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1. 发明专利

JP2003290165A Non-invasive apparatus system for monitoring autonomic nervous system and use thereof 审中-公开
标题翻译：用于监测自动神经系统的非入侵装置系统及其使用
公开(公告)号：JP2003290165A
公开(公告)日：2003-10-14
申请号：JP2002348375
申请日：2002-11-29
申请人： Ind Technol Res Inst , Terry B J Kuo , インダストリアル・テクノロジー・リサーチ・インスティテュート , クオ・テリー・ビー・ジェイ
发明人： SUN DEHCHUAN , KUO TERRY B J
IPC分类号： A61B5/00 , A61B5/022 , A61B5/0245 , A61B5/04 , A61B5/0452
CPC分类号： A61B5/0452 , A61B5/022 , A61B5/02405 , A61B5/4035 , A61B5/7257 , G06F19/3456 , G16H10/60 , G16H15/00 , G16H40/63
摘要： PROBLEM TO BE SOLVED: To provide a non-invasive system which monitors side effects caused by medicines to the autonomic nervous system to prevent acute and chronic side effects to the cranial nerves. SOLUTION: The side effects on functional changes in the autonomic nervous system are monitored by measuring arterial pulse curve and electrocardiogram and obtaining the parameters of heart beat variability by a spectral analysis. COPYRIGHT: (C)2004,JPO
摘要翻译：要解决的问题：提供一种非侵入性系统，其监测由药物引起的对自主神经系统的副作用，以预防对颅神经的急性和慢性副作用。
解决方案：通过测量动脉脉搏曲线和心电图并通过光谱分析获得心跳变化参数，监测自主神经系统功能变化的副作用。版权所有（C）2004，JPO

2. 发明专利

TW200642660A 心跳訊號分析方法及其裝置 AUTO DIAGNOSING METHOD AND DEVICE THEREOF FOR HIGH MOUNTAIN DISEASE 审中-公开
简体标题：心跳信号分析方法及其设备 AUTO DIAGNOSING METHOD AND DEVICE THEREOF FOR HIGH MOUNTAIN DISEASE
公开(公告)号：TW200642660A
公开(公告)日：2006-12-16
申请号：TW094119592
申请日：2005-06-14
申请人：威今基因科技股份有限公司 WE GENE TECHNOLOGIES, INC. , 郭博昭 TERRY B. J. KUO
发明人：郭博昭 TERRY B. J. KUO , 陳俊忠 CHEN, JIN-JONG , 高偉峰 KAO, WEI-FONG , 郭健中 KUO, CHEIN-CHUNG , 翁立窈 WENG, LI-YAO
IPC分类号： A61B
CPC分类号： A61B5/02405 , A61B5/04017 , A61B5/0452 , G06F19/00 , G16H15/00 , G16H50/30
摘要：一種心跳訊號分析方法及其裝置，其係以非侵體方式對受測者作高山症分析。此心跳訊號分析方法包括首先為先行量測受測者之心跳訊號，其次，對心跳訊號作轉換，並獲得多數個心率變異性參數。接著，根據心率變異性參數作分析，並輸出一分析結果。
简体摘要：一种心跳信号分析方法及其设备，其系以非侵体方式对受测者作高山症分析。此心跳信号分析方法包括首先为先行量测受测者之心跳信号，其次，对心跳信号作转换，并获得多数个心率变异性参数。接着，根据心率变异性参数作分析，并输出一分析结果。

3. 发明授权

US07769435B2 Earphone sensor system for measuring electrocardiogram signals 有权
标题翻译：用于测量心电图信号的耳机传感器系统
公开(公告)号：US07769435B2
公开(公告)日：2010-08-03
申请号：US11737016
申请日：2007-04-18
申请人： Terry B. J. Kuo , Cheryl C. H. Yang
发明人： Terry B. J. Kuo , Cheryl C. H. Yang
IPC分类号： A61B5/04
CPC分类号： A61B5/0404 , A61B5/02405 , A61B5/486 , A61B5/6815 , A61B5/6838
摘要： An earphone sensor system for measuring electrocardiogram signals provides convenient and comfortable noninvasive electrocardiogram signal measuring for a subject. The electrocardiogram signal measuring system includes an electrocardiogram signal analyzing apparatus and an earphone sensing apparatus. The electrocardiogram signal analyzing apparatus includes an amplifier module, a microcontroller, a display, a radio module and a housing having conductive contacts. The earphone sensing apparatus includes an earphone and an electrode. The electrode is disposed in the earphone, and can be electrically connected to the subject for collecting the weak electrocardiogram signal at the head of the subject. By contacting the body surface of the testee with the housing having conductive contacts and the electrode, a basic loop for collecting the electrocardiogram signals is formed. The earphone sensor system can be associated with commercial gadgets and used for musical treatments and bio-feedback.
摘要翻译：用于测量心电图信号的耳机传感器系统为受试者提供方便和舒适的无创心电图信号测量。心电图信号测量系统包括心电图信号分析装置和耳机感测装置。心电图信号分析装置包括放大器模块，微控制器，显示器，无线电模块和具有导电触点的壳体。耳机感测装置包括耳机和电极。电极设置在耳机中，并且可以电连接到被检体，用于收集被检体头部的弱心电图信号。通过使受检者的身体表面与具有导电接点和电极的壳体接触，形成用于收集心电图信号的基本回路。耳机传感器系统可以与商业小工具相关联，并用于音乐治疗和生物反馈。

4. 发明授权

US07672714B2 Miniature wireless apparatus for collecting physiological signals 有权
标题翻译：用于收集生理信号的微型无线设备
公开(公告)号：US07672714B2
公开(公告)日：2010-03-02
申请号：US11462103
申请日：2006-08-03
申请人： Terry B. J. Kuo , Cheryl C. H. Yang
发明人： Terry B. J. Kuo , Cheryl C. H. Yang
IPC分类号： A61B5/02
CPC分类号： G05G1/08 , A61B5/0006 , A61B5/0008 , A61B5/02405 , A61B5/04087 , A61B5/08 , A61B5/7232 , A61B2560/0412 , G05G5/04 , H01C10/32
摘要： A miniature wireless apparatus for collecting physiological signals comprises an electrode pair, an amplifier module, a microcontroller, a wireless module, and a battery. The electrode pair collects a pair of physiological signals of a person under test. The amplifier module amplifies the pair of physiological signals. The microcontroller performs an analog-to-digital conversion and a data compression for an amplified physiological signal generated by the amplifier module. The wireless module modulates a digital physiological signal generated by the microcontroller and transmitting the modulated digital physiological signal to a receiver at the far end. The apparatus can be implemented by a structure of multilayered circuit boards. With the progress of semiconductor technology, all the components of the miniature wireless apparatus can be further integrated to one circuit board, or even one chip.
摘要翻译：用于收集生理信号的微型无线装置包括电极对，放大器模块，微控制器，无线模块和电池。电极对收集被测试者的一对生理信号。放大器模块放大一对生理信号。微控制器对由放大器模块产生的放大的生理信号执行模数转换和数据压缩。无线模块调制由微控制器产生的数字生理信号，并将调制的数字生理信号发射到远端的接收机。该装置可以通过多层电路板的结构来实现。随着半导体技术的进步，微型无线设备的所有组件都可以进一步集成到一个电路板，甚至一个芯片上。

5. 发明申请

US20090124914A1 ANALYSIS SYSTEM AND A METHOD FOR PULSE DIAGNOSIS IN CHINESE MEDICINE 审中-公开
标题翻译：分析系统和中国医学中脉搏诊断的方法
公开(公告)号：US20090124914A1
公开(公告)日：2009-05-14
申请号：US11937376
申请日：2007-11-08
申请人： Terry B. J. Kuo , Cheryl C. H. Yang , Hsin-Yo Chen , Tian-Shung Wu , Hsien-Chang Wu
发明人： Terry B. J. Kuo , Cheryl C. H. Yang , Hsin-Yo Chen , Tian-Shung Wu , Hsien-Chang Wu
IPC分类号： A61B5/021
CPC分类号： A61B5/0402 , A61B5/02116 , A61B5/022 , A61B5/7253 , A61B5/7257
摘要： The present invention relates to an analysis system and method for pulse diagnosis in Chinese medicine, which analyzes quantitatively the variances of pulse condition, and in particular analyzes the “pulse POSITION”, “pulse PACE”, “pulse FORM” and “pulse DYNAMICS” elements in pulse condition with remarkable increase in the accuracy of pulse diagnosis. The analysis system for pulse diagnosis of the present invention comprises a pulse signal collecting device to collect and generate blood pressure and electrocardiogram signals; and a signal process unit to receive and analyze the blood pressure signal series and electrocardiogram signal series. The execution of the signal process unit includes: establishing the position parameters based on measurement of the blood pressure signals, the heart rate parameters based on calculation of the blood pressure or electrocardiogram signals, the wave form parameters based on analysis of the blood pressure signals, the spectrum analysis parameters based on heart rate variability (HRV) and arterial pressure variability (APV), and the quantitative indexes of the elements in pulse condition of Chinese medicine based on the parameters mentioned above.
摘要翻译：本发明涉及一种中医脉搏诊断分析系统及方法，定量分析了脉搏情况的差异，特别分析了“脉搏位置”，“脉冲PACE”，“脉冲形式”，“脉搏动态” 脉冲条件下的元件显着提高了脉搏诊断的准确性。本发明的脉冲诊断用分析系统包括：收集并产生血压和心电图信号的脉冲信号采集装置; 以及用于接收和分析血压信号序列和心电图信号序列的信号处理单元。信号处理单元的执行包括：基于血压信号的测量建立位置参数，基于血压或心电图信号的计算的心率参数，基于血压信号分析的波形参数，基于心率变异性（HRV）和动脉压变异性（APV）的频谱分析参数，以及基于上述参数的中医脉搏状态元素的定量指标。

6. 发明申请

US20080027340A1 EARPHONE SENSOR SYSTEM FOR MEASURING ELECTROCARDIOGRAM SIGNALS 有权
标题翻译：用于测量电子信号的耳机传感器系统
公开(公告)号：US20080027340A1
公开(公告)日：2008-01-31
申请号：US11737016
申请日：2007-04-18
申请人： Terry B. J. KUO , Cheryl C. H. Yang
发明人： Terry B. J. KUO , Cheryl C. H. Yang
IPC分类号： A61B5/04
CPC分类号： A61B5/0404 , A61B5/02405 , A61B5/486 , A61B5/6815 , A61B5/6838
摘要： An earphone sensor system for measuring electrocardiogram signals provides convenient and comfortable noninvasive electrocardiogram signal measuring for a subject. The electrocardiogram signal measuring system includes an electrocardiogram signal analyzing apparatus and an earphone sensing apparatus. The electrocardiogram signal analyzing apparatus includes an amplifier module, a microcontroller, a display, a radio module and a housing having conductive contacts. The earphone sensing apparatus includes an earphone and an electrode. The electrode is disposed in the earphone, and can be electrically connected to the subject for collecting the weak electrocardiogram signal at the head of the subject. By contacting the body surface of the testee with the housing having conductive contacts and the electrode, a basic loop for collecting the electrocardiogram signals is formed. The earphone sensor system can be associated with commercial gadgets and used for musical treatments and bio-feedback.
摘要翻译：用于测量心电图信号的耳机传感器系统为受试者提供方便和舒适的无创心电图信号测量。心电图信号测量系统包括心电图信号分析装置和耳机感测装置。心电图信号分析装置包括放大器模块，微控制器，显示器，无线电模块和具有导电触点的壳体。耳机感测装置包括耳机和电极。电极设置在耳机中，并且可以电连接到被检体，用于收集被检体头部的弱心电图信号。通过使受检者的身体表面与具有导电接点和电极的壳体接触，形成用于收集心电图信号的基本回路。耳机传感器系统可以与商业小工具相关联，并用于音乐治疗和生物反馈。

7. 发明授权

US07277746B2 Method and apparatus for analyzing heart rate variability 有权
标题翻译：心率变异性分析方法及装置
公开(公告)号：US07277746B2
公开(公告)日：2007-10-02
申请号：US10790508
申请日：2004-03-01
申请人： Terry B. J. Kuo , Cheryl C. H. Yang
发明人： Terry B. J. Kuo , Cheryl C. H. Yang
IPC分类号： A61B5/04
CPC分类号： A61B5/0456 , A61B5/7253
摘要： A user-friendly and statistic based heart rate variability analytical method includes the following steps of capturing an electrocardiogram signal of a person, performing analog-to-digital conversion of the electrocardiogram signal, selecting the peaks of the electrocardiogram signal, calculating the standard deviation of the heights, durations and inter-peak intervals of the peaks, removing the peaks whose heights, durations or inter-peak duration fall beyond a first predetermined standard deviation, sampling and interpolating the qualified peaks to form a consecutive peak signal, and performing spectrum analysis to the peak signal in frequency domain.
摘要翻译：基于用户友好和基于统计的心率变异性分析方法包括以下步骤：捕获人的心电图信号，执行心电图信号的模数转换，选择心电图信号的峰值，计算心电图信号的标准偏差峰值的高度，持续时间和峰间间隔，去除其高度，持续时间或峰间持续时间超过第一预定标准偏差的峰值，对合格峰值进行采样和插值以形成连续峰值信号，并进行频谱分析到频域的峰值信号。

8. 发明授权

US06989693B2 Pulse interval to voltage converter and conversion method thereof 有权
标题翻译：脉冲间隔电压转换器及其转换方法
公开(公告)号：US06989693B2
公开(公告)日：2006-01-24
申请号：US10708645
申请日：2004-03-17
申请人： Terry B. J. Kuo , Cheryl C. H. Yang
发明人： Terry B. J. Kuo , Cheryl C. H. Yang
IPC分类号： H03D3/00
CPC分类号： H03K9/08
摘要： A Pulse Interval to Voltage Converter (PIVC) and conversion method thereof is revealed. The PIVC comprises a clock generator, a counter, a latch, a digital-to-analog converter (DAC), a delay unit, a frequency regulator and an underflow protection unit. New components, such as the delay unit, the frequency regulator and the underflow protection unit, are incorporated into the present invention, unlike the conventional art. The delay unit is intended for the programming of the default duration of delay, so as to delay the time for the counter to reset to zero, and in consequence regulate the baseline of the output voltage. The frequency regulator can regulate the clock generation frequency of the clock generator, so as to regulate the resolution of the output voltage. The underflow protection unit turns back external signals while the delay unit is operating, so as to minimize interference from noise.
摘要翻译：显示了脉冲间隔电压转换器（PIVC）及其转换方法。 PIVC包括时钟发生器，计数器，锁存器，数模转换器（DAC），延迟单元，频率调节器和下溢保护单元。与传统技术不同，诸如延迟单元，频率调节器和下溢保护单元的新组件被并入本发明中。延迟单元用于编程默认的延迟持续时间，以便延迟计数器复位为零的时间，从而调节输出电压的基线。频率调节器可以调节时钟发生器的时钟产生频率，从而调节输出电压的分辨率。下溢保护单元在延迟单元运行时转向外部信号，以最大限度地减少噪声的干扰。

9. 发明授权

US06811536B2 Non-invasive apparatus system for monitoring autonomic nervous system and uses thereof 有权
公开(公告)号：US06811536B2
公开(公告)日：2004-11-02
申请号：US10244309
申请日：2002-09-16
申请人： Dehchuan Sun , Terry B. J. Kuo
发明人： Dehchuan Sun , Terry B. J. Kuo
IPC分类号： A61B502
CPC分类号： A61B5/0452 , A61B5/022 , A61B5/02405 , A61B5/4035 , A61B5/7257 , G06F19/00 , G06F19/3456 , G16H10/60 , G16H15/00 , G16H40/63
摘要： A non-invasive apparatus system for monitoring autonomic nervous system, and its uses in monitoring autonomic nervous system functional change side effects caused by drugs and monitoring the aging of autonomic nervous system and tracing therapeutic effect thereof.

10. 发明申请

US20070244370A1 MINIATURE WIRELESS APPARATUS FOR COLLECTING PHYSIOLOGICAL SIGNALS OF ANIMALS 审中-公开
标题翻译：用于收集动物生理信号的微型无线装置
公开(公告)号：US20070244370A1
公开(公告)日：2007-10-18
申请号：US11696820
申请日：2007-04-05
申请人： Terry B. J. KUO , Cheryl C. H. Yang
发明人： Terry B. J. KUO , Cheryl C. H. Yang
IPC分类号： A61B5/00 , A61B5/04
CPC分类号： A61B5/0002 , A61B5/0006 , A61B5/01 , A61B5/0476 , A61B5/0488 , A61B5/0816 , A61B5/7232 , A61B2503/40
摘要： A miniature wireless apparatus for collecting physiological signals of animals includes a connector, an amplifier module, a microcontroller, a radio module and a power supply. The connector is attached to an animal to be tested by buckling a joint of the connector to a joint of a connector on the animal to be tested, so as to collect various physiological signals. The amplifier module amplifies each of the physiological signals by an appropriate gain to generate an amplified physiological signal. The microcontroller performs analog-to-digital conversion and data compression on the amplified physiological signal to generate a digital physiological signal. The radio module modulates the digital physiological signal, and then transmits the modulated digital physiological signal to a remote receiver in a wireless transmission manner. The radio module receives remote wireless signals as well. The power supply is configured to provide power to the above circuits.
摘要翻译：用于收集动物的生理信号的微型无线装置包括连接器，放大器模块，微控制器，无线电模块和电源。连接器通过将连接器的接头屈曲到待测动物上的连接器的接头而连接到待测试的动物上，以收集各种生理信号。放大器模块通过适当的增益放大每个生理信号以产生放大的生理信号。微控制器对放大的生理信号执行模数转换和数据压缩以产生数字生理信号。无线电模块调制数字生理信号，然后以无线传输方式将调制的数字生理信号发送到远程接收机。无线电模块也接收远程无线信号。电源被配置为向上述电路供电。

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