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1. 发明申请

WO2003022296A1 METHOD AND COMPOSITION FOR TREATING IMMUNE COMPLEX ASSOCIATED DISORDERS 审中-公开
标题翻译：治疗免疫复合相关疾病的方法和组合
公开(公告)号：WO2003022296A1
公开(公告)日：2003-03-20
申请号：PCT/US2002/028708
申请日：2002-09-09
申请人： THE TRUSTEES OF BOSTON UNIVERSITY , MARSHAK-ROTHSTEIN, Ann , LEADBETTER, Elizabeth , RIFKIN, Ian
发明人： MARSHAK-ROTHSTEIN, Ann , LEADBETTER, Elizabeth , RIFKIN, Ian
IPC分类号： A61K38/00
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/18 , C07K16/44 , C07K2317/21 , G01N33/5047 , G01N33/564 , G01N2500/00 , G01N2500/02 , G01N2800/102
摘要： The present invention provides methods and compositions for treating immune complex associated diseases (ICAD), such as SLE, rheumatoid arthritis, and hepatitis-C related immune complex disease (e.g., cryoglobulinemia) in a subject having an ICAD or at risk for developing ICAD. The invention is based upon the surprising finding that chromatin-containing immune complexes activate autoreactive B cells and dendritic cells by a dual receptor engagement process which, in both cell types, involves a Toll-like receptor (TLR). The methods of treating ICAD comprise administering a compound to an individual in need thereof that either 1) inhibits formation of the immune complex either by preventing formation and/or binding to the TLR, or 2) interferes with binding of an autoantigen-containing immune complex (or the antigenic component thereof) to the TLR, or 3) inhibits signaling pathways initiated by dual engagement of BCR and TLR (in B cells) or FcR and TLR (in dendritic cells) via immune complexed or uncomplexed autoantigens.
摘要翻译：本发明提供用于治疗具有ICAD或处于发展中的ICAD风险的受试者中的免疫复合物相关疾病（ICAD）如SLE，类风湿性关节炎和丙型肝炎相关免疫复合物疾病（例如冷球蛋白血症）的方法和组合物。本发明基于惊人的发现，即含染色质的免疫复合物通过双重受体接合过程激活自身反应性B细胞和树突状细胞，其在两种细胞类型中涉及Toll样受体（TLR）。治疗ICAD的方法包括向有需要的个体施用化合物，其可以通过阻止与TLR的形成和/或结合来抑制免疫复合物的形成，或者2）干扰含有自身抗原的免疫复合物的结合（或其抗原性成分），或3）通过免疫复合或未复合的自身抗原抑制由BCR和TLR（在B细胞中）或FcR和TLR（在树突状细胞中）双重配对引发的信号通路。

2. 发明申请

WO2007051004A3 CONJUGATE VACCINES FOR NON-PROTEINACEOUS ANTIGENS 审中-公开
标题翻译：用于非蛋白质抗原的共轭疫苗
公开(公告)号：WO2007051004A3
公开(公告)日：2007-06-14
申请号：PCT/US2006042301
申请日：2006-10-30
申请人： BRIGHAM & WOMENS HOSPITAL , UNIV BIRMINGHAM , LEADBETTER ELIZABETH , BRENNER MICHAEL B , BESRA GURDYAL SINGH
发明人： LEADBETTER ELIZABETH , BRENNER MICHAEL B , BESRA GURDYAL SINGH
IPC分类号： A61K39/39
CPC分类号： A61K39/385 , A61K2039/6018
摘要： The present invention is directed to pharmaceutical compositions that can be used to immunize subjects using, for example, lipid, glycan, or nucleic acid antigens. These antigens are conjugated to a glycosphingolipid.
摘要翻译：本发明涉及可用于使用例如脂质，聚糖或核酸抗原免疫受试者的药物组合物。这些抗原与糖鞘脂结合。

3. 发明申请

WO2007051004A2 CONJUGATE VACCINES FOR NON-PROTEINACEOUS ANTIGENS 审中-公开
标题翻译：非侵入性抗原接种疫苗
公开(公告)号：WO2007051004A2
公开(公告)日：2007-05-03
申请号：PCT/US2006/042301
申请日：2006-10-30
申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , THE UNIVERSITY OF BIRMINGHAM , LEADBETTER, Elizabeth , BRENNER, Michael, B. , BESRA, Gurdyal, Singh
发明人： LEADBETTER, Elizabeth , BRENNER, Michael, B. , BESRA, Gurdyal, Singh
IPC分类号： A61K39/39
CPC分类号： A61K39/385 , A61K2039/6018 , Y02A50/484
摘要： The present invention is directed to pharmaceutical compositions that can be used to immunize subjects using, for example, lipid, glycan, or nucleic acid antigens. These antigens are conjugated to a glycosphingolipid.
摘要翻译：本发明涉及可用于使用例如脂质，聚糖或核酸抗原免疫受试者的药物组合物。这些抗原与鞘糖脂结合。

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