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1. 发明申请

WO2011094259A3 CD127 BINDING PROTEINS 审中-公开
标题翻译： CD127结合蛋白
公开(公告)号：WO2011094259A3
公开(公告)日：2011-09-29
申请号：PCT/US2011022507
申请日：2011-01-26
申请人： GLAXO GROUP LTD , KIRBY IAN , TAYLOR ALEXANDER H , WEBB THOMAS MATTHEW , XUE YU
发明人： KIRBY IAN , TAYLOR ALEXANDER H , WEBB THOMAS MATTHEW , XUE YU
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/24 , C07K2317/76 , C07K2317/92
摘要： Antigen binding proteins which bind to human IL-7 receptor (CD127) are provided. The antigen binding proteins are typically antibodies, and are useful in the treatment of diseases or disorders in humans, particularly autoimmune diseases such as multiple sclerosis.
摘要翻译：提供了结合人IL-7受体（CD127）的抗原结合蛋白。抗原结合蛋白通常是抗体，并且可用于治疗人类疾病或病症，特别是自身免疫性疾病如多发性硬化症。

2. 发明申请

WO2008079943A3 NOVEL METHODS 审中-公开
标题翻译：新方法
公开(公告)号：WO2008079943A3
公开(公告)日：2008-11-06
申请号：PCT/US2007088310
申请日：2007-12-20
申请人： SMITHKLINE BEECHAM CORP , TAYLOR ALEXANDER H , KRISHNA DELFI
发明人： TAYLOR ALEXANDER H , KRISHNA DELFI
IPC分类号： C12N15/09 , C12N15/00 , C12N15/63
CPC分类号： C12N15/1082 , C12N15/1086
摘要： The present invention provides methods for site-specifically integrating at least one first nucleic acid into a genome of at least one cell, comprising: transforming said genome with a reporter nucleic acid construct that is linked to a first att site; selecting at least one first transformed cell having at least one integrated reporter nucleic acid construct; introducing said at least one first nucleic acid and a homologous recombination mediating enzyme into said cell wherein said at least one first nucleic acid comprises at least one second att site that is complementary to said first att site; and maintaining said cell under conditions sufficient for said at least one first nucleic acid to integrate into said first att site producing at least one stably intergrated cell.
摘要翻译：本发明提供了用于将至少一种第一核酸位点特异性整合到至少一种细胞的基因组中的方法，包括：用与第一att位点连接的报道核酸构建体转化所述基因组; 选择具有至少一个整合的报道子核酸构建体的至少一个第一转化细胞; 将所述至少一种第一核酸和同源重组介导酶导入所述细胞中，其中所述至少一种第一核酸包含与所述第一att位点互补的至少一个第二att位点; 并且将所述细胞保持在足以使所述至少一种第一核酸整合到所述第一att位点的条件下，从而产生至少一个稳定整合的细胞。

3. 发明申请

WO2008079943A2 NOVEL METHODS 审中-公开
标题翻译：新方法
公开(公告)号：WO2008079943A2
公开(公告)日：2008-07-03
申请号：PCT/US2007/088310
申请日：2007-12-20
申请人： SMITHKLINE BEECHAM CORPORATION , TAYLOR, Alexander, H. , KRISHNA, Delfi
发明人： TAYLOR, Alexander, H. , KRISHNA, Delfi
IPC分类号： C12N15/74
CPC分类号： C12N15/1082 , C12N15/1086
摘要： The present invention provides methods for site-specifically integrating at least one first nucleic acid into a genome of at least one cell, comprising: transforming said genome with a reporter nucleic acid construct that is linked to a first att site; selecting at least one first transformed cell having at least one integrated reporter nucleic acid construct; introducing said at least one first nucleic acid and a homologous recombination mediating enzyme into said cell wherein said at least one first nucleic acid comprises at least one second att site that is complementary to said first att site; and maintaining said cell under conditions sufficient for said at least one first nucleic acid to integrate into said first att site producing at least one stably intergrated cell.
摘要翻译：本发明提供了将至少一种第一核酸位点特异性整合至至少一种细胞的基因组的方法，所述方法包括：用连接到第一att位点的报道核酸构建体转化所述基因组; 选择至少一个具有至少一个整合的报告核酸构建体的第一转化细胞; 将所述至少一种第一核酸和同源重组介导酶引入所述细胞中，其中所述至少一种第一核酸包含与所述第一att位点互补的至少一个第二att位点; 以及在足以使所述至少一种第一核酸整合入所述第一att位点的条件下维持所述细胞，产生至少一个稳定整合的细胞。

4. 发明申请

WO2012031198A3 NOVEL ANTIGEN BINDING PROTEINS 审中-公开
公开(公告)号：WO2012031198A3
公开(公告)日：2012-03-08
申请号：PCT/US2011/050322
申请日：2011-09-02
申请人： GLAXO GROUP LIMITED , CLARKE, Neil, James , JOHANSON, Kyung, Oh , JONAK, Zdenka, Ludmila , TAYLOR, Alexander, H. , HOPSON, Christopher, B. , TRULLI, Stephen, H. , HASKOVA, Zdenka , LEE, Judithann, M. , WHITE, John, R. , XUE, Yu
发明人： CLARKE, Neil, James , JOHANSON, Kyung, Oh , JONAK, Zdenka, Ludmila , TAYLOR, Alexander, H. , HOPSON, Christopher, B. , TRULLI, Stephen, H. , HASKOVA, Zdenka , LEE, Judithann, M. , WHITE, John, R. , XUE, Yu
IPC分类号： C07K16/18 , C12P21/08 , C07H21/00
摘要： The present disclosure relates to antigen binding proteins, such as antibodies, that bind to HER3, polynucleotides encoding such antigen binding proteins, pharmaceutical compositions comprising said antigen binding proteins and methods of manufacture. The present disclosure also concerns the use of such antigen binding proteins in the treatment or prophylaxis of diseases associated with breast cancer, ovarian cancer, prostate cancer, bladder cancer, pancreatic, gastric, melanoma and other cancers that overexpress HER3.

5. 发明申请

WO2010099195A1 HOST CELLS AND METHODS OF USE 审中-公开
标题翻译：宿主细胞和使用方法
公开(公告)号：WO2010099195A1
公开(公告)日：2010-09-02
申请号：PCT/US2010/025223
申请日：2010-02-24
申请人： GLAXOSMITHKLINE LLC. , JIN, Yong, Hwan , JOWETT, James, D. , TAYLOR, Alexander, H. , ZHU, Yuan
发明人： JIN, Yong, Hwan , JOWETT, James, D. , TAYLOR, Alexander, H. , ZHU, Yuan
IPC分类号： C12N1/00 , C07H21/04
CPC分类号： C12N15/815 , C07K14/605 , C07K2319/31 , C12N9/1051 , C12N9/60
摘要： The present invention provides genetically modified Pichia strains wherein at least one nucleic acid sequence encoding a functional gene product and/or at least one nucleic acid sequence necessary for expression of at least one functional gene product in said Pichia strain is genetically modified, wherein said gene product is responsible for proteolysis and/or glycosylation in said genetically modified Pichia strain. In particular, Pichia strains are provided wherein nucleic acid sequence encoding a functional gene product or expression of said gene product are genetically modified: PEP 4 , PRBl, YPSl , YPS2 , YMPl , YMP2 , YMP 3 and PMT4 . Also provided herein are genetically modified host cells wherein wild type parent of said genetically modified host cell comprises a gene encoding a polypeptide having at least 60% sequence identity to amino acids 1-865 of SEQ ID NO:4, SEQ ID NO:6 and SEQ ID NO: 8 wherein said gene is genetically modified in the genome of said host cell such that the gene product is reduced or eliminated in said genetically modified host cell compared with said wild type host cell.
摘要翻译：本发明提供了遗传修饰的毕赤酵母菌株，其中至少一个编码功能性基因产物的核酸序列和/或在所述毕赤酵母属菌株中表达至少一种功能性基因产物所必需的至少一种核酸序列被遗传修饰，其中所述基因产物负责所述遗传修饰的毕赤酵母菌株中的蛋白水解和/或糖基化。特别地，提供了毕赤酵母菌株，其中编码功能性基因产物的核酸序列或所述基因产物的表达被遗传修饰：PEP4，PRB1，YPS1，YPS2，YMP1，YMP2，YMP3和PMT4。本文还提供遗传修饰的宿主细胞，其中所述经遗传修饰的宿主细胞的野生型亲本包含编码与SEQ ID NO：4，SEQ ID NO：6的氨基酸1-865至少60％序列同一性的多肽的基因和 SEQ ID NO：8，其中所述基因在所述宿主细胞的基因组中被遗传修饰，使得与所述野生型宿主细胞相比，在所述遗传修饰的宿主细胞中基因产物被还原或消除。

6. 发明申请

WO2009023760A1 NOVEL METHODS AND CELL LINES 审中-公开
标题翻译：新的方法和细胞系
公开(公告)号：WO2009023760A1
公开(公告)日：2009-02-19
申请号：PCT/US2008/073114
申请日：2008-08-14
申请人： SMITHKLINE BEECHAN CORPORATION , TAYLOR, Alexander, H. , ZHU, Yuan
发明人： TAYLOR, Alexander, H. , ZHU, Yuan
IPC分类号： C12N5/02 , C12P21/00
CPC分类号： C07K16/18 , C07K16/00 , C07K16/248 , C12N2510/02
摘要： This invention relates to fermentation processes for producing antibodies and other antigen binding compounds. Specifically, the present invention provides methods for increasing the specific productivity of an antibody produced in cell culture, increasing cell growth and increasing viability of cells in cell culture. Also provided are, expression stable, viable cell lines comprising DNA encoding adenovirus GAM1 and capable of producing a monoclonal antibody or fragment and/or variant thereof.
摘要翻译：本发明涉及产生抗体和其他抗原结合化合物的发酵方法。具体而言，本发明提供了增加细胞培养中产生的抗体的比生产率，增加细胞生长和增加细胞培养中的细胞活力的方法。还提供了表达稳定的活细胞系，其包含编码腺病毒GAM1的DNA并且能够产生单克隆抗体或其片段和/或变体。

7. 发明申请

WO2004078936A2 METHODS FOR PREVENTING GLUCONOYLATION OF PROTEINS 审中-公开
标题翻译：防止蛋白质葡萄糖化的方法
公开(公告)号：WO2004078936A2
公开(公告)日：2004-09-16
申请号：PCT/US2004/006507
申请日：2004-03-04
申请人： SMITHKLINE BEECHAM CORPORATION , GARDNER, Alan, R. , SWEITZER, Thomas, D. , TAYLOR, Alexander, H. , PATEL, Pramathesh, S.
发明人： GARDNER, Alan, R. , SWEITZER, Thomas, D. , TAYLOR, Alexander, H. , PATEL, Pramathesh, S.
IPC分类号： C12N
CPC分类号： C07K14/54 , C12N9/18 , C12P21/00
摘要： The present invention relates to method of preventing glyconoylation of polypeptides produced in microorganisms.
摘要翻译：本发明涉及防止微生物中产生的多肽的糖基化反应的方法。

8. 发明申请

WO2012031198A2 NOVEL ANTIGEN BINDING PROTEINS 审中-公开
标题翻译：新型抗原蛋白结合蛋白
公开(公告)号：WO2012031198A2
公开(公告)日：2012-03-08
申请号：PCT/US2011050322
申请日：2011-09-02
申请人： GLAXO GROUP LTD , CLARKE NEIL JAMES , JOHANSON KYUNG OH , JONAK ZDENKA LUDMILA , TAYLOR ALEXANDER H , HOPSON CHRISTOPHER B , TRULLI STEPHEN H , HASKOVA ZDENKA , LEE JUDITHANN M , WHITE JOHN R , XUE YU
发明人： CLARKE NEIL JAMES , JOHANSON KYUNG OH , JONAK ZDENKA LUDMILA , TAYLOR ALEXANDER H , HOPSON CHRISTOPHER B , TRULLI STEPHEN H , HASKOVA ZDENKA , LEE JUDITHANN M , WHITE JOHN R , XUE YU
IPC分类号： A61K39/395
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/32 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92
摘要： The present disclosure relates to antigen binding proteins, such as antibodies, that bind to HER3, polynucleotides encoding such antigen binding proteins, pharmaceutical compositions comprising said antigen binding proteins and methods of manufacture. The present disclosure also concerns the use of such antigen binding proteins in the treatment or prophylaxis of diseases associated with breast cancer, ovarian cancer, prostate cancer, bladder cancer, pancreatic, gastric, melanoma and other cancers that overexpress HER3.
摘要翻译：本公开涉及结合HER3的抗原结合蛋白，例如抗体，编码这种抗原结合蛋白的多核苷酸，包含所述抗原结合蛋白的药物组合物和制备方法。本公开还涉及这种抗原结合蛋白在治疗或预防与乳腺癌，卵巢癌，前列腺癌，膀胱癌，胰腺，胃癌，黑素瘤和其它过表达HER3的癌症相关的疾病中的用途。

9. 发明申请

WO2011094259A2 CD127 BINDING PROTEINS 审中-公开
标题翻译： CD127结合蛋白
公开(公告)号：WO2011094259A2
公开(公告)日：2011-08-04
申请号：PCT/US2011/022507
申请日：2011-01-26
申请人： GLAXO GROUP LIMITED , KIRBY, Ian , TAYLOR, Alexander, H. , WEBB, Thomas, Matthew , XUE, Yu
发明人： KIRBY, Ian , TAYLOR, Alexander, H. , WEBB, Thomas, Matthew , XUE, Yu
IPC分类号： A61K39/395 , C07K16/00 , C07H21/04 , C12N15/63 , C12N1/21 , C12N5/10 , C12P21/08 , A61P37/06 , A61P29/00
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/24 , C07K2317/76 , C07K2317/92
摘要： Antigen binding proteins which bind to human IL-7 receptor (CD127) are provided. The antigen binding proteins are typically antibodies, and are useful in the treatment of diseases or disorders in humans, particularly autoimmune diseases such as multiple sclerosis.
摘要翻译：提供了结合人IL-7受体（CD127）的抗原结合蛋白。抗原结合蛋白通常是抗体，并且可用于治疗人的疾病或病症，特别是自身免疫疾病如多发性硬化症。

10. 发明申请

WO2004078936A3 METHODS FOR PREVENTING GLUCONOYLATION OF PROTEINS 审中-公开
标题翻译：防止蛋白质葡萄糖化的方法
公开(公告)号：WO2004078936A3
公开(公告)日：2006-02-16
申请号：PCT/US2004006507
申请日：2004-03-04
申请人： SMITHKLINE BEECHAM CORP , GARDNER ALAN R , SWEITZER THOMAS D , TAYLOR ALEXANDER H , PATEL PRAMATHESH S
发明人： GARDNER ALAN R , SWEITZER THOMAS D , TAYLOR ALEXANDER H , PATEL PRAMATHESH S
IPC分类号： H01L27/14 , C07K14/54 , C12N20060101 , C12N1/00 , C12N1/20 , C12N1/21 , C12N9/18 , C12N15/55 , C12P21/00 , C12P21/02 , H01L21/56 , H01L21/60 , H01L27/148 , H01L31/02 , C12N9/14 , C07H21/04 , C12N9/16 , C12N15/00
CPC分类号： C07K14/54 , C12N9/18 , C12P21/00
摘要： The present invention relates to method of preventing glyconoylation of polypeptides produced in microorganisms.
摘要翻译：本发明涉及防止微生物中产生的多肽的糖基化反应的方法。

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