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1. 发明授权

US10049368B2 Systems, methods and computer program products for providing compliant messaging services 有权
公开(公告)号：US10049368B2
公开(公告)日：2018-08-14
申请号：US12434244
申请日：2009-05-01
申请人： Michael Hansen , Simon Dennison , Sue Meyer , Bipin Patel , Timothy James Davis
发明人： Michael Hansen , Simon Dennison , Sue Meyer , Bipin Patel , Timothy James Davis
IPC分类号： G06Q50/00 , G06Q30/02 , G06Q10/10 , G06Q50/22 , H04L12/58
摘要： Systems, methods and computer program products for providing compliant messaging services are disclosed. Methods according to some embodiments include receiving input data from a campaign sponsor, encrypting at least a portion of the input data, generating a message schedule that includes message content, recipient identification data and temporal data corresponding to a plurality of messages, and sending and/or receiving one of the plurality of messages to and/or from a corresponding recipient.

2. 发明申请

US20130041046A1 SWEET FLAVOR MODIFIER 有权
公开(公告)号：US20130041046A1
公开(公告)日：2013-02-14
申请号：US13572237
申请日：2012-08-10
申请人： Catherine TACHDJIAN , Xiao Qing TANG , Donald S. KARANEWSKY , Guy SERVANT , Xiaodong LI , Feng ZHANG , Qing CHEN , Hong ZHANG , Timothy James DAVIS , Vincent DARMOHUSODO , Melissa Sue WONG , Victor SELCHAU
发明人： Catherine TACHDJIAN , Xiao Qing TANG , Donald S. KARANEWSKY , Guy SERVANT , Xiaodong LI , Feng ZHANG , Qing CHEN , Hong ZHANG , Timothy James DAVIS , Vincent DARMOHUSODO , Melissa Sue WONG , Victor SELCHAU
IPC分类号： A23L1/236 , A61K47/22 , A23L2/60 , C07D401/12 , C07D413/12 , C07D471/08 , C07D215/42 , C07D405/12
CPC分类号： C07D405/12 , A23L2/60 , A23L27/88 , A23V2002/00 , A61K47/22 , C07D215/42 , C07D215/54 , C07D401/12 , C07D451/06
摘要： The present invention includes compounds having structural formula (I), or salts or solvates thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of compositions.

3. 发明申请

US20090066430A1 BATCH-FABRICATED, RF-INTERROGATED, END TRANSITION, CHIP-SCALE ATOMIC CLOCK 有权
标题翻译：批量制造，射频内插，终端转换，芯片尺寸原子钟
公开(公告)号：US20090066430A1
公开(公告)日：2009-03-12
申请号：US12273852
申请日：2008-11-19
申请人： Alan Michael Braun , Joseph Hy Abeles , Winston Kong Chan , Martin Kwakernaak , Timothy James Davis
发明人： Alan Michael Braun , Joseph Hy Abeles , Winston Kong Chan , Martin Kwakernaak , Timothy James Davis
IPC分类号： H03B17/00 , H03L7/26
CPC分类号： G04F5/14 , H01S5/141
摘要： A chip scale atomic clock is disclosed that provides a low power atomic time/frequency reference that employs direct RF-interrogation on an end-state transition. The atomic time/frequency reference includes an alkali vapor cell containing alkali atoms, preferably cesium atoms, flex circuits for physically supporting, heating, and thermally isolating the alkali vapor cell, a laser source for pumping alkali atoms within the alkali vapor cell into an end resonance state by applying an optical signal along a first axis, a photodetector for detecting a second optical signal emanating from the alkali vapor cell along the first axis, a pair of RF excitation coils for applying an RF-interrogation signal to the alkali atoms along a second axis perpendicular to the first axis, a pair of bias coils for applying a uniform DC magnetic field along the first axis, and a pair of Zeeman coils for applying a Zeeman interrogation signal to the alkali atoms and oriented and configured to apply a time-varying magnetic field along the second axis through the alkali vapor cell. Another flex circuit is used for physically supporting the laser source, for heating the laser source, and for providing thermal isolation of the laser source. The laser source can be a vertical cavity surface emitting laser (VSCEL). The bias coils can be Helmholtz coils.
摘要翻译：公开了一种芯片级原子钟，其提供在终端状态转换时采用直接RF询问的低功率原子时间/频率参考。原子时间/频率参考值包括含有碱金属，优选铯原子的碱性蒸汽池，用于物理支撑，加热和热分离碱性蒸汽池的柔性电路，用于将碱性蒸气室内的碱性原子泵送到末端的激光源通过沿着第一轴施加光信号的共振状态，用于检测沿着第一轴从碱蒸气单元发出的第二光信号的光检测器，一对RF激励线圈，用于沿着第一轴向碱金属原子施加RF询问信号与第一轴垂直的第二轴，用于沿着第一轴施加均匀的DC磁场的一对偏置线圈，以及一对塞曼线圈，用于向碱原子施加塞曼询问信号，并且被定向和配置为施加时间 - 沿着第二轴的变化的磁场通过碱性蒸汽池。另一个柔性电路用于物理支撑激光源，用于加热激光源，并提供激光源的热隔离。激光源可以是垂直腔表面发射激光器（VSCEL）。偏置线圈可以是亥姆霍兹线圈。

4. 发明授权

US07468637B2 Batch-fabricated, RF-interrogated, end transition, chip-scale atomic clock 失效
标题翻译：批量制造，RF询问，终端转换，芯片级原子钟
公开(公告)号：US07468637B2
公开(公告)日：2008-12-23
申请号：US11736657
申请日：2007-04-18
申请人： Alan Michael Braun , Joseph Hy Abeles , Winston Kong Chan , Martin Kwakernaak , Timothy James Davis
发明人： Alan Michael Braun , Joseph Hy Abeles , Winston Kong Chan , Martin Kwakernaak , Timothy James Davis
IPC分类号： H01S1/06 , H03L7/26
CPC分类号： G04F5/14 , H01S5/141
摘要： A chip scale atomic clock is disclosed that provides a low power atomic time/frequency reference that employs direct RF-interrogation on an end-state transition. The atomic time/frequency reference includes an alkali vapor cell containing alkali atoms, preferably cesium atoms, flex circuits for physically supporting, heating, and thermally isolating the alkali vapor cell, a laser source for pumping alkali atoms within the alkali vapor cell into an end resonance state by applying an optical signal along a first axis, a photodetector for detecting a second optical signal emanating from the alkali vapor cell along the first axis, a pair of RF excitation coils for applying an RF-interrogation signal to the alkali atoms along a second axis perpendicular to the first axis, a pair of bias coils for applying a uniform DC magnetic field along the first axis, and a pair of Zeeman coils for applying a Zeeman interrogation signal to the alkali atoms and oriented and configured to apply a time-varying magnetic field along the second axis through the alkali vapor cell. Another flex circuit is used for physically supporting the laser source, for heating the laser source, and for providing thermal isolation of the laser source. The laser source can be a vertical cavity surface emitting laser (VSCEL). The bias coils can be Helmholtz coils.
摘要翻译：公开了一种芯片级原子钟，其提供在终端状态转换时采用直接RF询问的低功率原子时间/频率参考。原子时间/频率参考值包括含有碱金属，优选铯原子的碱性蒸汽池，用于物理支撑，加热和热分离碱性蒸汽池的柔性电路，用于将碱性蒸气室内的碱性原子泵送到末端的激光源通过沿着第一轴施加光信号的共振状态，用于检测沿着第一轴从碱蒸气单元发出的第二光信号的光检测器，一对RF激励线圈，用于沿着第一轴向碱金属原子施加RF询问信号与第一轴垂直的第二轴，用于沿着第一轴施加均匀的DC磁场的一对偏置线圈，以及一对塞曼线圈，用于向碱原子施加塞曼询问信号，并且被定向和配置为施加时间 - 沿着第二轴的变化的磁场通过碱性蒸汽池。另一个柔性电路用于物理支撑激光源，用于加热激光源，并提供激光源的热隔离。激光源可以是垂直腔表面发射激光器（VSCEL）。偏置线圈可以是亥姆霍兹线圈。

5. 发明授权

US07361760B2 Substituted naphthyridine derivatives as inhibitors of macrophage migration inhibitory factor and their use in the treatment of human diseases 失效
标题翻译：取代萘啶衍生物作为巨噬细胞迁移抑制因子的抑制剂及其在治疗人类疾病中的应用
公开(公告)号：US07361760B2
公开(公告)日：2008-04-22
申请号：US11687601
申请日：2007-03-16
申请人： Jagadish Sircar , Sunil Kumar K. C. , Wenbin Ying , Timothy James Davis
发明人： Jagadish Sircar , Sunil Kumar K. C. , Wenbin Ying , Timothy James Davis
IPC分类号： C07D471/04 , A61K31/496
CPC分类号： C07D471/04
摘要： Inhibitors of MIF having a naphthyridine backbone are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R, R1, R2, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.
摘要翻译：提供了具有萘啶主链的MIF抑制剂，其可用于治疗各种疾病，包括治疗与MIF活性相关的病理状况。 MIF的抑制剂具有以下结构：包括其立体异构体，前药和药学上可接受的盐，其中n，R 1，R 1，R 2，X，Y和Z是如本文所定义。还提供了含有与药学上可接受的载体组合的MIF抑制剂的组合物，以及使用该组合物的方法。

6. 发明申请

US20090281829A1 Systems, Methods and Computer Program Products for Providing Compliant Messaging Services 有权
标题翻译：用于提供符合消息传递服务的系统，方法和计算机程序产品
公开(公告)号：US20090281829A1
公开(公告)日：2009-11-12
申请号：US12434244
申请日：2009-05-01
申请人： Michael Hansen , Simon Dennison , Sue Meyer , Bipin Patel , Timothy James Davis
发明人： Michael Hansen , Simon Dennison , Sue Meyer , Bipin Patel , Timothy James Davis
IPC分类号： G06Q50/00
CPC分类号： G06Q30/02 , G06Q10/107 , G06Q50/22 , H04L51/00
摘要： Systems, methods and computer program products for providing compliant messaging services are disclosed. Methods according to some embodiments include receiving input data from a campaign sponsor, encrypting at least a portion of the input data, generating a message schedule that includes message content, recipient identification data and temporal data corresponding to a plurality of messages, and sending and/or receiving one of the plurality of messages to and/or from a corresponding recipient.
摘要翻译：公开了用于提供符合消息服务的系统，方法和计算机程序产品。根据一些实施例的方法包括从运动赞助者接收输入数据，加密输入数据的至少一部分，生成包括消息内容，接收者标识数据和对应于多个消息的时间数据的消息调度，以及发送和/ 或者从相应的接收者接收和/或从相应的接收者接收多个消息中的一个消息。

7. 发明授权

US07365200B2 Thienopyridinone derivatives as macrophage migration inhibitory factor inhibitors 失效
标题翻译：噻吩并吡啶酮衍生物作为巨噬细胞迁移抑制因子抑制剂
公开(公告)号：US07365200B2
公开(公告)日：2008-04-29
申请号：US11687598
申请日：2007-03-16
申请人： Jagadish Sircar , Sunil Kumar K. C. , Timothy James Davis , Wenbin Ying
发明人： Jagadish Sircar , Sunil Kumar K. C. , Timothy James Davis , Wenbin Ying
IPC分类号： C07D495/04 , A61K31/496
CPC分类号： C07D495/04 , C07D498/02
摘要： Inhibitors of macrophage migration inhibitory factor having a thienopyridinone backbone are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with macrophage migration inhibitory factor activity. The inhibitors of macrophage migration inhibitory factor have the following structures: including forms such as stereoisomers, free forms, pharmaceutically acceptable salts or esters thereof, solvates, or combinations of such forms, wherein n, R1, R2, R3, X, and Y are as defined herein. Compositions comprising an inhibitor of macrophage migration inhibitory factor in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.
摘要翻译：提供具有噻吩并吡啶酮骨架的巨噬细胞迁移抑制因子的抑制剂，其可用于治疗各种疾病，包括治疗与巨噬细胞迁移抑制因子活性相关的病理状况。巨噬细胞迁移抑制因子的抑制剂具有以下结构：包括形式如立体异构体，游离形式，药学上可接受的盐或酯，溶剂合物或这些形式的组合，其中n，R 1，R R 3，R 3，X和Y如本文所定义。还提供了包含与药学上可接受的载体组合的巨噬细胞迁移抑制因子抑制剂的组合物，以及其用途的方法。

8. 发明授权

US07852163B2 Batch-fabricated, RF-interrogated, end transition, chip-scale atomic clock 有权
标题翻译：批量制造，RF询问，终端转换，芯片级原子钟
公开(公告)号：US07852163B2
公开(公告)日：2010-12-14
申请号：US12273852
申请日：2008-11-19
申请人： Alan Michael Braun , Joseph Hy Abeles , Winston Kong Chan , Martin Kwakernaak , Timothy James Davis
发明人： Alan Michael Braun , Joseph Hy Abeles , Winston Kong Chan , Martin Kwakernaak , Timothy James Davis
IPC分类号： H01S1/06 , H03L7/26
CPC分类号： G04F5/14 , H01S5/141
摘要： A chip scale atomic clock is disclosed that provides a low power atomic time/frequency reference that employs direct RF-interrogation on an end-state transition. The atomic time/frequency reference includes an alkali vapor cell containing alkali atoms, preferably cesium atoms, flex circuits for physically supporting, heating, and thermally isolating the alkali vapor cell, a laser source for pumping alkali atoms within the alkali vapor cell into an end resonance state by applying an optical signal along a first axis, a photodetector for detecting a second optical signal emanating from the alkali vapor cell along the first axis, a pair of RF excitation coils for applying an RF-interrogation signal to the alkali atoms along a second axis perpendicular to the first axis, a pair of bias coils for applying a uniform DC magnetic field along the first axis, and a pair of Zeeman coils for applying a Zeeman interrogation signal to the alkali atoms and oriented and configured to apply a time-varying magnetic field along the second axis through the alkali vapor cell. Another flex circuit is used for physically supporting the laser source, for heating the laser source, and for providing thermal isolation of the laser source. The laser source can be a vertical cavity surface emitting laser (VSCEL). The bias coils can be Helmholtz coils.
摘要翻译：公开了一种芯片级原子钟，其提供在终端状态转换时采用直接RF询问的低功率原子时间/频率参考。原子时间/频率参考值包括含有碱金属，优选铯原子的碱性蒸汽池，用于物理支撑，加热和热分离碱性蒸汽池的柔性电路，用于将碱性蒸气室内的碱性原子泵送到末端的激光源通过沿着第一轴施加光信号的共振状态，用于检测沿着第一轴从碱蒸气单元发出的第二光信号的光检测器，一对RF激励线圈，用于沿着第一轴向碱金属原子施加RF询问信号与第一轴垂直的第二轴，用于沿着第一轴施加均匀的DC磁场的一对偏置线圈，以及一对塞曼线圈，用于向碱原子施加塞曼询问信号，并且被定向和配置为施加时间 - 沿着第二轴的变化的磁场通过碱性蒸汽池。另一个柔性电路用于物理支撑激光源，用于加热激光源，并提供激光源的热隔离。激光源可以是垂直腔表面发射激光器（VSCEL）。偏置线圈可以是亥姆霍兹线圈。

9. 发明授权

US08815956B2 Sweet flavor modifier 有权
标题翻译：甜味调味剂
公开(公告)号：US08815956B2
公开(公告)日：2014-08-26
申请号：US13572237
申请日：2012-08-10
申请人： Catherine Tachdjian , Xiao-Qing Tang , Donald S. Karanewsky , Guy Servant , Xiaodong Li , Feng Zhang , Qing Chen , Hong Zhang , Timothy James Davis , Vincent Darmohusodo , Melissa Sue Wong , Victor Selchau
发明人： Catherine Tachdjian , Xiao-Qing Tang , Donald S. Karanewsky , Guy Servant , Xiaodong Li , Feng Zhang , Qing Chen , Hong Zhang , Timothy James Davis , Vincent Darmohusodo , Melissa Sue Wong , Victor Selchau
IPC分类号： A23L1/236
CPC分类号： C07D405/12 , A23L2/60 , A23L27/88 , A23V2002/00 , A61K47/22 , C07D215/42 , C07D215/54 , C07D401/12 , C07D451/06
摘要： The present invention includes compounds having structural formula (I), or salts or solvates thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of compositions.
摘要翻译：本发明包括具有结构式（I）的化合物或其盐或溶剂化物。这些化合物可用作甜味调味剂。本发明还包括包含本发明化合物的组合物和增强组合物甜味的方法。

10. 发明申请

US20080139551A1 TUMOR NECROSIS FACTOR ALPHA INHIBITORS AND THEIR USE IN THE TREATMENT OF HUMAN DISEASES 审中-公开
标题翻译：肿瘤坏死因子ALPHA抑制剂及其在治疗人类疾病中的应用
公开(公告)号：US20080139551A1
公开(公告)日：2008-06-12
申请号：US11842144
申请日：2007-08-21
申请人： Jagadish Sircar , Sunil Kumar , Timothy James Davis , Wenbin Ying , Peter Nussbaumer , Andreas Billich
发明人： Jagadish Sircar , Sunil Kumar , Timothy James Davis , Wenbin Ying , Peter Nussbaumer , Andreas Billich
IPC分类号： A61K31/5377 , A61K31/497 , A61P11/06 , A61P5/46 , A61P19/02
CPC分类号： C07D215/46 , C07D401/06 , C07D409/12 , C07D487/08 , C07D491/04 , C07D495/04
摘要： treatment of a variety of disorders, including the treatment of pathological conditions associated with tumor necrosis factor alpha. The inhibitors of tumor necrosis factor alpha have the following structures: including stereoisomers, pharmaceutically acceptable salts, and solvates thereof, wherein substituents are as defined herein. Compositions containing an inhibitor of tumor necrosis factor alpha in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.
摘要翻译：治疗各种疾病，包括治疗与肿瘤坏死因子α相关的病理状况。肿瘤坏死因子α的抑制剂具有以下结构：包括立体异构体，其药学上可接受的盐和溶剂合物，其中取代基如本文所定义。还提供了含有肿瘤坏死因子α与药学上可接受的载体组合的抑制剂的组合物，以及使用它们的方法。

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