial planes interspaced at equal angular distances. The catheter which is derived from the method is also part of the invention.
摘要翻译：用于检查心脏的装置设置有适于放置在心脏内并且在其一端包括用于超声波的发射和接收的周向布置的等距分布的元件的导管。导管具有轴线，并且元件在垂直于该轴线的平面中没有方向性。这些元件在轴向上的尺寸如此，使得在穿过轴线的平面中，它们确实显示方向性。提供激励装置，其连续地激发相邻排列的元件组并提供时间延迟，用于延迟用于元件的发送和接收脉冲，以补偿行进时间差。提供加法器用于回波脉冲的求和，并且提供用于可视地显示围绕导管的被检查心脏的一部分的装置。提供了一种方法，其中通过将压电圆筒定位在芯上，然后沿相等的角距间隔的多个径向平面沿圆柱体锯切而将元件设置在导管上。从该方法得到的导管也是本发明的一部分。

2. 发明公开

KR20180017005A 스파이널 네비게이션 방법, 스파이널 네비게이션 시스템 및 컴퓨터 프로그램 제품 审中-公开
标题翻译：多刺导航方法，螺旋导航系统和计算机程序产品
公开(公告)号：KR20180017005A
公开(公告)日：2018-02-20
申请号：KR20177034826
申请日：2016-05-06
申请人： UNIV ERASMUS MED CT ROTTERDAM
发明人： LEENSTRA SIEGER
IPC分类号： A61B34/20 , A61B5/00 , A61B5/055 , A61B6/00 , A61B6/03 , A61B8/00 , A61B8/14 , G06T7/33
CPC分类号： A61B5/0035 , A61B5/055 , A61B5/4566 , A61B6/03 , A61B6/032 , A61B6/463 , A61B6/506 , A61B6/5247 , A61B8/0841 , A61B8/085 , A61B8/14 , A61B8/15 , A61B8/4477 , A61B8/463 , A61B8/468 , A61B8/5261 , A61B34/20 , A61B2090/364 , A61B2090/374 , A61B2090/376 , A61B2090/378 , G06T7/33 , G06T2207/10072 , G06T2207/10116 , G06T2207/10132 , G06T2207/30012
摘要： 본발명은스파이널네비게이션(spinal navigation) 방법에관한것이다. 상기방법은서브젝트(subject)의상기스파인(spine)의엠알아이(MRI), 엑스레이(X-ray) 또는씨티(CT) 기반 2차원이미지를제공하는단계와상기서브젝트의상기스파인상에울트라사운드이미징디바이스(ultrasound imaging device)를사용하여울트라사운드 2 차원이미지(ultrasound two-dimensional)를생성하는단계를포함한다. 또한, 상기방법은상기울트라사운드 2 차원이미지를상기엠알아이(MRI), 엑스레이(X-ray) 또는씨티(CT) 기반 2 차원이미지에매칭하는단계와상기엠알아이(MRI), 엑스레이(X-ray) 또는씨티(CT) 기반 2 차원이미지내의스파이널프로파일(spinal profile)의미리특정된세그먼트(pre-specified segment)를상기울트라사운드 2 차원이미지내의대응하는세그먼트(corresponding segment)와관련시키는단계를포함한다.
摘要翻译：本发明涉及一种脊柱导航方法。该方法包括基于对象的脊柱的MRI，X射线或CT图像和超声成像来提供二维图像并且使用超声波成像装置产生超声波二维图像。此外，该方法其特征在于，超音EMAL儿童（MRI）的二维图像，并且步骤EMAL儿童（MRI），其匹配到基于二维图像的透视（X射线）或花旗银行（CT），X射线（X- 在超声二维图像中具有相应段的基于CT的二维图像，的。

3. 发明申请

WO2014045254A3 HUMAN BETACORONAVIRUS LINEAGE C AND IDENTIFICATION OF N-TERMINAL DIPEPTIDYL PEPTIDASE AS ITS VIRUS RECEPTOR 审中-公开
标题翻译：人类乙型肝炎病毒C标记和N-末端胰蛋白酶作为其病毒受体的鉴定
公开(公告)号：WO2014045254A3
公开(公告)日：2015-02-26
申请号：PCT/IB2013058772
申请日：2013-09-23
申请人： UNIV ERASMUS MEDICAL CT
发明人： HAAGMANS BARTHOLOMEUS LEONARDUS , BESTEBROER THEODORUS MARINUS , VAN BOHEEMEN SANDER , FOUCHIER RONALDUS ADRIANUS MARIA , OSTERHAUS ALBERTUS DOMINICUS MARCELLINUS ERASMUS , ZAKI ALI MOH , RAJ VICTOR STALIN , BOSCH BEREND JAN
IPC分类号： C12N7/00 , A61K39/215 , C07K14/005
CPC分类号： C12N7/00 , A61K35/76 , C07K14/005 , C07K14/70596 , C07K16/10 , C07K2319/30 , C12N9/485 , C12N2770/20021 , C12N2770/20022 , C12N2770/20032 , C12N2770/20034 , C12Q1/701 , C12Q2600/158 , C12Y304/14005 , G01N33/56983 , G01N33/573 , G01N2333/165 , G01N2333/948 , G01N2500/02
摘要： The invention provides an isolated essentially mammalian positive-sense single stranded RNA virus classifiable as belonging to the Order: Nidovirales; Family: Coronaviridae; Subfamily: Coronavirinae; Genus: Betacoronavirus; and non-Lineage A, non-Lineage B or non-Lineage D, human betacoronavirus. The invention also provides a human virus having a receptor binding domain (RBD) capable of binding to a dipeptidyl peptidase 4. The invention also provides diagnostic means and methods, prophylactic means and methods and therapeutic means and methods to be employed in the diagnosis, prevention and/or treatment of disease, in particular of respiratory disease, in particular of mammals, more in particular in humans.
摘要翻译：本发明提供了分离的基本上哺乳动物的正义单链RNA病毒，其可归类为属于Nidovirales; 家庭：冠状病毒科亚科：Coronavirinae; 属：Betacoronavirus; 和非谱系A，非谱系B或非谱系D，人类betacoronavirus。本发明还提供具有能够结合二肽基肽酶4的受体结合结构域（RBD）的人类病毒。本发明还提供了用于诊断，预防的诊断手段和方法，预防手段和方法以及治疗方法和方法和/或治疗疾病，特别是呼吸系统疾病，特别是哺乳动物疾病，特别是在人类中。

4. 发明申请

WO2011107973A3 METHOD FOR PREDICTION OF HUMAN IRIS COLOR 审中-公开
标题翻译：人红细胞染料预测方法
公开(公告)号：WO2011107973A3
公开(公告)日：2012-04-26
申请号：PCT/IB2011050951
申请日：2011-03-07
申请人： UNIV ERASMUS MEDICAL CT , IDENTITAS INC , KAYSER MANFRED HEINZ , LIU FAN , HOFMAN ALBERT , UITTERLINDEN ANDREAS GERARDUS
发明人： KAYSER MANFRED HEINZ , LIU FAN , HOFMAN ALBERT , UITTERLINDEN ANDREAS GERARDUS
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/16 , C12Q2600/178
摘要： A method for predicting the iris color of a human, the method comprising: (a) obtaining a sample of the nucleic acid of the human; (b) genotyping the nucleic acid for the single nucleotide polymorphism (SNP) rs 12913832 or a polymorphic site which is in linkage disequilibrium with rs12913832 at an r2 value of at least 0.9; and genotyping the nucleic acid for at least one of the following polymorphisms: (i) a SNP selected from the group consisting of rs1800407, rs12896399, rs12203592, rs1325127, rs1393350, rs728405, rs1129038, and a polymorphic site which is in linkage disequilibrium with one of said SNPs at an r2 value of at least 0.5 (c) predicting at least one quantitative color parameter of the iris as a numericvariable based on the results of step (b), and thereby predicting the iris color.
摘要翻译：一种用于预测人的虹膜颜色的方法，所述方法包括：（a）获得所述人的核酸样品; （b）将单核苷酸多态性（SNP）rs 12913832的核酸或rs12913832与r2值至少为0.9的多态性位点进行基因分型; 以及对以下多态性中的至少一个对所述核酸进行基因分型：（i）选自rs1800407，rs12896399，rs12203592，rs1325127，rs1393350，rs728405，rs1129038的SNP，以及与一个连锁不平衡的多态性位点（c）基于步骤（b）的结果预测虹膜的至少一个定量颜色参数作为数值变量，从而预测虹膜颜色。

5. 发明申请

WO2010108638A9 TUMOUR GENE PROFILE 审中-公开
标题翻译：肿瘤基因概况
公开(公告)号：WO2010108638A9
公开(公告)日：2011-04-28
申请号：PCT/EP2010001773
申请日：2010-03-22
申请人： UNIV ERASMUS MEDICAL CT , HOU JUN , AERTS JOAN GERTRUDIS JACOBUS VICTOR , GROSVELDM FRANKLIN GERARDUS , PHILIPSEN JACOBUS NICHOLAAS JOZEF
发明人： HOU JUN , AERTS JOAN GERTRUDIS JACOBUS VICTOR , GROSVELDM FRANKLIN GERARDUS , PHILIPSEN JACOBUS NICHOLAAS JOZEF
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158
摘要： The present invention provides gene signatures, which are useful for characterising NSCLC tumours, and can distinguish cancerous from normal tissue, are useful in classifying NSCLC, and can be used to provide a prognosis for NSCLC patients.
摘要翻译：本发明提供了可用于表征NSCLC肿瘤并且可以区分癌性与正常组织的基因特征，可用于分类NSCLC，并且可用于为NSCLC患者提供预后。

6. 发明申请

WO2009124901A8 METHODS AND KITS FOR DETECTING TUMOR-SPECIFIC FUSION PROTEINS 审中-公开
标题翻译：检测肿瘤特异性融合蛋白的方法和试剂盒
公开(公告)号：WO2009124901A8
公开(公告)日：2011-04-14
申请号：PCT/EP2009054072
申请日：2009-04-06
申请人： UNIV ERASMUS MEDICAL CT , DONGEN VAN JACOBUS JOHANNES MARIA
发明人： DONGEN VAN JACOBUS JOHANNES MARIA
IPC分类号： G01N33/574
CPC分类号： G01N33/57484 , G01N15/14 , G01N33/57426 , G01N33/582 , G01N2333/82
摘要： The invention relates to the field of cancer diagnosis and the application of diagnostic techniques in pathology and hematology. Specifically, the invention relates to improved flow cytometric techniques, and kits related thereto, for the detection of chromosomal aberrations and the detection of tumor specific gene products exclusively expressed by tumor cells.
摘要翻译：本发明涉及癌症诊断领域和诊断技术在病理学和血液学中的应用。具体地，本发明涉及改进的流式细胞术技术及其相关的试剂盒，用于检测染色体畸变和检测由肿瘤细胞专门表达的肿瘤特异性基因产物。

7. 发明申请

WO2008122886A3 TRANSGENIC NON-HUMAN MAMMAL WITH HOMODIMERIC VH BINDING COMPLEX 审中-公开
标题翻译：具有HOMAILERIC VH结合复合物的转基因非人类哺乳动物
公开(公告)号：WO2008122886A3
公开(公告)日：2009-02-05
申请号：PCT/IB2008000953
申请日：2008-04-04
申请人： UNIV ERASMUS MEDICAL CT , GROSVELD FRANK , JANSSENS RICK
发明人： GROSVELD FRANK , JANSSENS RICK
IPC分类号： C12N15/85 , A01K67/027 , C07K16/00 , C07K16/46
CPC分类号： C12N15/8509 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K2317/22 , C07K2317/31
摘要： The present invention relates to methods for the manufacture in transgenic non-human mammals of a diverse repertoire of functional, affinity-matured homodimeric VH binding complexes in response to antigen challenge and uses thereof, especially the derivation of antigen specific VH binding domains. In particular the methods of the present invention involve the step of providing one or more heterologous VH binding complex loci in transgenic non-human mammal, wherein each VH binding complex locus is defined by the formula 5'-A-B-C-D-3' wherein: A comprises one or more V gene segments, one or more D gene segments and one or more J gene segments; B is optional and encodes one or more characterised binding domains of known specificity; C encodes a CH2-CH3 dimerisation domain; and D encodes one or more characterised binding domains of known specificity. The homodimeric VH binding complexes are minimally tetravalent and bispecific but may also be multivalent and bispecific or multivalent and multispecific.
摘要翻译：本发明涉及用于在转基因非人哺乳动物中制备功能性，亲和力成熟的同二聚VH结合复合物响应于抗原攻击及其用途，特别是衍生抗原特异性VH结合结构域的方法。特别地，本发明的方法包括在转基因非人哺乳动物中提供一个或多个异源VH结合复合基因座的步骤，其中每个VH结合复合基因座由式5'-ABCD-3'定义，其中：A包含一个或多个V基因区段，一个或多个D基因区段和一个或多个J基因区段; B是任选的，并编码一个或多个已知特异性的特征结合结构域; C编码CH2-CH3二聚化结构域; D编码一个或多个已知特异性的特征性结合结构域。同型二聚体VH结合复合物最低限度为四价和双特异性，但也可以是多价和双特异性或多价和多特异性。

8. 发明申请

WO2008084405A3 CIRCULAR CHROMOSOME CONFORMATION CAPTURE (4C) 审中-公开
标题翻译：圆形染色体构象捕获（4C）
公开(公告)号：WO2008084405A3
公开(公告)日：2009-01-29
申请号：PCT/IB2008000625
申请日：2008-01-10
申请人： UNIV ERASMUS MEDICAL CT , DE LAAT WOUTER , GROSVELD FRANK
发明人： DE LAAT WOUTER , GROSVELD FRANK
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6823 , C12Q2523/101
摘要： The present invention relates in one aspect to a method for analysing the frequency of interaction of a target nucleotide sequence with one or more nucleotide sequences of interest (eg. one or more genomic loci) comprising the steps of: (a) providing a sample of cross-linked DNA; (b) digesting the cross-linked DNA with a primary restriction enzyme; (c) ligating the cross-linked nucleotide sequences; (d) reversing the cross linking; (e) optionally digesting the nucleotide sequences with a secondary restriction enzyme; (f) optionally ligating one or more DNA sequences of known nucleotide composition to the available secondary restriction enzyme digestion site(s) that flank the one or more nucleotide sequences of interest; (g) amplifying the one or more nucleotide sequences of interest using at least two oligonucleotide primers, wherein each primer hybridises to the DNA sequences that flank the nucleotide sequences of interest; (h) hybridising the amplified sequence(s) to an array; and (i) determining the frequency of interaction between the DNA sequences.
摘要翻译：本发明在一个方面涉及用于分析靶核苷酸序列与感兴趣的一个或多个核苷酸序列（例如一个或多个基因座）的相互作用频率的方法，包括以下步骤：（a）提供交联DNA; （b）用主要限制酶消化交联的DNA; （c）连接交联的核苷酸序列; （d）反转交联; （e）任选地用第二限制酶消化核苷酸序列; （f）任选地将已知核苷酸组合物的一个或多个DNA序列连接到所述一个或多个感兴趣的核苷酸序列侧翼的可用第二限制酶消化位点; （g）使用至少两个寡核苷酸引物扩增所述一个或多个目标核苷酸序列，其中每个引物与感兴趣的核苷酸序列侧翼的DNA序列杂交; （h）将扩增的序列与阵列杂交; 和（i）确定DNA序列之间的相互作用频率。

9. 发明申请

WO2008035216A9 BINDING MOLECULES 审中-公开
标题翻译：绑定分子
公开(公告)号：WO2008035216A9
公开(公告)日：2008-10-02
申请号：PCT/IB2007003647
申请日：2007-09-18
申请人： UNIV ERASMUS MEDICAL CT , GROSVELD FRANKLIN GERARDUS , JANSSENS RICHARD WILHELM , DRABEK DUBRAVKA
发明人： GROSVELD FRANKLIN GERARDUS , JANSSENS RICHARD WILHELM , DRABEK DUBRAVKA
CPC分类号： C07K16/00 , C07K2317/21 , C07K2317/56 , C07K2317/569
摘要： The present invention relates to methods for engineering VH domains to improve their solubility and stability. The invention provides for the incorporation of defined amino acid substitutions based on 3-D structural information into the V segments of a heavy chain locus, expressing the locus in a non-human mammal and selecting soluble VH domains. Further stabilising or solubilising mutations maybe introduced as a result affinity maturation during B-cell maturation in vivo.
摘要翻译：本发明涉及用于工程化VH结构域以提高其溶解度和稳定性的方法。本发明提供了将基于3-D结构信息的限定的氨基酸取代掺入重链基因座的V区段中，在非人哺乳动物中表达基因座并选择可溶性VH结构域。进一步的稳定或增溶突变可能是B体细胞在体内成熟期间的亲和力成熟引入的。

10. 发明申请

WO2007004057A3 CHROMOSOME CONFORMATION CAPTURE-ON-CHIP (4C) ASSAY 审中-公开
标题翻译：染色体配合捕获芯片（4C）测定
公开(公告)号：WO2007004057A3
公开(公告)日：2007-05-18
申请号：PCT/IB2006002268
申请日：2006-07-03
申请人： UNIV ERASMUS MEDICAL CT , DE LAAT WOUTER , GROSVELD FRANK
发明人： DE LAAT WOUTER , GROSVELD FRANK
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6809 , C12Q2521/501 , C12Q2523/101 , C12Q2525/307 , C12Q2565/501
摘要： The present invention relates in one aspect to a method for analysing the frequency of interaction of a target nucleotide sequence with one or more nucleotide sequences of interest (eg. one or more genomic loci) comprising the steps of: (a) providing a sample of cross-linked DNA; (b) digesting the cross-linked DNA with a primary restriction enzyme; (c) ligating the cross-linked nucleotide sequences; (d) reversing the cross linking; (e) digesting the nucleotide sequences with a secondary restriction enzyme; (f) ligating one or more DNA sequences of known nucleotide composition to the available secondary restriction enzyme digestion site(s) that flank the one or more nucleotide sequences of interest; (g) amplifying the one or more nucleotide sequences of interest using at least two oligonucleotide primers, wherein each primer hybridises to the DNA sequences that flank the nucleotide sequences of interest; (h) hybridising the amplified sequence(s) to an array; and (i) determining the frequency of interaction between the DNA sequences.
摘要翻译：本发明在一个方面涉及用于分析靶核苷酸序列与感兴趣的一个或多个核苷酸序列（例如一个或多个基因座）的相互作用频率的方法，包括以下步骤：（a）提供交联DNA; （b）用主要限制酶消化交联的DNA; （c）连接交联的核苷酸序列; （d）反转交联; （e）用第二限制酶消化核苷酸序列; （f）将已知核苷酸组合物的一个或多个DNA序列连接到所述一个或多个感兴趣的核苷酸序列侧翼的可用次级限制酶消化位点; （g）使用至少两个寡核苷酸引物扩增所述一个或多个目标核苷酸序列，其中每个引物与感兴趣的核苷酸序列侧翼的DNA序列杂交; （h）将扩增的序列与阵列杂交; 和（i）确定DNA序列之间的相互作用频率。

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