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1. 发明申请

WO2005097261A1 METHOD OF REDUCING C-REACTIVE PROTEIN USING GROWTH HORMONE SECRETAGOGUES 审中-公开
标题翻译：减少C反应蛋白使用生长激素分泌的方法
公开(公告)号：WO2005097261A1
公开(公告)日：2005-10-20
申请号：PCT/US2005/010927
申请日：2005-03-30
申请人： REJUVENON CORPORATION , POLVINO, William, J. , CARPI, David, B. , SMITH, Roy, G.
发明人： POLVINO, William, J. , CARPI, David, B. , SMITH, Roy, G.
IPC分类号： A61P9/00
CPC分类号： A61K31/454 , A61K38/05 , C07K5/06078 , C07K5/06156
摘要： The present invention relates to a method of reducing C-reactive protein in a subject in need of treatment thereof, wherein the subject is at risk of having or the subject has already had a vascular event or suffering from an inflammatory disease or disorder. In one embodiment, the vascular event is a cardiovascular event (e.g., myocardial infarction). In another embodiment, the vascular event is a cerebrovascular event (e.g., stroke (such as transient ischemic attacks (TIAs)). In yet another embodiment the vascular event is a peripheral vascular event (e.g., intermittent claudication). The method comprises administering a therapeutically effective amount of at least one growth hormone secretagogue compound or a pharmaceutically acceptable salt, hydrate or solvate thereof. The growth hormone secretagogue can be coadministered with a second growth hormone secretagogue, HMG CoA reductase inhibitor, an ACAT inhibitor, a CETP inhibitor, an anti-inflammatory agent, an ACE inhibitor, a Beta blocker, a cholesterol absorption inhibitor, a nicotonic acid, a fabric acid derivative, a bile acid sequestering agent or a combination thereof.
摘要翻译：本发明涉及一种在需要治疗的受试者中降低C反应蛋白的方法，其中受试者处于患有或受试者已经具有血管事件或患有炎性疾病或病症的风险中。在一个实施方案中，血管事件是心血管事件（例如，心肌梗死）。在另一个实施方案中，血管事件是脑血管事件（例如，中风（例如短暂性脑缺血发作（TIA）））。在另一个实施方案中，血管事件是外周血管事件（例如间歇性跛行），该方法包括施用生长激素促分泌素可与第二生长激素促分泌素，HMG CoA还原酶抑制剂，ACAT抑制剂，CETP抑制剂，抗炎剂，ACE抑制剂，β阻断剂，胆固醇吸收抑制剂，烟酸，织物酸衍生物，胆汁酸螯合剂或其组合。

2. 发明申请

WO2002061037A2 ADMINISTRATION OF NUCLEIC ACID SEQUENCE TO FEMALE ANIMAL 审中-公开
标题翻译：核酸序列对女性动物的管理
公开(公告)号：WO2002061037A2
公开(公告)日：2002-08-08
申请号：PCT/US2001/048726
申请日：2001-12-12
申请人： BAYLOR COLLEGE OF MEDICINE , ADVISYS , SCHWARTZ, Robert, J. , CARPENTER, Robert, H. , DRAGHIA-AKLI, Ruxandra , KERN, Douglas, R. , SMITH, Roy, G.
发明人： SCHWARTZ, Robert, J. , CARPENTER, Robert, H. , DRAGHIA-AKLI, Ruxandra , KERN, Douglas, R. , SMITH, Roy, G.
IPC分类号： C12N
CPC分类号： A01K67/0271 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2267/02 , A61K48/00 , C07K14/60 , C12N15/8509 , C12N2799/021 , C12N2830/008 , C12N2830/15 , C12N2830/85
摘要： Growth is improved by utilizing growth enhancement potential methodology to administer a nucleic acid sequence, such as GHRH or an analog, to a female animal, preferably through a parenteral route of administration. Piglets born from sows injected with DNA encoding GHRH are larger, and effects ae demonstrated in subsequent pregnancies without additional administration(s) of the vector.
摘要翻译：通过利用生长增强潜力方法将哺乳动物的核酸序列（如GHRH或类似物）施用于雌性动物，优选通过肠胃外给药途径来改善生长。从注射编码GHRH的DNA的母猪出生的仔猪较大，并且在随后的妊娠中证明了效果，而没有额外施用载体。

3. 发明申请

WO1997021435A1 ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE 审中-公开
标题翻译： GONADOTROPIN释放激素的拮抗剂
公开(公告)号：WO1997021435A1
公开(公告)日：1997-06-19
申请号：PCT/US1996020004
申请日：1996-12-10
申请人： MERCK & CO., INC. , GOULET, Mark , BUGIANESI, Robert, L. , ASHTON, Wallace, T. , CHU, Lin , FISHER, Michael, H. , LIN, Peter , SMITH, Roy, G. , PONPIPOM, Mitree, M. , WYVRATT, Matthew, J. , YANG, Yi, Tien
发明人： MERCK & CO., INC.
IPC分类号： A61K31/40
CPC分类号： C07D209/16
摘要： There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
摘要翻译：公开了式（I）化合物及其药学上可接受的盐，其可用作GnRH的拮抗剂，因此可用于治疗男性和女性中各种性激素相关和其他病症。

4. 发明申请

WO1996040150A1 TREATMENT AND PREVENTION OF PROSTATIC DISEASE 审中-公开
标题翻译：治疗和预防预防疾病
公开(公告)号：WO1996040150A1
公开(公告)日：1996-12-19
申请号：PCT/US1996008873
申请日：1996-06-05
申请人： MERCK & CO., INC. , ST. LUKE'S/ROOSEVELT HOSPITAL CENTER , SMITH, Roy, G. , ROSNER, William , NAKHLA, Atif, M.
发明人： MERCK & CO., INC. , ST. LUKE'S/ROOSEVELT HOSPITAL CENTER
IPC分类号： A61K31/56
CPC分类号： A61K31/568 , A61K31/565 , A61K31/58 , A61K2300/00
摘要： The present invention is related to a method for treating and preventing benign prostatic hyperplasia (BPH) and prostatic carcinoma by administering a therapeutically effective amount of a compound which binds to SHBG and antagonizes the SHBG-mediated effects of both estradiol and 5 alpha -androstan-3 alpha ,17 beta diol by preventing the binding of estradiol and 5 alpha -androstan-3 alpha ,17 beta diol. The present invention further relates to the compounds which bind SHBG and prevent the binding of estradiol and 5 alpha -androstan-3 alpha ,17 beta diol as well as to a method of finding compounds which bind to SHBG and prevent the binding of estradiol
摘要翻译：本发明涉及一种治疗和预防良性前列腺增生（BPH）和前列腺癌的方法，其通过施用治疗有效量的与SHBG结合的化合物并拮抗SHBG介导的雌二醇和5α-和雄激素 - 3α，17β二醇通过阻止雌二醇和5α-雄甾烷-3α，17β二醇的结合。本发明还涉及结合SHBG并防止雌二醇和5α-雄甾烷-3α，17β二醇的结合的化合物以及找到结合SHBG并防止雌二醇结合的化合物的方法

5. 发明申请

WO1997016189A1 COMBINATION THERAPY FOR THE TREATMENT OF DIABETES AND OBESITY 审中-公开
标题翻译：用于治疗糖尿病和肥胖的组合治疗
公开(公告)号：WO1997016189A1
公开(公告)日：1997-05-09
申请号：PCT/US1996017444
申请日：1996-10-31
申请人： MERCK & CO., INC. , SMITH, Roy, G.
发明人： MERCK & CO., INC.
IPC分类号： A61K31/44
CPC分类号： C07K14/5759 , A61K38/2264 , A61K38/22 , A61K31/63 , A61K31/44 , A61K2300/00
摘要： The combination of the beta 3 adrenergic receptor agonist Compound A and a compound which modifies feeding behavior (e.g., the OB protein) is useful in the treatment of obesity and diabetes, either as compounds, pharmaceutically acceptable salts, pharmaceutical compoisition ingredients. Methods of treating obesity and diabetes are also described.
摘要翻译： β3肾上腺素能受体激动剂化合物A和改变进食行为的化合物（例如，OB蛋白）的组合可用作治疗肥胖症和糖尿病，作为化合物，药学上可接受的盐，药物成分。还描述了治疗肥胖和糖尿病的方法。

6. 发明申请

WO1995011029A1 COMBINATION OF BISPHOSPHONATES AND GROWTH HORMONE SECRETAGOGUES 审中-公开
标题翻译：二硫代磷酸盐与生长激素密度的组合
公开(公告)号：WO1995011029A1
公开(公告)日：1995-04-27
申请号：PCT/US1994011912
申请日：1994-10-18
申请人： MERCK & CO., INC. , GERTZ, Barry, J. , RODAN, Gideon, A. , SMITH, Roy, G. , WYVRATT, Matthew, J. , PATCHETT, Arthur, A.
发明人： MERCK & CO., INC.
IPC分类号： A61K31/66
CPC分类号： A61K45/06 , A61K38/04 , A61K31/675 , A61K31/66 , A61K2300/00
摘要： Bisphosphonates in combination with growth hormone secretagogues reduce the deleterious effects of osteoporosis in elderly patients.
摘要翻译：双膦酸盐与生长激素促分泌素联合可减少老年患者骨质疏松症的有害作用。

7. 发明申请

WO2002061037A3 ADMINISTRATION OF NUCLEIC ACID SEQUENCE TO FEMALE ANIMAL 审中-公开
公开(公告)号：WO2002061037A3
公开(公告)日：2002-08-08
申请号：PCT/US2001/048726
申请日：2001-12-12
申请人： BAYLOR COLLEGE OF MEDICINE , ADVISYS, INC. , SCHWARTZ, Robert, J. , CARPENTER, Robert, H. , DRAGHIA-AKLI, Ruxandra , KERN, Douglas, R. , SMITH, Roy, G.
发明人： SCHWARTZ, Robert, J. , CARPENTER, Robert, H. , DRAGHIA-AKLI, Ruxandra , KERN, Douglas, R. , SMITH, Roy, G.
IPC分类号： A61K67/027
摘要： Growth is improved by utilizing growth enhancement potential methodology to administer a nucleic acid sequence, such as GHRH or an analog, to a female animal, preferably through a parenteral route of administration. Piglets born from sows injected with DNA encoding GHRH are larger, and effects ae demonstrated in subsequent pregnancies without additional administration(s) of the vector.

8. 发明申请

WO0009538A3 CANINE GROWTH HORMONE SECRETAGOGUE RECEPTOR 审中-公开
标题翻译： CANINE生长激素SECRETAGOGUE受体
公开(公告)号：WO0009538A3
公开(公告)日：2000-06-22
申请号：PCT/US9917915
申请日：1999-08-06
申请人： MERCK & CO INC , HOWARD ANDREW D , PALYHA OKSANA C , SMITH ROY G , TAN CARINA P
发明人： HOWARD ANDREW D , PALYHA OKSANA C , SMITH ROY G , TAN CARINA P
IPC分类号： G01N33/50 , C07K14/705 , C07K14/72 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/02 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/02 , G01N33/15 , G01N33/566 , C07H21/04
CPC分类号： C07K14/72 , C07K14/723
摘要： A novel canine cDNA sequence that encodes the canine growth hormone secretagogue receptor (GHSR) protein is provided. Also provided is canine GHSR protein encoded by the novel cDNA sequence. Methods of expressing canine GHSR protein in recombinant systems are provided. Also provided are methods for identifying agonists and antagonists of the canine GHSR.
摘要翻译：提供了编码犬生长激素促分泌素受体（GHSR）蛋白的新型犬cDNA序列。还提供了由新的cDNA序列编码的犬GHSR蛋白。提供了在重组系统中表达犬GHSR蛋白的方法。还提供了用于鉴定犬GHSR的激动剂和拮抗剂的方法。

9. 发明申请

WO1997044321A1 ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE 审中-公开
标题翻译：促性腺激素释放激素的拮抗剂
公开(公告)号：WO1997044321A1
公开(公告)日：1997-11-27
申请号：PCT/US1997008479
申请日：1997-05-16
申请人： MERCK & CO., INC. , GOULET, Mark , ALLEN, Eric, E. , JIANG, Jinlong , SMITH, Roy, G. , WALSH, Thomas, F. , WYVRATT, Matthew, J., Jr. , YANG, Yi, Tien , YOUNG, Jonathan, R. , DEVITA, Robert, J.
发明人： MERCK & CO., INC.
IPC分类号： C07D213/22
CPC分类号： C07D215/22 , C07D215/36 , C07D215/46 , C07D401/06 , C07D401/12 , C07D413/12 , C07D453/02 , C07D471/08
摘要： There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related conditions in both men and women.
摘要翻译：式（I）化合物及其可药用盐，可用作GnRH拮抗剂，因此可用于治疗人类和人类中与性激素有关的多种病症。女子。

10. 发明申请

WO1997041878A1 TREATMENT OF MOOD DISORDERS WITH A GROWTH HORMONE SECRETAGOGUE 审中-公开
标题翻译：用生长激素分泌物治疗阴道疾病
公开(公告)号：WO1997041878A1
公开(公告)日：1997-11-13
申请号：PCT/US1997007508
申请日：1997-05-05
申请人： MERCK & CO., INC. , SMITH, Roy, G.
发明人： MERCK & CO., INC.
IPC分类号： A61K38/00
CPC分类号： A61K45/06 , A61K31/438 , A61K31/4747 , A61K38/05 , A61K38/25 , A61K2300/00
摘要： A growth hormone secretagogue is useful, alone or in combination with antidepressants, for the prevention or the treatment of mood disorders, in particular depression.
摘要翻译：生长激素促分泌素单独或与抗抑郁药组合用于预防或治疗情绪障碍，特别是抑郁症。

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