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    • 4. 发明申请
    • NOVEL PYRIDOPYRAZINE N-OXIDES
    • 新型吡咯烷腈氧化物
    • WO2008031566A3
    • 2008-09-18
    • PCT/EP2007007912
    • 2007-09-11
    • SYNGENTA PARTICIPATIONS AGSYNGENTA LTDCROWLEY PATRICK JELFLAMBERTH CLEMENSWENDEBORN SEBASTIAN VOLKERTRAH STEPHAN
    • CROWLEY PATRICK JELFLAMBERTH CLEMENSWENDEBORN SEBASTIAN VOLKERTRAH STEPHAN
    • A01N43/90C07D471/04
    • C07D471/04A01N43/90
    • The present invention relates to novel N -oxide derivatives of pyridopyrazines of formula (I) as active ingredients which have microbiocidal activity, in particular fungicidal activity :wherein X is N + -O" and Y is N; or X is N and Y is N + -O"; or X and Y are both N + -O"; R is for example H, halo, cyano, C 1-6 alkyl or C 1-6 alkoxy; R 1 is optionally substituted aryl or heteroaryl; R 2 is for example halo, C 1-8 alkyl, C 3-8 CycloaIkyI, aryl, or heteroaryl; R 3 and R 4 independently of each other are for example H, C 1-8 alkyl, halo(d-8)alkyl, C 2-8 alkenyl, C 2-8 alkynyl or aryl; or R 3 and R 4 together with the nitrogen atom to which they are attached form a C 3-10 alkylene chain or C 3-7 alkenylene chain optionally substituted with halo, C 1-4 alkyl, C 1-4 haloalkyl, C1-4 alkoxy; or R 3 and R 4 together with the nitrogen atom to which they are attached form for example a morpholine, thiomorpholine or thiomorpholine S-oxide ring; or R 3 and R 4 together with the nitrogen atom to which they are attached form a bicyclic annelated or fused ring; and R 7 and R 8 independently of each other are for example H, halo, cyano, C 1-4 alkyl, C 1-4 aIkoxy or halo(C 1-4 )alkyl.
    • 本发明涉及式(I)吡啶并吡嗪的新型N-氧化物衍生物作为具有杀微生物活性,特别是杀真菌活性的活性成分:其中X为N + O,Y为N; 或X为N且Y为N + O“; 或X和Y均为N + O-O“; R为例如H,卤素,氰基,C 1-6烷基或C 1-6烷基, R 1是任选取代的芳基或杂芳基; R 2是例如卤素,C 1-8烷基,C 1-4烷基, 环烷基,芳基或杂芳基; R 3和R 4彼此独立地是例如H,C 1〜 烷基,卤代(C 1-8)烷基,C 2-8链烯基,C 2-8炔基或芳基;或R 3, R 4和R 4与它们所连接的氮原子一起形成C 3-10亚烷基链或C 3-7亚烷基, 任选被卤素取代的亚烯基链,C 1-4烷基,C 1-4卤代烷基,C 1-4烷氧基或R 3和R 3 与它们所连接的氮原子一起形成例如吗啉,硫代吗啉或硫代吗啉S-氧化物环;或R 3和R 4, SUP与它们所连接的氮原子一起形成a 双环环或稠环; R 7和R 8彼此独立地是例如H,卤素,氰基,C 1-4烷基,C 1 -C 4烷基, 1-4烷氧基或卤代(C 1-4烷基)烷基。
    • 5. 发明申请
    • PYRIDAZINE DERIVATIVES
    • 吡啶衍生物
    • WO2008049585A1
    • 2008-05-02
    • PCT/EP2007/009189
    • 2007-10-23
    • SYNGENTA PARTICIPATIONS AGTRAH, StephanLAMBERTH, ClemensWENDEBORN, Sebastian
    • TRAH, StephanLAMBERTH, ClemensWENDEBORN, Sebastian
    • C07D237/08C07D237/12C07D237/14C07D237/18C07D237/04C07D405/04C07D409/04C07D401/04C07D403/04C07D413/04C07D417/04C07D401/12C07D409/12C07D307/60
    • C07D237/14A01N43/58C07D237/08C07D237/12C07D307/60C07D307/79C07D401/04C07D401/12C07D403/04C07D405/04C07D405/12C07D407/04C07D409/04C07D409/12C07D413/04C07D417/04
    • The present invention relates to novel pyridazine derivatives of formula (I) as active ingredients which have microbiocidal activity, in particular fungicidal activity: wherein R 1 is hydrogen, C 1 -C 6 alkyl, C 1 -C 8 haloalkyl or C 3 -C 6 cycloalkyl; R 2 is cycloalkyl, cycloalkylalkyl, halocycloalkyl, cycloalkoxy, halocycloalkoxy, cycloalkylalkoxy, halocycloalkylalkoxy, alkoxyalkyl, cycloalkoxyalkoxyalkyl, haloalkoxyalkyl, trialkylsilyl, alkylthioalkyl, haloalkylthioalkyl, cycloalkylthio, halocycloalkylthio, cycloalkylalkylthio, halocycloalkylalkylthio, alkylsulfinylalkyl, alkylsulfonylalkyl, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, optionally substituted arylsulfonyl, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted arylthio, optionally substituted heteroarylthio; or R 2 together with an adjacent carbon atom forms an optionally substituted fused ring; R 3 is an optionally substituted aryl; R 4 is hydrogen, halogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 8 alkoxy, C 1 -C 6 haloalkoxy, hydroxy or cyano; and n is a whole number from 1 to 4; or an agrochemically usable salt form thereof.
    • 本发明涉及式(I)的新颖哒嗪衍生物作为具有杀微生物活性,特别是杀真菌活性的活性成分:其中R 1是氢,C 1 -C C 1 -C 6烷基,C 1 -C 8卤代烷基或C 3 -C 6烷基, 环烷基; R 2是环烷基,环烷基烷基,卤代环烷基,环烷氧基,卤代环烷氧基,环烷基烷氧基,卤代环烷基烷氧基,烷氧基烷基,环烷氧基烷氧基烷基,卤代烷氧基烷基,三烷基甲硅烷基,烷硫基烷基,卤代烷硫基烷基,环烷硫基,卤代环烷基硫基,环烷基烷硫基,卤代环烷基烷硫基,烷基亚磺酰基烷基, 卤代烷基亚磺酰基,烷基磺酰基,卤代烷基磺酰基,C 2 -C 6亚烷基,C 2 -C 6 - 炔基,任选取代的 芳基磺酰基,任选取代的芳氧基,任选取代的杂芳氧基,任选取代的芳硫基,任选取代的杂芳硫基; 或R 2与相邻碳原子一起形成任选取代的稠合环; R 3是任选取代的芳基; R 4是氢,卤素,C 1 -C 6烷基,C 1 -C 6烷基,C 1 -C 6烷基,C 1 -C 6烷基,C 1 -C 6 - 卤代烷基,C 1 -C 8烷氧基,C 1 -C 6卤代烷氧基,羟基或 氰基; n为1〜4的整数; 或其农业化学上可用的盐形式。
    • 6. 发明申请
    • PESTICIDAL HETEROCYCLIC DIHALOALLYL COMPOUNDS
    • 杀虫剂杂环二氢化合物
    • WO2005068445A3
    • 2005-09-22
    • PCT/EP2005000094
    • 2005-01-07
    • SYNGENTA PARTICIPATIONS AGHALL ROGER GRAHAMTRAH STEPHANZAMBACH WERNERTULEJA JURAJ
    • HALL ROGER GRAHAMTRAH STEPHANZAMBACH WERNERTULEJA JURAJ
    • C07D233/72C07D237/14C07D239/36C07D241/18C07D249/12C07D271/10C07D271/113C07D273/04C07D285/12C07D285/13C07D257/04
    • C07D271/113C07D233/72C07D237/14C07D239/36C07D241/18C07D249/12C07D273/04C07D285/13
    • The invention relates to compounds of formula (I) wherein Het, A1, A2, A3, A4, D, W, T, Q, Y, X1, X2, R1, R2, R3, R4, k and m are as defined hereinabove, and, where applicable, to possible E/Z isomers, mixtures of E/Z isomers and/or tautomers thereof, in each case in free form or in salt form, to a process for the preparation of and to the use of those compounds, E/Z isomers, mixtures of E/Z isomers and/or tautomers, to pesticidal compositions in which the active ingredient has been selected from those compounds, E/Z isomers, mixtures of E/Z isomers and/or tautomers, in each case in free form or in agrochemically usable salt form, to a process for the preparation of and to the use of those compositions, to plant propagation material treated with those compositions, to a method of controlling pests, to intermediates and, where applicable, to possible E/Z isomers, mixtures of E/Z isomers and/or tautomers thereof, in each case in free form or in salt form, for the preparation of those compounds, E/Z isomers, mixtures of E/Z isomers and/or tautomers, and to a process for the preparation of and to the use of those intermediates and, where applicable, possible E/Z isomers, mixtures of E/Z isomers and/or tautomers thereof.
    • 本发明涉及式(I)化合物,其中Het,A1,A2,A3,A4,D,W,T,Q,Y,X1,X2,R1,R2,R3,R4,k和m如上所定义 ,以及(如适用)可能的E / Z异构体,E / Z异构体和/或其互变异构体的混合物,在每种情况下为游离形式或盐形式,用于制备和使用这些化合物的方法 ,E / Z异构体,E / Z异构体和/或互变异构体的混合物,其中活性成分选自那些化合物,E / Z异构体,E / Z异构体和/或互变异构体的混合物的农药组合物 游离形式或农业可用盐形式的情况,制备和使用这些组合物的方法,用这些组合物处理的繁殖材料,控制害虫的方法,中间体以及在适用的情况下 可能的E / Z异构体,E / Z异构体和/或其互变异构体的混合物,在每种情况下为游离形式或盐形式,用于制备那些 磅,E / Z异构体,E / Z异构体和/或互变异构体的混合物,以及制备和使用那些中间体的方法,以及可能的E / Z异构体,E / Z异构体的混合物 和/或其互变异构体。
    • 7. 发明申请
    • DIHALO-ALLYLOXY-PHENOL DERIVATIVES HAVING PESTICIDAL ACTIVITY
    • 具有杀虫活性的二氢 - 全氟代苯酚衍生物
    • WO2004052816A1
    • 2004-06-24
    • PCT/EP2003/014009
    • 2003-12-10
    • SYNGENTA PARTICIPATIONS AGZAMBACH, WernerRENOLD, PeterHALL, Roger, GrahamTRAH, Stephan
    • ZAMBACH, WernerRENOLD, PeterHALL, Roger, GrahamTRAH, Stephan
    • C07C43/225
    • A01N37/34C07C43/225C07C43/23C07C43/315C07C45/29C07C45/71C07C49/255C07C69/76C07C205/32C07C251/40C07C255/37C07C255/41C07C271/16C07C2601/02C07D213/57C07D261/08C07D307/54C07D307/81C07D333/24C07C49/84
    • Compounds of formula (I), wherein A 1 and A 2 are each independently of the other a bond or a C 1 -C 6 alkylene bridge; A 3 is a C 1 -C 6 alkylene bridge; X 1 and X 2 are each independently of the other fluorine, chlorine or bromine; Y is O, NR 7 , S, SO or SO 2 ; R 1 , R 2 and R 3 are each independently of the others, for example, H, halogen, OH, SH, CN, nitro, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkylcarbonyl or C 2 -C 6 alkenyl; Q is O, NR 5 , S, SO or SO 2 ; W is, for example, O, NR 5 or SO; T is for example, a bond, O or NR 5 ; D is CH or N; R 4 is, for example, H, halogen, OH, SH, CN or nitro; R 5 and R 7 are, for example, H, C 1 -C 6 alkyl or C 1 -C 3 haloalkyl; k is 1, 2, 3 or 4; m is 1 or 2; R 10 is a radical which contains O, N or S; R 11 is, for example, H, C 1 -C 12 alkyl or a radical which contains from one to three hetero atoms selected from O, N and S; or R 11 together with R 12 is a bond; R 12 is, for example, H, C 1 -C 6 alkyl, halo-C 1 -C 6 alkyl or C 1 -C 6 alkoxy-C 1 -C 6 -alkyl; and, where applicable, their possible E/Z isomers, E/Z isomeric mixtures and/or tautomers, in each case in free from or in salt form, a process for the preparation of those compounds and their use, pesticidal compositions in which the active ingredient has been selected from those compounds or an agrochemically acceptable salt thereof; a process for the preparation of those compositions and their use, plant propagation material treated with those compositions, and a method of controlling pests.
    • 式(I)化合物,其中A1和A2各自独立地为一个键或C1-C6亚烷基桥; A3是C1-C6亚烷基桥; X1和X2各自独立地为氟,氯或溴; Y是O,NR7,S,SO或SO2; R 1,R 2和R 3各自独立地为H,卤素,OH,SH,CN,硝基,C 1 -C 6烷基,C 1 -C 6卤代烷基,C 1 -C 6烷基羰基或C 2 -C 6烯基; Q是O,NR5,S,SO或SO2; W是例如O,NR5或SO; T为例如O或NR5的键; D是CH或N; R4是例如H,卤素,OH,SH,CN或硝基; R5和R7是例如H,C1-C6烷基或C1-C3卤代烷基; k为1,2,3或4; m为1或2; R10是含有O,N或S的基团; R 11是例如H,C 1 -C 12烷基或含有1至3个选自O,N和S的杂原子的基团; 或R11与R12一起为键; R 12是例如H,C 1 -C 6烷基,卤代-C 1 -C 6烷基或C 1 -C 6烷氧基-C 1 -C 6 - 烷基; 在适用情况下,它们可能的E / Z异构体,E / Z异构体混合物和/或互变异构体在每种情况下不含或以盐形式,制备这些化合物的方法及其用途,其中 从这些化合物或其农业化学上可接受的盐中选择活性成分; 制备这些组合物及其用途的方法,用这些组合物处理的植物繁殖材料以及防治害虫的方法。
    • 8. 发明申请
    • TRIAZOLINE AND ISOXAZOLINE BIS-OXIME DERIVATIVES AND THEIR USE AS PESTICIDES
    • 三唑和异辛唑双异构体衍生物及其作为杀虫剂的用途
    • WO1997002255A1
    • 1997-01-23
    • PCT/EP1996002695
    • 1996-06-21
    • CIBA-GEIGY AGZIEGLER, HugoTRAH, StephanZURFLUH, RenéO'SULLIVAN, Anthony, Cornelius
    • CIBA-GEIGY AG
    • C07D261/12
    • C07D261/10A01N43/647A01N43/80C07C251/52C07C251/58C07C251/60C07C265/12C07C279/18C07C331/28C07C335/18C07D249/12C07D261/12C07D401/12C07D403/12C07D413/12C07D417/12
    • Bis-oxime derivatives of formula (I) in which A is (a) or (b), where W is oxygen or sulfur, and the other substituents defined as follows: R1 = hydrogen, C1-C4alkyl; cyclopropyl; R2 = hydrogen, C1-C6alkyl; halo(C1-C6) alkyl; C2-C6alkoxyalkyl; C3-C6cycloalkyl; substituted or unsubstituted aryl; substituted or unsubstituted heteroaryl; cyano; C1-C6alkoxycarbonyl; C1-C6alkyl-S(O)n; substituted or unsubstituted aryl-S(O)n; C1-C6alkoxy; substituted or unsubstituted aryloxy; substituted or unsubstituted heteroaryloxy; unsubstituted or mono- to trimethyl-substituted heterocyclyl; substituted or unsubstituted aryl-C1-C6alkyl; substituted or unsubstituted heteroaryl-C1-C6alkyl; R3 = hydrogen; C1-C6alkyl; C1-C6haloalkyl having 1 to 5 halogen atoms; C1-C4alkoxy-C1-C2-alkyl; unsubstituted or mono- to trihalo-substituted C1-C6alkenyl; C2-C6alkynyl; unsubstituted or mono- to tetrahalo-substituted C3-C6cycloalkyl-C1-C4alkyl; n = 0 to 2; R8 = H, C1-C4alkyl, C1-C4haloalkyl, C3-C6cycloalkyl; X = OR5, SR5, NR6R7, halogen (especially Cl); R6, R7 = independently of one another H, C1-C4alkyl, C3-C4alkenyl, C3-C4alkynyl; R5 = C1-C4alkyl, C1-C3haloalkyl are fungicidal, acaricidal and insecticidal active ingredients for agriculture. They can be employed as formulated crop protection compositions.
    • 其中A为(a)或(b)的式(I)的双肟衍生物,其中W为氧或硫,其它取代基定义如下:R1 =氢,C1-C4烷基; 环丙基; R2 =氢,C1-C6烷基; 卤代(C 1 -C 6)烷基; C2-C6烷氧基; C3-C6环烷基; 取代或未取代的芳基; 取代或未取代的杂芳基; 氰基; C1-C6烷氧基羰; C1-C6烷基-S(O)n表示 取代或未取代的芳基-S(O)n; C1-C6烷氧基; 取代或未取代的芳氧基; 取代或未取代的杂芳氧基; 未取代或单 - 三甲基取代的杂环基; 取代或未取代的芳基-C 1 -C 6烷基; 取代或未取代的杂芳基-C 1 -C 6烷基; R3 =氢; C1-C6烷基; 具有1至5个卤素原子的C 1 -C 6卤代烷基; C1-C4烷氧基,C1-C2烷基; 未取代或单 - 三卤代取代的C 1 -C 6烯基; C2-C6炔基; 未取代或单 - 四卤代取代的C 3 -C 6环烷基-C 1 -C 4烷基; n = 0〜2; R8 = H,C1-C4烷基,C1-C4卤代烷基,C3-C6环烷基; X = OR5,SR5,NR6R7,卤素(特别是Cl); R6,R7 =彼此独立地为H,C1-C4烷基,C3-C4链烯基,C3-C4炔基; R5 = C1-C4烷基,C1-C3卤代烷基是农业的杀真菌剂,杀螨剂和杀虫活性成分。 它们可以用作配制的作物保护组合物。
    • 9. 发明申请
    • PESTICIDES
    • 农药
    • WO1995018789A1
    • 1995-07-13
    • PCT/EP1994004318
    • 1994-12-27
    • CIBA-GEIGY AGZIEGLER, HugoTRAH, StephanFAROOQ, SaleemZURFLÜH, René
    • CIBA-GEIGY AG
    • C07C251/60
    • C07D213/77A01N37/36A01N37/50A01N43/28A01N43/30A01N43/36A01N43/40A01N43/46A01N43/653A01N43/84A01N55/00C07C251/60C07C251/76C07C251/80C07C255/54C07C255/61C07C2601/02C07D231/12C07D233/56C07D249/08C07D295/088C07D295/30C07D317/18C07D317/58C07D333/22
    • Compounds of formula (I) and the isomers, and isomer mixtures thereof, which are possible, in which either a) X is an N atom and Y is OR11 or N(R12)R13, or b) X is CH and Y is OR11, and in which furthermore: R11 is C1-C4alkyl; R12 and R13, independently, are hydrogen or C1-C4alkyl; A is an O atom or the group NR4; R1 is hydrogen, C1-C4alkyl, halo-C1-C4alkyl, cyclopropyl, cyano or methylthio; R2 is hydrogen, C1-C6alkyl, C3-C6cycloalkyl, a group (i), a group (ii), or thienyl; R3 is hydrogen, C1-C6alkyl, C1-C6haloalkyl having 1 to 5 halogen atoms, C1-C4alkoxy-C1-C2alkyl, C2-C4alkenyl-C1-C2alkyl, which is unsubstituted or substituted by 1 to 3 halogen atoms, C2-C4alkynyl-C1-C2-alkyl, C3-C6cycloalkyl which is unsubstituted or substituted by 1 to 4 halogen atoms, C3-C6-cycloalkyl-C1-C4alkyl which is unsubstituted or substituted by 1 to 4 halogen atoms, cyano-C1-C4alkyl; C1-C4alkoxycarbonyl-C1-C2alkyl, C1-C4alkoxycarbamoyl-C1-C2alkyl, phenyl-C1-C3alkyl which is unsubstituted or substituted by halogen, C1-C3alkyl, C1-C4alkoxy, C1-C4haloalkyl, cyano, nitro or C1-C4alkylenedioxy, it being possible for the phenyl group to be monosubstituted to trisubstituted by identical or different substituents; phenyl which is unsubstituted or mono- to disubstituted, independently, by C1-C4alkyl, C1-C4alkoxy, halogen, C1-C2haloalkyl having 1 to 3 halogen atoms, nitro or cyano, or pyridyl which is unsubstituted or mono- to disubstituted, independently, by C1-C4alkyl, C1-C4alkoxy, halogen, C1-C2haloalkyl having 1 to 3 halogen atoms, nitro or cyano; R4 is C1-C4alkyl, phenyl, or R3 and R4 together with the nitrogen atom to which they are bonded form a saturated or unsaturated 5- to 7-membered ring which is unsubstituted or substituted by C1-C4alkyl and which can have 1 to 3 additional hetero atoms selected from amongst N, O and S, and in which the substituents Z, B, D and n are as defined in the present publication, are pesticidal active ingredients. They can be used for pest control, in particular as microbicides, insecticides and acaricides in agriculture, horticulture and in the hygiene sector.
    • 其中a)X为N原子,Y为OR 11或N(R 12)R 13或b)X为CH且Y为OR 11的式(I)化合物及其异构体及其异构体混合物, ,此外:R 11是C 1 -C 4烷基; R 12和R 13独立地是氢或C 1 -C 4烷基; A是O原子或NR4基团; R1是氢,C1-C4烷基,卤代-C1-C4烷基,环丙基,氰基或甲硫基; R2是氢,C1-C6烷基,C3-C6环烷基,基团(ⅰ),基团(ⅱ)或噻吩基; R3是氢,C1-C6烷基,具有1-5个卤素原子的C1-C6卤代烷基,C1-C4烷氧基C1-C2烷基,未被取代或被1-3个卤素原子取代的C2-C4链烯基C1-C2烷基,C2-C4炔基 - C 1 -C 2烷基,未被取代或被1至4个卤素原子取代的C 3 -C 6环烷基,未被取代或被1至4个卤素原子取代的C 3 -C 6环烷基-C 1 -C 4烷基,氰基-C 1 -C 4烷基; C 1 -C 4烷氧基羰基-C 1 -C 2烷基,C 1 -C 4烷氧基氨基甲酰基-C 1 -C 2烷基,未被取代或被卤素,C 1 -C 3烷基,C 1 -C 4烷氧基,C 1 -C 4卤代烷基,氰基,硝基或C 1 -C 4亚烷基二氧基取代的苯基-C 1 -C 3烷基 苯基可被相同或不同取代基单取代三取代; 苯基,其未被取代或独立地被C 1 -C 4烷基,C 1 -C 4烷氧基,卤素,具有1至3个卤素原子的C 1 -C 2卤代烷基,硝基或氰基或未取代或单取代的吡啶基, C 1 -C 4烷基,C 1 -C 4烷氧基,卤素,具有1至3个卤素原子的C 1 -C 2卤代烷基,硝基或氰基; R4是C1-C4烷基,苯基或R3和R4与它们所键合的氮原子一起形成饱和或不饱和的5-至7-元环,其未被取代或被C 1 -C 4烷基取代,并且可以具有1至3个 选自N,O和S,并且其中取代基Z,B,D和n如本出版物中所定义的另外的杂原子是杀虫活性成分。 它们可以用于害虫控制,特别是作为农业,园艺和卫生领域的杀菌剂,杀虫剂和杀螨剂。