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1. 发明授权

US08076124B2 Method and apparatus for sustaining viability of biological cells on a substrate 有权
标题翻译：维持生物细胞在基质上的生存力的方法和装置
公开(公告)号：US08076124B2
公开(公告)日：2011-12-13
申请号：US11624040
申请日：2007-01-17
申请人： Timothy E. McKnight , Anatoli V. Melechko , Michael L. Simpson
发明人： Timothy E. McKnight , Anatoli V. Melechko , Michael L. Simpson
IPC分类号： C12M3/00
CPC分类号： B01L3/02 , Y10S977/876
摘要： A method for the transient transformation of a living biological cell having an intact cell membrane defining an intracellular domain, and an apparatus for the transient transformation of biological cells. The method and apparatus include introducing a compartmentalized extracellular component fixedly attached to a cellular penetrant structure to the intracellular domain of the cell, wherein the cell is fixed in a predetermined location and wherein the component is expressed within in the cell while being retained within the compartment and wherein the compartment restricts the mobility and interactions of the component within the cell and prevents transference of the component to the cell.
摘要翻译：用于瞬时转化具有限定细胞内结构域的完整细胞膜的活的生物细胞的方法和用于瞬时转化生物细胞的装置。所述方法和装置包括将固定连接到细胞渗透结构的分隔的细胞外组分引入细胞的细胞内结构域，其中细胞被固定在预定位置，并且其中所述成分在细胞内表达，同时被保留在隔室内并且其中所述隔室限制所述部件在所述电池内的移动性和相互作用并且防止所述部件移动到所述电池。

2. 发明授权

US08003220B2 Nanotransfer and nanoreplication using deterministically grown sacrificial nanotemplates 有权
标题翻译：使用确定性生长的牺牲纳米模板进行纳米转移和纳米应用
公开(公告)号：US08003220B2
公开(公告)日：2011-08-23
申请号：US11985395
申请日：2007-11-13
申请人： Anatoli V. Melechko , Timothy E. McKnight , Michael A. Guillorn , Bojan Ilic , Vladimir I. Merkulov , Mitchel J. Doktycz , Douglas H. Lowndes , Michael L. Simpson
发明人： Anatoli V. Melechko , Timothy E. McKnight , Michael A. Guillorn , Bojan Ilic , Vladimir I. Merkulov , Mitchel J. Doktycz , Douglas H. Lowndes , Michael L. Simpson
IPC分类号： B32B9/00
CPC分类号： B01D67/0062 , B01D67/0069 , B01D67/0072 , B01D71/02 , B01D71/027 , B01D2323/24 , B01D2325/08 , B01J23/755 , B01J35/0013 , B01J35/006 , B01J37/0238 , B01J37/342 , B01L3/5027 , B01L2300/0663 , B01L2300/0896 , B81B2201/058 , B81B2203/0361 , B81C1/00119 , B82Y30/00 , Y10S977/70 , Y10S977/781 , Y10S977/784 , Y10T428/13 , Y10T428/1303 , Y10T428/1352 , Y10T428/1359 , Y10T428/139 , Y10T428/24174 , Y10T428/24273 , Y10T428/24322 , Y10T428/2902 , Y10T428/2991 , Y10T428/31504 , Y10T428/31678
摘要： Methods, manufactures, machines and compositions are described for nanotransfer and nanoreplication using deterministically grown sacrificial nanotemplates. An apparatus, includes a substrate and a nanoreplicant structure coupled to a surface of the substrate.
摘要翻译：使用确定性生长的牺牲纳米模板描述了用于纳米转移和纳米应用的方法，制造商，机器和组合物。一种装置，包括与衬底的表面耦合的衬底和纳米复合结构。

3. 发明授权

US07621878B2 Implant for in-vivo parameter monitoring, processing and transmitting 失效
标题翻译：植入物用于体内参数监测，处理和传输
公开(公告)号：US07621878B2
公开(公告)日：2009-11-24
申请号：US10374928
申请日：2003-02-24
申请人： Milton N. Ericson , Timothy E. McKnight , Stephen F. Smith , James O. Hylton
发明人： Milton N. Ericson , Timothy E. McKnight , Stephen F. Smith , James O. Hylton
IPC分类号： A61B5/00 , A61B5/103 , A61B5/117
CPC分类号： A61B5/0031 , A61B5/031 , A61B2562/028 , A61M27/006 , Y10S128/903
摘要： The present invention relates to a completely implantable intracranial pressure monitor, which can couple to existing fluid shunting systems as well as other internal monitoring probes. The implant sensor produces an analog data signal which is then converted electronically to a digital pulse by generation of a spreading code signal and then transmitted to a location outside the patient by a radio-frequency transmitter to an external receiver. The implanted device can receive power from an internal source as well as an inductive external source. Remote control of the implant is also provided by a control receiver which passes commands from an external source to the implant system logic. Alarm parameters can be programmed into the device which are capable of producing an audible or visual alarm signal. The utility of the monitor can be greatly expanded by using multiple pressure sensors simultaneously or by combining sensors of various physiological types.
摘要翻译：本发明涉及一种完全可植入的颅内压监测器，其可以耦合到现有的流体分流系统以及其它内部监测探针。植入物传感器产生模拟数据信号，然后通过产生扩展码信号将其电子地转换为数字脉冲，然后通过射频发射器发送到患者外部位置到外部接收器。植入的设备可以从内部源以及感应外部源接收电力。植入物的远程控制也由控制接收器提供，控制接收器将命令从外部源传递到植入物系统逻辑。可以将报警参数编程到能够产生声音或视觉报警信号的设备中。可以通过同时使用多个压力传感器或通过组合各种生理类型的传感器来大大扩展显示器的效用。

4. 发明申请

US20090087899A1 Method and structure for extracting molecular species 有权
标题翻译：提取分子种类的方法和结构
公开(公告)号：US20090087899A1
公开(公告)日：2009-04-02
申请号：US11904862
申请日：2007-09-28
申请人： Timothy E. McKnight , Anatoli V. Melechko , Michael L. Simpson
发明人： Timothy E. McKnight , Anatoli V. Melechko , Michael L. Simpson
IPC分类号： C07G17/00 , C12M1/00
CPC分类号： C07K1/22
摘要： The present invention in one embodiment provides a method for extracting molecular material including providing a probe comprising a penetration portion having a nanoscale surface for penetrating a biological compartment, a receptor present on the penetrating portion of the probe, wherein the receptor has an affinity for a target molecular material from the biological compartment; inserting the probe into the biological compartment, the receptor present on the penetrating portion of the probe engages the target molecular material; and extracting the probe and the target molecular material engaged to the inserting portion of the probe from the biological compartment.
摘要翻译：本发明在一个实施方案中提供了一种提取分子材料的方法，包括提供包含穿透部分的探针，所述探针具有用于穿透生物室的纳米级表面，存在于探针的穿透部分上的受体，其中所述受体对来自生物室的靶分子物质; 将探针插入生物室中，存在于探针的穿透部分上的受体与目标分子材料接合; 以及从所述生物室提取与所述探针的插入部分接合的所述探针和所述靶分子材料。

5. 发明授权

US08101388B2 Method and structure for extracting molecular species 有权
标题翻译：提取分子种类的方法和结构
公开(公告)号：US08101388B2
公开(公告)日：2012-01-24
申请号：US11904862
申请日：2007-09-28
申请人： Timothy E. McKnight , Anatoli V. Melechko , Michael L. Simpson
发明人： Timothy E. McKnight , Anatoli V. Melechko , Michael L. Simpson
IPC分类号： C12N13/00 , C12P1/00 , C12P21/00 , C12M1/00
CPC分类号： C07K1/22
摘要： The present invention in one embodiment provides a method for extracting molecular material including providing a probe comprising a penetration portion having a nanoscale surface for penetrating a biological compartment, a receptor present on the penetrating portion of the probe, wherein the receptor has an affinity for a target molecular material from the biological compartment; inserting the probe into the biological compartment, the receptor present on the penetrating portion of the probe engages the target molecular material; and extracting the probe and the target molecular material engaged to the inserting portion of the probe from the biological compartment.
摘要翻译：本发明在一个实施方案中提供了一种提取分子材料的方法，包括提供包含穿透部分的探针，所述探针具有用于穿透生物室的纳米级表面，存在于探针的穿透部分上的受体，其中所述受体对来自生物室的靶分子物质; 将探针插入生物室中，存在于探针的穿透部分上的受体与目标分子材料接合; 以及从所述生物室提取与所述探针的插入部分接合的所述探针和所述靶分子材料。

6. 发明授权

US07943196B2 Nanotransfer and nanoreplication using deterministically grown sacrificial nanotemplates 有权
标题翻译：使用确定性生长的牺牲纳米模板进行纳米转移和纳米应用
公开(公告)号：US07943196B2
公开(公告)日：2011-05-17
申请号：US11273316
申请日：2005-11-14
申请人： Anatoli V. Melechko , Timothy E. McKnight , Michael A. Guillorn , Bojan Ilic , Vladimir I. Merkulov , Mitchel J. Doktycz , Douglas H. Lowndes , Michael L. Simpson
发明人： Anatoli V. Melechko , Timothy E. McKnight , Michael A. Guillorn , Bojan Ilic , Vladimir I. Merkulov , Mitchel J. Doktycz , Douglas H. Lowndes , Michael L. Simpson
IPC分类号： B05D3/00 , B05D1/32 , B05D5/12 , C23C16/00 , D02G3/00 , B32B5/12
CPC分类号： B01D67/0062 , B01D67/0069 , B01D67/0072 , B01D71/02 , B01D71/027 , B01D2323/24 , B01D2325/08 , B01J23/755 , B01J35/0013 , B01J35/006 , B01J37/0238 , B01J37/342 , B01L3/5027 , B01L2300/0663 , B01L2300/0896 , B81B2201/058 , B81B2203/0361 , B81C1/00119 , B82Y30/00 , Y10S977/70 , Y10S977/781 , Y10S977/784 , Y10T428/13 , Y10T428/1303 , Y10T428/1352 , Y10T428/1359 , Y10T428/139 , Y10T428/24174 , Y10T428/24273 , Y10T428/24322 , Y10T428/2902 , Y10T428/2991 , Y10T428/31504 , Y10T428/31678
摘要： Methods, manufactures, machines and compositions are described for nanotransfer and nanoreplication using deterministically grown sacrificial nanotemplates. A method includes depositing a catalyst particle on a surface of a substrate to define a deterministically located position; growing an aligned elongated nanostructure on the substrate, an end of the aligned elongated nanostructure coupled to the substrate at the deterministically located position; coating the aligned elongated nanostructure with a conduit material; removing a portion of the conduit material to expose the catalyst particle; removing the catalyst particle; and removing the elongated nanostructure to define a nanoconduit.
摘要翻译：使用确定性生长的牺牲纳米模板描述了用于纳米转移和纳米应用的方法，制造商，机器和组合物。一种方法包括在衬底的表面上沉积催化剂颗粒以限定确定性定位的位置; 在衬底上生长对准的细长纳米结构，在确定位置的位置处将对准的细长纳米结构的端部耦合到衬底; 用导管材料涂覆对准的细长纳米结构; 去除所述导管材料的一部分以暴露所述催化剂颗粒; 除去催化剂颗粒; 并移除细长的纳米结构以限定纳米管。

7. 发明授权

US07641863B2 Nanoengineered membranes for controlled transport 有权
标题翻译：用于受控运输的纳米工程膜
公开(公告)号：US07641863B2
公开(公告)日：2010-01-05
申请号：US10383309
申请日：2003-03-06
申请人： Mitchel J. Doktycz , Michael L. Simpson , Timothy E. McKnight , Anatoli V. Melechko , Douglas H. Lowndes , Michael A. Guillorn , Vladimir I. Merkulov
发明人： Mitchel J. Doktycz , Michael L. Simpson , Timothy E. McKnight , Anatoli V. Melechko , Douglas H. Lowndes , Michael A. Guillorn , Vladimir I. Merkulov
IPC分类号： B01D63/00
CPC分类号： B01D67/0072 , B01D67/0088 , B01D67/0093 , B01D69/02 , B01D69/141 , B01D71/021 , B01D2323/30 , B01D2325/10 , B01J23/755 , B01J35/0013 , B01J37/34 , B82Y30/00 , Y10S977/701 , Y10S977/704 , Y10S977/705 , Y10S977/706 , Y10S977/745 , Y10S977/746 , Y10S977/747 , Y10S977/789 , Y10S977/906 , Y10S977/92 , Y10S977/962
摘要： A nanoengineered membrane for controlling material transport (e.g., molecular transport) is disclosed. The membrane includes a substrate, a cover defining a material transport channel between the substrate and the cover, and a plurality of fibers positioned in the channel and connected to and extending away from a surface of the substrate. The fibers are aligned perpendicular to the surface of the substrate, and have a width of 100 nanometers or less. The diffusion limits for material transport are controlled by the separation of the fibers. In one embodiment, chemical derivatization of carbon fibers may be undertaken to further affect the diffusion limits or affect selective permeability or facilitated transport. For example, a coating can be applied to at least a portion of the fibers. In another embodiment, individually addressable carbon nanofibers can be integrated with the membrane to provide an electrical driving force for material transport.
摘要翻译：公开了一种用于控制材料输送的纳米工程膜（例如分子传输）。膜包括衬底，限定衬底和盖之间的材料传输通道的盖，以及定位在通道中并连接到衬底表面并远离衬底的表面的多个光纤。纤维垂直于衬底的表面排列，并且具有100纳米或更小的宽度。材料输送的扩散限制是通过纤维的分离来控制的。在一个实施方案中，可以进行碳纤维的化学衍生化以进一步影响扩散极限或影响选择性渗透性或促进转运。例如，可以对至少一部分纤维施加涂层。在另一个实施方案中，单独可寻址的碳纳米纤维可以与膜结合以提供材料输送的电驱动力。

8. 发明授权

US06533733B1 Implantable device for in-vivo intracranial and cerebrospinal fluid pressure monitoring 失效
标题翻译：用于体内颅内和脑脊液压监测的植入式装置
公开(公告)号：US06533733B1
公开(公告)日：2003-03-18
申请号：US09406280
申请日：1999-09-24
申请人： Milton N. Ericson , Timothy E. McKnight , Stephen F. Smith , James O. Hylton
发明人： Milton N. Ericson , Timothy E. McKnight , Stephen F. Smith , James O. Hylton
IPC分类号： A61B500
CPC分类号： A61B5/0031 , A61B5/031 , A61B2562/028 , A61M27/006 , Y10S128/903
摘要： The present invention relates to a completely implantable intracranial pressure monitor, which can couple to existing fluid shunting systems as well as other internal monitoring probes. The implant sensor produces an analog data signal which is then converted electronically to a digital pulse by generation of a spreading code signal and then transmitted to a location outside the patient by a radio-frequency transmitter to an external receiver. The implanted device can receive power from an internal source as well as an inductive external source. Remote control of the implant is also provided by a control receiver which passes commands from an external source to the implant system logic. Alarm parameters can be programmed into the device which are capable of producing an audible or visual alarm signal. The utility of the monitor can be greatly expanded by using multiple pressure sensors simultaneously or by combining sensors of various physiological types.
摘要翻译：本发明涉及一种完全可植入的颅内压监测器，其可以耦合到现有的流体分流系统以及其它内部监测探针。植入物传感器产生模拟数据信号，然后通过产生扩展码信号将其电子地转换为数字脉冲，然后通过射频发射器发送到患者外部位置到外部接收器。植入的设备可以从内部源以及感应外部源接收电力。植入物的远程控制也由控制接收器提供，控制接收器将命令从外部源传递到植入物系统逻辑。可以将报警参数编程到能够产生声音或视觉报警信号的设备中。可以通过同时使用多个压力传感器或通过组合各种生理类型的传感器来大大扩展显示器的效用。

9. 发明授权

US08993327B2 Parallel macromolecular delivery and biochemical/electrochemical interface to cells employing nanostructures 有权
标题翻译：使用纳米结构的平行大分子递送和生物化学/电化学界面
公开(公告)号：US08993327B2
公开(公告)日：2015-03-31
申请号：US10408294
申请日：2003-04-07
申请人： Timothy E. McKnight , Anatoli V. Melechko , Guy D. Griffin , Michael A. Guillorn , Vladimir L. Merkulov , Michael L. Simpson
发明人： Timothy E. McKnight , Anatoli V. Melechko , Guy D. Griffin , Michael A. Guillorn , Vladimir L. Merkulov , Michael L. Simpson
IPC分类号： C12N15/00 , C12N15/88 , C12N15/87 , C12N15/82 , C12N15/74 , A61K48/00 , C12N11/00 , B82Y5/00 , C12N11/06
CPC分类号： B82Y5/00 , C12N11/00 , C12N11/06 , Y10S977/732 , Y10S977/734 , Y10S977/742 , Y10S977/746
摘要： Systems and methods are described for parallel macromolecular delivery and biochemical/electrochemical interface to whole cells employing carbon nanostructures including nanofibers and nanotubes. A method includes providing a first material on at least a first portion of a first surface of a first tip of a first elongated carbon nanostructure; providing a second material on at least a second portion of a second surface of a second tip of a second elongated carbon nanostructure, the second elongated carbon nanostructure coupled to, and substantially parallel to, the first elongated carbon nanostructure; and penetrating a boundary of a biological sample with at least one member selected from the group consisting of the first tip and the second tip.
摘要翻译：描述了用于使用包括纳米纤维和纳米管的碳纳米结构的全细胞的平行大分子递送和生物化学/电化学界面的系统和方法。一种方法包括在第一细长碳纳米结构的第一尖端的第一表面的至少第一部分上提供第一材料; 在第二细长碳纳米结构的第二尖端的第二表面的至少第二部分上提供第二材料，所述第二细长碳纳米结构耦合并且基本上平行于所述第一细长碳纳米结构; 并用至少一个选自第一末端和第二末端的构件穿透生物样品的边界。

10. 发明授权

US08657883B2 Remote actuated valve implant 有权
标题翻译：远程致动阀门植入
公开(公告)号：US08657883B2
公开(公告)日：2014-02-25
申请号：US12729671
申请日：2010-03-23
申请人： Timothy E. McKnight , Anthony Johnson , Kenneth J. Moise, Jr. , Milton Nance Ericson , Justin S. Baba , John B. Wilgen , Boyd McCutchen Evans, III
发明人： Timothy E. McKnight , Anthony Johnson , Kenneth J. Moise, Jr. , Milton Nance Ericson , Justin S. Baba , John B. Wilgen , Boyd McCutchen Evans, III
IPC分类号： A61F2/04 , A61F2/48 , A61M5/00
CPC分类号： A61F2/04 , A61B17/1204 , A61B17/12104 , A61B17/12136 , A61B17/42 , A61B2017/00411 , A61B2017/00876 , A61B2017/1205 , A61M5/16813 , A61M5/172 , A61M27/006 , A61M2205/0283 , A61M2205/04 , A61M2205/3334 , A61M2205/3523 , A61M2205/3569 , A61M2205/3653 , A61M2205/8243 , A61M2210/1032 , A61M2210/1075 , A61M2210/1089 , A61M2210/145
摘要： Valve implant systems positionable within a flow passage, the systems having an inlet, an outlet, and a remotely activatable valve between the inlet and outlet, with the valves being operable to provide intermittent occlusion of the flow path. A remote field is applied to provide thermal or magnetic activation of the valves.
摘要翻译：阀门植入系统可定位在流动通道内，该系统在入口和出口之间具有入口，出口和可远程激活的阀，其中阀可操作以提供流路的间歇闭塞。应用远程场来提供阀门的热或磁性激活。

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