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1. 发明专利

JPS62281821A VACCINE AGAINST HERPES SIMPLEX 失效
公开(公告)号：JPS62281821A
公开(公告)日：1987-12-07
申请号：JP4897187
申请日：1987-03-05
申请人： UNIV BIRMINGHAM
发明人： GOODON ROBAATO BURUSU SUKINAA , AREKUSANDAA BUCHIYAN
IPC分类号： A61K39/245

2. 发明专利

JPH11143074A ELECTRON BEAM RESIST 失效
公开(公告)号：JPH11143074A
公开(公告)日：1999-05-28
申请号：JP25712297
申请日：1997-09-22
申请人： UNIV BIRMINGHAM , KANAYAMA TOSHIHIKO , TADA TETSUYA , AGENCY IND SCIENCE TECHN
发明人： KANAYAMA TOSHIHIKO , TADA TETSUYA , PALMER RICHARD EDWARD , ROBINSON ALEXANDER PHILLIP GRAHAM
IPC分类号： C07C69/76 , G03F7/038 , H01L21/027
摘要： PROBLEM TO BE SOLVED: To obtain an electron beam resist responsive to electron beams, superior in dry etching resistance, resolution and sensitivity, capable of forming a thin film by the spin coating method on a substrate and high in aptitude to micro-fabrication in a nanometer order by using a metanofullerene obtained by chemical modification of fullerene for the electron beam resist. SOLUTION: The metanofullerene obtained by chemically modifying the fulerene, preferably, the one having an organic group containing an oxygen atom on the side chain is used for the electron beam resist. The metanofullerene is prepared by cross-linking a carbon atom with the network of 6-membered and 5-membered carbon atom rings for forming the fullerene represented by the formula and adding the side chains R and R to this carbon atom. In the formula, each of R and R is, independently, an organic group and each may combine with each other to form a ring and with the other carbon atom of the fullerene.

3. 发明授权

US3750505A Billet production 失效
标题翻译： BILLET生产
公开(公告)号：US3750505A
公开(公告)日：1973-08-07
申请号：US3750505D
申请日：1971-12-27
申请人： UNIV BIRMINGHAM
发明人： ORGAN A , PRICE C
IPC分类号： B23D21/14 , B26D3/16
CPC分类号： B23D21/14 , Y10T83/0596 , Y10T83/396 , Y10T83/398 , Y10T83/75 , Y10T83/7547
摘要： An apparatus and method for shearing tubular billets, the billet being engaged within apertures in a fixed and a moveable shear blade, the end part of the stock to be sheared off being located in the moveable shear blade and adjacent part of the stock in the fixed shear blade. A mandrel comprising three relatively moveable parts is provided. The free end or location part of the mandrel is engaged in the part of the stock within the fixed shear blade and the mandrel has a location part externally of the stock and fixed relative to a base part of the apparatus, and there being a moveable part engaged in the part of the stock within the moveable blade and engaged with guide surfaces on the location end support parts. In use, the moveable blade is moved relative to the fixed blade transversely of the tubular stock so that the moveable part of the mandrel moves with the end part of the tube and the end part of the tube and adjacent part of the tube are internally supported by the mandrel.
摘要翻译：一种用于剪切管状坯料的装置和方法，坯料接合在固定和可移动的剪切刀片的孔内，要剪切的坯料的端部位于可移动的剪切刀片中，并且在固定的剪切刀片中的相邻部分剪刀提供了包括三个相对可移动部件的心轴。心轴的自由端或位置部分接合在固定剪切刀片内的原料的部分中，并且心轴具有位于坯料外部的位置部分并且相对于设备的基部固定，并且存在可移动部件接合在可移动刀片内的库存部分并与定位端支撑部件上的引导表面接合。在使用中，可移动刀片相对于横向于管状坯料的固定刀片移动，使得心轴的可移动部分与管的端部一起移动，并且管的端部和管的相邻部分被内部支撑通过心轴。

4. 发明授权

US3617683A Method and apparatus for working material using laser beams 失效
标题翻译：使用激光束工作材料的方法和装置
公开(公告)号：US3617683A
公开(公告)日：1971-11-02
申请号：US3617683D
申请日：1970-01-13
申请人： UNIV BIRMINGHAM , SPACRATRON LTD
发明人： BERESFORD MICHAEL PATRICK , SCOTT BRIAN FREDERICK
IPC分类号： B23K26/38 , B23K26/42 , B23K9/00
CPC分类号： B23K26/702 , B23K26/382 , B23K26/40 , B23K2203/52
摘要： The invention relates to methods and apparatus for working materials using laser beams. The workpiece is laid on support means which include table beneath which is located a laser beam emitter and an associated optical system for focusing the laser beam. The support means, which include the worktable, has a generally vertical through hole and the workpiece is laid over this hole. The laser optical system is arranged to direct the beam from below through the hole in the support means and to focus the beam at the level of the upper end of the hole, that is, substantially on the underside of the workpiece. Means are provided above the worktable for indicating the position of the optical axis of the laser beam. Means are provided for shrouding the laser beam to prevent stray emission.

5. 发明申请

WO2014009733A2 THERAPEUTIC TARGETS FOR ALZHEIMER'S DISEASE 审中-公开
标题翻译：阿尔茨海默病的治疗目标
公开(公告)号：WO2014009733A2
公开(公告)日：2014-01-16
申请号：PCT/GB2013051843
申请日：2013-07-11
申请人： UNIV BIRMINGHAM
发明人： NAGY ZSUZSANNA
IPC分类号： C07K14/47
CPC分类号： C12Q1/6883 , A61K31/436 , C12N15/113 , C12N2310/14 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/5023
摘要： The present invention relates to novel methods for the prevention, treatment and diagnosis of Alzheimer's disease. In addition, the invention relates to methods for assessing an individual's susceptibility or pre-disposition to Alzheimer's disease. The methods of the present invention involve the use of therapeutic targets and diagnostic and/or predictive markers within the m TOR signalling pathway. The methods also involve screening subjects for genetic polymorphisms associated with rapamycin-sensitive genes.
摘要翻译：本发明涉及用于预防，治疗和诊断阿尔茨海默氏病的新方法。此外，本发明涉及评估个体易感性或预处理阿尔茨海默氏病的方法。本发明的方法涉及在mTOR信号通路内使用治疗靶标和诊断和/或预测标记物。该方法还涉及筛选受试者与雷帕霉素敏感基因相关的遗传多态性。

6. 发明申请

WO2007051004A3 CONJUGATE VACCINES FOR NON-PROTEINACEOUS ANTIGENS 审中-公开
标题翻译：用于非蛋白质抗原的共轭疫苗
公开(公告)号：WO2007051004A3
公开(公告)日：2007-06-14
申请号：PCT/US2006042301
申请日：2006-10-30
申请人： BRIGHAM & WOMENS HOSPITAL , UNIV BIRMINGHAM , LEADBETTER ELIZABETH , BRENNER MICHAEL B , BESRA GURDYAL SINGH
发明人： LEADBETTER ELIZABETH , BRENNER MICHAEL B , BESRA GURDYAL SINGH
IPC分类号： A61K39/39
CPC分类号： A61K39/385 , A61K2039/6018
摘要： The present invention is directed to pharmaceutical compositions that can be used to immunize subjects using, for example, lipid, glycan, or nucleic acid antigens. These antigens are conjugated to a glycosphingolipid.
摘要翻译：本发明涉及可用于使用例如脂质，聚糖或核酸抗原免疫受试者的药物组合物。这些抗原与糖鞘脂结合。

7. 发明申请

WO2007010258A3 POLYMORPHISM IN CYSTEINE DIOXYGENASE 审中-公开
标题翻译： CYSTEINE DIOXYGENASE中的多态性
公开(公告)号：WO2007010258A3
公开(公告)日：2007-05-31
申请号：PCT/GB2006002698
申请日：2006-07-20
申请人： UNIV BIRMINGHAM , WARING ROSEMARY HOPE , RAMSDEN DAVID BOYER , WILKINSON LUCY JANE , KIKUCHI HUGH
发明人： WARING ROSEMARY HOPE , RAMSDEN DAVID BOYER , WILKINSON LUCY JANE , KIKUCHI HUGH
IPC分类号： C12Q1/68 , A61K38/20 , A61K38/21
CPC分类号： A61K38/217 , A61K38/2026 , A61K38/2066 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , A61K2300/00
摘要： The invention relates to the detection and identification of polymorphisms in cysteine dioxygenase (CDO) for the use of that diagnosis to identify a propensity in a patient towards rheumatoid arthritis and/or to have side effects with a number of drugs, to nucleic acid and isolated proteins encoding the polymorphisms, to assays for CDO activity and for the identification of compounds affecting CDO activity, and additionally to use of interferon-y optionally in combination with different compounds, to treat rheumatoid arthritis.
摘要翻译：本发明涉及检测和鉴定半胱氨酸双加氧酶（CDO）中的多态性，以便使用该诊断来确定患者对类风湿性关节炎的倾向和/或具有多种药物的副作用，以核酸和分离编码多态性的蛋白质，CDO活性的测定和影响CDO活性的化合物的鉴别，以及任选地与不同化合物组合使用干扰素-γ治疗类风湿性关节炎。

8. 发明申请

WO2006030240A3 NOVEL RESIST MATERIAL 审中-公开
标题翻译：新材料
公开(公告)号：WO2006030240A3
公开(公告)日：2006-07-06
申请号：PCT/GB2005003606
申请日：2005-09-19
申请人： UNIV BIRMINGHAM , ROBINSON ALEX , PALMER RICHARD EDWARD
发明人： ROBINSON ALEX , PALMER RICHARD EDWARD
IPC分类号： G03F7/038
CPC分类号： G03F7/0382
摘要： The present invention relates to the use of fullerols having the formula C 2x (OH) n where x is at least 10 and n is at least 2 as resist materials. The invention also includes within its scope methods of patterning a fullerol-based resist layer.
摘要翻译：本发明涉及使用具有式C 2 x（OH）N n的富勒醇，其中x为至少10，n为至少2作为抗蚀剂材料。本发明还包括在其范围内构图富烯醇基抗蚀剂层的方法。

9. 发明申请

WO2005056780A3 CELL CULTURE WITH NM23, CELL CULTURE MEDIA COMPRISING NM23 AND THERAPEUTIC USE OF CELLS CULTURED IN THE PRESENCE OF NM23. 审中-公开
标题翻译：细胞培养与NM23，包含NM23的细胞培养基和NM23存在下培养的细胞的治疗用途。
公开(公告)号：WO2005056780A3
公开(公告)日：2005-07-28
申请号：PCT/GB2004004826
申请日：2004-11-16
申请人： UNIV BIRMINGHAM , BUNCE CHRISTOPHER MARTIN
发明人： BUNCE CHRISTOPHER MARTIN
IPC分类号： A61K35/12 , C12N5/00 , C12N5/0789 , C12N5/08 , C12N5/06
CPC分类号： C12N5/0647 , A61K2035/124 , C12N5/0037 , C12N2501/70
摘要： The protein NM23 is disclosed as an agent for the maintenance of undifferentiated biological cells in culture. The NM23 protein may act as a survival factor for such cultured cells, or to prevent the differentiation and maturation of the cultured cells. The use of NM23 protein is applicable to culture of stem and/or progenitor cells, and particularly to such cells cultured and adapted for therapeutic use. The invention provides methods, media and media supplements for use in the culture of biological cells, and further provides methods of preparing biological cells for therapeutic use, as well as methods of therapy utilising biological cells and medicaments comprising biological cells adapted for therapeutic use.
摘要翻译：公开了蛋白NM23作为培养中未分化生物细胞的维持剂。 NM23蛋白可以作为这种培养细胞的存活因子，或者可以防止培养细胞的分化和成熟。 NM23蛋白的应用适用于干细胞和/或祖细胞的培养，特别适用于培养和适应治疗用途的细胞培养。本发明提供了用于生物细胞培养的方法，培养基和培养基补充剂，并且还提供了制备用于治疗用途的生物细胞的方法，以及利用生物细胞的治疗方法和包含适于治疗用途的生物细胞的药物。

10. 发明申请

WO2012127240A3 IMMUNE ASSAY 审中-公开
标题翻译：免疫测定
公开(公告)号：WO2012127240A3
公开(公告)日：2016-01-14
申请号：PCT/GB2012050635
申请日：2012-03-22
申请人： UNIV BIRMINGHAM , QURESHI OMAR SALEEM , SANSOM DAVID MICHAEL
发明人： QURESHI OMAR SALEEM , SANSOM DAVID MICHAEL
IPC分类号： A61K38/00 , G01N33/50
CPC分类号： G01N33/5047 , G01N33/505 , G01N2333/70521 , G01N2333/70532
摘要： The invention relates to a method of identifying a modulator of the immune response system, comprising assaying for the effect of a compound on the internalisation and recycling of CTLA-4 in a cell, wherein an increase in cycling of CTLA-4 compared to a control without the compound indicates that the compound suppresses the immune response and a decrease in the cycling of CTLA-4 compared to a control without the compound, indicates that the compound increases the immune response. The cycling of CTLA-4 may be determined by monitoring CTLA-4 or monitoring uptake of a CTLA-4 label into a cell.
摘要翻译：本发明涉及鉴定免疫应答系统调节剂的方法，包括测定化合物对CTLA-4在细胞内部化和再循环中的作用，其中CTLA-4与对照相比增加循环没有化合物表明化合物抑制免疫应答和CTLA-4与没有化合物的对照相比的循环减少，表明该化合物增加免疫应答。 CTLA-4的循环可以通过监测CTLA-4或监测CTLA-4标记进入细胞的摄取来确定。

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