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1. 发明授权

US07498145B2 Concentration measuring method, concentration measuring kit, and sensor chip for use in the method 失效
标题翻译：浓度测定方法，浓度测定试剂盒，传感器芯片用于该方法
公开(公告)号：US07498145B2
公开(公告)日：2009-03-03
申请号：US11363094
申请日：2006-02-28
申请人： Kenichi Uchiyama , Kayoko Oomiya , Isao Kishimoto , Masami Hirata , Hideo Eto , Ichiro Tono , Ikuo Uematsu , Shingo Kasai , Tomohiro Takase , Tsutomu Honjoh , Masanori Sugitani
发明人： Kenichi Uchiyama , Kayoko Oomiya , Isao Kishimoto , Masami Hirata , Hideo Eto , Ichiro Tono , Ikuo Uematsu , Shingo Kasai , Tomohiro Takase , Tsutomu Honjoh , Masanori Sugitani
IPC分类号： G01N33/53 , G01N33/551 , G01N33/552 , G01N33/58
CPC分类号： G01N33/54373 , Y10S435/808 , Y10S436/805
摘要： The method for measuring the concentration of the measuring object uses a sensor chip comprising an optical waveguide layer and an antibody immobilized layer formed on the surface of the optical waveguide layer, which comprises immobilizing the measuring object and an enzyme-labeled antibody labeled with a labeling enzyme on the antibody immobilized layer of the sensor chip having an immobilized antibody, producing a color-developing and precipitating enzyme reaction product by allowing to react a coloring reagent with the labeling enzyme on the antibody immobilized layer to precipitate the enzyme reaction product on the antibody immobilized layer, allowing to totally reflect a light impinged on the sensor chip from the outside at an interface between the optical waveguide layer and the antibody immobilized layer, and observing to a physical value of the totally reflected light.
摘要翻译：用于测量对象浓度的方法使用包括形成在光波导层表面上的光波导层和抗体固定层的传感器芯片，其包括固定测量对象和用标记的酶标记的抗体酶在具有固定化抗体的传感器芯片的抗体固定化层上，通过使着色试剂与抗体固定化层上的标记酶反应，使酶反应产物沉淀在抗体上，产生显色和沉淀酶反应产物使得能够在光波导层和抗体固定化层之间的界面处从外部全面反射入射到传感器芯片上的光，并观察全反射光的物理值。

2. 发明申请

US20070081758A1 Optical waveguide type biochemical sensor chip and method of manufacturing the same 有权
公开(公告)号：US20070081758A1
公开(公告)日：2007-04-12
申请号：US11393771
申请日：2006-03-31
申请人： Ichiro Tono , Kayoko Oomiya , Tomohiro Takase , Ikuo Uematsu
发明人： Ichiro Tono , Kayoko Oomiya , Tomohiro Takase , Ikuo Uematsu
IPC分类号： G02B6/00
CPC分类号： G02B6/124 , G01N21/7703 , G01N21/78 , G01N2021/7709 , G01N2021/775 , G01N2021/7783
摘要： An optical waveguide type biochemical sensor chip includes a light beam transmittable substrate having at least a first optical element that allows light beam to be impinged to the inside and a second optical element that emits light beam from the inside, an optical waveguide layer that is formed on a main surface of the substrate on which at least one of the first and second optical elements is formed, has a thickness of 3 to 300 μm and is made of a polymer resin material having a higher refractive index than that of the substrate material, and a sensing membrane that is formed on the optical waveguide layer and creates a reaction product having the ability of absorbing the light beam or an evanescent wave of the light beam in response to an introduced specimen.

3. 发明申请

US20070146718A1 OPTICAL INSPECTION METHOD AND OPTICAL INSPECTION APPARATUS USED FOR THE SAME 审中-公开
标题翻译：光学检测方法和光学检测装置
公开(公告)号：US20070146718A1
公开(公告)日：2007-06-28
申请号：US11565897
申请日：2006-12-01
申请人： Tomohiro TAKASE , Ikuo Uematsu , Isao Nawata
发明人： Tomohiro TAKASE , Ikuo Uematsu , Isao Nawata
IPC分类号： G01N21/55
CPC分类号： G01N21/7703 , G01N21/553 , G01N21/648
摘要： An inspection method using a portable optical inspection apparatus adapted to be driven by a battery and capable of producing an accurate sensing result without being adversely affected by the environmental temperature conditions is disclosed. The light is radiated on a sensor chip for a predetermined length of time and the amount of a substance contained in a specimen placed on a sensing thin film is measured by an optical signal obtained from the sensing chip, using an optical inspection apparatus comprising the sensor chip including a substrate 5, an optical waveguide layer 6 arranged on the substrate and the sensing thin film 7 attached on the surface of the optical waveguide layer, a light source 8 for radiating the light on the sensor chip and a photodetector 9 for receiving and converting the light output from the sensor chip into an electrical signal The light source is turned on and off a plurality of times for a predetermined length of time during which the inspection light is radiated. The amount of light with the light source on is measured by the photodetector thereby to determine the amount of the substance. In the process, the light amount with the light source off can also be measured so that the amount of the substance is determined from the difference between the light amount with the light source on and off.
摘要翻译：公开了一种使用便携式光学检查装置的检查方法，该便携式光学检查装置适于由电池驱动并且能够产生精确的感测结果而不受环境温度条件的不利影响。将光照射在传感器芯片上预定的时间长度，并且通过使用包括传感器的光学检查装置的感测芯片获得的光学信号来测量放置在感测薄膜上的样本中所含有的物质的量芯片，其包括基板5，布置在基板上的光波导层6和安装在光波导层的表面上的感测薄膜7，用于在传感器芯片上照射光的光源8和用于接收和将来自传感器芯片的光输出转换为电信号。在其中辐射检查光的预定长度的时间内，光源被多次打开和关闭。通过光电检测器测量光源的光量，从而确定物质的量。在该过程中，也可以测量光源关闭的光量，使得物质的量由光源的光量的开启和关闭之间的差确定。

4. 发明申请

US20060194345A1 Concentration measuring method, concentration measuring kit, and sensor chip for use in the method 失效
公开(公告)号：US20060194345A1
公开(公告)日：2006-08-31
申请号：US11363094
申请日：2006-02-28
申请人： Kenichi Uchiyama , Kayoko Oomiya , Isao Kishimoto , Masami Hirata , Hideo Eto , Ichiro Tono , Ikuo Uematsu , Shingo Kasai , Tomohiro Takase , Tsutomu Honjoh , Masanori Sugitani
发明人： Kenichi Uchiyama , Kayoko Oomiya , Isao Kishimoto , Masami Hirata , Hideo Eto , Ichiro Tono , Ikuo Uematsu , Shingo Kasai , Tomohiro Takase , Tsutomu Honjoh , Masanori Sugitani
IPC分类号： G01N33/543 , C12M1/34
CPC分类号： G01N33/54373 , Y10S435/808 , Y10S436/805
摘要： The method for measuring the concentration of the measuring object uses a sensor chip comprising an optical waveguide layer and an antibody immobilized layer formed on the surface of the optical waveguide layer, which comprises immobilizing the measuring object and an enzyme-labeled antibody labeled with a labeling enzyme on the antibody immobilized layer of the sensor chip having an immobilized antibody, producing a color-developing and precipitating enzyme reaction product by allowing to react a coloring reagent with the labeling enzyme on the antibody immobilized layer to precipitate the enzyme reaction product on the antibody immobilized layer, allowing to totally reflect a light impinged on the sensor chip from the outside at an interface between the optical waveguide layer and the antibody immobilized layer, and observing to a physical value of the totally reflected light.

5. 发明授权

US08642319B2 Optical-waveguide sensor chip, method of manufacturing the same, method of measuring substance, substance-measuring kit and optical-waveguide sensor 有权
标题翻译：光波导传感器芯片，其制造方法，测量物质的方法，物质测量套件和光波导传感器
公开(公告)号：US08642319B2
公开(公告)日：2014-02-04
申请号：US13462196
申请日：2012-05-02
申请人： Shingo Kasai , Ikuo Uematsu , Ichiro Tono , Tomohiro Takase , Isao Nawata , Kayoko Oomiya , Yuriko Oyama , Tsutomu Honjoh
发明人： Shingo Kasai , Ikuo Uematsu , Ichiro Tono , Tomohiro Takase , Isao Nawata , Kayoko Oomiya , Yuriko Oyama , Tsutomu Honjoh
IPC分类号： C12M1/34
CPC分类号： G01N21/75 , G01N21/552 , G01N21/7703 , G01N33/54313 , G01N33/54373 , G02B6/12007 , G02B6/124
摘要： An optical-waveguide sensor chip includes an optical waveguide having a first substance immobilized on the surface thereof, the first substance being specifically reactive with an analyte substance, and fine particles dispersed on the optical waveguide and having a second substance immobilized on the surface thereof, the second substance being specifically reactive with the analyte substance.
摘要翻译：光波导传感器芯片包括具有固定在其表面上的第一物质的光波导，第一物质与分析物质特异性反应，以及分散在光波导上并且固定在其表面上的第二物质的细颗粒，第二物质与分析物质特异性反应。

6. 发明授权

US08567127B2 Glass run 有权
标题翻译：玻璃跑
公开(公告)号：US08567127B2
公开(公告)日：2013-10-29
申请号：US11790602
申请日：2007-04-26
申请人： Tomohiro Takase , Norimasa Iwasa , Masanori Aritake , Satoshi Toki
发明人： Tomohiro Takase , Norimasa Iwasa , Masanori Aritake , Satoshi Toki
IPC分类号： E05D15/16
CPC分类号： B60J10/74
摘要： A sub-lip is provided on an interior side wall portion of a main body having a U-shaped cross section in a vertical section of a glass run. The sub-lip extends from the interior side wall portion of the main body while inclined towards an inner side of a glass opening. A projecting length of the sub-lip is set such that a distal end portion of the sub-lip is brought into contact with a back surface of an interior seal lip when a door glass is inserted into an inner space of the main body.
摘要翻译：在玻璃导管的垂直部分具有U形横截面的主体的内侧壁部分上设置有一个子唇缘。子唇缘从主体的内侧壁部分延伸，同时向玻璃开口的内侧倾斜。设置子唇缘的突出长度，使得当门玻璃插入主体的内部空间时，子唇缘的远端部分与内部密封唇的后表面接触。

7. 发明申请

US20120252111A1 MEASURING SYSTEM USING OPTICAL WAVEGUIDE, MEASURING DEVICE, MEASURING METHOD, OPTICAL WAVEGUIDE TYPE SENSOR CHIP, AND MAGNETIC FINE PARTICLE 有权
标题翻译：使用光波导的测量系统，测量装置，测量方法，光波导型传感器芯片和磁性微粒
公开(公告)号：US20120252111A1
公开(公告)日：2012-10-04
申请号：US13436115
申请日：2012-03-30
申请人： Ichiro Tono , Shingo Kasai , Takaaki Wada , Isao Nawata , Masaaki Hirakawa , Tomohiro Takase , Kayoko Oomiya , Takeshi Yamauchi , Tadahiro Nakayama , Isamu Nitta
发明人： Ichiro Tono , Shingo Kasai , Takaaki Wada , Isao Nawata , Masaaki Hirakawa , Tomohiro Takase , Kayoko Oomiya , Takeshi Yamauchi , Tadahiro Nakayama , Isamu Nitta
IPC分类号： C12M1/34 , G01N21/00
CPC分类号： G01N33/54326 , G01N15/0656 , G01N33/5434 , G01N33/54373 , G01N33/585
摘要： According to one embodiment, a measuring system using an optical waveguide is provided. The measuring system has an optical waveguide, magnetic fine particles, a magnetic field applying unit, a light source and a light receiving element. The optical waveguide has a sensing area to which first substances having a property of specifically bonding to subject substances to be measured are fixed. Second substances having a property of specifically bonding to the subject substances are fixed to the magnetic fine particle. The magnetic field applying unit generates a magnetic field for moving the magnetic fine particles. The light source inputs a light into the optical waveguide. The light receiving element receives the light output from the optical waveguide.
摘要翻译：根据一个实施例，提供了使用光波导的测量系统。测量系统具有光波导，磁性微粒，磁场施加单元，光源和光接收元件。光波导具有感测区域，第一物质具有特异性地结合待测物质的特性固定。具有特异性地结合到被摄体物质的特性的第二物质被固定在磁性细颗粒上。磁场施加单元产生用于移动磁性细颗粒的磁场。光源将光输入到光波导中。光接收元件接收从光波导输出的光。

8. 发明申请

US20120213669A1 OPTICAL-WAVEGUIDE SENSOR CHIP, METHOD OF MANUFACTURING THE SAME, METHOD OF MEASURING SUBSTANCE, SUBSTANCE-MEASURING KIT AND OPTICAL-WAVEGUIDE SENSOR 有权
标题翻译：光波导传感器芯片，其制造方法，测量物质的方法，物质测量套件和光波导传感器
公开(公告)号：US20120213669A1
公开(公告)日：2012-08-23
申请号：US13462196
申请日：2012-05-02
申请人： Shingo Kasai , Ikuo Uematsu , Ichiro Tono , Tomohiro Takase , Isao Nawata , Kayoko Oomiya , Yuriko Oyama , Tsutomu Honjoh
发明人： Shingo Kasai , Ikuo Uematsu , Ichiro Tono , Tomohiro Takase , Isao Nawata , Kayoko Oomiya , Yuriko Oyama , Tsutomu Honjoh
IPC分类号： G01N33/53 , B05D5/06
CPC分类号： G01N21/75 , G01N21/552 , G01N21/7703 , G01N33/54313 , G01N33/54373 , G02B6/12007 , G02B6/124
摘要： An optical-waveguide sensor chip includes an optical waveguide having a first substance immobilized on the surface thereof, the first substance being specifically reactive with an analyte substance, and fine particles dispersed on the optical waveguide and having a second substance immobilized on the surface thereof, the second substance being specifically reactive with the analyte substance.
摘要翻译：光波导传感器芯片包括具有固定在其表面上的第一物质的光波导，第一物质与分析物质特异性反应，以及分散在光波导上并且固定在其表面上的第二物质的细颗粒，第二物质与分析物质特异性反应。

9. 发明申请

US20110104009A1 CLINICAL EXAMINATION DISK, DISK PACK, AND CLINICAL EXAMINATION DEVICE 审中-公开
标题翻译：临床检查盘，盘盒和临床检查装置
公开(公告)号：US20110104009A1
公开(公告)日：2011-05-05
申请号：US12986846
申请日：2011-01-07
申请人： Toshimi Kawamura , Seiichirou Ishioka , Masaki Tonari , Takashi Kawamura , Akira Nakajima , Tetsuo Sekino , Kyoichi Iwahashi , Kenichi Uchiyama , Tomohiro Takase , Isao Nawata
发明人： Toshimi Kawamura , Seiichirou Ishioka , Masaki Tonari , Takashi Kawamura , Akira Nakajima , Tetsuo Sekino , Kyoichi Iwahashi , Kenichi Uchiyama , Tomohiro Takase , Isao Nawata
IPC分类号： G01N33/00
CPC分类号： G01N33/491 , B01L3/5027 , B01L2200/16 , B01L2300/0803 , B01L2300/0816 , B01L2300/0887 , B01L2300/1827 , B01L2400/0406 , B01L2400/0409 , B01L2400/0677 , G01N35/00069
摘要： A clinical examination disk according to the invention includes a disk body in a disk form, and at least one cell formed in the disk body, wherein the cell comprises a specimen reservoir formed in the disk body and having a specimen injecting port, a reaction tank formed in the disk body so as to position nearer to the outer circumference of the body than a position of the specimen reservoir, and holding a reagent which is reactive with the specimen and is beforehand gelatinized, a first narrow tube formed in the disk body, and communicating to the specimen reservoir and the reaction tank, and a second narrow tube formed in the disk body, and having one end connected to the reaction tank and the other end made open.
摘要翻译：根据本发明的临床检查盘包括盘形的盘体和形成在盘体中的至少一个单元，其中所述单元包括形成在所述盘体中的样本储存器，并且具有样本注入口，反应罐形成在所述盘体上，以比所述检体容器的位置更靠近所述本体的外周的位置，并且保持与所述检体反应的试剂，并预先糊化，形成在所述盘体上的第一窄管，并且与样品容器和反应槽连通，以及形成在盘体中的第二窄管，其一端连接到反应罐，另一端打开。

10. 发明申请

US20110020852A1 METHOD OF ANALYZING BIOLOGICAL COMPONENT, BIOLOGICAL COMPONENT ANALYZER AND EXTRACTION CARTRIDGE 审中-公开
标题翻译：分析生物成分，生物成分分析仪和提取物盒的方法
公开(公告)号：US20110020852A1
公开(公告)日：2011-01-27
申请号：US12935434
申请日：2009-03-27
申请人： Junko Kojima , Yasunori Maekawa , Tomohiro Takase , Ikuo Uematsu , Masaaki Hirakawa , Isao Nawata , Ichiro Tono , Shingo Kasai
发明人： Junko Kojima , Yasunori Maekawa , Tomohiro Takase , Ikuo Uematsu , Masaaki Hirakawa , Isao Nawata , Ichiro Tono , Shingo Kasai
IPC分类号： C12Q1/54 , C12M1/40
CPC分类号： A61B5/14514 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150091 , A61B5/150229 , A61B5/150251 , A61B5/150343 , A61B5/150358 , A61B5/150748 , A61B5/150984 , A61B5/15113 , A61B5/15186 , A61B5/1519 , A61B5/157 , A61B5/6824 , A61B5/685 , C12Q1/006
摘要： This method of analyzing a biological component includes steps of arranging an extraction medium holding part configured to be capable of holding a prescribed quantity of extraction medium for holding an extract extracted from a subject on the skin of the subject, transferring the extraction medium stored in a liquid storing part storing substantially the same quantity of the extraction medium as the prescribed quantity to the extraction medium holding part, transferring at least part of the extraction medium holding the extracted extract to a reaction part, and analyzing a result of detecting the extract.
摘要翻译：这种分析生物成分的方法包括以下步骤：将提取介质保持部件配置为能够保持规定量的提取介质，用于保持从被检体提取的提取物在被检体的皮肤上，将存储在对象物中的提取介质将与所述规定量大致相同量的所述提取介质的液体储存部分提取到所述提取介质保持部，将保持所述萃取液的所述萃取介质的至少一部分转移到反应部，并且对所述提取物的检测结果进行分析。

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