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1. 发明申请

WO2011084046A1 ANTI-OBESITY AND ANTI-DYSLIPIDEMIC EFFECTS OF OIL PALM PHENOLICS IN PREVENTING ATHEROSCLEROSIS AND CARDIOVASCULAR DISEASE 审中-公开
标题翻译：油棕榈酚在预防甲状腺功能亢进和心血管疾病中的抗生素和抗血小板效应
公开(公告)号：WO2011084046A1
公开(公告)日：2011-07-14
申请号：PCT/MY2011/000002
申请日：2011-01-07
申请人： MALAYSIAN PALM OIL BOARD , SAMBANTHAMURTHI, Ravigadevi , TAN, Yew Ai , P. MANICKAM, Kalyana, Sundram , WAHID, Mohd, Basri
发明人： SAMBANTHAMURTHI, Ravigadevi , TAN, Yew Ai , P. MANICKAM, Kalyana, Sundram , WAHID, Mohd, Basri
IPC分类号： A61K36/889 , A61P3/06 , A61K31/05 , A61P9/10
CPC分类号： A61K36/889 , A61K31/05
摘要： Water-soluble phenolics from the oil palm (Elaeis guineensis) possess significant antioxidant and health-promoting properties. This invention documents the effects of administering oil palm phenolics to mice, with the aim of identifying whether these compounds possess significant anti-obesity or anti-dyslipidemics properties for the prevention of atherosclerosis and cardiovascular disease. We first explored the gene expression changes caused by oil palm phenolics in livers of mice given a low-fat normal diet, in which fatty acid beta oxidation genes were up-regulated while five cholesterol biosynthesis genes were down-regulated. In addition, the weight gain of mice given oil palm palm phenolics was delayed, suggesting that oil palm phenolics may play a role in delaying the onset of obesity. Using Illumina microarrays, we found that the atherogenic diet caused oxidative stress, up-regulated the inflammatory response and increased the turnover of metabolites and cells in the liver, spleen and heart. In contrast, we found that oil palm phenolics showed signs of attenuating the effects of the atherogenic diet in mice. The extract increased unfolded protein response in the liver, while attenuated antigen presentation and processing in the spleen. Oil palm phenolics also increased the expression of antioxidant genes in the heart. A majority of the genes regulated by oil palm phenolics in the different organs showed a difference in direction of regulation when compared to the atherogenic diet.
摘要翻译：来自油棕（Elaeis guineensis）的水溶性酚类具有显着的抗氧化和促进健康的性质。本发明记录了给予棕榈油酚醛树脂对小鼠的作用，目的是鉴定这些化合物是否具有显着的抗肥胖症或抗血脂异常特性以预防动脉粥样硬化和心血管疾病。我们首先探讨了脂肪酸β氧化基因在脂肪酸β氧化基因上调，而五种胆固醇生物合成基因下调的小鼠肝脏中油棕酚类物质引起的基因表达变化。此外，给予油棕榈酚酚的小鼠的体重增加被延迟，这表明油棕榈酚可能在延缓肥胖发作中起作用。使用Illumina微阵列，我们发现致动脉粥样化饮食导致氧化应激，上调了炎症反应，增加了肝脏，脾脏和心脏中代谢物和细胞的周转。相比之下，我们发现油棕酚酚酸显示出减弱动脉粥样硬化饮食对小鼠的影响的迹象。提取物增加了肝脏中未折叠的蛋白质反应，同时减弱了脾脏中的抗原呈递和加工。油棕榈酚类也增加了抗氧化基因在心脏中的表达。与致动脉粥样化饮食相比，不同器官中油棕榈酚调节的大多数基因显示出调节方向的差异。

2. 发明申请

WO2010134799A1 COMPOSITIONS COMPRISING COMPOUNDS FROM PALM OIL MILL EFFLUENTS FOR USE IN THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES 审中-公开
标题翻译：包含来自棕榈油的化合物的组合物用于预防和治疗心血管疾病的用途
公开(公告)号：WO2010134799A1
公开(公告)日：2010-11-25
申请号：PCT/MY2010/000081
申请日：2010-05-18
申请人： MALAYSIAN PALM OIL BOARD , HJ CHE IDRIS, Hjh Che Anishas , BALASUNDRAM, Nagendran , SAMBANTHAMURTHI, Ravigadevi , TAN, Yew Ai , P. MANICKAM, Kalyana Sundram , WAHID, Mohd Basri
发明人： HJ CHE IDRIS, Hjh Che Anishas , BALASUNDRAM, Nagendran , SAMBANTHAMURTHI, Ravigadevi , TAN, Yew Ai , P. MANICKAM, Kalyana Sundram , WAHID, Mohd Basri
IPC分类号： A61K36/889 , A61P9/00 , A61P9/10
CPC分类号： A61K36/889 , A61K31/192 , A61K31/353 , A61K31/355 , A61K2300/00
摘要： The invention provides a composition the prevention and treatment of cardiovascular disease, wherein said composition compounds obtained from palm oil mill effluents, in particular from vegetative liquor from the milling of palm oil fruit.
摘要翻译：本发明提供了预防和治疗心血管疾病的组合物，其中所述从棕榈油研磨废水获得的组合物化合物，特别是来自研磨棕榈油果实的营养液。

3. 发明申请

WO2009072862A3 AN ANTIMICROBIAL COMPOSITION BASED ON BOTANICAL EXTRACTS FROM OIL PALM VEGETATION LIQUOR 审中-公开
标题翻译：基于油棕榈植物提取物的抗微生物组合物
公开(公告)号：WO2009072862A3
公开(公告)日：2009-10-15
申请号：PCT/MY2008000177
申请日：2008-12-05
申请人： MALAYSIAN PALM OIL BOARD , RAVIGADEVI SAMBANTHAMURTHI , TAN YEW AI
发明人： RAVIGADEVI SAMBANTHAMURTHI , TAN YEW AI
IPC分类号： A01N65/00 , A01P1/00
CPC分类号： A01N65/00
摘要： The present invention provides an antimicrobial composition comprising compounds extracted from the vegetation liquor of the palm oil milling process has been suggested. This composition is rich in antioxidants and exhibits enhanced antimicrobial activity and bactericidal effect against a number of micro-organisms.
摘要翻译：本发明提供了一种抗菌组合物，其包含从棕榈油研磨方法的植物液中提取的化合物。这种组合物具有丰富的抗氧化剂，并且对许多微生物表现出增强的抗微生物活性和杀菌作用。

4. 发明申请

WO2010087693A1 COMPOSITION COMPRISING OIL PALM PHENOLICS FOR USE IN PROVIDING NEUROPROTECTIVE EFFECTS AND COGNITIVE-ENHANCEMENT 审中-公开
标题翻译：包含油棕榈酚的组合物用于提供神经保护作用和认知增强
公开(公告)号：WO2010087693A1
公开(公告)日：2010-08-05
申请号：PCT/MY2010/000019
申请日：2010-01-29
申请人： MALAYSIAN PALM OIL BOARD , SAMBANTHAMURTHI, Ravigadevi , LEOW, Soon-Sen , TAN, Yew Ai , P. MANICKAM, Kalyana, Sundram , WAHID, Mohd, Basri
发明人： SAMBANTHAMURTHI, Ravigadevi , LEOW, Soon-Sen , TAN, Yew Ai , P. MANICKAM, Kalyana, Sundram , WAHID, Mohd, Basri
IPC分类号： A61K36/889 , A61K31/05 , A61P25/28 , A61P25/16
CPC分类号： A23L33/105 , A23V2002/00 , A23V2200/322 , A23V2250/21
摘要： The present invention relates to a composition comprising oil palm phenolics for use in providing neuroprotective effects and improving cognitive and motor functions abilities.
摘要翻译：本发明涉及包含油棕酚类的组合物，其用于提供神经保护作用并改善认知和运动功能。

5. 发明申请

WO2009072862A2 AN ANTIMICROBIAL COMPOSITION BASED ON BOTANICAL EXTRACTS FROM OIL PALM VEGETATION LIQUOR 审中-公开
标题翻译：基于油棕植物液提取物的抗菌组合物
公开(公告)号：WO2009072862A2
公开(公告)日：2009-06-11
申请号：PCT/MY2008/000177
申请日：2008-12-05
申请人： MALAYSIAN PALM OIL BOARD , RAVIGADEVI, Sambanthamurthi , TAN, Yew Ai
发明人： RAVIGADEVI, Sambanthamurthi , TAN, Yew Ai
IPC分类号： A01N65/00 , A01P1/00
CPC分类号： A01N65/00
摘要： The present invention provides an antimicrobial composition comprising compounds extracted from the vegetation liquor of the palm oil milling process has been suggested. This composition is rich in antioxidants and exhibits enhanced antimicrobial activity and bactericidal effect against a number of micro-organisms.
摘要翻译：本发明提供了包含从棕榈油碾磨过程的植物液中提取的化合物的抗微生物组合物。这种组合物含有丰富的抗氧化剂，并且对多种微生物具有增强的抗微生物活性和杀菌作用。

6. 发明申请

WO2012067491A3 COMPOSITIONS COMPRISING EXTRACTS OBTAINED FROM OIL PALM BASED MATERIALS FOR PROVIDING ANTI -INFLAMMATORY EFFECTS AND METHOD OF PRODUCING THEREOF 审中-公开
公开(公告)号：WO2012067491A3
公开(公告)日：2012-05-24
申请号：PCT/MY2011/000234
申请日：2011-11-16
申请人： MALAYSIAN PALM OIL BOARD , KANG, Hyun , RHA, Chokyun , SAMBANTHAMURTHI, Ravigadevi , J SINSKEY, Anthony , TAN, Yew Ai , MANICKAM, Kalyana Sundram , WAHID, Mohd Basri
发明人： KANG, Hyun , RHA, Chokyun , SAMBANTHAMURTHI, Ravigadevi , J SINSKEY, Anthony , TAN, Yew Ai , MANICKAM, Kalyana Sundram , WAHID, Mohd Basri
IPC分类号： A61K36/889 , A61K9/20 , A61K9/48 , A61P29/00
摘要： The present invention provides compositions and method for production of a composition used to provide anti-inflammatory effects on microglial cells in the brain. The composition comprises extracts obtained from oil palm based materials.

7. 发明申请

WO2011159144A1 COMPOSITIONS COMPRISING SHIKIMIC ACID OBTAINED FROM OIL PALM BASED MATERIALS AND METHOD OF PRODUCING THEREOF 审中-公开
标题翻译：包含从基于棕榈的材料获得的活性酸的组合物及其生产方法
公开(公告)号：WO2011159144A1
公开(公告)日：2011-12-22
申请号：PCT/MY2011/000097
申请日：2011-06-16
申请人： MALAYSIAN PALM OIL BOARD , TG Sambandan , RHA, ChoKyun , SAMBANTHAMURTHI, Ravigadevi , J SINSKEY, Anthony , TAN Yew Ai , P. MANICKAM, Kalyana Sundram , WAHID, Mohd Basri
发明人： TG Sambandan , RHA, ChoKyun , SAMBANTHAMURTHI, Ravigadevi , J SINSKEY, Anthony , TAN Yew Ai , P. MANICKAM, Kalyana Sundram , WAHID, Mohd Basri
IPC分类号： C07C62/32
CPC分类号： C07C51/50 , C07C51/42 , C07C51/48 , C07C2101/16 , C07C2601/16 , C12N9/1092 , C12Y205/01019 , C07C62/32
摘要： The present invention provides compositions and method for production of shikimic acid based on extracts obtained from oil palm-based materials, and more particularly oil palm based waste materials and by-products. The method includes purifying shikimic acid from extracts comprising oil palm phenolics (OPP).
摘要翻译：本发明提供了基于由油棕基材料提取的提取物，特别是油棕基废料和副产物的莽草酸生产组合物和方法。该方法包括从包含油棕榈酚（OPP）的提取物中纯化莽草酸。

8. 发明申请

WO2010137943A1 COMPOSITION COMPRISING CAFFEOYLSHIKIMIC ACIDS, PROTOCATECHUIC ACID, HYDROXYTYROSOL, HYDROXYBENZOIC ACID AND THEIR DERIVATIVES AND METHOD OF PREPARATION THEREOF 审中-公开
标题翻译：包含CAFFEOYLSHIICIC酸，丙酸酸，羟基苯甲酸，羟基苯甲酸及其衍生物的组合物及其制备方法
公开(公告)号：WO2010137943A1
公开(公告)日：2010-12-02
申请号：PCT/MY2010/000089
申请日：2010-05-26
申请人： MALAYSIAN PALM OIL BOARD , SAMBANDAN, T., J. , RHA, Chokyun , ANTHONY, J., Sinskey , SAMBANTHAMURTHI, Ravigadevi , TAN, Yew, Ai , P. MANICKAM, Kalyana, Sundram , WAHID, Mohd, Basri
发明人： SAMBANDAN, T., J. , RHA, Chokyun , ANTHONY, J., Sinskey , SAMBANTHAMURTHI, Ravigadevi , TAN, Yew, Ai , P. MANICKAM, Kalyana, Sundram , WAHID, Mohd, Basri
IPC分类号： C07C69/618 , C07C39/11 , A61K36/889 , C07C65/03
CPC分类号： A61K36/889
摘要： The present invention discloses a composition comprising caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, said caffeoylshikimic acids and their derivatives extracted from any part of oil palm including but not confined to the vegetation liquor of palm oil milling and palm oil mill effluent, and a method for use in the preparation of a composition containing caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, said caffeoylshikimic acids and their derivatives „ said method comprising the steps of pre-concentrating an extract containing said caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, said caffeoylshikimic acids and their derivatives and isolating said caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, said caffeoylshikimic acids and their derivatives from said extract by liquid chromatography, wherein the elution activity of said caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, said caffeoylshikimic acids and their derivatives vary depending on the stationaryphase and the composition of the mobile phase. In the present example, elution of the fractions containing Caffeoylshikimic acid occurs between 40 and 48 minutes with C18 column and a gradient mobile phase containing 0.1% TF A( in water) and acetonitrile
摘要翻译：本发明公开了一种组合物，其包含咖啡酰基莽草酸，原儿茶酸，羟基酪醇，羟基苯甲酸，所述咖啡酰基莽草酸及其衍生物从油棕榈油的任何部分提取，包括但不限于棕榈油研磨和棕榈油磨出料的植物液，以及用于制备含有咖啡酰基莽草酸，原儿茶酸，羟基酪醇，羟基苯甲酸，所述咖啡酰基莽草酸及其衍生物的组合物的组合物的方法“，所述方法包括以下步骤：将含有所述咖啡酰基莽草酸，原儿茶酸，羟基酪醇，羟基苯甲酸，所述咖啡酰基莽草酸及其衍生物，并通过液相色谱从所述提取物中分离所述咖啡酰基莽草酸，原儿茶酸，羟基酪醇，羟基苯甲酸，所述咖啡酰莽卡米酸及其衍生物，其中所述咖啡酰基莽草酸眼酸，羟基酪醇，羟基苯甲酸，所述咖啡酰基莽草酸及其衍生物根据流动相的固定相和组成而变化。在本实施例中，使用C18柱和含有0.1％TFA（水溶液）和乙腈的梯度流动相洗脱含有咖啡酰基莽草酸的级分，在40和48分钟之间进行洗脱

9. 发明申请

WO2009035314A8 A BOTANICAL EXTRACT FROM THE AQUEOUS STREAM OF THE PALM OIL MILLING PROCESS FOR THE PREVENTION AND INHIBITION OF OXIDATIVE STRESS AND HAEMOLYSIS IN HUMAN RED BLOOD CELLS 审中-公开
标题翻译：用于预防和抑制人红细胞中氧化应激和血液分解的棕榈油研磨过程的水溶液的植物提取物
公开(公告)号：WO2009035314A8
公开(公告)日：2010-09-23
申请号：PCT/MY2008000100
申请日：2008-09-11
申请人： MALAYSIAN PALM OIL BOARD , BALASUNDRAM NAGENDRAN , SAMBANTHAMURTHI RAVIGADEVI , TAN YEW AI , SUNDRAM KALYANA , WAHID MOHD BASRI , SAMMAN SAMIR , AGAR NIHAL S
发明人： BALASUNDRAM NAGENDRAN , SAMBANTHAMURTHI RAVIGADEVI , TAN YEW AI , SUNDRAM KALYANA , WAHID MOHD BASRI , SAMMAN SAMIR , AGAR NIHAL S
IPC分类号： A61K36/889 , A61K36/18
CPC分类号： A61K36/889
摘要： The invention provides a composition for the prevention and inhibition of oxidative stress and haemolysis in human red blood cell wherein said composition compounds obtained from the aqueous stream of palm oil milling ( palm oil vegetation liquor), in particular from vegetative liquor from the milling of palm oil fruit.
摘要翻译：本发明提供了一种用于预防和抑制人类红细胞中的氧化应激和溶血的组合物，其中所述由棕榈油研磨（棕榈油植物液）的水溶液获得的组合物化合物，特别是来自研磨棕榈的营养液油果。

10. 发明申请

WO2012158018A3 COMPOSITIONS COMPRISING EXTRACTS OR MATERIALS DERIVED FROM PALM OIL VEGETATION LIGUOR FOR INHIBITION OF VISION LOSS DUE TO ANGIOGENESIS AND METHOD OF PREPARATION THEREOF 审中-公开
标题翻译：包含从棕榈油植物提取物提取的提取物或材料的组合物，用于抑制血液发生的视力损失及其制备方法
公开(公告)号：WO2012158018A3
公开(公告)日：2013-03-28
申请号：PCT/MY2012000102
申请日：2012-05-18
申请人： MALAYSIAN PALM OIL BOARD , MOGHADAM ALI HAFEZI , SAMBANTHAMURTHI RAVIGADEVI , TAN YEW AI , P MANICKAM KALYANA SUNDRAM , HAYES KENNETH C , SOUSKA ZANDI
发明人： MOGHADAM ALI HAFEZI , SAMBANTHAMURTHI RAVIGADEVI , TAN YEW AI , P MANICKAM KALYANA SUNDRAM , HAYES KENNETH C , SOUSKA ZANDI
IPC分类号： A61K36/889 , A61P3/00 , A61P3/10 , A61P17/00
CPC分类号： A61K36/889 , A23L33/105 , A61K31/05
摘要： The present invention relates generally to a composition comprising palm fruit juice for use in a method of preventing and inhibiting vision loss due to angiogenesis related diseases. The composition of the present invention aids to decrease in CNV size using confocal microscopy, in addition to reduction in macrophage infiltration using immune staining; decrease in VEGF- A-induced angiogenesis using established cornea pocket assay, inhibition of IKB-D phosphorylation in laser treated choroidal tissues and reduction in macrophage recruitment to CNV lesions.
摘要翻译：本发明一般涉及包含棕榈果汁的组合物，其用于预防和抑制由血管生成相关疾病引起的视力丧失的方法。本发明的组合物除了通过免疫染色减少巨噬细胞浸润外，还有助于使用共焦显微镜降低CNV大小; 使用已建立的角膜口袋测定法，激光治疗的脉络膜组织中IKB-D磷酸化的抑制以及巨噬细胞募集到CNV病变中的VEGF-A诱导的血管生成降低。

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