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1. 发明申请

WO2010137943A1 COMPOSITION COMPRISING CAFFEOYLSHIKIMIC ACIDS, PROTOCATECHUIC ACID, HYDROXYTYROSOL, HYDROXYBENZOIC ACID AND THEIR DERIVATIVES AND METHOD OF PREPARATION THEREOF 审中-公开
标题翻译：包含CAFFEOYLSHIICIC酸，丙酸酸，羟基苯甲酸，羟基苯甲酸及其衍生物的组合物及其制备方法
公开(公告)号：WO2010137943A1
公开(公告)日：2010-12-02
申请号：PCT/MY2010/000089
申请日：2010-05-26
申请人： MALAYSIAN PALM OIL BOARD , SAMBANDAN, T., J. , RHA, Chokyun , ANTHONY, J., Sinskey , SAMBANTHAMURTHI, Ravigadevi , TAN, Yew, Ai , P. MANICKAM, Kalyana, Sundram , WAHID, Mohd, Basri
发明人： SAMBANDAN, T., J. , RHA, Chokyun , ANTHONY, J., Sinskey , SAMBANTHAMURTHI, Ravigadevi , TAN, Yew, Ai , P. MANICKAM, Kalyana, Sundram , WAHID, Mohd, Basri
IPC分类号： C07C69/618 , C07C39/11 , A61K36/889 , C07C65/03
CPC分类号： A61K36/889
摘要： The present invention discloses a composition comprising caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, said caffeoylshikimic acids and their derivatives extracted from any part of oil palm including but not confined to the vegetation liquor of palm oil milling and palm oil mill effluent, and a method for use in the preparation of a composition containing caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, said caffeoylshikimic acids and their derivatives „ said method comprising the steps of pre-concentrating an extract containing said caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, said caffeoylshikimic acids and their derivatives and isolating said caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, said caffeoylshikimic acids and their derivatives from said extract by liquid chromatography, wherein the elution activity of said caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, said caffeoylshikimic acids and their derivatives vary depending on the stationaryphase and the composition of the mobile phase. In the present example, elution of the fractions containing Caffeoylshikimic acid occurs between 40 and 48 minutes with C18 column and a gradient mobile phase containing 0.1% TF A( in water) and acetonitrile
摘要翻译：本发明公开了一种组合物，其包含咖啡酰基莽草酸，原儿茶酸，羟基酪醇，羟基苯甲酸，所述咖啡酰基莽草酸及其衍生物从油棕榈油的任何部分提取，包括但不限于棕榈油研磨和棕榈油磨出料的植物液，以及用于制备含有咖啡酰基莽草酸，原儿茶酸，羟基酪醇，羟基苯甲酸，所述咖啡酰基莽草酸及其衍生物的组合物的组合物的方法“，所述方法包括以下步骤：将含有所述咖啡酰基莽草酸，原儿茶酸，羟基酪醇，羟基苯甲酸，所述咖啡酰基莽草酸及其衍生物，并通过液相色谱从所述提取物中分离所述咖啡酰基莽草酸，原儿茶酸，羟基酪醇，羟基苯甲酸，所述咖啡酰莽卡米酸及其衍生物，其中所述咖啡酰基莽草酸眼酸，羟基酪醇，羟基苯甲酸，所述咖啡酰基莽草酸及其衍生物根据流动相的固定相和组成而变化。在本实施例中，使用C18柱和含有0.1％TFA（水溶液）和乙腈的梯度流动相洗脱含有咖啡酰基莽草酸的级分，在40和48分钟之间进行洗脱

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