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1. 发明申请

WO0236076A3 CELL LINES EXPRESSING A MCH RECEPTOR 审中-公开
标题翻译：细胞系表达MCH受体
公开(公告)号：WO0236076A3
公开(公告)日：2002-11-21
申请号：PCT/US0147027
申请日：2001-10-26
申请人： MERCK & CO INC , BANYU PHARMA CO LTD , TAN CARINA , NOSSOUGHI MARGARITA , TOKITA SHIGERU
发明人： TAN CARINA , NOSSOUGHI MARGARITA , TOKITA SHIGERU
IPC分类号： C12N5/09 , C12N15/12 , C07H21/04 , C12N15/63 , C12N15/85 , C12N15/86 , C12P21/06 , G01N33/53
CPC分类号： C12N5/0693 , C12N2503/02 , C12N2510/00
摘要： The present invention features neuroblastoma and skin cell carcinoma cell lines functionally expressing MCHR1 and the use of such cells to measure MCHR1 activity. Functional expression is preferably achieved in a neuroblastoma or skin cell carcinoma using a recombinant gene expressing MCHR1. The presence of a recombinant MCHR1 gene increases the level of MCHR1 expression facilitating the production and detection of MCHR1 activity.
摘要翻译：本发明的特征在于功能性表达MCHR1的神经母细胞瘤和皮肤细胞癌细胞系以及使用这些细胞测量MCHR1活性。使用表达MCHR1的重组基因优选在神经母细胞瘤或皮肤细胞癌中实现功能表达。重组MCHR1基因的存在提高了MCHR1表达水平，促进MCHR1活性的产生和检测。

2. 发明申请

WO2004093785A2 RHESUS MONKEY BOMBESIN RECEPTOR SUBTYPE-3 (BRS-3), NUCLEOTIDES ENCODING SAME, AND USES THEREOF 审中-公开
标题翻译： RHESUS MONKEY BOMBESIN受体亚型3（BRS-3），编码它们的核苷酸及其用途
公开(公告)号：WO2004093785A2
公开(公告)日：2004-11-04
申请号：PCT/US2004/011473
申请日：2004-04-14
申请人： MERCK & CO., INC. , BANYU PHARMACEUTICAL CO., LTD. , TAN, Carina, P. , HOWARD, Andrew, D. , SANO, Hideki
发明人： TAN, Carina, P. , HOWARD, Andrew, D. , SANO, Hideki
IPC分类号： A61K
CPC分类号： C07K14/70571 , C07K14/723 , G01N2333/70571
摘要： A rhesus monkey bombesin receptor subtype-3 has been isolated, cloned and sequenced. This receptor is characteristic of the G-protein family of receptors. Isolated rhesus monkey bombesin receptor subtype-3 may be used to screen and identify novel bombesin receptor modulators that may contribute to the regulation of endocrine processes, metabolism, or the cell cycle. Such compounds may be used in the treatment of conditions that result from deregulated expression of bombesin receptor subtype-3.
摘要翻译：已经分离，克隆和测序了恒河猴铃蟾肽受体亚型3。该受体是G-蛋白家族受体的特征。分离的恒河猴铃蟾肽受体亚型-3可用于筛选和鉴定可能有助于调节内分泌过程，代谢或细胞周期的新型bombesin受体调节剂。这些化合物可用于治疗由bombesin受体亚型-3的失调表达引起的病症。

3. 发明申请

WO2002097394A2 RHESUS MONKEY, DOG AND FERRET MELANIN-CONCENTRATING HORMONE TYPE 2 RECEPTOR 审中-公开
标题翻译：鹿茸，OG OG AND ET TOR TOR TOR TOR TOR TOR TOR TOR TOR TOR TOR TOR TOR
公开(公告)号：WO2002097394A2
公开(公告)日：2002-12-05
申请号：PCT/US2002/016702
申请日：2002-05-28
申请人： MERCK & CO., INC. , BANYU PHARMACEUTICAL CO., LTD. , TAN, Carina , SANO, Hideki
发明人： TAN, Carina , SANO, Hideki
IPC分类号： G01N
CPC分类号： C07K14/72 , G01N33/74 , G01N33/9406
摘要： The present invention identifies the presence of MCH-2R in the dog, ferret and rhesus monkey. MCH-2R is a G-protein coupled receptor that responds to MCH and is distinct from MCH-1R. MCH-2R polypeptide and nucleic acid sequences related to the dog, ferret, and rhesus monkey MCH-2R are described herein along with uses of such polypeptides and nucleic acids.
摘要翻译：本发明鉴定了狗，白鼬和恒河猴中MCH-2R的存在。 MCH-2R是对MCH反应的G蛋白偶联受体，不同于MCH-1R。本文中描述了与狗，白鼬和恒河猴MCH-2R相关的MCH-2R多肽和核酸序列以及这些多肽和核酸的用途。

4. 发明申请

WO0009538A3 CANINE GROWTH HORMONE SECRETAGOGUE RECEPTOR 审中-公开
标题翻译： CANINE生长激素SECRETAGOGUE受体
公开(公告)号：WO0009538A3
公开(公告)日：2000-06-22
申请号：PCT/US9917915
申请日：1999-08-06
申请人： MERCK & CO INC , HOWARD ANDREW D , PALYHA OKSANA C , SMITH ROY G , TAN CARINA P
发明人： HOWARD ANDREW D , PALYHA OKSANA C , SMITH ROY G , TAN CARINA P
IPC分类号： G01N33/50 , C07K14/705 , C07K14/72 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/02 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/02 , G01N33/15 , G01N33/566 , C07H21/04
CPC分类号： C07K14/72 , C07K14/723
摘要： A novel canine cDNA sequence that encodes the canine growth hormone secretagogue receptor (GHSR) protein is provided. Also provided is canine GHSR protein encoded by the novel cDNA sequence. Methods of expressing canine GHSR protein in recombinant systems are provided. Also provided are methods for identifying agonists and antagonists of the canine GHSR.
摘要翻译：提供了编码犬生长激素促分泌素受体（GHSR）蛋白的新型犬cDNA序列。还提供了由新的cDNA序列编码的犬GHSR蛋白。提供了在重组系统中表达犬GHSR蛋白的方法。还提供了用于鉴定犬GHSR的激动剂和拮抗剂的方法。

5. 发明申请

WO1998029439A1 GALANIN RECEPTOR GALR2 AND NUCLEOTIDES ENCODING SAME 审中-公开
标题翻译：加兰林受体GALR2和核苷酸编码
公开(公告)号：WO1998029439A1
公开(公告)日：1998-07-09
申请号：PCT/US1997023890
申请日：1997-12-18
申请人： MERCK & CO., INC. , TAN, Carina , SULLIVAN, Kathleen
发明人： MERCK & CO., INC.
IPC分类号： C07K14/00
CPC分类号： C07K14/72 , G01N2333/72
摘要： A new galanin receptor, GALR2, is described. Also provided are nucleic acids encoding same and various assays to identify ligands particular to said receptor. Ligands so identified are useful for the treatment of obesity, treatment of pain, and treatment of cognitive disorders.
摘要翻译：描述了一种新的甘丙肽受体GALR2。还提供了编码相同的核酸和用于鉴定所述受体特异性的配体的各种测定法。如此鉴定的配体可用于治疗肥胖症，治疗疼痛和治疗认知障碍。

6. 发明申请

WO2004093785A3 RHESUS MONKEY BOMBESIN RECEPTOR SUBTYPE-3 (BRS-3), NUCLEOTIDES ENCODING SAME, AND USES THEREOF 审中-公开
标题翻译： RHESUS MONKEY BOMBESIN受体亚型3（BRS-3），编码它们的核苷酸及其用途
公开(公告)号：WO2004093785A3
公开(公告)日：2005-05-06
申请号：PCT/US2004011473
申请日：2004-04-14
申请人： MERCK & CO INC , BANYU PHARMA CO LTD , TAN CARINA P , HOWARD ANDREW D , SANO HIDEKI
发明人： TAN CARINA P , HOWARD ANDREW D , SANO HIDEKI
IPC分类号： A61K20060101 , C07H21/04 , C07K14/47 , C07K14/705 , C12N15/12 , C12N15/63 , G01N33/566 , G01N33/567
CPC分类号： C07K14/70571 , C07K14/723 , G01N2333/70571
摘要： A rhesus monkey bombesin receptor subtype-3 has been isolated, cloned and sequenced. This receptor is characteristic of the G-protein family of receptors. Isolated rhesus monkey bombesin receptor subtype-3 may be used to screen and identify novel bombesin receptor modulators that may contribute to the regulation of endocrine processes, metabolism, or the cell cycle. Such compounds may be used in the treatment of conditions that result from deregulated expression of bombesin receptor subtype-3.
摘要翻译：已经分离，克隆和测序了恒河猴铃蟾肽受体亚型3。该受体是G-蛋白家族受体的特征。分离的恒河猴铃蟾肽受体亚型-3可用于筛选和鉴定可能有助于调节内分泌过程，代谢或细胞周期的新型bombesin受体调节剂。这些化合物可用于治疗由bombesin受体亚型-3的失调表达引起的病症。

7. 发明申请

WO2003027240A2 RHESUS MONKEY, DOG AND FERRET MELANIN-CONCENTRATING HORMONE TYPE 1 RECEPTOR 审中-公开
标题翻译：罗氏猴，狗和麦芽单糖浓缩激素1型受体
公开(公告)号：WO2003027240A2
公开(公告)日：2003-04-03
申请号：PCT/US2002/029932
申请日：2002-09-20
申请人： MERCK & CO., INC. , BANYU PHARMACEUTICAL CO., LTD. , TAN, Carina , SAILER, Andreas, W. , PAN, Jie , SANO, Hideki
发明人： TAN, Carina , SAILER, Andreas, W. , PAN, Jie , SANO, Hideki
IPC分类号： C12N
CPC分类号： C07K14/72
摘要： The present invention features polypeptide and nucleic acid sequences related to the dog, ferret and rhesus monkey MCH-1R. Preferred polypeptides and nucleic acid contain a region common to the dog, ferret and rhesus monkey MCH-1R, which is not present in the human, rat, or mouse MCH-1R.
摘要翻译：本发明涉及与狗，白鼬和恒河猴MCH-1R相关的多肽和核酸序列。优选的多肽和核酸含有与人，大鼠或小鼠MCH-1R中不存在的狗，白鼬和恒河猴MCH-1R共有的区域。

8. 发明申请

WO1998029440A1 MOUSE GALANIN RECEPTOR GALR2 AND NUCLEOTIDES ENCODING SAME 审中-公开
标题翻译：小鼠GALANIN受体GALR2和核苷酸编码
公开(公告)号：WO1998029440A1
公开(公告)日：1998-07-09
申请号：PCT/US1997023891
申请日：1997-12-18
申请人： MERCK & CO., INC. , UNIVERSITY OF TEXAS HEALTH SCIENCE , TAN, Carina, P. , KOLAKOWSKI, Lee, F., Jr.
发明人： MERCK & CO., INC. , UNIVERSITY OF TEXAS HEALTH SCIENCE
IPC分类号： C07K14/00
CPC分类号： C07K14/72 , G01N2333/72
摘要： A new galanin receptor, GALR2, is described. Also provided are nucleic acids encoding same and various assays to identify ligands particular to said receptor. Ligands so identified are useful for the treatment of obesity, treatment of pain, and treatment of cognitive disorders.
摘要翻译：描述了一种新的甘丙肽受体GALR2。还提供了编码相同的核酸和用于鉴定所述受体特异性的配体的各种测定法。如此鉴定的配体可用于治疗肥胖症，治疗疼痛和治疗认知障碍。

9. 发明申请

WO1996023809A1 NEUROPEPTIDE Y RECEPTOR 审中-公开
标题翻译：神经元Y受体
公开(公告)号：WO1996023809A1
公开(公告)日：1996-08-08
申请号：PCT/US1996001444
申请日：1996-01-30
申请人： MERCK & CO., INC. , CASCIERI, Margaret, A. , LINEMEYER, David, L. , MacNEIL, Douglas, J. , SHIAO, Lin-Lin , STRADER, Catherine, , WEINBERG, David, H. , TAN, Carina, P.
发明人： MERCK & CO., INC.
IPC分类号： C07H21/02
CPC分类号： C07K14/70571 , A61K38/00 , C12N2799/026 , G01N33/74
摘要： A novel mammalian neuropeptide Y receptor and method of making the receptor are provided. The invention includes DNA encoding the receptor, assays employing the receptor, cells expressing the receptor, antibodies which bind specifically to the receptor, RNA encoded by the DNA sequence or its complementary sequence, and single-stranded DNA with a sequence complementary to the RNA which encodes the receptor. The receptor and assays employing the receptor are useful for identifying compounds which bind to the receptor, including specific modulators of the receptor. Such compounds are useful for treating a variety of disease conditions, including obesity, diabetes, anxiety, hypertension, cocaine withdrawal, congestive heart failure, memory enhancement, cardiac and cerebral vasospasm, pheochromocytoma and ganglioneuroblastoma, and Huntington's, Alzheimer's and Parkinson's diseases.
摘要翻译：提供了一种新型哺乳动物神经肽Y受体和制备受体的方法。本发明包括编码受体的DNA，使用受体的测定，表达受体的细胞，与受体特异性结合的抗体，由DNA序列或其互补序列编码的RNA，以及与RNA互补的序列的单链DNA 编码受体。使用受体的受体和测定可用于鉴定结合受体的化合物，包括受体的特异性调节剂。这些化合物可用于治疗各种疾病状况，包括肥胖症，糖尿病，焦虑症，高血压，可卡因戒断，充血性心力衰竭，记忆增强，心脏和脑血管痉挛，嗜铬细胞瘤和神经节细胞瘤，以及亨廷顿舞蹈症，阿尔茨海默病和帕金森病。

10. 发明申请

WO2003027240A3 RHESUS MONKEY, DOG AND FERRET MELANIN-CONCENTRATING HORMONE TYPE 1 RECEPTOR 审中-公开
公开(公告)号：WO2003027240A3
公开(公告)日：2003-04-03
申请号：PCT/US2002/029932
申请日：2002-09-20
申请人： MERCK & CO., INC. , BANYU PHARMACEUTICAL CO., LTD. , TAN, Carina , SAILER, Andreas, W. , PAN, Jie , SANO, Hideki
发明人： TAN, Carina , SAILER, Andreas, W. , PAN, Jie , SANO, Hideki
IPC分类号： C07K1/00
摘要： The present invention features polypeptide and nucleic acid sequences related to the dog, ferret and rhesus monkey MCH-1R. Preferred polypeptides and nucleic acid contain a region common to the dog, ferret and rhesus monkey MCH-1R, which is not present in the human, rat, or mouse MCH-1R.

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