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1. 发明授权

US09006220B2 23-yne-vitamin D3 derivative 有权
标题翻译： 23-维生素D3衍生物
公开(公告)号：US09006220B2
公开(公告)日：2015-04-14
申请号：US13880637
申请日：2011-10-24
申请人： Hiroshi Saito , Masato Komiyama , Eiji Ochiai , Kenichiro Takagi , Takayuki Chida , Mariko Fujita , Keiichiro Imaizumi , Toshiyuki Kaneko
发明人： Hiroshi Saito , Masato Komiyama , Eiji Ochiai , Kenichiro Takagi , Takayuki Chida , Mariko Fujita , Keiichiro Imaizumi , Toshiyuki Kaneko
IPC分类号： C07C401/00 , C07F7/18
CPC分类号： C07C401/00 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/24 , C07F7/1804 , C07F7/1852 , Y02P20/55
摘要： To provide a novel vitamin D3 derivative useful as a therapeutic agent for osteoporosis.Provided is a vitamin D3 derivative represented by the following formula (1) or a medicinally acceptable solvate thereof: wherein R1 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, an alkylcarbonyloxyalkyl group with each alkyl having 1 to 6 carbon atoms, or an arylcarbonyloxyalkyl group with the aryl having 6 to 10 carbon atoms and the alkyl having 1 to 6 carbon atoms; R2 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms or, together with the other R2 and the carbon atom to which they are bound to, may form a cyclic alkyl group having 3 to 6 carbon atoms; R3 represents an alkyl group having 1 to 6 carbon atoms or, together with the other R3 and the carbon atom to which they are bound to, may form a cyclic alkyl group having 3 to 6 carbon atoms; X represents an oxygen atom or a methylene group; and n represents an integer of 1 or 2.
摘要翻译：提供可用作骨质疏松症治疗剂的新型维生素D3衍生物。本发明提供由下式（1）表示的维生素D3衍生物或其药学上可接受的溶剂合物：其中，R1表示氢原子，碳原子数1〜6的烷基，碳原子数1〜6的烷基的烷基羰氧基烷基或芳基具有6至10个碳原子的芳基羰氧基烷基和具有1至6个碳原子的烷基; R 2表示氢原子或碳原子数1〜6的烷基，或者与其它的R 2和与它们相连的碳原子一起形成可以形成碳原子数为3〜6的环状烷基。 R 3表示碳原子数为1〜6的烷基，或者与另外的R 3及与它们相连的碳原子一起形成碳原子数为3〜6的环状烷基。 X表示氧原子或亚甲基; n表示1或2的整数。

2. 发明申请

US20090315970A1 DRAWING APPARATUS AND METHOD, AND COMPUTER PROGRAM 有权
标题翻译：绘图设备和方法以及计算机程序
公开(公告)号：US20090315970A1
公开(公告)日：2009-12-24
申请号：US12439898
申请日：2006-09-22
申请人： Wataru Hasegawa , Toshiyuki Kaneko , Takashi Nakamura , Tetsuya Hayashi
发明人： Wataru Hasegawa , Toshiyuki Kaneko , Takashi Nakamura , Tetsuya Hayashi
IPC分类号： B41J2/435
CPC分类号： B41J3/4071 , B41J2/442 , G11B7/0037
摘要： A drawing apparatus (1) is provided with: a drawing device (13) for drawing a predetermined pattern onto a label surface (120), which is provided for a recording medium (100), by irradiating the label surface with a laser beam (LB); a driving device (15) for driving the drawing device along the label surface; a voltage applying device (17) for applying each of a first voltage and a second voltage for driving the driving device, to the driving device; and a controlling device (31) for controlling the voltage applying device such that the first voltage and the second voltage have a same polarity and amplitude when the drawing device is located at an initial position corresponding to a position at which the drawing of the desired pattern is started with respect to the label surface.
摘要翻译：一种绘图装置（1）具有：用于通过用激光束照射标签表面来将预定图案拉伸到设置在记录介质（100）上的标签表面（120）上的绘图装置（13）磅）; 用于沿着所述标签表面驱动所述绘制装置的驱动装置（15）; 用于将驱动装置驱动的第一电压和第二电压各自施加到驱动装置的电压施加装置（17）以及控制装置（31），用于控制电压施加装置，使得当绘图装置位于与所需图案的绘制位置相对应的初始位置时，第一电压和第二电压具有相同的极性和幅度相对于标签表面开始。

3. 发明申请

US20060184950A1 Disc drive 审中-公开
标题翻译：磁盘驱动器
公开(公告)号：US20060184950A1
公开(公告)日：2006-08-17
申请号：US11092980
申请日：2005-03-30
申请人： Toshiyuki Kaneko , Keiichi Takagi , Yuji Yamada , Naozumi Teramoto , Kouichi Yaeguchi
发明人： Toshiyuki Kaneko , Keiichi Takagi , Yuji Yamada , Naozumi Teramoto , Kouichi Yaeguchi
IPC分类号： G11B17/04
CPC分类号： G11B17/051
摘要： When an optical sensor 410 disposed near an opening of a casing 10 (translator's comment: correctly, 110) detects an optical disc 10, a disc processing section 200 is rotated to a retracted position where a rotating shaft 222A is retracted from the moving path of the optical disc 10. When the optical disc 10 moves to a certain position from the opening, the loading unit 400 loads the optical disc 10. When the optical disc 10 is located at a loading-completion position, a sensing switch 420 is turned off, and the disc processing section 200 is rotated to an advanced position where the rotating shaft 222A is advanced onto the moving path to rotatably support the optical disc 10. In response to a request for ejecting the optical disc 10, the disc processing section 200 is rotated to the retracted position to release the rotatably supporting state and the loading unit 400 is activated to eject the optical disc 10. The disc processing section 200 is rotated to the advanced position if the optical sensor 410 is no longer able to detect the optical disc 10.
摘要翻译：当设置在壳体10的开口附近的光学传感器410（转换器的注释正确地，110）检测到光盘10时，盘处理部200旋转到缩回位置，其中旋转轴222A从移动路径缩回的光盘10。当光盘10从开口移动到特定位置时，装载单元400装载光盘10。当光盘10位于加载完成位置时，感测开关420被关闭，并且盘处理部200旋转到旋转轴222A前进到移动路径上的前进位置，以可旋转地支撑光盘10。响应于弹出光盘10的请求，盘处理部200旋转到缩回位置以释放可旋转支撑状态，并且启动装载单元400以弹出光盘10。如果光学传感器410不再能够检测光盘10，则光盘处理部分200旋转到提前位置。

4. 发明授权

US06316558B1 Transition metal compound, olefin polymerization catalyst comprising the compound, and process for production of olefin polymer 失效
标题翻译：过渡金属化合物，包含该化合物的烯烃聚合催化剂和烯烃聚合物的制备方法
公开(公告)号：US06316558B1
公开(公告)日：2001-11-13
申请号：US09039495
申请日：1998-03-16
申请人： Toshiyuki Kaneko , Ryuji Ikeda , Akihiro Yano , Morihiko Sato
发明人： Toshiyuki Kaneko , Ryuji Ikeda , Akihiro Yano , Morihiko Sato
IPC分类号： C08F452
CPC分类号： C07F17/00 , C08F4/63908 , C08F4/63912 , C08F4/63927 , C08F4/65916 , C08F10/00 , Y10S526/943
摘要： A polyolefin of a high molecular weight is produced by using a catalyst comprising a transition metal compound represented by General Formula (1):
摘要翻译：通过使用包含由通式（1）表示的过渡金属化合物的催化剂制备高分子量的聚烯烃：

5. 发明授权

US5807938A Catalyst for olefin polymerization and process for producing olefin polymers 失效
标题翻译：用于烯烃聚合的催化剂和用于生产烯烃聚合物的方法
公开(公告)号：US5807938A
公开(公告)日：1998-09-15
申请号：US603439
申请日：1996-02-20
申请人： Toshiyuki Kaneko , Morihiko Sato
发明人： Toshiyuki Kaneko , Morihiko Sato
IPC分类号： C08F4/02 , C08F4/642 , C08F4/643 , C08F4/646 , C08F4/649 , C08F4/658 , C08F4/659 , C08F4/6592 , C08F10/00
CPC分类号： C08F10/00 , C08F4/65908 , C08F4/65912 , C08F4/65916 , C08F4/6592 , Y10S526/904 , Y10S526/943
摘要： A catalyst for olefin polymerization obtainable by contacting: (a) a transition metal compound containing a transition metal of the Group 4 of the Periodic Table, (b) an organometallic compound, and (c) a solid catalyst component comprising a carrier and an ionized ionic compound capable of forming a stable anion on reaction with a transition metal compound, wherein the ionized ionic compound comprises a cationic component and an anionic component and the cationic component is fixed on the surface of the carrier. The catalyst system of the invention enables production of olefin polymers with excellent physical properties at good productivity without causing contamination of a polymerization vessel.
摘要翻译：通过使（a）含有周期表第4族的过渡金属的过渡金属化合物，（b）有机金属化合物和（c）含有载体和电离的离子化合物能够与过渡金属化合物反应形成稳定的阴离子，其中离子化离子化合物包含阳离子组分和阴离子组分，阳离子组分固定在载体的表面上。本发明的催化剂体系能够以良好的生产率生产具有优异的物理性能的烯烃聚合物，而不会引起聚合容器的污染。

6. 发明申请

US20130210781A1 23-YNE-VITAMIN D3 DERIVATIVE 有权
公开(公告)号：US20130210781A1
公开(公告)日：2013-08-15
申请号：US13880637
申请日：2011-10-24
申请人： Hiroshi Saito , Masato Komiyama , Eiji Ochiai , Kenichiro Takagi , Takayuki Chida , Mariko Fujita , Keiichiro Imaizumi , Toshiyuki Kaneko
发明人： Hiroshi Saito , Masato Komiyama , Eiji Ochiai , Kenichiro Takagi , Takayuki Chida , Mariko Fujita , Keiichiro Imaizumi , Toshiyuki Kaneko
IPC分类号： C07C401/00 , C07F7/18
CPC分类号： C07C401/00 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/24 , C07F7/1804 , C07F7/1852 , Y02P20/55
摘要： To provide a novel vitamin D3 derivative useful as a therapeutic agent for osteoporosis.Provided is a vitamin D3 derivative represented by the following formula (1) or a medicinally acceptable solvate thereof: wherein R1 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, an alkylcarbonyloxyalkyl group with each alkyl having 1 to 6 carbon atoms, or an arylcarbonyloxyalkyl group with the aryl having 6 to 10 carbon atoms and the alkyl having 1 to 6 carbon atoms; R2 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms or, together with the other R2 and the carbon atom to which they are bound to, may form a cyclic alkyl group having 3 to 6 carbon atoms; R3 represents an alkyl group having 1 to 6 carbon atoms or, together with the other R3 and the carbon atom to which they are bound to, may form a cyclic alkyl group having 3 to 6 carbon atoms; X represents an oxygen atom or a methylene group; and n represents an integer of 1 or 2.

7. 发明申请

US20090291945A1 CYSTEINE PROTEASE INHIBITORS 审中-公开
标题翻译： CYSTEINE PROTEASE抑制剂
公开(公告)号：US20090291945A1
公开(公告)日：2009-11-26
申请号：US12419722
申请日：2009-04-07
申请人： Gen Unoki , Takashi Hayamizu , Hiroshi Eguchi , Yumiko Muroga , Toshiyuki Kaneko , Naoki Yajima
发明人： Gen Unoki , Takashi Hayamizu , Hiroshi Eguchi , Yumiko Muroga , Toshiyuki Kaneko , Naoki Yajima
IPC分类号： A61K31/54 , A61K31/535 , A61K31/445 , A61K31/165 , C07D279/12 , C07D265/28 , C07D211/60 , C07C237/02
CPC分类号： C07C255/16 , C07C237/10 , C07C237/14 , C07C237/20 , C07C237/24 , C07C259/06 , C07C317/18 , C07C317/28 , C07C317/32 , C07C323/12 , C07C323/41 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D209/34 , C07D211/60 , C07D211/62 , C07D213/26 , C07D213/40 , C07D231/12 , C07D231/14 , C07D233/61 , C07D265/30 , C07D295/155 , C07D295/185 , C07D317/50 , C07D401/12
摘要： To provide a compound having an excellent cysteine protease inhibitory effect, and to provide a drug for treatment or prevention of the disease selected from the group consisting of osteoporosis, osteoarthritis, chronic rheumatoid arthritis, Paget's disease of bone, hypercalcemia, bone metastasis of cancer, and ostealgia. A compound represented by formula (1) or a pharmaceutically acceptable salt thereof, or a drug or pharmaceutical composition containing the same as an effective component.
摘要翻译：提供具有优异的半胱氨酸蛋白酶抑制作用的化合物，提供治疗或预防选自骨质疏松症，骨关节炎，慢性类风湿性关节炎，骨关节炎，高钙血症，癌症骨转移的疾病的药物，和骨痛。由式（1）表示的化合物或其药学上可接受的盐，或其含有与有效成分相同的药物或药物组合物。

8. 发明申请

US20080251042A1 Device for Controlling Phase of Cam Shaft in Internal Combustion Engine and Phase Controlling device 审中-公开
标题翻译：内燃机凸轮轴控制装置及相控装置
公开(公告)号：US20080251042A1
公开(公告)日：2008-10-16
申请号：US11834969
申请日：2007-08-07
申请人： Isao HAYASE , Seiji Suga , Yoshinori Ichinosawa , Toshiyuki Kaneko
发明人： Isao HAYASE , Seiji Suga , Yoshinori Ichinosawa , Toshiyuki Kaneko
IPC分类号： F01L1/344
CPC分类号： F01L1/3442 , F01L2001/34453 , F01L2001/34463 , F01L2001/34469
摘要： A device for controlling a phase of a cam shaft in an internal combustion engine has a structure which can return a phase of a cam shaft to an intermediate position on the basis of its own power by utilizing a variable torque applied to a cam shaft at a time of starting an engine so as to lock, and has a high practicability and mass production performance. This device is provided with a first rotating body rotating together with a cam shaft, a second rotating body provided coaxially in the first rotating body so as to control a phase angle and rotating together with a sprocket, and a fixing mechanism fixing the phase angle, in which the fixing mechanism has a wedge member wherein a wedge-shaped portion is formed, the first rotating body and the second rotating body have contact surfaces brought into contact with the wedge member, and at least any one of the contact surfaces of the first rotating body and the second rotating body is formed such that a distance from a center of rotation to an application line of a load applied to the contact surface is smaller than a distance from the center of rotation to an application point of the load on the contact surface.
摘要翻译：用于控制内燃机中的凸轮轴的相位的装置具有这样的结构，其可以通过利用施加到凸轮轴上的可变扭矩，将凸轮轴的相位基于其自身功率返回到中间位置起动发动机以锁定的时间，具有很高的实用性和大规模生产性能。该装置设置有与凸轮轴一起旋转的第一旋转体，同轴地设置在第一旋转体中的第二旋转体，以便控制相位角并与链轮一起旋转，以及固定相位角的固定机构，其中固定机构具有楔形部件，其中形成楔形部分，第一旋转体和第二旋转体具有与楔形部件接触的接触表面，并且第一部分的至少任一个接触表面旋转体和第二旋转体形成为使得从旋转中心到施加到接触表面的负载的施加线的距离小于从旋转中心到接触点上的负载的施加点的距离表面。

9. 发明授权

US06799324B1 Disc driving apparatus 失效
标题翻译：盘驱动装置
公开(公告)号：US06799324B1
公开(公告)日：2004-09-28
申请号：US09061519
申请日：1998-04-16
申请人： Keiichi Takagi , Toshiyuki Kaneko , Masaaki Kiyomiya
发明人： Keiichi Takagi , Toshiyuki Kaneko , Masaaki Kiyomiya
IPC分类号： G11B17028
CPC分类号： G11B17/0284
摘要： A disc driving apparatus is provided with: a turn table on which a disc type record medium is loaded; a clamper opposed to the turn table for clamping the disc type record medium on the turn table by means of a magnetic force applied between the turn table and the clamper; and a spindle motor for rotationally driving the turn table. The clamper has at least 3 abutting portions for abutting to the disc type record medium such that only one of the abutting portions is respectively on a line passing through a center of the clamper in a plain parallel to a record surface of the disc type record medium.
摘要翻译：盘驱动装置具有：装载有盘式记录介质的转台; 与转台相对的夹持器，用于通过施加在转台和夹持器之间的磁力将盘型记录介质夹紧在转台上; 以及用于旋转地转动转台的主轴电机。夹持器具有至少3个邻接部分，用于邻接盘型记录介质，使得只有一个邻接部分分别在平行于盘型记录介质的记录表面的平原中穿过夹持器的中心的线上。

10. 发明授权

US6110858A Olefin polymerization catalysts and process for producing olefin polymers 失效
标题翻译：烯烃聚合催化剂和烯烃聚合物的制备方法
公开(公告)号：US6110858A
公开(公告)日：2000-08-29
申请号：US991658
申请日：1997-12-16
申请人： Toshiyuki Kaneko , Akihiro Yano
发明人： Toshiyuki Kaneko , Akihiro Yano
IPC分类号： C08F4/02 , C08F4/602 , C08F4/619 , C08F4/6192 , C08F4/642 , C08F10/00 , C08F110/06 , C08F210/16 , C08F210/18 , B01J29/00
CPC分类号： C08F10/00 , C08F110/06 , C08F210/16 , C08F210/18 , C08F4/61912 , C08F4/61916 , C08F4/61922
摘要： Catalysts for olefin polymerization which consist essentially of a transition metal compound, a modified clay compound and an organic aluminum compound, wherein the modified clay compound comprises a reaction product of a clay mineral and a proton acid salt of a specific amine compound, as well as a method of polymerizing olefins using such catalysts. It is possible thereby to obtain olefin polymers with high productivity and low ash content.
摘要翻译：用于烯烃聚合的催化剂，其基本上由过渡金属化合物，改性粘土化合物和有机铝化合物组成，其中改性粘土化合物包括粘土矿物和特定胺化合物的质子酸盐的反应产物，以及使用这种催化剂聚合烯烃的方法。从而可以获得具有高生产率和低灰分含量的烯烃聚合物。

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