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1. 发明专利

JP2010091577A Method and composition for detection of cervical disease 审中-公开
标题翻译：检测宫颈疾病的方法和组成
公开(公告)号：JP2010091577A
公开(公告)日：2010-04-22
申请号：JP2009273812
申请日：2009-12-01
申请人： Tripath Imaging Inc , トライパスイメイジングインク
发明人： FISCHER TIMOTHY J , MALINOWSKI DOUGLAS P , TAYLOR ADRIANN J , PARKER MARGARET R
IPC分类号： G01N33/574 , C07K16/18 , C07K16/30 , C12P19/34 , C12Q1/68 , C12Q1/70 , G01N33/48 , G01N33/53 , G01N33/543 , G01N33/68
CPC分类号： G01N33/57411 , C07K16/3069 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/6875 , G01N2333/025
摘要： PROBLEM TO BE SOLVED: To provide a method and composition for identifying high-grade cervical disease in a patient sample.
SOLUTION: The method includes detecting overexpression of at least one biomarker in a body sample, wherein the biomarker is selectively overexpressed in high-grade cervical disease. In specific claims, the body sample is a cervical smear or monolayer of cervical cells. The biomarkers include genes and proteins that are involved in cell cycle regulation, signal transduction, and DNA replication and transcription. In concrete claims, the biomarker is an S-phase gene. In some aspects of the invention, overexpression of a biomarker of interest is detected at the protein level using biomarker-specific antibodies or at the nucleic acid level using nucleic acid hybridization techniques. A kit for practicing the method is further provided.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供用于鉴定患者样品中的高级子宫颈疾病的方法和组合物。解决方案：该方法包括检测身体样品中至少一种生物标志物的过表达，其中生物标志物在高级子宫颈疾病中选择性地过表达。在具体的权利要求中，身体样品是子宫颈涂片或单层宫颈细胞。生物标志物包括参与细胞周期调节，信号转导和DNA复制和转录的基因和蛋白质。具体地说，生物标志物是S期基因。在本发明的一些方面，使用生物标志物特异性抗体或在核酸水平使用核酸杂交技术在蛋白质水平上检测目标生物标志物的过表达。还提供了用于实施该方法的套件。版权所有（C）2010，JPO＆INPIT

2. 发明专利

JP2012188442A Monoclonal antibody and method for its use in the detection of cervical disease 有权
标题翻译：单克隆抗体及其用于检测宫颈疾病的方法
公开(公告)号：JP2012188442A
公开(公告)日：2012-10-04
申请号：JP2012127116
申请日：2012-06-04
申请人： Tripath Imaging Inc , トリパスイメージング, インコーポレイテッド
发明人： FISCHER TIMOTHY J , MALINOWSKI DOUGLAS P , TAYLOR ADRIANN J
IPC分类号： C07K16/18 , C12N5/10 , C12N15/02 , C12P21/08
CPC分类号： G01N33/57411 , C07K14/4738 , C07K16/3069 , C07K2317/34
摘要： PROBLEM TO BE SOLVED: To provide antibodies that are capable of detecting expression of a biomarker that is selectively overexpressed in high-grade cervical disease.SOLUTION: There are provided: novel monoclonal antibodies, variants and fragments thereof that specifically bind to MCM2; and hybridoma cell lines that produce the monoclonal antibodies. There are also provided: compositions for diagnosing high-grade cervical disease, including the monoclonal antibodies and the variants and fragments thereof; and methods for diagnosing high-grade cervical disease.
摘要翻译：要解决的问题：提供能够检测在高级子宫颈疾病中选择性过表达的生物标志物的表达的抗体。提供：提供：特异性结合MCM2的新型单克隆抗体，其变体和片段; 和产生单克隆抗体的杂交瘤细胞系。还提供：用于诊断高级宫颈疾病的组合物，包括单克隆抗体及其变体和片段; 以及诊断高级子宫颈疾病的方法。版权所有（C）2013，JPO＆INPIT

3. 发明专利

JP2014110797A Method of chromogen separation-based image analysis 审中-公开
标题翻译：基于色谱分离的图像分析方法
公开(公告)号：JP2014110797A
公开(公告)日：2014-06-19
申请号：JP2014006669
申请日：2014-01-17
申请人： Tripath Imaging Inc , トリパスイメージングインコーポレイテッド
发明人： RAPHAEL MARCELPOIL , RYAN WILLIAMS , CEDRICK ORNY
IPC分类号： C12Q1/04 , G01N21/78 , G01N33/48 , G06T1/00
CPC分类号： G06K9/34 , G01N1/30 , G01N1/31 , G06K9/0014 , G06T7/0012 , G06T7/11 , G06T7/136 , G06T7/155 , G06T2207/10016 , G06T2207/10056 , G06T2207/20152 , G06T2207/30024
摘要： PROBLEM TO BE SOLVED: To provide a method for chromogen separation-based image analysis.SOLUTION: Such a method is directed to quantitative video-microscopy techniques in cellular biology and pathology applications.
摘要翻译：要解决的问题：提供基于色素分离的图像分析的方法。解决方案：这种方法涉及细胞生物学和病理学应用中的定量视频显微技术。

4. 发明专利

JP2010078611A Method for quantitative video-microscopy and associated system therewith and computer software program product 有权
标题翻译：量化视频显微镜及其相关系统及计算机软件程序产品的方法
公开(公告)号：JP2010078611A
公开(公告)日：2010-04-08
申请号：JP2009273163
申请日：2009-12-01
申请人： Tripath Imaging Inc , トライパスイメージングインコーポレイテッド
发明人： MARCELPOIL RAPHAEL , GAHM THOMAS
IPC分类号： G01J3/51 , G01N21/27 , G01N21/64 , G01N33/48 , G01N33/483 , G02B21/36 , G06F19/00 , G06K9/00 , G06T7/00 , G06T7/60
CPC分类号： G06K9/00127 , G01N21/27 , G06T7/60 , G06T2207/10056
摘要： PROBLEM TO BE SOLVED: To provide an excellent colorimetric analysis technique with respect to a method for quantitative video-microscopy and associated system, etc. SOLUTION: The method for quantitative video-microscopy determining an amount of at least one molecular specie comprising a sample, each molecular specie being indicated by a dye, is provided. The amount of the molecular specie is determined from the image of a sample captured as image data by a color image acquisition device in a video-microscopy system. An optical density of the sample is first determined in each of a red, green, and blue channels at a particular pixel in the image. A corresponding optical density matrix is thereafter formed for the pixel. The optical density matrix is then multiplied by the inverse of a relative absorption coefficient matrix to form a resultant matrix for the pixel. The relative absorption coefficient matrix includes a relative absorption coefficient for each dye, independent of the sample, in each of the red, green, and blue channels. The resultant matrix thus includes the amount of each molecular specie, as indicated by the respective dye, for the pixel. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：为定量视频显微镜和相关系统等提供优异的比色分析技术。解决方案：定量视频显微镜的方法确定至少一个量提供了包含样品的分子物质，每种分子物质由染料表示。通过视频显微镜系统中的彩色图像获取装置，从作为图像数据捕获的样本的图像确定分子种类的量。首先在图像中的特定像素处的红色，绿色和蓝色通道中的每一个中确定样本的光密度。此后为像素形成对应的光密度矩阵。然后将光密度矩阵乘以相对吸收系数矩阵的倒数，以形成用于像素的合成矩阵。相对吸收系数矩阵包括在每个红色，绿色和蓝色通道中的每种染料的独立于样品的相对吸收系数。所得到的基质因此包括像素所示的每种分子物质的量，如各染料所示。版权所有（C）2010，JPO＆INPIT

5. 发明申请

US20220178797A1 POLYCATIONIC QUATERNARY AMMONIUM POLYMER COATINGS FOR IMMOBILIZING BIOLOGICAL SAMPLES 有权
公开(公告)号：US20220178797A1
公开(公告)日：2022-06-09
申请号：US17592271
申请日：2022-02-03
申请人： TriPath Imaging, Inc.
发明人： William A. Fox , William Carl Ray, III
IPC分类号： G01N1/40 , G01N33/543
摘要： The present invention is directed to a pre-coated substrate, such as a slide, that is useful for immobilizing a sample. The invention is further provides methods of preparing such pre-coated substrates and methods of analyzing biological samples immobilized on such pre-coated substrate. The substrate is coated with a polycationic polymeric coating material specifically selected such that that coated substrate exhibits increased stability and prolonged shelf-life. Preferred polymeric coating materials include allylic or vinylic polymers having cationic groups thereon and having no more than a small percentage of peptidic monomeric linkages, particularly polydiallyldimethylammonium (PDDA).

6. 发明申请

US20150298131A1 OFFSET SAMPLE TUBE HOLDER 有权
标题翻译：偏移样品管支架
公开(公告)号：US20150298131A1
公开(公告)日：2015-10-22
申请号：US14443897
申请日：2013-11-20
申请人： TRIPATH IMAGING, INC.
发明人： William Alan Fox
IPC分类号： B01L9/06
CPC分类号： B01L9/06 , B01L3/5021 , B01L2200/021 , B01L2200/025 , B01L2200/028
摘要： A sample tube holder assembly may include a base comprising a base cavity defined therein. The sample tube holder assembly may include at least one first engagement member disposed within the base cavity and a plurality of sample tube holder racks configured to be received within the base cavity, at least one of the sample tube holder racks comprising at least one second engagement member, wherein each of the plurality of sample tube holder racks further comprises at least one sample tube cavity configured to receive a respective sample tube therein. The first and second engagement members may be configured to engage with one another when the plurality of sample tube holder racks are positioned within the base cavity such that the sample tube holder racks are offset at a different depth from one another within the base cavity.
摘要翻译：样品管保持器组件可以包括其中限定在其中的基部腔的基部。样品管保持器组件可以包括设置在基体腔内的至少一个第一接合构件和被配置为容纳在基腔内的多个样品管保持器架，至少一个样品管固定架包括至少一个第二接合其中所述多个样品管夹持架中的每一个进一步包括至少一个样品管腔，其构造成在其中容纳相应的样品管。第一和第二接合构件可以被构造成当多个样品管保持器架位于基体腔内时彼此接合，使得样品管保持器架在基腔内彼此不同的深度偏移。

7. 发明申请

US20030091221A1 Method for quantitative video-microscopy and associated system and computer software program product 有权
标题翻译：定量视频显微镜及相关系统和计算机软件程序产品的方法
公开(公告)号：US20030091221A1
公开(公告)日：2003-05-15
申请号：US09957446
申请日：2001-09-19
申请人： Tripath Imaging, Inc.
发明人： Raphael Marcelpoil , Thomas Gahm
IPC分类号： G06K009/00
CPC分类号： G06K9/00127 , G01N21/27 , G06T7/60 , G06T2207/10056
摘要： A method of determining an amount of at least one molecular specie comprising a sample is provided, each molecular specie being indicated by a dye. The amount of the molecular specie is determined from an image of the sample captured as image data by a color image acquisition device in a video-microscopy system. An optical density of the sample is first determined in each of a red, green, and blue channel at a particular pixel in the image. A corresponding optical density matrix is thereafter formed for that pixel. The optical density matrix is then multiplied by the inverse of a relative absorption coefficient matrix so as to form a resultant matrix for the pixel. The relative absorption coefficient matrix comprises a relative absorption coefficient for each dye, independently of the sample, in each of the red, green, and blue channels. The resultant matrix thus comprises the amount of each molecular specie, as indicated by the respective dye, for that pixel. Associated systems and computer software program products are also provided.
摘要翻译：提供了确定包含样品的至少一种分子物质的量的方法，每种分子物质由染料指示。通过视频显微镜系统中的彩色图像获取装置，从作为图像数据捕获的样本的图像确定分子种类的量。首先在图像中的特定像素处的红色，绿色和蓝色通道中的每一个中确定样本的光密度。此后为该像素形成对应的光密度矩阵。然后将光密度矩阵乘以相对吸收系数矩阵的倒数，以形成像素的合成矩阵。相对吸收系数矩阵包括在红色，绿色和蓝色通道中的每一个中独立于样品的每种染料的相对吸收系数。所得到的基质因此包含针对该像素的每种分子物质的量，如各染料所示。还提供相关系统和计算机软件程序产品。

8. 发明授权

US09547801B2 Methods of chromogen separation-based image analysis 有权
标题翻译：基于色素分离的图像分析方法
公开(公告)号：US09547801B2
公开(公告)日：2017-01-17
申请号：US13946723
申请日：2013-07-19
申请人： TRIPATH IMAGING, INC.
发明人： Raphaël Marcelpoil , Ryan Williams , Cédrick Orny
IPC分类号： G06K9/34 , G06K9/00 , G01N1/30 , G01N1/31 , G06T7/00
CPC分类号： G06K9/34 , G01N1/30 , G01N1/31 , G06K9/0014 , G06T7/0012 , G06T7/11 , G06T7/136 , G06T7/155 , G06T2207/10016 , G06T2207/10056 , G06T2207/20152 , G06T2207/30024
摘要： Methods for chromogen separation-based image analysis are provided, with such methods being directed to quantitative video-microscopy techniques in cellular biology and pathology applications.
摘要翻译：提供了基于色素分离的图像分析方法，这些方法涉及细胞生物学和病理学应用中的定量视频显微技术。

9. 发明申请

US20130112016A1 CONTAINER AND CAP FOR A BIOLOGICAL SPECIMEN 有权
公开(公告)号：US20130112016A1
公开(公告)日：2013-05-09
申请号：US13672205
申请日：2012-11-08
申请人： TriPath Imaging, Inc.
发明人： Timothy R. Hansen
IPC分类号： G01N1/10
CPC分类号： A61B10/0096 , A61B2010/0074 , A61B2010/0216 , A61J1/1406 , A61J1/1412 , A61J1/1418 , B65D25/04 , B65D41/005 , C12M45/00 , G01N33/48778
摘要： A container for collecting a biological specimen is provided that includes a peripheral wall extending from a base. The container further includes a longitudinal tower disposed within the container. The tower forms a partition within the container to form at least a first chamber and a second chamber therein, wherein the first and second chambers are in fluid communication with one another. In addition, the container include an insert disposed within the container opposite the base, the insert comprising at least a first opening and a second opening. The second opening provides access to the second chamber and is further configured to engage a specimen collecting device to leave a portion of the specimen collecting device within the second chamber. The first opening provides access to the first chamber and is further configured to receive a syringe therein for accessing the biological specimen. Associated systems and methods are also provided.

10. 发明申请

US20030138140A1 Method for quantitative video-microscopy and associated system and computer software program product 有权
公开(公告)号：US20030138140A1
公开(公告)日：2003-07-24
申请号：US10057729
申请日：2002-01-24
申请人： TriPath Imaging, Inc.
发明人： Raphael Marcelpoil , Didier Morel
IPC分类号： G06K009/00
CPC分类号： G01N15/1475 , G01N21/31 , G01N2015/1472 , G06K9/0014 , G06K9/4652 , G06T7/0012 , G06T7/90 , G06T2200/24 , G06T2207/10056 , G06T2207/30024
摘要： A method of determining an amount of at least one molecular species in a sample from an image of the sample captured by an image acquisition device is provided, each molecular species being indicated by a dye. A dye space representation of a plurality of dyes is formed by orthogonally adding the correspondence tables of the dyes, each correspondence table having a plurality of normalized RGB triplets and incrementally extending from 0% to 100% transmittance. The dye space representation has one dimension for each dye and provides a reference model for a combination of the plurality of dyes. Each pixel of an image of the sample stained with the combination of the plurality of dyes is compared to the reference model, each pixel having a color defined by an RGB triplet, so as to determine an optimal combination of normalized RGB triplets from the respective correspondence tables of the dyes producing the color of the respective pixel. An artificial image of the sample is then formed from the normalized RGB triplets for each dye as determined from the optimal combination. The artificial image thereby indicates a distribution of the respective dye over the sample image and facilitates determination of the amount of the corresponding molecular species. Associated methods, systems, and computer software program products are also provided.

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