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1. 发明授权

US09067970B2 Anticancer agents comprising peptides with cancer-specific toxicity 有权
标题翻译：包含具有癌症特异性毒性的肽的抗癌剂
公开(公告)号：US09067970B2
公开(公告)日：2015-06-30
申请号：US13700722
申请日：2010-12-24
申请人： Sun Chang Kim , Su A Jang , Da Jung Kim , Bong Hyun Sung , Ki Jeong Lim , Ju Ri Shin , Young Woong Lee
发明人： Sun Chang Kim , Su A Jang , Da Jung Kim , Bong Hyun Sung , Ki Jeong Lim , Ju Ri Shin , Young Woong Lee
IPC分类号： G01N33/574 , A61K38/10 , C07K7/08 , G01N33/53
CPC分类号： C07K7/08 , A61K38/10 , G01N33/53 , G01N33/574
摘要： The present invention relates a prophylactic or therapeutic composition for cancer, and more particularly, to a prophylactic or therapeutic composition for cancer comprising a peptide which is represented by an amino acid sequence of the following Formula (I), a method for preventing or treating cancer comprising the step of administering the peptide to a subject, and use of the peptide in the preparation of the prophylactic or therapeutic composition for cancer. (I) APKAMX1LLX2X3L-LX4LQKKGI wherein X1, X2, X3 and X4 are each independently R or K.
摘要翻译：本发明涉及用于癌症的预防或治疗组合物，更具体地，涉及用于癌症的预防或治疗组合物，其包含由下式（I）的氨基酸序列表示的肽，预防或治疗癌症的方法包括向受试者施用该肽的步骤，以及该肽在制备用于癌症的预防或治疗组合物中的用途。（I）APKAMX1LLX2X3L-LX4LQKKGI其中X1，X2，X3和X4各自独立地为R或K.

2. 发明授权

US08927232B2 Fusion protein capable of binding VEGF-A and TNF-alpha 有权
标题翻译：能够结合VEGF-A和TNF-α的融合蛋白
公开(公告)号：US08927232B2
公开(公告)日：2015-01-06
申请号：US12636013
申请日：2009-12-11
申请人： Keehoon Jung , Young Jun Koh , Gyun Min Lee , Sun Chang Kim , Gou Young Koh
发明人： Keehoon Jung , Young Jun Koh , Gyun Min Lee , Sun Chang Kim , Gou Young Koh
IPC分类号： A61K38/17 , C07K14/71 , C07K14/715 , C12N5/10 , C12N15/12
CPC分类号： C07K16/241 , C07K14/71 , C07K14/715 , C07K16/22 , C07K2317/31 , C07K2319/70
摘要： The present application describes an isolated nucleic acid molecule encoding a polypeptide capable of synchronously binding VEGF polypeptide and TNF polypeptide comprising: (a) a nucleotide sequence encoding a TNFR2 component and VEGFR1 component operatively linked to (b) a nucleotide sequence encoding a multimerizing component, wherein the TNFR2 component consists essentially of a nucleotide sequence encoding the amino acid sequences of cystein rich domain 1, cystein rich domain 2, cystein rich domain 3, and cystein rich domain 4 of the extracellular domain of TNFR2, and wherein the VEGFR1 component consists essentially of a nucleotide sequence encoding the amino acid sequences of Ig-like domain 2 of the extracellular domain of VEGFR1.
摘要翻译：本申请描述了编码能够同时结合VEGF多肽和TNF多肽的多肽的分离的核酸分子，其包含：（a）编码TNFR2组分的核苷酸序列和可操作地连接到（b）编码多聚化成分的核苷酸序列的VEGFR1组分，其中TNFR2组分基本上由编码TNFR2细胞外结构域的富含半胱氨酸域1，半胱氨酸富含结构域2，半胱氨酸富含结构域3和半胱氨酸富含结构域4的氨基酸序列的核苷酸序列组成，其中VEGFR1组分基本上组成的编码VEGFR1细胞外结构域的Ig样结构域2的氨基酸序列的核苷酸序列。

3. 发明授权

US06531446B1 Peptides having biological activity 有权
标题翻译：具有生物活性的肽
公开(公告)号：US06531446B1
公开(公告)日：2003-03-11
申请号：US09600710
申请日：2000-11-02
申请人： Sun-Chang Kim , Chan-Bae Park , Jae-Hyun Lee , Seung-Suh Hong , Hyun-Soo Lee
发明人： Sun-Chang Kim , Chan-Bae Park , Jae-Hyun Lee , Seung-Suh Hong , Hyun-Soo Lee
IPC分类号： C07K400
CPC分类号： C07K7/08 , A61K38/00 , C07K14/463
摘要： The present invention relates to peptides that are more potent than or equally potent as the conventional antimicrobial peptides and has strong antimicrobial activities at high salt concentration.
摘要翻译：本发明涉及比常规抗微生物肽更有效或同样有效的肽，并且在高盐浓度下具有很强的抗微生物活性。

4. 发明申请

US20150044712A1 METHOD AND KIT FOR ANALYZING PROTEIN-PROTEIN INTERACTION USING NANOCLUSTER FORMATION 有权
标题翻译：使用纳米聚糖形成分析蛋白质 - 蛋白质相互作用的方法和工具包
公开(公告)号：US20150044712A1
公开(公告)日：2015-02-12
申请号：US14234243
申请日：2012-07-23
申请人： Won Do Heo , Sun Chang Kim , Sang Kyu Lee
发明人： Won Do Heo , Sun Chang Kim , Sang Kyu Lee
IPC分类号： G01N33/68 , G01N33/58
CPC分类号： G01N33/6845 , C07K2319/00 , C07K2319/60 , C07K2319/735 , C12N15/1055 , C12N15/79 , G01N33/582 , G01N2333/91205
摘要： For efficient analysis of a protein-protein interaction, the present disclosure provides a kit for analyzing a protein-protein interaction, the kit including: a 1st expression vector including a 1st polynucleotide and a multi-cloning site, wherein, the 1st polynucleotide is operably linked to a promoter and encodes a 1st fusion protein having a 1st fluorescence protein and a 1st self-assembly protein, and the multi-cloning site is a site where a polynucleotide encoding a bait protein may be operably linked to the polynucleotide encoding the 1st fusion protein; and a 2nd expression vector including a 2nd polynucleotide and a multi-cloning site, wherein, the 2nd polynucleotide is operably linked to a promoter and encodes a 2nd fusion protein having a 2nd fluorescence protein and a 2nd self-assembly protein, and the multi-cloning site is a site where a polynucleotide encoding a prey protein may be operably linked to the polynucleotide encoding the 2nd fusion protein.
摘要翻译：为了有效分析蛋白质 - 蛋白质的相互作用，本公开提供了一种用于分析蛋白质 - 蛋白质相互作用的试剂盒，所述试剂盒包括：包含第一多核苷酸和多克隆位点的第一表达载体，其中第一多核苷酸可操作地连接到启动子并编码具有第一荧光蛋白和第一自组装蛋白的第一融合蛋白，并且多克隆位点是其中编码诱饵蛋白的多核苷酸可操作地连接到编码第一融合物的多核苷酸的位点蛋白; 和包含第二多核苷酸和多克隆位点的第二表达载体，其中第二多核苷酸可操作地连接于启动子并编码具有第二荧光蛋白和第二自组装蛋白的第二融合蛋白，克隆位点是编码猎物蛋白的多核苷酸可以可操作地连接到编码第二融合蛋白的多核苷酸的位点。

5. 发明申请

US20130244949A1 NOVEL ANTICANCER AGENTS COMPRISING PEPTIDES WITH CANCER-SPECIFIC TOXICITY 有权
标题翻译：包含特定癌症的肽的新型抗体药剂
公开(公告)号：US20130244949A1
公开(公告)日：2013-09-19
申请号：US13700722
申请日：2010-12-24
申请人： Sun Chang Kim , Su A Jang , Da Jung Kim , Bong Hyun Sung , Ki Jeong Lim , Ju Ri Shin , Young Woong Lee
发明人： Sun Chang Kim , Su A Jang , Da Jung Kim , Bong Hyun Sung , Ki Jeong Lim , Ju Ri Shin , Young Woong Lee
IPC分类号： C07K7/08
CPC分类号： C07K7/08 , A61K38/10 , G01N33/53 , G01N33/574
摘要： The present invention relates a prophylactic or therapeutic composition for cancer, and more particularly, to a pro-phylactic or therapeutic composition for cancer comprising a peptide which is represented by an amino acid sequence of the following Formula (I), a method for preventing or treating cancer comprising the step of administering the peptide to a subject, and use of the peptide in the preparation of the prophylactic or therapeutic composition for cancer. (I) APKAMX1LLX2X3L-LX4LQKKGI wherein X1, X2, X3 and X4 are each independently R or K.
摘要翻译：本发明涉及用于癌症的预防或治疗组合物，更具体地，涉及用于癌症的前药或治疗组合物，其包含由下式（I）的氨基酸序列表示的肽，预防或治疗组合物包括向受试者施用该肽的步骤，以及在制备用于癌症的预防或治疗组合物中使用该肽。（I）APKAMX1LLX2X3L-LX4LQKKGI其中X1，X2，X3和X4各自独立为R或K.

6. 发明授权

US08367380B2 Compositions and methods for amino acid biosynthesis 有权
标题翻译：氨基酸生物合成的组成和方法
公开(公告)号：US08367380B2
公开(公告)日：2013-02-05
申请号：US12863958
申请日：2009-02-19
申请人： Frederick R. Blattner , Sun Chang Kim , Jun Hyoung Lee
发明人： Frederick R. Blattner , Sun Chang Kim , Jun Hyoung Lee
IPC分类号： C12P13/24
CPC分类号： C12N9/93 , C12P13/04
摘要： The present invention relates generally to compositions and methods useful for, inter alia, production of commercial biologic products such as amino acids. More specifically, the present invention relates to genetically modified strains of microorganisms and the use thereof for the production of commercial products. The present invention also provides, inter alia, novel isolated DNA, nucleic acid, vectors and reduced genome bacteria.
摘要翻译：本发明一般涉及用于生产商业生物制品例如氨基酸的组合物和方法。更具体地，本发明涉及转基因微生物菌株及其用于生产商业产品的用途。本发明尤其提供了新的分离的DNA，核酸，载体和还原的基因组细菌。

7. 发明授权

US08242242B2 Preparation of an artificial transcription factor comprising zinc finger protein and transcription factor of prokaryote, and a use thereof 有权
标题翻译：包含锌指蛋白质和原核生物转录因子的人工转录因子的制备及其用途
公开(公告)号：US08242242B2
公开(公告)日：2012-08-14
申请号：US12444842
申请日：2006-12-15
申请人： Sun-Chang Kim , Ju-Young Lee , Bong-Hyun Sung , Jun-Hyoung Lee , Sang-Hee Lee , Kui-Hyeon Kang
发明人： Sun-Chang Kim , Ju-Young Lee , Bong-Hyun Sung , Jun-Hyoung Lee , Sang-Hee Lee , Kui-Hyeon Kang
IPC分类号： C12N1/21
CPC分类号： C07K14/4702 , C07K2319/81
摘要： The present invention relates to an artificial transcription factor which can artificially regulate gene expression of an E. coli, wherein the transcription factor comprising zinc finger proteins and transcription factors of prokaryote, and to be engineered E. coli using the same. Specifically, the artificial transcription factors comprising zinc finger domains and transcription factors in E. coli as effector domains are prepared and said artificial transcription library is introduced to E. coli to effectively and artificially regulate gene expression regardless of an activity of endogenous transcription factors in the E. coli and to induce E. coli having various desired phenotypes. Thus, only E. coli having the desired phenotypes useful for industries can be selected and used.
摘要翻译：本发明涉及人工调节大肠杆菌基因表达的人工转录因子，其中包含锌指蛋白的转录因子和原核生物的转录因子，以及使用其的工程化大肠杆菌。具体地说，制备了包含锌指结构域和转录因子在大肠杆菌中作为效应子结构域的人工转录因子，并且将所述人工转录文库导入大肠杆菌以有效和人工调节基因表达，而不管内源性转录因子的活性如何并诱导具有各种所需表型的大肠杆菌。因此，可以选择和使用仅具有用于工业的期望表型的大肠杆菌。

8. 发明申请

US20120088733A1 NOVEL USE OF ANTIMICROBIAL PEPTIDES IN REGENERATION OF SKIN CELLS 有权
标题翻译：在皮肤细胞再生中使用抗微生物肽
公开(公告)号：US20120088733A1
公开(公告)日：2012-04-12
申请号：US13095763
申请日：2011-04-27
申请人： Sun-Chang Kim , Da-Jung Kim , Su-A Jang , Bong Hyun Sung , Ki-Jung Lim , Ju-Ri Shin , Young Woong Lee
发明人： Sun-Chang Kim , Da-Jung Kim , Su-A Jang , Bong Hyun Sung , Ki-Jung Lim , Ju-Ri Shin , Young Woong Lee
IPC分类号： A61K38/10 , A61P17/02 , A61P17/00
CPC分类号： A61K38/10
摘要： Disclosed are novel antimicrobial peptides which can promote the regeneration of skin cells, thus healing wounds. Pharmaceutical compositions comprising the peptides as active ingredients are also provided for wound healing and skin rejuvenation.The antimicrobial peptides exhibit inhibitory activity against antibiotic-resistant strains, and their antimicrobial activity is maintained without loss of structural stability even under a high salt condition. Also, being proven to promote the migration and regeneration of skin cells in mice as well as in vitro, the antimicrobial peptides may be widely used as an agent for regenerating skin cells. Further, they can find applications in various fields including the medical industry and the cosmetic industry. Hence, the novel antimicrobial peptides are anticipated to have considerable repercussions in the market for antibiotics, wound healing agents and cosmetics.
摘要翻译：公开了可以促进皮肤细胞再生的新型抗微生物肽，从而伤口愈合。包含肽作为活性成分的药物组合物也用于伤口愈合和皮肤年轻化。抗菌肽对抗生素抗性菌株表现出抑制活性，即使在高盐条件下，其抗微生物活性仍保持不失结构稳定性。此外，被证明可促进小鼠和体外皮肤细胞的迁移和再生，抗微生物肽可以广泛用作再生皮肤细胞的药剂。此外，他们可以在包括医疗行业和化妆品行业在内的各个领域找到应用。因此，预期新型抗菌肽在市场上对抗生素，伤口愈合剂和化妆品具有相当大的影响。

9. 发明申请

US20100184949A1 Method for the mass expression of an antimicrobial peptide by using a translational coupling system 有权
标题翻译：通过使用平移耦合系统大量表达抗微生物肽的方法
公开(公告)号：US20100184949A1
公开(公告)日：2010-07-22
申请号：US12313513
申请日：2008-11-19
申请人： Sun Chang Kim , Su A. Jang , Bong Hyun Sung , Jung Min Kim , Ki Jung Lim , Ju Ri Shin , Ju Young Lee
发明人： Sun Chang Kim , Su A. Jang , Bong Hyun Sung , Jung Min Kim , Ki Jung Lim , Ju Ri Shin , Ju Young Lee
IPC分类号： C07K14/00 , C12P21/00 , C07H21/04
CPC分类号： C12N15/67 , C07K14/4702
摘要： The present invention relates to a gene construct which is capable of achieving efficient production of an antimicrobial peptide in a microorganism, and a method for efficient mass production and separation of an antimicrobial peptide using the same. The gene construct of the present invention has a translationally coupled configuration of two independent and separate cistrons which encode an acidic peptide and a basic antimicrobial peptide, each having an opposite charge, under the control of a single promoter. The translationally coupled acidic peptide and basic antimicrobial peptide undergo charge-charge interaction simultaneously with expression thereof to neutralize the potential cytotoxicity of the antimicrobial peptide, resulting in prevention of antimicrobial peptide-mediated killing of host microorganisms. In addition, a conjugate of the acidic peptide and the antimicrobial peptide can be separated without chemical or enzymatic treatment. Therefore, it is possible to achieve easy mass production of antimicrobial peptides from recombinant microorganisms.
摘要翻译：本发明涉及能够实现微生物中抗微生物肽的高效生产的基因构建体，以及使用该抗体肽高效批量生产和分离的方法。本发明的基因构建体具有两个独立和分离的顺反子的翻译偶联构型，其在单个启动子的控制下编码各自具有相反电荷的酸性肽和碱性抗微生物肽。翻译偶联的酸性肽和碱性抗微生物肽与其表达同时进行电荷 - 电荷相互作用以中和抗微生物肽的潜在细胞毒性，从而防止抗微生物肽介导的宿主微生物的杀伤。此外，酸性肽和抗微生物肽的缀合物可以在没有化学或酶处理的情况下分离。因此，可以从重组微生物容易地大量生产抗微生物肽。

10. 发明申请

US20090312249A1 TLR4 decoy receptor protein 审中-公开
标题翻译： TLR4诱饵受体蛋白
公开(公告)号：US20090312249A1
公开(公告)日：2009-12-17
申请号：US12315989
申请日：2008-12-08
申请人： Keehoon Jung , HoMin Kim , Hak-Zoo Kim , Jung-Eun Lee , Gyun Min Lee , Sun Chang Kim , Jie-Oh Lee , Hak-Sung Kim , Gou Young Koh
发明人： Keehoon Jung , HoMin Kim , Hak-Zoo Kim , Jung-Eun Lee , Gyun Min Lee , Sun Chang Kim , Jie-Oh Lee , Hak-Sung Kim , Gou Young Koh
IPC分类号： A61K38/17 , C12N15/12 , C12N15/85 , C12N15/74 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/04 , C07K14/47 , A61P29/00 , A61P31/04
CPC分类号： C07K14/705 , C07K2319/32
摘要： The present application discloses a nucleic acid molecule encoding a fusion polypeptide capable of binding myeloid differentiation protein-2 (MD-2) polypeptide, which includes: a nucleotide sequence encoding an MD-2 polypeptide-binding portion of human toll-like receptor 4 (TLR4), a leucine-rich repeats (LRR) module, and a multimerizing component.
摘要翻译：本申请公开了编码能够结合骨髓分化蛋白-2（MD-2）多肽的融合多肽的核酸分子，其包括：编码人类toll样受体4的MD-2多肽结合部分的核苷酸序列（ TLR4），富含亮氨酸的重复序列（LRR）模块和多聚体组分。

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