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1. 发明授权

US08437168B2 Josephson quantum computing device and integrated circuit using such devices 有权
公开(公告)号：US08437168B2
公开(公告)日：2013-05-07
申请号：US13607516
申请日：2012-09-07
申请人： Sadamichi Maekawa , Taro Yamashita , Saburo Takahashi
发明人： Sadamichi Maekawa , Taro Yamashita , Saburo Takahashi
IPC分类号： G11C11/00
CPC分类号： G06N99/002 , B82Y10/00
摘要： A Josephson quantum computing device and an integrated circuit using Josephson quantum computing devices which can realize a NOT gate operation controlled with 2 bits will be provided. The Josephson quantum computing device (1) comprises: a superconducting ring member (10) having a π-junction (6) and a 0-junction (7); and a quantum state detecting member (20) constituted by a superconducting quantum interference device arranged outside of the superconducting ring member, wherein a bonding and an antibonding state brought about by a tunneling effect between a |↑> and a |↓> state as two states degenerate in energy of the superconducting ring member (10) are regarded as quantum bits. The bonding and antibonding states as the quantum bits are read out by the quantum state detecting member (20). The two bit controlled NOT gate operation can be performed by the two quantum bits comprising said quantum bits.

2. 发明授权

US08258244B2 Process for production of thermoplastic copolymer 失效
标题翻译：热塑性共聚物生产工艺
公开(公告)号：US08258244B2
公开(公告)日：2012-09-04
申请号：US12919171
申请日：2009-02-27
申请人： Taro Yamashita , Hajime Takamura
发明人： Taro Yamashita , Hajime Takamura
IPC分类号： C08F2/00 , C08F12/28 , C08F14/06 , C08F12/02
CPC分类号： C08F2/01 , C08F2/38 , C08F212/10 , C08F220/44 , C08F222/40
摘要： Disclosed is a process for producing a thermoplastic copolymer, which comprises step of supplying a monomer mixture (a) to a loop reactor continuously to produce a copolymer (A), the monomer mixture (a) comprising an aromatic vinyl monomer (a1), a vinyl cyanide monomer (a2) and an N-substituted maleimide monomer (a3). The process enables the production of a thermoplastic copolymer which has an excellent balance among physical properties such as heat resistance, color and flow property, reduces the amount of bleeding that may cause mold staining during molding processing and has excellent handleability and productivity.
摘要翻译：公开了一种生产热塑性共聚物的方法，其包括将单体混合物（a）连续供给到环管反应器以制备共聚物（A）的步骤，包含芳族乙烯基单体（a1）的单体混合物（a）乙烯基氰单体（a2）和N-取代马来酰亚胺单体（a3）。该方法能够生产在诸如耐热性，颜色和流动性的物理性能之间具有优异平衡的热塑性共聚物，减少在模塑加工期间可能引起模子污染的渗色量，并且具有优异的可操作性和生产率。

3. 发明申请

US20050112578A1 Dna nanocage by self-organization of dna and process for producing the same, and dna nanotube and molecule carrier using the same 审中-公开
标题翻译：通过dna的自组织和生产相同的方法，和dna纳米管和分子载体使用相同的纳米纳米颗粒
公开(公告)号：US20050112578A1
公开(公告)日：2005-05-26
申请号：US10505551
申请日：2003-03-06
申请人： Kazunori Matsuura , Nobuo Kimizuka , Taro Yamashita
发明人： Kazunori Matsuura , Nobuo Kimizuka , Taro Yamashita
IPC分类号： C12N15/09 , A61K9/51 , C07H21/04 , C12N15/10 , C12Q1/68
CPC分类号： C12N15/10 , A61K9/5115 , B82Y10/00 , B82Y30/00 , G11C13/025
摘要： The invention provides a process for producing DNA nanocages, characterized by comprising a step of two-dimensionally assembling three types of oligonucleotides by hybridization to form tridirectionally branched double-strand DNA having self-complementary chains in the terminals, and a step of three-dimensionally self-organizing the resulting tridirectionally branched double-strand DNAs so as to consume all of the self-complementary terminals. Since the DNA nanocages according to the invention can easily be formed from DNAs by one-step procedure and include nanoparticles in the interior, the DNA nanocages are significantly effective for the development of functional materials using DNAs.
摘要翻译：本发明提供了一种生产DNA纳米笼的方法，其特征在于包括通过杂交二维组装三种类型的寡核苷酸的步骤，以形成在末端中具有自互补链的三向分支的双链DNA，以及三维自组织得到的三向分支双链DNA，以便消耗所有的自互补末端。由于根据本发明的DNA纳米笼可以通过一步法由DNA形成，并且在内部包括纳米颗粒，所以DNA纳米笼对于使用DNA开发功能材料是显着有效的。

4. 发明申请

US20120326130A1 JOSEPHSON QUANTUM COMPUTING DEVICE AND INTEGRATED CIRCUIT USING SUCH DEVICES 有权
标题翻译： JOSEPHSON量子计算设备和使用此类设备的集成电路
公开(公告)号：US20120326130A1
公开(公告)日：2012-12-27
申请号：US13607516
申请日：2012-09-07
申请人： Sadamichi MAEKAWA , Taro YAMASHITA , Saburo TAKAHASHI
发明人： Sadamichi MAEKAWA , Taro YAMASHITA , Saburo TAKAHASHI
IPC分类号： H01L39/22
CPC分类号： G06N99/002 , B82Y10/00
摘要： A Josephson quantum computing device and an integrated circuit using Josephson quantum computing devices which can realize a NOT gate operation controlled with 2 bits will be provided. The Josephson quantum computing device (1) comprises: a superconducting ring member (10) having a π-junction (6) and a 0-junction (7); and a quantum state detecting member (20) constituted by a superconducting quantum interference device arranged outside of the superconducting ring member, wherein a bonding and an antibonding state brought about by a tunneling effect between a | ↑ > and a | ↓ > state as two states degenerate in energy of the superconducting ring member (10) are regarded as quantum bits. The bonding and antibonding states as the quantum bits are read out by the quantum state detecting member (20). The two bit controlled NOT gate operation can be performed by the two quantum bits comprising said quantum bits.
摘要翻译：将提供约瑟夫森量子计算设备和使用约瑟夫森量子计算设备的集成电路，其可以实现以2位控制的非门操作。约瑟夫森量子计算装置（1）包括：具有结点（6）和0结（7）的超导环构件（10）; 以及由超导量子干涉元件构成的量子态检测元件（20），所述超导量子干涉元件设置在所述超导环构件的外侧，其中，在所述超导环形构件之间的隧道效应引起的接合和反应状态， ↑>和a | ↓>状态为超导环形元件（10）的能量退化的两个状态被认为是量子位。作为量子比特的键合反应状态由量子状态检测部件（20）读出。两位控制的非门操作可以由包括所述量子位的两个量子位执行。

5. 发明授权

US08334349B2 Method for producing thermoplastic copolymer 失效
标题翻译：生产热塑性共聚物的方法
公开(公告)号：US08334349B2
公开(公告)日：2012-12-18
申请号：US13003253
申请日：2009-07-07
申请人： Taro Yamashita , Hajime Takamura
发明人： Taro Yamashita , Hajime Takamura
IPC分类号： C08F2/00 , C08F12/28 , C08F220/44 , C08G85/00
CPC分类号： C08F2/06 , C08F2/001 , C08F2/01 , C08F212/10 , C08F220/42 , C08F279/04 , C08L55/02 , C09D155/02 , C08F2/22
摘要： A thermoplastic copolymer having an excellent balance among properties such as coating resistance, color stability and fluidity and having high operability and productivity can be obtained by a method for producing a thermoplastic copolymer, comprising step (I) of supplying a monomer mixture (a) containing an aromatic vinyl monomer (a1) and a vinyl cyanide monomer (a2) to a complete mixing type reactor continuously to produce a copolymer (A) and step (II) of supplying the copolymer (A) continuously to a tubular reactor with a static mixing structure therein, which is placed in series with the complete mixing type reactor, and reacting the copolymer (A) to produce a copolymer (B).
摘要翻译：通过制造热塑性共聚物的方法可以获得具有耐涂层性，颜色稳定性和流动性等特性和具有高可操作性和生产率的性能之间优异平衡的热塑性共聚物，该方法包括供给单体混合物（a）的步骤（I）将芳族乙烯基单体（a1）和乙烯基氰单体（a2）连续混合到完全混合型反应器中以产生共聚物（A）和将共聚物（A）连续供给到具有静态混合的管式反应器的步骤（II）结构，其与完全混合型反应器串联放置，并使共聚物（A）反应生成共聚物（B）。

6. 发明申请

US20090261319A1 Josephson quantum computing device and integrated circuit using such devices 有权
标题翻译：约瑟夫森量子计算设备和使用这种设备的集成电路
公开(公告)号：US20090261319A1
公开(公告)日：2009-10-22
申请号：US11658647
申请日：2005-07-25
申请人： Sadamichi Maekawa , Taro Yamashita , Saburo Takahshi
发明人： Sadamichi Maekawa , Taro Yamashita , Saburo Takahshi
IPC分类号： H01L39/22
CPC分类号： G06N99/002 , B82Y10/00
摘要： A Josephson quantum computing device and an integrated circuit using Josephson quantum computing devices which can realize a NOT gate operation controlled with 2 bits will be provided. The Josephson quantum computing device (1) comprises: a superconducting ring member (10) having a π-junction (6) and a 0-junction (7); and a quantum state detecting member (20) constituted by a superconducting quantum interference device arranged outside of the superconducting ring member, wherein a bonding and an antibonding state brought about by a tunneling effect between a |↑> and a |↓> state as two states degenerate in energy of the superconducting ring member (10) are regarded as quantum bits. The bonding and antibonding states as the quantum bits are read out by the quantum state detecting member (20). The two bit controlled NOT gate operation can be performed by the two quantum bits comprising said quantum bits.
摘要翻译：将提供约瑟夫森量子计算设备和使用约瑟夫森量子计算设备的集成电路，其可以实现以2位控制的非门操作。约瑟夫森量子计算装置（1）包括：具有π结（6）和0结（7）的超导环构件（10）; 和由超导量子干涉元件构成的量子态检测元件（20），该超导量子干涉元件设置在超导环形元件外部，其中由|↑>↑>状态之间的隧道效应引起的接合和反应状态为二超导环构件（10）的能量退化的状态被认为是量子位。作为量子比特的键合反应状态由量子状态检测部件（20）读出。两位控制的非门操作可以由包括所述量子位的两个量子位执行。

7. 发明授权

US08932990B2 Detection of digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, and biliary tract cancer by gene expression profiling 有权
标题翻译：通过基因表达谱检测消化器官癌，胃癌，结肠直肠癌，胰腺癌和胆道癌
公开(公告)号：US08932990B2
公开(公告)日：2015-01-13
申请号：US13391858
申请日：2010-08-03
申请人： Shuichi Kaneko , Masao Honda , Yoshio Sakai , Taro Yamashita
发明人： Shuichi Kaneko , Masao Honda , Yoshio Sakai , Taro Yamashita
IPC分类号： C40B30/04 , C12Q1/68 , C40B40/06
CPC分类号： C12Q1/6886 , C12Q2600/158 , C12Q2600/16
摘要： The present invention provides a method and a reagent for detecting a digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer patient by analyzing genes with expression levels (in peripheral blood) that vary in association with digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer cases, compared with normal healthy subjects. Specifically, the method for detecting a digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer patient based on expression profiles comprises obtaining the expression profile of at least one gene selected from the group consisting of probes corresponding to genes with expression levels (in peripheral blood) that vary in digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, and biliary tract cancer cases, compared with normal healthy subjects. The reagent for detecting digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer contains nucleotides or partial sequences thereof consisting of the nucleotide sequence of at least one gene selected from the group consisting of probes with expression levels that vary in digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer, or nucleotides containing sequences complementary thereto.
摘要翻译：本发明提供了通过分析与消化器官癌相关的变化的表达水平（外周血）的基因来检测消化器官癌，胃癌，结肠直肠癌，胰腺癌或胆道癌患者的方法和试剂，胃癌，结肠直肠癌，胰腺癌或胆道癌，与正常健康人相比。具体地，基于表达谱，检测消化器官癌，胃癌，结肠直肠癌，胰腺癌或胆道癌患者的方法包括获得至少一种基因的表达谱，所述基因选自对应于具有与正常健康受试者相比，消化器官癌，胃癌，结肠直肠癌，胰腺癌和胆道癌患者的表达水平（外周血）差异不大。用于检测消化器官癌，胃癌，结肠直肠癌，胰腺癌或胆道癌的试剂含有由至少一种基因的核苷酸序列组成的核苷酸或其部分序列，所述核苷酸序列选自下组的探针：表达水平在消化器官癌，胃癌，结肠直肠癌，胰腺癌或胆道癌，或含有与其互补的序列的核苷酸。

8. 发明授权

US07888456B2 Process for production of thermoplastic copolymer 有权
标题翻译：热塑性共聚物生产工艺
公开(公告)号：US07888456B2
公开(公告)日：2011-02-15
申请号：US12442343
申请日：2007-09-13
申请人： Daisuke Yamamoto , Ken Sudo , Hajime Takamura , Taro Yamashita , Koji Yamauchi , Hideki Matsumoto , Kenichi Utazaki
发明人： Daisuke Yamamoto , Ken Sudo , Hajime Takamura , Taro Yamashita , Koji Yamauchi , Hideki Matsumoto , Kenichi Utazaki
IPC分类号： C08F6/00 , C08G63/02
CPC分类号： C08F220/14 , C08F8/44 , C08F8/48 , C08F220/06 , C08F2800/20 , C08F2810/20 , C08F2810/30 , C08F2220/1825 , C08F265/06
摘要： A process for continuously producing a thermoplastic copolymer, in which a copolymer (A) containing unsaturated carboxylic acid alkyl ester units and unsaturated carboxylic acid units is produced and in succession heat-treated to perform intramolecular cyclization reaction by dehydration and/or dealcoholization reaction, for producing a thermoplastic copolymer (B) containing glutaric anhydride units and the unsaturated carboxylic acid alkyl ester units. The obtained copolymer is excellent in heat resistance and colorless transparency and very small in foreign matter content.
摘要翻译：一种连续制造热塑性共聚物的方法，其中制备含有不饱和羧酸烷基酯单元和不饱和羧酸单元的共聚物（A），并连续热处理以通过脱水和/或脱醇反应进行分子内环化反应，用于生产含有戊二酸酐单元和不饱和羧酸烷基酯单元的热塑性共聚物（B）。所得共聚物的耐热性和无色透明性优异，异物含量非常小。

9. 发明申请

US20100197770A1 Methods for Determining Heptocellular Carcinoma Subtype and Detecting Hepatic Cancer Stem Cells 有权
标题翻译：确定肝细胞癌亚型和检测肝癌干细胞的方法
公开(公告)号：US20100197770A1
公开(公告)日：2010-08-05
申请号：US12663586
申请日：2008-06-09
申请人： Xin Wei Wang , Junfang Ji , Taro Yamashita , Carlo M. Croce
发明人： Xin Wei Wang , Junfang Ji , Taro Yamashita , Carlo M. Croce
IPC分类号： A61K31/7088 , C12Q1/68 , C40B30/04 , C12Q1/02 , G01N33/559
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158 , C12Q2600/178 , G01N33/6893
摘要： The invention provides a method of determining an HCC subtype in a subject comprising a) obtaining a sample from the subject, b) assaying the sample to detect the expression of 1 or more biomarkers, and c) correlating the expression of the biomarkers with an HCC subtype in a subject. The invention further provides methods of detecting HCC stem cells in a sample. Additionally, the invention provides methods and compositions for treating subjects with HCC that take advantage of the biomarkers associated with HCC stem cells.
摘要翻译：本发明提供了确定受试者中HCC亚型的方法，其包括a）从受试者获得样品，b）测定样品以检测1种或更多种生物标志物的表达，以及c）将生物标志物的表达与HCC相关联受试者的亚型。本发明还提供了检测样品中HCC干细胞的方法。另外，本发明提供用于治疗HCC受试者利用与HCC干细胞相关的生物标志物的方法和组合物。

10. 发明授权

US08465917B2 Methods for determining heptocellular carcinoma subtype and detecting hepatic cancer stem cells 有权
标题翻译：确定肝细胞癌亚型和检测肝癌干细胞的方法
公开(公告)号：US08465917B2
公开(公告)日：2013-06-18
申请号：US12663586
申请日：2008-06-09
申请人： Xin Wei Wang , Junfang Ji , Taro Yamashita , Carlo M. Croce
发明人： Xin Wei Wang , Junfang Ji , Taro Yamashita , Carlo M. Croce
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158 , C12Q2600/178 , G01N33/6893
摘要： The invention provides a method of determining an HCC subtype in a subject comprising a) obtaining a sample from the subject, b) assaying the sample to detect the expression of 1 or more biomarkers, and c) correlating the expression of the biomarkers with an HCC subtype in a subject. The invention further provides methods of detecting HCC stem cells in a sample. Additionally, the invention provides methods and compositions for treating subjects with HCC that take advantage of the biomarkers associated with HCC stem cells.
摘要翻译：本发明提供了确定受试者中HCC亚型的方法，其包括a）从受试者获得样品，b）测定样品以检测1种或更多种生物标志物的表达，以及c）将生物标志物的表达与HCC相关联受试者的亚型。本发明还提供了检测样品中HCC干细胞的方法。另外，本发明提供用于治疗HCC受试者利用与HCC干细胞相关的生物标志物的方法和组合物。

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