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1. 发明授权

US08394792B2 Heterocyclic derivatives 有权
标题翻译：杂环衍生物
公开(公告)号：US08394792B2
公开(公告)日：2013-03-12
申请号：US12935478
申请日：2009-03-31
申请人： Sung Oh Ahn , Chan Hee Park , Jun Hwan Im , Soon Ok Lee , Kyoung June Lee , Seong Wook Cho , Kwang Seok Ko , Sun Young Han , Won Il Lee
发明人： Sung Oh Ahn , Chan Hee Park , Jun Hwan Im , Soon Ok Lee , Kyoung June Lee , Seong Wook Cho , Kwang Seok Ko , Sun Young Han , Won Il Lee
IPC分类号： C07D498/04 , A61K31/538
CPC分类号： C07D498/04
摘要： Disclosed are heterocyclic derivatives, and more particularly heterocyclic derivatives having the following Formula I which are useful for the preparation of medicaments for treating diseases related to uric acid: wherein R1, R2, R3, R4, R5, R6, R7, R8, X1, X2, X3, L and Y are the same as defined in the detailed description.
摘要翻译：公开了具有下式I的杂环衍生物，更具体地说可用于制备用于治疗与尿酸相关疾病的药物的式I化合物：其中R1，R2，R3，R4，R5，R6，R7，R8，X1， X2，X3，L和Y与详细描述中所定义的相同。

2. 发明申请

US20110028467A1 HETEROCYCLIC DERIVATIVES 有权
标题翻译：杂环衍生物
公开(公告)号：US20110028467A1
公开(公告)日：2011-02-03
申请号：US12935478
申请日：2009-03-31
申请人： Sung Oh Ahn , Chan Hee Park , Jun Hwan Im , Soon Ok Lee , Kyoung June Lee , Seong Wook Cho , Kwang Seok Ko , Sun Young Han , Won Il Lee
发明人： Sung Oh Ahn , Chan Hee Park , Jun Hwan Im , Soon Ok Lee , Kyoung June Lee , Seong Wook Cho , Kwang Seok Ko , Sun Young Han , Won Il Lee
IPC分类号： A61K31/5383 , C07D498/04 , A61P3/06 , A61P9/10 , A61P3/10 , A61P9/12
CPC分类号： C07D498/04
摘要： The present invention relates to heterocyclic derivatives, and more particularly, to novel heterocyclic derivatives useful for the preparation of medicaments for treating diseases related to uric acid.
摘要翻译：本发明涉及杂环衍生物，更具体地说，涉及用于制备治疗与尿酸相关疾病的药物的新型杂环衍生物。

3. 发明申请

US20140315888A1 NOVEL HETEROCYCLIC DERIVATIVES AND THEIR USES 有权
标题翻译：新型杂环衍生物及其用途
公开(公告)号：US20140315888A1
公开(公告)日：2014-10-23
申请号：US14347950
申请日：2012-09-28
申请人： Pil Su Ho , Dong Oh Yoon , Sun Young Han , Won Il Lee , Jung Sook Kim , Woul Seong Park , Sung Oh Ahn , Hye Jung Kim
发明人： Pil Su Ho , Dong Oh Yoon , Sun Young Han , Won Il Lee , Jung Sook Kim , Woul Seong Park , Sung Oh Ahn , Hye Jung Kim
IPC分类号： C07D471/14
CPC分类号： C07D471/14 , C07D487/14 , C07D498/14 , C07D519/00
摘要： The present invention relates to novel heterocyclic compounds useful in preparing drugs for treatment of diseases associated with various functions of the histamine 4 receptor. Especially, the said drugs are useful for treatment of inflammatory diseases, allergy, pain, nasal polyps, rhinitis, chronic sinusitis, nasal congestion, nasal itch, asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, atopic dermatitis, psoriasis, eczema, pruritus, itchy skin, urticaria, idiopathic chronic urticaria, scleroderma, conjunctivitis, keratoconjunctivitis, ocular inflammation, dry eye, cardiac dysfunction, arrhythmia, atherosclerosis, multiple sclerosis, inflammatory bowel disease (including colitis, Crohn's disease, ulcerative colitis), inflammatory pain, neuropathic pain, osteoarthritic pain, autoimmune thyroid disease, immune-mediated (also known as type I) diabetes, lupus, post-operative adhesions, vestibular disorders and cancer.
摘要翻译：本发明涉及可用于制备用于治疗与组胺4受体的各种功能相关的疾病的药物的新型杂环化合物。特别地，所述药物可用于治疗炎性疾病，过敏，疼痛，鼻息肉，鼻炎，慢性鼻窦炎，鼻塞，鼻痒，哮喘，慢性阻塞性肺病，类风湿性关节炎，特应性皮炎，牛皮癣，湿疹，瘙痒，瘙痒皮肤，荨麻疹，特发性慢性荨麻疹，硬皮病，结膜炎，角膜结膜炎，眼部炎症，干眼症，心脏功能障碍，心律失常，动脉粥样硬化，多发性硬化，炎性肠病（包括结肠炎，克罗恩病，溃疡性结肠炎），炎性疼痛，神经性疼痛，骨关节炎，自身免疫性甲状腺疾病，免疫介导（也称为I型）糖尿病，狼疮，术后粘连，前庭障碍和癌症。

4. 发明授权

US09586959B2 Substituted tricyclic heterocycles as histamine 4 receptor inhibitors 有权
标题翻译：取代三环杂环作为组胺4受体抑制剂
公开(公告)号：US09586959B2
公开(公告)日：2017-03-07
申请号：US14347950
申请日：2012-09-28
申请人： Pil Su Ho , Dong Oh Yoon , Sun Young Han , Won Il Lee , Jung Sook Kim , Woul Seong Park , Sung Oh Ahn , Hye Jung Kim
发明人： Pil Su Ho , Dong Oh Yoon , Sun Young Han , Won Il Lee , Jung Sook Kim , Woul Seong Park , Sung Oh Ahn , Hye Jung Kim
IPC分类号： A61K31/4353 , A61K31/4985 , A61K31/519 , C07D471/14 , C07D487/14 , C07D491/147 , C07D498/14 , C07D519/00
CPC分类号： C07D471/14 , C07D487/14 , C07D498/14 , C07D519/00
摘要： The present invention relates to novel heterocyclic compounds of formula 1 useful in preparing drugs for treatment of diseases associated with various functions of the histamine 4 receptor. Especially, the said drugs are useful for treatment of inflammatory diseases, allergy, pain, nasal polyps, rhinitis, chronic sinusitis, nasal congestion, nasal itch, asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, atopic dermatitis, psoriasis, eczema, pruritus, itchy skin, urticaria, idiopathic chronic urticaria, scleroderma, conjunctivitis, keratoconjunctivitis, ocular inflammation, dry eye, cardiac dysfunction, arrhythmia, atherosclerosis, multiple sclerosis, inflammatory bowel disease (including colitis, Crohn's disease, ulcerative colitis), inflammatory pain, neuropathic pain, osteoarthritic pain, autoimmune thyroid disease, immune-mediated (also known as type I) diabetes, lupus, post-operative adhesions, vestibular disorders and cancer.
摘要翻译：本发明涉及可用于制备用于治疗与组胺4受体的各种功能相关的疾病的药物的新型杂环化合物。特别地，所述药物可用于治疗炎性疾病，过敏，疼痛，鼻息肉，鼻炎，慢性鼻窦炎，鼻塞，鼻痒，哮喘，慢性阻塞性肺病，类风湿性关节炎，特应性皮炎，牛皮癣，湿疹，瘙痒，瘙痒皮肤，荨麻疹，特发性慢性荨麻疹，硬皮病，结膜炎，角膜结膜炎，眼部炎症，干眼症，心脏功能障碍，心律失常，动脉粥样硬化，多发性硬化，炎性肠病（包括结肠炎，克罗恩病，溃疡性结肠炎），炎性疼痛，神经性疼痛，骨关节炎，自身免疫性甲状腺疾病，免疫介导（也称为I型）糖尿病，狼疮，术后粘连，前庭障碍和癌症。

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