专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2011056073A3 NOVEL COMPOUNDS FOR MODULATING NEOVASCULARISATION AND METHODS OF TREATMENT USING THESE COMPOUNDS 审中-公开
标题翻译：用于调节新化合物的新型化合物和使用这些化合物的治疗方法
公开(公告)号：WO2011056073A3
公开(公告)日：2011-12-22
申请号：PCT/NL2010050736
申请日：2010-11-04
申请人： UNIV ERASMUS MEDICAL CT , DUCKERS HENRICUS JOHANNES
发明人： DUCKERS HENRICUS JOHANNES
IPC分类号： A61K38/16
CPC分类号： A61K38/1709 , A61K38/177 , A61K48/00 , C12N15/113 , C12N2310/11 , C12N2310/14
摘要： The invention relates to a method for modulating neovascularisation of a tissue in a subject in need thereof, said method comprising administering to said subject a therapeutically effective amount of a compound or a combination of compounds selected from an isolated nucleic acid molecule comprising a gene selected from the group consisting of RIKEN c DNA 9430020K01, Agtrl1, Apelin, Stabilin 1, Stabilin 2, TNFaip8l1, TNFaip8 and FGD5, and homologues thereof; a gene product encoded by said genes, or encoded by homologues of these genes, and functional fragments thereof; an antibody or derivative thereof directed against a gene product of said genes, or encoded by homologues of these genes, and functional fragments thereof, said derivative preferably being selected from the group consisting of scFv fragments, Fab fragments, chimeric antibodies, bifunctional antibodies, intrabodies, and other antibody-derived molecules; an antisense molecule, in particular an antisense RNA or antisense oligodeoxynucleotide, an RNAi molecule (siRNA or mi RNA) or a ribozyme capable of binding under stringent hybridization conditions to a gene or an m RNA gene product of said genes and homologues thereof; a small molecule interfering with the biological activity of a gene product of said genes and homologues thereof, and a (glycol)protein, a hormone and other biologically active compounds capable of interacting with said genes and homologues thereof or with a gene product thereof.
摘要翻译：本发明涉及一种用于调节有需要的受试者的组织新血管形成的方法，所述方法包括向所述受试者施用治疗有效量的化合物或化合物组合，所述化合物或组合选自包含选自以下的基因的分离的核酸分子：由RIKEN c DNA 9430020K01，Agtrl1，Apelin，Stabilin 1，Stabilin 2，TNFaip8I1，TNFaip8和FGD5组成的组及其同源物; 由所述基因编码或由这些基因的同源物编码的基因产物及其功能片段; 针对所述基因的基因产物或由这些基因的同系物编码的抗体或其衍生物及其功能片段，所述衍生物优选选自scFv片段，Fab片段，嵌合抗体，双功能抗体，胞内抗体，和其他抗体衍生的分子; 反义分子，特别是反义RNA或反义寡脱氧核苷酸，RNAi分子（siRNA或miRNA）或能够在严格杂交条件下与所述基因及其同源物的基因或m RNA基因产物结合的核酶; 干扰所述基因及其同系物的基因产物的生物学活性的小分子，以及能够与所述基因及其同系物或其基因产物相互作用的（二醇）蛋白质，激素和其他生物活性化合物。

2. 发明申请

WO2010109165A3 SOLUBLE "HEAVY-CHAIN ONLY " ANTIBODIES 审中-公开
标题翻译：可溶性“仅重链”抗体
公开(公告)号：WO2010109165A3
公开(公告)日：2011-02-24
申请号：PCT/GB2010000500
申请日：2010-03-19
申请人： UNIV ERASMUS MEDICAL CT , KINGDON CRAIG R , JANSSENS RICHARD WILHELM , DRABEK DUBRAVKA , CHEN TAO , DE BOER ERNIE
发明人： JANSSENS RICHARD WILHELM , DRABEK DUBRAVKA , CHEN TAO , DE BOER ERNIE
IPC分类号： C07K16/00 , C07K16/10 , C07K16/12 , C07K16/28
CPC分类号： C07K16/46 , A01K2267/01 , C07K16/00 , C07K16/1018 , C07K16/1271 , C07K16/2896 , C07K2317/21 , C07K2317/22 , C07K2317/24 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/92 , C12N15/8509
摘要： The present invention provides a high affinity, antigen-specific, soluble heavy chain-only antibody which: lacks hallmark camelid-related amino acid substitutions and has FR2 substitutions which are not found in antibodies which comprise heavy and light chain; shows increased net hydrophobicity within CDRl and an increased number of charged amino acids present in CDR3; and comprises one or more amino acid substitutions within the framework ß-pleated sheet leading to increased net hydrophobicity within FRl and an increased number of charged amino acids present in FR3. Also provided are VH domains having the same properties, gene segments for their production, methods for their production, transgenic animals and uses of the antibody of the VH domains in therapy.
摘要翻译：本发明提供了一种高亲和力，抗原特异性，可溶于重链的抗体，其缺乏标记骆驼相关氨基酸取代，并且具有在包含重链和轻链的抗体中不存在的FR2取代; 显示CDR1内的净疏水性增加，CDR3中存在的带电氨基酸数量增加; 并且在骨架β-折叠片中包含一个或多个氨基酸取代，导致FR1内的净疏水性增加，FR3中存在的带电氨基酸数量增加。还提供了具有相同性质的VH结构域，其生产的基因片段，其制备方法，转基因动物以及VH结构域的抗体在治疗中的用途。

3. 发明申请

WO2010123354A3 METHOD OF DIAGNOSING BLADDER CANCER 审中-公开
标题翻译：诊断乳腺癌的方法
公开(公告)号：WO2010123354A3
公开(公告)日：2011-01-20
申请号：PCT/NL2010050213
申请日：2010-04-20
申请人： UNIV ERASMUS MEDICAL CT , ZWARTHOFF ELLEN CATHARINA , VAN TILBORG ANNECHIENA GEERTRUIDE
发明人： ZWARTHOFF ELLEN CATHARINA , VAN TILBORG ANNECHIENA GEERTRUIDE
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/154 , C12Q2600/16
摘要： The present invention relates to a method of diagnosing cancer in a subject comprising detecting in the DNA of said subject at least one hypermethylated CpG island associated with said cancer, wherein an elevation in the level of methylation in said CpG island of said subject, relative to the level of methylation in said CpG island of a control subject, is indicative of said CpG island being hypermethylated.
摘要翻译：本发明涉及一种诊断受试者癌症的方法，包括在所述受试者的DNA中检测与所述癌症相关联的至少一个甲基化CpG岛，其中所述受试者的所述CpG岛中的甲基化水平相对于对照受试者的所述CpG岛中的甲基化水平指示所述CpG岛是高甲基化的。

4. 发明申请

WO2008136670A3 IMPROVED METHODS AND MEANS FOR LENTIVIRAL GENE DELIVERY 审中-公开
标题翻译：改进的方法和手段用于LENIVEIRAL GENE DELIVERY
公开(公告)号：WO2008136670A3
公开(公告)日：2009-02-19
申请号：PCT/NL2008050269
申请日：2008-05-02
申请人： UNIV ERASMUS MEDICAL CT , VAN TIL NICO PETER , VERSTEGEN MONIQUE MARIA ANDREA , WAGEMAKER GERARD
发明人： VAN TIL NICO PETER , VERSTEGEN MONIQUE MARIA ANDREA , WAGEMAKER GERARD
IPC分类号： C12N15/09
CPC分类号： C12N15/86 , C12N2740/16043
摘要： The invention relates to the field of gene therapy and more in specific to lentiviral gene delivery vehicles and methods for efficient transduction of lentiviral gene delivery vehicles into hematopoietic stem cells and their descendants. Preferably, the invention provides in one of its embodiments a method of gene transfer into e.g. pluripotent hematopoietic stem cells and their descendants, enabling successful transduction of cells, including transplantable cell populations comprising hematopoietic stem cells that give rise to progeny expressing the transduced gene(s). The invention further comprises a method for treating a variety of hereditary and acquired human disease by transfer of therapeutically active genes into hematopoietic stem cells. As a non-limiting example, the invention shows that symptoms associated with Pompe disease are (completely) reduced and/or alleviated by treatment of a subject suffering from Pompe disease withJiematopoietic stem cell transduced with an alpha- glucosidase comprising lentiviral vector.
摘要翻译：本发明涉及基因治疗领域，更具体涉及慢病毒基因递送载体以及用于将慢病毒基因递送载体有效转导至造血干细胞及其后代的方法。优选地，本发明在其一个实施方案中提供了将基因转移到例如多能造血干细胞及其后代，能够成功地转导细胞，包括可引起表达转导基因的后代的造血干细胞的可移植细胞群。本发明还包括通过将治疗活性基因转移至造血干细胞来治疗各种遗传和获得性人类疾病的方法。作为非限制性实例，本发明表明，通过用包含慢病毒载体的α-葡糖苷酶转导的造血干细胞治疗患有庞培病的受试者，（完全）减少和/或减轻与庞皮病相关的症状。

5. 发明申请

WO2005054512A3 METHOD TO DIAGNOSE OR SCREEN FOR TYPE 1 DIABETES MELLITUS 审中-公开
标题翻译：诊断或筛查1型糖尿病的方法
公开(公告)号：WO2005054512A3
公开(公告)日：2005-11-03
申请号：PCT/NL2004000843
申请日：2004-12-03
申请人： UNIV ERASMUS MEDICAL CT , DREXHAGE HEMMO ARJAN , RUWHOF CINDY
发明人： DREXHAGE HEMMO ARJAN , RUWHOF CINDY
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6837 , C12Q2600/158
摘要： The invention relates to the field of medical diagnostics. More specifically, the invention relates to methods to diagnose or screen for Diabetes Mellitus type 1 (DM1) in a subject, preferably a human subject, by assaying for a marker for DM1. Provided is a method to diagnose or screen for DM1 in a subject, preferably a human subject, said method comprising determining the level of at least one, preferably at least two, more preferably at least three, most preferred at least four, DM1-specific gene product(s) in a biological sample isolated from said subject, preferably peripheral blood monocytes, wherein said DM1-specific gene is selected from the group comprising STX1A, MCP-3, CCL2, HSPA1A, HSPA1B, EMP1, BAZ1A, CD9, PTPN7, CDC42, FABP5, NAB2 and SDR1.
摘要翻译：本发明涉及医学诊断领域。更具体地说，本发明涉及通过测定DM1标志物来诊断或筛选受试者，优选人受试者中的1型糖尿病（DM1）的方法。提供了诊断或筛选受试者，优选人受试者中DM1的方法，所述方法包括测定至少一种，优选至少两种，更优选至少三种，最优选至少四种DM1特异性的水平基因产物，其中所述DM1特异性基因选自包含STX1A，MCP-3，CCL2，HSPA1A，HSPA1B，EMP1，BAZ1A，CD9，PTPN7 ，CDC42，FABP5，NAB2和SDR1。

6. 发明申请

WO2015190921A2 METHODS FOR CHARACTERIZING ALTERNATIVELY OR ABERRANTLY SPLICED MRNA ISOFORMS 审中-公开
标题翻译：用于表征替代或绝对分离的MRNA ISOFORMS的方法
公开(公告)号：WO2015190921A2
公开(公告)日：2015-12-17
申请号：PCT/NL2015050420
申请日：2015-06-10
申请人： UNIV ERASMUS MEDICAL CT
发明人： BERGSMA ATZE JACOBUS , VAN DER WAL ERIK , PIJNAPPEL WILHELMUS WENCESLAUS MATTHIAS , VAN DER PLOEG ANTJE TJITSKE , REUSER ARNOLDUS
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2320/33 , C12N2330/30 , C12N2330/50 , C12N2330/51 , C12Q1/6846 , C12Q1/6851 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156
摘要： The disclosure provides method and kits for characterizing spliced m RNA isoforms. The disclosure also provides methods of screening for mutations and oligonucleotides that modulate splicing.
摘要翻译：本公开提供用于表征剪接的m RNA亚型的方法和试剂盒。本公开还提供筛选调节剪接的突变和寡核苷酸的方法。

7. 发明申请

WO2012121594A1 METHODS AND MEANS FOR MONITORING DISRUPTION OF TISSUE HOMEOSTASIS IN THE TOTAL BODY 审中-公开
标题翻译：用于监测全身组织破坏的方法和手段
公开(公告)号：WO2012121594A1
公开(公告)日：2012-09-13
申请号：PCT/NL2012050132
申请日：2012-03-05
申请人： UNIV ERASMUS MEDICAL CT , VAN DONGEN JACOBUS JOHANNES MARIA , ORFAO DE MATOS CORREIA E VALE JOSE ALBERTO
发明人： VAN DONGEN JACOBUS JOHANNES MARIA , ORFAO DE MATOS CORREIA E VALE JOSE ALBERTO
IPC分类号： G01N33/569
CPC分类号： G01N33/5094 , G01N33/5091 , G01N33/56972 , G01N2800/52
摘要： The invention relates to the field of medical diagnostics. Provided are methods and kits for determining the health status of a subject, for early detection of tissue damage, for early diagnosis and monitoring of a disease, and/or for evaluation of treatment effectiveness in a subject using circulating tissue macrophages (CTM) as a mirror of disrupted tissue homeostasis and disease.
摘要翻译：本发明涉及医疗诊断领域。提供了用于确定受试者的健康状况的方法和试剂盒，用于早期检测组织损伤，用于早期诊断和监测疾病，和/或用于使用循环组织巨噬细胞（CTM）作为评估受试者的治疗有效性破坏组织体内平衡和疾病的镜子。

8. 发明申请

WO2009142483A3 GENETIC MARKERS PREDICTING AGE AT MENOPAUSE 审中-公开
标题翻译：遗传标记预测年龄在MENOPAUSE
公开(公告)号：WO2009142483A3
公开(公告)日：2010-01-28
申请号：PCT/NL2009050265
申请日：2009-05-18
申请人： UNIV ERASMUS MEDICAL CT , KING S COLLEGE LONDON , UITTERLINDEN ANDREAS GERARDUS , STOLK LISETTE , SPECTOR TIMOTHY DAVID , ZHAI GUANGJU
发明人： UITTERLINDEN ANDREAS GERARDUS , STOLK LISETTE , SPECTOR TIMOTHY DAVID , ZHAI GUANGJU
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6876 , C12Q2600/156
摘要： The present relates to a method of predicting the age at natural menopause in a female individual comprising detecting at least one SNP in a gene selected from the group consisting of CLCA4, KALRN, TOPBP1, the gene for hypothetical protein FLJ16641, VCAN, MCTP1, BAI3, AGR2,LSM5, SEMA3E, CSMD1, CPA6, LINGO2, the gene for hypothetical protein C9orf85, EHMT1, ADARB2, DNA2L, MGMT, SPATA19, the gene for hypothetical protein LOC146167, MSI2, BRSK1, SUV4-20H2, HSPB1, and SCARF2.
摘要翻译：本发明涉及一种预测女性个体天然绝经年龄的方法，包括检测选自CLCA4，KALRN，TOPBP1，假想蛋白FLJ16641，VCAN，MCTP1，BAI3的基因中的至少一种SNP ，AGR2，LSM5，SEMA3E，CSMD1，CPA6，LINGO2，假定蛋白C9orf85，EHMT1，ADARB2，DNA2L，MGMT，SPATA19的基因，假定蛋白质LOC146167，MSI2，BRSK1，SUV4-20H2，HSPB1和SCARF2的基因。

9. 发明申请

WO2009013620A3 HOMOLOGOUS RECOMBINATION 审中-公开
标题翻译：同源重组
公开(公告)号：WO2009013620A3
公开(公告)日：2009-05-14
申请号：PCT/IB2008002572
申请日：2008-06-11
申请人： UNIV ERASMUS MEDICAL CT , GROSVELD FRANK , JANSSENS RICK
发明人： GROSVELD FRANK , JANSSENS RICK
IPC分类号： C07K16/00
CPC分类号： C07K16/00 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2217/15 , A01K2227/105 , A01K2267/01 , C07K16/462 , C07K2317/52 , C12N15/8509
摘要： The present invention relates to methods for the production of heavy chain only antibodies in vivo in non-human mammals from natural and modified heavy chain immunoglobulin genes lacking CHl functionality in response to antigen challenge. In particular human heavy chain-only antibodies and soluble human VH binding domains generated using the methods of the present invention are also described. The invention also provides non-human mammals suited to the expression of diverse vertebrate heavy chain only gene loci lacking CHl functionality, and hybrid heavy chain only loci comprising mixtures of V, D and J gene segments and combinations of constant effector regions lacking CHl functionality sourced from diverse vertebrate species suited to the production of heavy chain only antibodies and soluble VH domains.
摘要翻译：本发明涉及用于从天然和修饰的重链免疫球蛋白基因体内产生非人类哺乳动物体内重链抗体的方法，所述天然和修饰的重链免疫球蛋白基因响应于抗原攻击而缺乏CH1功能性。具体地，还描述了使用本发明的方法产生的仅人重链抗体和可溶人VH结合结构域。本发明还提供了适用于表达缺乏CH1功能性的仅有脊椎动物重链的基因座的非人哺乳动物，以及仅包含V，D和J基因区段的混合物的杂合重链基因座以及缺乏CH1功能性的恒定效应子区的组合来自适合于产生仅有重链的抗体和可溶性VH结构域的各种脊椎动物物种。

10. 发明申请

WO2007096779A3 GENERATION OF HEAVY-CHAIN ONLY ANTIBODIES IN TRANSGENIC ANIMALS 审中-公开
标题翻译：仅在转基因动物中产生重链抗体
公开(公告)号：WO2007096779A3
公开(公告)日：2008-06-26
申请号：PCT/IB2007001491
申请日：2007-01-25
申请人： UNIV ERASMUS MEDICAL CT , GROSVELD FRANKLIN GERARDUS , JANSSENS RICHARD WILHELM
发明人： GROSVELD FRANKLIN GERARDUS , JANSSENS RICHARD WILHELM
IPC分类号： C07K16/00 , C12N15/85
CPC分类号： A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K16/1009 , C07K16/1232 , C07K16/1282 , C07K16/1285 , C07K16/241 , C07K2317/24 , C07K2317/569 , C12N15/8509 , C12N2015/8518
摘要： The present invention relates to a method for the generation of V H heavy chain-only antibodies in a transgenic non-human mammal. In particular, the present invention relates to a method for the production of a V H heavy chain-only antibody in a transgenic non-human mammal comprising the step of expressing more than one heterologous V H heavy chain locus in that mammal.
摘要翻译：本发明涉及用于在转基因非人哺乳动物中产生V H H H重链抗体的方法。特别地，本发明涉及一种在转基因非人哺乳动物中产生V H H H H链重链的抗体的方法，该方法包括以下步骤：表达多于一个异源的V H 该哺乳动物中的重链基因座。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式