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1. 发明授权

US07732573B2 Method for producing porous body comprising apatite/collagen composite fibers 有权
标题翻译：包含磷灰石/胶原复合纤维的多孔体的制造方法
公开(公告)号：US07732573B2
公开(公告)日：2010-06-08
申请号：US11718135
申请日：2005-10-13
申请人： Junzo Tanaka , Masanori Kikuchi , Toshiyuki Ikoma , Daisuke Shoji , Katsumi Kawamura , Takehiko Nakajima , Naomi Mochizuki
发明人： Junzo Tanaka , Masanori Kikuchi , Toshiyuki Ikoma , Daisuke Shoji , Katsumi Kawamura , Takehiko Nakajima , Naomi Mochizuki
IPC分类号： A61K38/17 , A61F2/02 , A61F2/28 , A61L27/32 , D04H1/54 , D04H1/00 , C03B37/00 , B29C65/00
CPC分类号： C04B38/0045 , A61F2/28 , A61F2/3094 , A61F2/30965 , A61F2310/00293 , A61F2310/00365 , A61L27/46 , A61L27/56 , C04B35/447 , C04B35/80 , C04B2111/00836 , Y10T442/692 , Y10T442/696 , C04B38/0074 , C04B14/38 , C04B24/14 , C04B30/02 , C08L89/06
摘要： A method for producing a porous body comprising apatite/collagen composite fibers comprising the steps of gelling a dispersion comprising long apatite/collagen composite fibers having an average length of 10-75 mm, short apatite/collagen composite fibers having an average length of 0.05-1 mm, and a liquid; freezing and drying the resultant gel to form a porous body; and cross-linking collagen in the porous body.
摘要翻译：一种包含磷灰石/胶原复合纤维的多孔体的制造方法，其特征在于，包括使平均长度为10-75mm的长磷灰石/胶原复合纤维的分散液凝胶化的工序，平均长度为0.05〜 1mm，液体; 冷冻并干燥所得凝胶以形成多孔体; 并在多孔体中交联胶原蛋白。

2. 发明授权

US07637912B2 Surgical instruments 失效
标题翻译：手术器械
公开(公告)号：US07637912B2
公开(公告)日：2009-12-29
申请号：US10558357
申请日：2004-05-26
申请人： Yoshinobu Iwasaki , Kazutoshi Hida , Takehiko Nakajima , Masahiro Kohketsu
发明人： Yoshinobu Iwasaki , Kazutoshi Hida , Takehiko Nakajima , Masahiro Kohketsu
IPC分类号： A61F2/00
CPC分类号： A61B17/7062
摘要： An object of the present invention is to provide surgical instruments which can insert a block-shaped interspinous spacer into a space between adjacent spinous processes with easier operations. The surgical instruments of the present invention are instruments for inserting the interspinous spacer having a block-like shape formed with a hollow portion into the space between the adjacent spinous processes. The surgical instruments include an insertion instrument having an inserting portion adapted to be passed through the hollow portion of the interspinous spacer, and a grasping instrument for grasping the insertion instrument, wherein the insertion instrument and the grasping instrument are adapted to be used under the condition that the insertion instrument is inserted into the hollow portion of the interspinous spacer and in such a state the grasped portion of the insertion instrument which is provided near the first end of the insertion instrument is grasped by the grasping instrument. The insertion instrument is provided with a support portion for preventing the interspinous spacer from being fallen off from the insertion instrument when the insertion instrument is inserted into the hollow portion of the interspinous spacer, at the second end thereof which is the opposite end of the first end.
摘要翻译：本发明的一个目的是提供一种手术器械，其能够将块状棘突间间隔物插入到相邻棘突之间的空间中，并且操作更简单。本发明的手术器械是将具有中空部分形成的块状形状的棘突间间隔物插入相邻棘突之间的空间的装置。手术器械包括具有适于穿过椎间间隔垫的中空部分的插入部分的插入器具和用于抓住插入器具的把持器械，其中插入器械和把持器械适于在该条件下使用插入器械插入棘突间隔件的中空部分中，并且在这种状态下，设置在插入器具的第一端附近的插入器具的被抓握部被抓握器夹持。所述插入器具具有支撑部，所述支撑部在所述插入器械插入所述椎间间隔物的中空部的第二端部处设置有用于防止所述椎间间隔物从所述插入器具脱落的第二端部结束。

3. 发明申请

US20070112354A1 Surgical instruments 失效
标题翻译：手术器械
公开(公告)号：US20070112354A1
公开(公告)日：2007-05-17
申请号：US10558357
申请日：2004-05-26
申请人： Yoshinobu Iwasaki , Kazutoshi Hida , Takehiko Nakajima , Masahiro Kohketsu
发明人： Yoshinobu Iwasaki , Kazutoshi Hida , Takehiko Nakajima , Masahiro Kohketsu
IPC分类号： A61F2/00
CPC分类号： A61B17/7062
摘要： An object of the present invention is to provide surgical instruments which can insert a block-shaped interspinous spacer into a space between adjacent spinous processes with easier operations. The surgical instruments of the present invention are instruments for inserting the interspinous spacer having a block-like shape formed with a hollow portion into the space between the adjacent spinous processes. The surgical instruments include an insertion instrument having an inserting portion adapted to be passed through the hollow portion of the interspinous spacer, and a grasping instrument for grasping the insertion instrument, wherein the insertion instrument and the grasping instrument are adapted to be used under the condition that the insertion instrument is inserted into the hollow portion of the interspinous spacer and in such a state the grasped portion of the insertion instrument which is provided near the first end of the insertion instrument is grasped by the grasping instrument. The insertion instrument is provided with a support portion for preventing the interspinous spacer from being fallen off from the insertion instrument when the insertion instrument is inserted into the hollow portion of the interspinous spacer, at the second end thereof which is the opposite end of the first end.
摘要翻译：本发明的一个目的是提供一种手术器械，其能够将块状棘突间间隔物插入到相邻棘突之间的空间中，并且操作更简单。本发明的手术器械是将具有中空部分形成的块状形状的棘突间间隔物插入相邻棘突之间的空间的装置。手术器械包括具有适于穿过椎间间隔垫的中空部分的插入部分的插入器具和用于抓住插入器具的把持器械，其中插入器械和把持器械适于在该条件下使用插入器械插入棘突间隔件的中空部分中，并且在这种状态下，设置在插入器具的第一端附近的插入器具的被抓握部被抓握器夹持。所述插入器具具有支撑部，所述支撑部在所述插入器械插入所述椎间间隔物的中空部的第二端部处设置有用于防止所述椎间间隔物从所述插入器具脱落的第二端部结束。

4. 发明申请

US20060292350A1 Porous composite containing calcium phosphate and process for producing the same 有权
标题翻译：含磷酸钙的多孔复合材料及其制备方法
公开(公告)号：US20060292350A1
公开(公告)日：2006-12-28
申请号：US10558245
申请日：2004-05-26
申请人： Katsumi Kawamura , Takehiko Nakajima , Daisuke Shoji , Junzo Tanaka , Masanori Kikuchi , Toshiyuki Ikoma
发明人： Katsumi Kawamura , Takehiko Nakajima , Daisuke Shoji , Junzo Tanaka , Masanori Kikuchi , Toshiyuki Ikoma
IPC分类号： B32B3/00
CPC分类号： A61L27/56 , A61L27/12 , A61L27/425 , Y10T428/24752
摘要： A porous composite comprising a porous layer containing a calcium phosphate ceramic, and a dense layer formed on part of the porous layer and having a smaller average pore size than that of the porous layer. The porous composite can be produced by (1) introducing a slurry containing a calcium phosphate ceramic/collagen composite and collagen into a molding die having a high thermal conductivity, (2) rapidly freezing and drying the slurry in the molding die, to form a porous body comprising a porous layer and a dense layer formed on the porous layer, (3) cross-linking collagen in the porous body, and (4) removing the dense layer except for a portion thereof on a surface coming into contact with a soft tissue when implanted in a human body, so that the porous layer is exposed.
摘要翻译：一种多孔复合体，其包含含有磷酸钙陶瓷的多孔层，以及形成在所述多孔层的一部分上并且具有比所述多孔层的平均孔径更小的致密层。多孔复合材料可以通过（1）将含有磷酸钙陶瓷/胶原复合材料和胶原的浆料引入到具有高导热性的成型模具中，（2）快速冷冻并干燥成型模具中的浆料，从而形成多孔体包括多孔层和形成在多孔层上的致密层，（3）在多孔体中交联胶原，以及（4）在与柔软接触的表面上去除除了其一部分之外的致密层植入人体时的组织，使得多孔层被暴露。

5. 发明授权

US08652524B2 Organ regeneration device 有权
标题翻译：器官再生装置
公开(公告)号：US08652524B2
公开(公告)日：2014-02-18
申请号：US12325015
申请日：2008-11-28
申请人： Ichiro Ono , Yoshikiyo Akasaka , Takehiko Nakajima
发明人： Ichiro Ono , Yoshikiyo Akasaka , Takehiko Nakajima
IPC分类号： A61K9/14 , A61K47/42 , A61K47/02 , A61K31/7088 , A61K38/18 , A61K35/12
CPC分类号： A61K31/7088 , A61K38/18 , A61K38/1825 , A61K38/1875 , A61K48/0075 , A61K48/0091 , A61K2300/00
摘要： An organ regeneration device adapted to be used by placing it into a defective portion of an organ to regenerate the organ is provided. The organ regeneration device has a base body having a shape corresponding to a shape of the defective portion of the organ. The organ regeneration device also has particles carried on the base body, wherein the particles are composed of a different material from that of the base body. The organ regeneration device also has a growth-related substance contained in the organ regeneration device for growth and differentiation of cells around the defective portion. The growth-related substance contains an angiogenesis factor. Further, the growth-related substance contains nucleic acid containing a base sequence coding for amino-acid sequence of a growth factor different from the angiogenesis factor. Furthermore, the nucleic acid is introduced into a host cell.
摘要翻译：提供了一种适于通过将其置于器官的缺陷部分以再生器官而使用的器官再生装置。器官再生装置具有与器官的有缺陷部的形状对应的形状的基体。器官再生装置还具有承载在基体上的颗粒，其中颗粒由与基体不同的材料构成。器官再生装置还具有包含在器官再生装置中的生长相关物质，用于在缺陷部分周围的细胞的生长和分化。生长相关物质含有血管生成因子。此外，生长相关物质含有含有编码不同于血管生成因子的生长因子的氨基酸序列的碱基序列的核酸。此外，将核酸引入宿主细胞。

6. 发明申请

US20070202703A1 Polishing composition and polishing method 审中-公开
标题翻译：抛光组合物和抛光方法
公开(公告)号：US20070202703A1
公开(公告)日：2007-08-30
申请号：US11711234
申请日：2007-02-27
申请人： Mikikazu Shimizu , Takehiko Nakajima
发明人： Mikikazu Shimizu , Takehiko Nakajima
IPC分类号： H01L21/461 , B24D3/02 , C09K3/14
CPC分类号： H01L21/31053 , C09G1/02 , C09K3/1409 , C09K3/1445 , C09K3/1463 , H01L21/3212
摘要： A polishing composition contains silica abrasive grains and an iodine compound. The silica abrasive grains exhibit a negative zeta potential in the polishing composition. The silica abrasive grains have an average primary particle size of 30 nm or smaller, and the polishing composition has a pH of 4 or lower. The polishing composition is suitable for polishing a polysilicon film and a silicon nitride film.
摘要翻译：抛光组合物含有二氧化硅磨粒和碘化合物。二氧化硅磨粒在抛光组合物中表现出负ζ电位。二氧化硅磨粒的平均一次粒径为30nm以下，抛光组合物的pH为4以下。抛光组合物适用于抛光多晶硅膜和氮化硅膜。

7. 发明申请

US20090166580A1 METHOD FOR PRODUCING POROUS BODY COMPRISING APATITE/COLLAGEN COMPOSITE FIBERS 有权
标题翻译：生产包含APATITE / COLLAGEN复合纤维的多孔体的方法
公开(公告)号：US20090166580A1
公开(公告)日：2009-07-02
申请号：US11718135
申请日：2005-10-13
申请人： Junzo Tanaka , Masanori Kikuchi , Toshiyuki Ikoma , Daisuke Shoji , Katsumi Kawamura , Takehiko Nakajima , Naomi Mochizuki
发明人： Junzo Tanaka , Masanori Kikuchi , Toshiyuki Ikoma , Daisuke Shoji , Katsumi Kawamura , Takehiko Nakajima , Naomi Mochizuki
IPC分类号： C09K3/00
CPC分类号： C04B38/0045 , A61F2/28 , A61F2/3094 , A61F2/30965 , A61F2310/00293 , A61F2310/00365 , A61L27/46 , A61L27/56 , C04B35/447 , C04B35/80 , C04B2111/00836 , Y10T442/692 , Y10T442/696 , C04B38/0074 , C04B14/38 , C04B24/14 , C04B30/02 , C08L89/06
摘要： A method for producing a porous body comprising apatite/collagen composite fibers comprising the steps of gelling a dispersion comprising long apatite/collagen composite fibers having an average length of 10-75 mm, short apatite/collagen composite fibers having an average length of 0.05-1 mm, and a liquid; freezing and drying the resultant gel to form a porous body; and cross-linking collagen in the porous body.
摘要翻译：一种包含磷灰石/胶原复合纤维的多孔体的制造方法，其特征在于，包括使平均长度为10-75mm的长磷灰石/胶原复合纤维的分散液凝胶化的工序，平均长度为0.05〜 1mm，液体; 冷冻并干燥所得凝胶以形成多孔体; 并在多孔体中交联胶原蛋白。

8. 发明申请

US20090142403A1 ORGAN REGENERATION DEVICE 有权
标题翻译：组织再生装置
公开(公告)号：US20090142403A1
公开(公告)日：2009-06-04
申请号：US12325015
申请日：2008-11-28
申请人： Ichiro ONO , Yoshikiyo AKASAKA , Takehiko NAKAJIMA
发明人： Ichiro ONO , Yoshikiyo AKASAKA , Takehiko NAKAJIMA
IPC分类号： A61K9/14 , A61K47/42 , A61K31/7088 , A61K35/12 , A61K38/18 , A61K47/02
CPC分类号： A61K31/7088 , A61K38/18 , A61K38/1825 , A61K38/1875 , A61K48/0075 , A61K48/0091 , A61K2300/00
摘要： An organ regeneration device adapted to be used by placing it into a defective portion of an organ to regenerate the organ is provided. The organ regeneration device has a base body having a shape corresponding to a shape of the defective portion of the organ. The organ regeneration device also has particles carried on the base body, wherein the particles are composed of a different material from that of the base body. The organ regeneration device also has a growth-related substance contained in the organ regeneration device for growth and differentiation of cells around the defective portion. The growth-related substance contains an angiogenesis factor. Further, the growth-related substance contains nucleic acid containing a base sequence coding for amino-acid sequence of a growth factor different from the angiogenesis factor. Furthermore, the nucleic acid is introduced into a host cell.
摘要翻译：提供了一种适于通过将其置于器官的缺陷部分以再生器官而使用的器官再生装置。器官再生装置具有与器官的有缺陷部的形状对应的形状的基体。器官再生装置还具有承载在基体上的颗粒，其中颗粒由与基体不同的材料构成。器官再生装置还具有包含在器官再生装置中的生长相关物质，用于在缺陷部分周围的细胞的生长和分化。生长相关物质含有血管生成因子。此外，生长相关物质含有含有编码不同于血管生成因子的生长因子的氨基酸序列的碱基序列的核酸。此外，将核酸引入宿主细胞。

9. 发明授权

US5550775A Semiconductor device for generating high voltage potentials 失效
标题翻译：用于产生高电压电位的半导体器件
公开(公告)号：US5550775A
公开(公告)日：1996-08-27
申请号：US361551
申请日：1994-12-22
申请人： Wataru Abe , Akihiro Yamamoto , Takehiko Nakajima , Makoto Kojima
发明人： Wataru Abe , Akihiro Yamamoto , Takehiko Nakajima , Makoto Kojima
IPC分类号： G11C11/407 , G11C5/14 , G11C8/08 , H03K17/06 , G11C7/00 , H03K4/58
CPC分类号： H03K17/063 , G11C5/145 , G11C8/08
摘要： A semiconductor device comprises: a signal of high voltage not less than the power voltage; a first transistor for transmitting the high voltage signal; a second transistor for electrically charging and discharging the gate potential of the first transistor; and a circuit for generating a pulse signal of which "H" level is a voltage higher than the power voltage by the threshold voltage of the second transistor. The pulse signal generating circuit is connected to the gate electrode of the second transistor. This cancels the drop of a voltage corresponding to the threshold voltage generated at the time when the electric charge is transferred to the gate electrode of the first transistor. Accordingly, even though the power voltage is low, a high voltage signal can be transferred through the first transistor and the word line potential can be boosted to a voltage not less than the power voltage.
摘要翻译：半导体器件包括：不小于电源电压的高电压信号; 用于发送高电压信号的第一晶体管; 用于对第一晶体管的栅极电位进行充电和放电的第二晶体管; 以及电路，用于产生“H”电平是比第二晶体管的阈值电压高于电源电压的电压的脉冲信号。脉冲信号发生电路连接到第二晶体管的栅电极。这取消了与将电荷转移到第一晶体管的栅电极时产生的阈值电压相对应的电压的下降。因此，即使电源电压低，可以通过第一晶体管传输高电压信号，并且可以将字线电位升高到不低于电源电压的电压。

10. 发明申请

US20080234396A1 Method For Controlling Average Pore Diameter of Porous Body Comprising Apatite/Collagen Composite Fibers 有权
标题翻译：用于控制包含磷灰石/胶原复合纤维的多孔体的平均孔径的方法
公开(公告)号：US20080234396A1
公开(公告)日：2008-09-25
申请号：US10599435
申请日：2005-03-23
申请人： Daisuke Shoji , Katsumi Kawamura , Takehiko Nakajima , Junzo Tanaka , Masanori Kikuchi , Toshiyuki Ikoma , Naomi Mochizuki
发明人： Daisuke Shoji , Katsumi Kawamura , Takehiko Nakajima , Junzo Tanaka , Masanori Kikuchi , Toshiyuki Ikoma , Naomi Mochizuki
IPC分类号： C08J3/02
CPC分类号： A61L27/56 , A61L27/12 , A61L27/24 , A61L27/46 , C08L9/06
摘要： In the process of producing a porous body containing a fibrous apatite/collagen composite by gelating a dispersion comprising said fibrous apatite/collagen composite, collagen and water, freeze-drying the resultant gel to form a porous body, and cross-linking collagen in said porous body, a method for controlling the average pore diameter of said porous body by the solidification time of said gel in said freezing step.
摘要翻译：在通过使包含所述纤维状磷灰石/胶原复合材料，胶原和水的分散体凝胶化制造含有纤维状磷灰石/胶原复合材料的多孔体的方法中，将所得凝胶冷冻干燥以形成多孔体，并将所述胶原蛋白交联多孔体，用于在所述冷冻步骤中通过所述凝胶的固化时间控制所述多孔体的平均孔径的方法。

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