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1. 发明专利

IL268351D0 Low ph pharmaceutical composition comprising t cell engaging antibody constructs 未知
公开(公告)号：IL268351D0
公开(公告)日：2019-09-26
申请号：IL26835119
申请日：2019-07-30
申请人： AMGEN RES MUNICH GMBH , AMGEN INC , MCAULEY ARNOLD , GHATTYVENKATAKRISHNA PAVAN , ABEL JEFF , HUH JOON , POMPE CORNELIUS , KANAPURAM SEKHAR , TREUHEIT MICHAEL , JAGANNATHAN BHARADWAJ
发明人： MCAULEY ARNOLD , GHATTYVENKATAKRISHNA PAVAN , ABEL JEFF , HUH JOON , POMPE CORNELIUS , KANAPURAM SEKHAR , TREUHEIT MICHAEL , JAGANNATHAN BHARADWAJ
IPC分类号： A61K20060101
摘要： The present disclosure provides a low pH pharmaceutical composition comprising (a) an antibody constructs comprising a first domain binding to a target cell surface antigen, a second domain binding to a second antigen and preferably a third domain, which is a specific Fc modality, (b) at least one buffer agent, (c) at least one saccharide, and (d) at least one surfactant; and wherein the pH of the pharmaceutical composition is in the range of 3.5 to 6.

2. 发明申请

WO2006065861A2 THERAPEUTIC FORMULATIONS OF KERATINOCYTE GROWTH FACTOR 审中-公开
标题翻译： KERATINOCYTE生长因子的治疗方法
公开(公告)号：WO2006065861A2
公开(公告)日：2006-06-22
申请号：PCT/US2005/045169
申请日：2005-12-12
申请人： AMGEN INC , TREUHEIT, Michael, J. , DHARMAVARAM, Vasumathi , PURTELL, Judith , ROY, Suzanne, E.
发明人： TREUHEIT, Michael, J. , DHARMAVARAM, Vasumathi , PURTELL, Judith , ROY, Suzanne, E.
IPC分类号： A61K38/18 , A61K47/18 , A61K47/26
CPC分类号： A61K9/19 , A61K38/1825 , A61K47/183 , A61K47/26 , C07K14/50
摘要： The present invention provides long-term stable formulations of lyophilized keratinocyte growth factor and methods for making a lyophilized composition comprising keratinocyte growth factor.
摘要翻译：本发明提供了冻干角化细胞生长因子的长期稳定制剂和制备包含角化细胞生长因子的冻干组合物的方法。

3. 发明申请

WO2006065861A3 THERAPEUTIC FORMULATIONS OF KERATINOCYTE GROWTH FACTOR 审中-公开
标题翻译：角化细胞生长因子的治疗方案
公开(公告)号：WO2006065861A3
公开(公告)日：2006-08-17
申请号：PCT/US2005045169
申请日：2005-12-12
申请人： AMGEN INC , TREUHEIT MICHAEL J , DHARMAVARAM VASUMATHI , PURTELL JUDITH , ROY SUZANNE E
发明人： TREUHEIT MICHAEL J , DHARMAVARAM VASUMATHI , PURTELL JUDITH , ROY SUZANNE E
IPC分类号： A61K38/18 , A61K47/18 , A61K47/26
CPC分类号： A61K9/19 , A61K38/1825 , A61K47/183 , A61K47/26 , C07K14/50
摘要： The present invention provides long-term stable formulations of lyophilized keratinocyte growth factor and methods for making a lyophilized composition comprising keratinocyte growth factor.
摘要翻译：本发明提供了冻干角质形成细胞生长因子的长期稳定制剂和制备包含角质形成细胞生长因子的冻干组合物的方法。

4. 发明申请

WO2009015345A1 PHARMACEUTICAL COMPOSITIONS COMPRISING FC FUSION PROTEINS 审中-公开
标题翻译：包含FC融合蛋白的药物组合物
公开(公告)号：WO2009015345A1
公开(公告)日：2009-01-29
申请号：PCT/US2008/071209
申请日：2008-07-25
申请人： AMGEN INC. , TREUHEIT, Michael , RATNASWAMY, Gaya
发明人： TREUHEIT, Michael , RATNASWAMY, Gaya
IPC分类号： A61K9/06 , A61K9/00 , A61K38/00 , A61K39/00 , A61K47/48
CPC分类号： A61K9/0019 , A61K9/08 , A61K39/39591 , A61K47/6835 , C07K16/00 , C07K2319/30
摘要： The invention herein described provides, among other things: methods for making protein formulations based on isoelectric points; protein formulations made by the methods; and uses of the methods and of the protein formulations.
摘要翻译：本文所述的本发明尤其提供了：基于等电点制备蛋白质制剂的方法; 蛋白质制剂的制备方法; 以及方法和蛋白质制剂的使用。

5. 发明申请

WO1998014476A1 PHARMACEUTICAL COMPOSITIONS CONTAINING AN MPL LIGAND 审中-公开
标题翻译：包含MPL配体的药物组合物
公开(公告)号：WO1998014476A1
公开(公告)日：1998-04-09
申请号：PCT/US1997016196
申请日：1997-09-12
申请人： AMGEN INC. , BREMS, David, N. , TREUHEIT, Michael, J.
发明人： AMGEN INC.
IPC分类号： C07K14/52
CPC分类号： C07K14/524 , A61K9/0019 , A61K38/00 , A61K47/02 , A61K47/12 , A61K47/183 , A61K47/22 , A61K47/26
摘要： The subject invention relates to compositions of mpl ligands, comprising a full-length or truncated mpl ligand having a sequence of amino acids corresponding to amino acids 7-151 through 1-332, inclusive, of native human mpl ligand, optionally covalently linked to at least one water-soluble polymer; a buffering agent selected from glutamate, phosphate, histidine, imidazole, and acetate; an excipient selected from sorbitol, sucrose, mannitol, glycerol, polyethylene glycol, and non-polar amino acids; optionally, a detergent or lipid such as Tween; optionally, an antioxidant or chelating agent selected from glutathione, methionine, citrate and EDTA; and having a pH preferably ranging from 5.0 to 6.0 (inclusive). Such compositions may be liquid (preferably, aqueous), frozen (preferably, aqueous), or lyophilized.
摘要翻译：本发明涉及mpl配体的组合物，其包含全长或截短的mpl配体，其具有对应于天然人mpl配体的氨基酸7-151至1-332的氨基酸序列，任选地共价连接到至少一种水溶性聚合物; 选自谷氨酸盐，磷酸盐，组氨酸，咪唑和乙酸盐的缓冲剂; 选自山梨糖醇，蔗糖，甘露糖醇，甘油，聚乙二醇和非极性氨基酸的赋形剂; 任选地，洗涤剂或脂质如吐温; 任选地，选自谷胱甘肽，甲硫氨酸，柠檬酸盐和EDTA的抗氧化剂或螯合剂; 并且pH优选为5.0〜6.0（含）以上。这样的组合物可以是液体（优选水性），冷冻（优选水性）或冻干。

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