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1. 发明申请

US20110237647A1 INHIBITORY RNA FOR MODULATING THE MOLECULAR FUNCTION OF ZFAT GENE 有权
标题翻译：用于调节ZFAT基因的分子功能的抑制RNA
公开(公告)号：US20110237647A1
公开(公告)日：2011-09-29
申请号：US13062673
申请日：2008-09-08
申请人： Senji Shirasawa , Takahiro Fujimoto , Toshiyuki Tsunoda , Keiko Doi , Midori Koyanagi
发明人： Senji Shirasawa , Takahiro Fujimoto , Toshiyuki Tsunoda , Keiko Doi , Midori Koyanagi
IPC分类号： A61K31/713 , C12N15/63 , C12N5/071 , C07H21/02 , A61P35/00 , A61P37/06
CPC分类号： A61K31/713 , C12N15/113 , C12N2310/14 , C12N2310/531
摘要： The inhibitory RNA for inhibiting the expression of ZFAT gene according to this invention is a siRNA comprising a sense RNA having a base sequence of contiguous 20 to 20 bases, preferably 23 to 27 bases, of ZFAT mRNA and an anti-sense RNA having a base sequence complementary to the base sequence of the sense RNA or a shRNA comprising a double-stranded RNA (dsRNA) with the sense RNA connected to the anti-sense RNA via a loop sequence.The inhibitory RNA for inhibiting the expression of ZFAT gene according to this invention decreases a rate of cell proliferation of cancer cells, etc., induces apoptosis of cells including cancer cells, or inhibits an immunoresponse by inhibiting the expression of the ZFAT gene. Therefore, the inhibitory RNA of this invention is useful for development of molecular target agents particularly for cancer cells or immunosuppressive agents.
摘要翻译：用于抑制本发明的ZFAT基因表达的抑制性RNA是包含具有ZFAT mRNA连续20至20个碱基，优选23至27个碱基的碱基序列的正义RNA和具有碱基的反义RNA的siRNA 与有义RNA的碱基序列互补的序列或包含通过环序列连接到反义RNA的有义RNA的双链RNA（dsRNA）的shRNA。根据本发明抑制ZFAT基因表达的抑制性RNA降低了癌细胞等的细胞增殖速度，诱导包括癌细胞在内的细胞的凋亡，或通过抑制ZFAT基因的表达来抑制免疫应答。因此，本发明的抑制性RNA可用于开发特别用于癌细胞或免疫抑制剂的分子靶因子。

2. 发明申请

US20090212851A1 POWER SUPPLY UNIT 失效
标题翻译：供电单元
公开(公告)号：US20090212851A1
公开(公告)日：2009-08-27
申请号：US12342710
申请日：2008-12-23
申请人： Osamu YAMASHITA , Yasuhiko Kokami , Masahiro Ishihara , Toshiyuki Tsunoda
发明人： Osamu YAMASHITA , Yasuhiko Kokami , Masahiro Ishihara , Toshiyuki Tsunoda
IPC分类号： G05F1/10
CPC分类号： H02M1/32 , H02M3/158 , H02M2001/0009 , H02M2001/0025
摘要： High-accuracy overcurrent detection is performed, while a loss resulting from the current detection is significantly reduced. A switch section outputs the voltage between the both terminals of a current detection resistor using an AND signal between an output signal from a hysteresis comparator and an output signal from a pre-driver. The voltage is filtered by an electrostatic capacitor element and a resistor, and inputted to a comparator. The comparator makes a comparison between the signals inputted to the two input terminals thereof, and outputs the result of the comparison to a digital filter. When an overcurrent begins to flow in a power supply unit, the levels of the voltages inputted to the two input terminals of the comparator are inverted so that the comparator outputs an inversion signal to the digital filter. The digital filter outputs a detection signal to an overcurrent detection circuit when an arbitrary time has elapsed.
摘要翻译：执行高精度过电流检测，而由电流检测导致的损耗显着降低。开关部分使用来自迟滞比较器的输出信号和来自预驱动器的输出信号之间的AND信号来输出电流检测电阻器的两端之间的电压。电压由静电电容器元件和电阻器滤波，并输入到比较器。比较器对输入到其两个输入端的信号进行比较，并将比较结果输出到数字滤波器。当过电流在电源单元中流动时，输入到比较器的两个输入端的电压的电平被反相，使得比较器向数字滤波器输出反相信号。当任意时间过去时，数字滤波器将检测信号输出到过电流检测电路。

3. 发明授权

US4878746A Surgical microscope apparatus 失效
标题翻译：手术显微镜装置
公开(公告)号：US4878746A
公开(公告)日：1989-11-07
申请号：US178967
申请日：1988-04-07
申请人： Hiroshi Nakano , Toyoaki Takeuchi , Toshiyuki Tsunoda , Masahiko Kinukawa
发明人： Hiroshi Nakano , Toyoaki Takeuchi , Toshiyuki Tsunoda , Masahiko Kinukawa
IPC分类号： A61B19/00 , G02B21/00 , G02B21/08 , G02B21/22 , G02B21/24
CPC分类号： G02B21/24 , G02B21/0012 , G02B21/082 , G02B21/22
摘要： A surgical microscope apparatus provided with a failure detecting device for conducting an initial examination and an ordinary examination of an illumination device and a failure detecting device for conducting the ordinary examination of an electric magnification and focusing device, in order to make it possible to self-examine what is defective and indicate the result when failure is caused. The failure of the illumination device is immediately indicated by the self examination of the failure detecting device when a power source is turned on for use.
摘要翻译：一种手术显微镜装置，具有进行初次检查的故障检测装置和普通的照明装置的检查以及进行电放大和聚焦装置的普通检查的故障检测装置，检查有无故障，并在发生故障时指示结果。当电源接通使用时，通过故障检测装置的自检立即表示照明装置的故障。

4. 发明授权

US4871245A Surgical microscope 失效
标题翻译：手术显微镜
公开(公告)号：US4871245A
公开(公告)日：1989-10-03
申请号：US112440
申请日：1987-10-26
申请人： Tomonori Ishikawa , Takashi Fukaya , Toshiyuki Tsunoda , Hiroshi Fujiwara
发明人： Tomonori Ishikawa , Takashi Fukaya , Toshiyuki Tsunoda , Hiroshi Fujiwara
IPC分类号： A61B19/00 , G02B21/08 , G02B21/12 , G02B21/36
CPC分类号： G02B21/082 , G02B21/12 , G02B21/361
摘要： A surgical microscope arranging, so as to be insertable into and removable from an illuminating optical path for observation, a semi-transparent mirror capable of introducing illuminating light for photographing in a coaxial relation into illuminating light for observation or a totally reflecting mirror having such size as not to entirely interrupt the illuminating light for observation, in order to make it possible that compact size and low cost are attained, the amounts of illuminating light for observation and photographing are sufficiently secured, both the illuminating light are conducted along a common optical axis, and the illuminating light for observation is not interrupted even for a moment in photographing.
摘要翻译：一种手术显微镜布置成可插入到用于观察的照明光路中并且可以从照明光路中移除的半透明镜，能够将用于以同轴关系拍摄的照明光引入用于观察的照明光或具有这种尺寸的全反射镜为了不完全中断观察用的照明光，为了使得可以实现小型化和低成本，用于观察和拍摄的照明光的量被充分确保，照明光都沿共同的光轴并且用于观察的照明光即使在摄影时刻也不会中断。

5. 发明授权

US4807989A Surgical microscope system 失效
标题翻译：手术显微镜系统
公开(公告)号：US4807989A
公开(公告)日：1989-02-28
申请号：US1585
申请日：1987-01-09
申请人： Takashi Nagano , Toshiyuki Tsunoda , Takashi Fukaya
发明人： Takashi Nagano , Toshiyuki Tsunoda , Takashi Fukaya
IPC分类号： A61B19/00 , A61F9/013 , G02B21/00 , A61B3/10
CPC分类号： A61F9/013 , G02B21/0012 , A61B90/20
摘要： A surgical microscope comprises an illuminating light source for observation and/or photographing, an observation optical system, an index projecting optical system and a cornea configuration measuring optical system. The index projecting optical system includes an index which is removably inserted in the illuminating light beam emitted from the illuminating light source and transmitted through an objective of the observation optical system, thereby dispensing with any particular light source for measuring a cornea configuration, and a cornea configuration measuring mode and a photographing mode being automatically changeable by automatically detecting the presence or absence of the index within the optical path of the microscope.
摘要翻译：手术显微镜包括用于观察和/或拍摄的照明光源，观察光学系统，折射率投影光学系统和角膜构造测量光学系统。折射率投影光学系统包括可拆卸地插入从照明光源发射并通过观察光学系统的物镜透射的照明光束中的索引，从而分配用于测量角膜构造的任何特定光源，以及角膜配置测量模式和通过自动检测显微镜的光路内的索引的存在或不存在而自动改变的拍摄模式。

6. 发明申请

US20110063021A1 POWER SUPPLY UNIT 失效
标题翻译：供电单元
公开(公告)号：US20110063021A1
公开(公告)日：2011-03-17
申请号：US12950161
申请日：2010-11-19
申请人： Osamu YAMASHITA , Yasuhiko KOKAMI , Masahiro ISHIHARA , Toshiyuki TSUNODA
发明人： Osamu YAMASHITA , Yasuhiko KOKAMI , Masahiro ISHIHARA , Toshiyuki TSUNODA
IPC分类号： G05F1/10
CPC分类号： H02M1/32 , H02M3/158 , H02M2001/0009 , H02M2001/0025
摘要： High-accuracy overcurrent detection is performed, while a loss resulting from the current detection is significantly reduced. A switch section outputs the voltage between the both terminals of a current detection resistor using an AND signal between an output signal from a hysteresis comparator and an output signal from a pre-driver. The voltage is filtered by an electrostatic capacitor element and a resistor, and inputted to a comparator. The comparator makes a comparison between the signals inputted to the two input terminals thereof, and outputs the result of the comparison to a digital filter. When an overcurrent begins to flow in a power supply unit, the levels of the voltages inputted to the two input terminals of the comparator are inverted so that the comparator outputs an inversion signal to the digital filter. The digital filter outputs a detection signal to an overcurrent detection circuit when an arbitrary time has elapsed.
摘要翻译：执行高精度过电流检测，而由电流检测导致的损耗显着降低。开关部分使用来自迟滞比较器的输出信号和来自预驱动器的输出信号之间的AND信号来输出电流检测电阻器的两端之间的电压。电压由静电电容器元件和电阻器滤波，并输入到比较器。比较器对输入到其两个输入端的信号进行比较，并将比较结果输出到数字滤波器。当过电流在电源单元中流动时，输入到比较器的两个输入端的电压的电平被反相，使得比较器向数字滤波器输出反相信号。当任意时间过去时，数字滤波器将检测信号输出到过电流检测电路。

7. 发明授权

US06771033B2 Drive control system for sensor-less motor 失效
标题翻译：无传感器电机驱动控制系统
公开(公告)号：US06771033B2
公开(公告)日：2004-08-03
申请号：US10341342
申请日：2003-01-14
申请人： Yasuhiko Kokami , Kunihiro Kawauchi , Toshiyuki Tsunoda , Reiichi Kimura
发明人： Yasuhiko Kokami , Kunihiro Kawauchi , Toshiyuki Tsunoda , Reiichi Kimura
IPC分类号： H02P600
CPC分类号： H02P6/182 , Y10S388/911
摘要： A drive control system, with PLL control, drives a rotatable multi-phase sensor-less motor by switching a current of a field coil of each phase depending on the rotating phase of the motor. When the motor is driven, a desired phase is selected as a detection phase, and a voltage induced on the coil of the detection phase is detected when power is fed for a predetermined time to the field coils other than the detection phase. A magnetic pole position is detected from the amplitude condition of the detected induced voltage. Based on this detection, the power-feeding phase of the motor drive is determined. Power feeding and pole position detection are performed alternately.
摘要翻译：具有PLL控制的驱动控制系统通过根据电动机的旋转相位切换每相的励磁线圈的电流来驱动可旋转的多相无传感器电动机。当电机被驱动时，选择期望的相位作为检测相位，并且当向除了检测相位之外的励磁线圈供电预定时间时检测在检测相位线圈上感应的电压。从检测到的感应电压的振幅条件检测磁极位置。基于该检测，确定电动机驱动器的供电相位。交替执行供电和极位置检测。

8. 发明授权

US06344721B2 Semiconductor integrated circuit for brushless motor drive control and brushless motor drive control apparatus 有权
公开(公告)号：US06344721B2
公开(公告)日：2002-02-05
申请号：US09818511
申请日：2001-03-28
申请人： Kunio Seki , Toshiyuki Tsunoda , Yasuhiko Kokami , Kunihiro Kawauchi
发明人： Kunio Seki , Toshiyuki Tsunoda , Yasuhiko Kokami , Kunihiro Kawauchi
IPC分类号： H02P540
CPC分类号： H02P6/22
摘要： A pulse current having such a short duration as the rotor does not react is passed through field coils of respective phases of a brushless motor in first and second, mutually opposite, directions sequentially, voltages induced, by the pulse currents in two directions at each of the field coils of the non-conducting phase are combined, the polarity of a combined voltage is detected, and a field coil pair where a current is to be passed to start the motor is determined based on the result of detection for each of field coil of the non-conducting phase.

9. 发明授权

US06340873B2 Semiconductor integrated circuit for brushless motor drive control and brushless motor drive control apparatus 有权
公开(公告)号：US06340873B2
公开(公告)日：2002-01-22
申请号：US09893549
申请日：2001-06-29
申请人： Kunio Seki , Toshiyuki Tsunoda , Yasuhiko Kokami , Kunihiro Kawauchi
发明人： Kunio Seki , Toshiyuki Tsunoda , Yasuhiko Kokami , Kunihiro Kawauchi
IPC分类号： H02P540
CPC分类号： H02P6/22
摘要： A pulse current having such a short duration as the rotor does not react is passed through field coils of respective phases of a brushless motor in first and second, mutually opposite, directions sequentially, voltages induced, by the pulse currents in two directions at each of the field coils of the non-conducting phase are combined, the polarity of a combined voltage is detected, and a field coil pair where a current is to be passed to start the motor is determined based on the result of detection for each of field coil of the non-conducting phase.

10. 发明授权

US08580562B2 Inhibitory RNA for modulating the molecular function of ZFAT gene 有权
标题翻译：用于调节ZFAT基因分子功能的抑制性RNA
公开(公告)号：US08580562B2
公开(公告)日：2013-11-12
申请号：US13062673
申请日：2008-09-08
申请人： Senji Shirasawa , Takahiro Fujimoto , Toshiyuki Tsunoda , Keiko Doi , Midori Koyanagi
发明人： Senji Shirasawa , Takahiro Fujimoto , Toshiyuki Tsunoda , Keiko Doi , Midori Koyanagi
IPC分类号： C12N15/85 , C12N15/63 , C07H21/02 , C07H21/04
CPC分类号： A61K31/713 , C12N15/113 , C12N2310/14 , C12N2310/531
摘要： The inhibitory RNA for inhibiting the expression of ZFAT gene according to this invention is a siRNA comprising a sense RNA having a base sequence of contiguous 20 to 20 bases, preferably 23 to 27 bases, of ZFAT mRNA and an anti-sense RNA having a base sequence complementary to the base sequence of the sense RNA or a shRNA comprising a double-stranded RNA (dsRNA) with the sense RNA connected to the anti-sense RNA via a loop sequence.The inhibitory RNA for inhibiting the expression of ZFAT gene according to this invention decreases a rate of cell proliferation of cancer cells, etc., induces apoptosis of cells including cancer cells, or inhibits an immunoresponse by inhibiting the expression of the ZFAT gene. Therefore, the inhibitory RNA of this invention is useful for development of molecular target agents particularly for cancer cells or immunosuppressive agents.
摘要翻译：用于抑制本发明的ZFAT基因表达的抑制性RNA是包含具有ZFAT mRNA连续20至20个碱基，优选23至27个碱基的碱基序列的正义RNA和具有碱基的反义RNA的siRNA 与有义RNA的碱基序列互补的序列或包含通过环序列连接到反义RNA的有义RNA的双链RNA（dsRNA）的shRNA。根据本发明抑制ZFAT基因表达的抑制性RNA降低了癌细胞等的细胞增殖速度，诱导包括癌细胞在内的细胞的凋亡，或通过抑制ZFAT基因的表达来抑制免疫应答。因此，本发明的抑制性RNA可用于开发特别用于癌细胞或免疫抑制剂的分子靶因子。

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