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    • 4. 发明授权
    • Polyamine modified particles
    • 多胺改性颗粒
    • US08399025B2
    • 2013-03-19
    • US11145589
    • 2005-06-06
    • Krishnendu RoySudhir Pai Kasturi
    • Krishnendu RoySudhir Pai Kasturi
    • A61K51/00
    • A61K9/0019A61K9/06A61K9/1647A61K9/1652A61K31/7088A61K38/195A61K47/59A61K47/61A61K48/0041A61K2039/53C08J3/12C08J2300/16C08L77/02C08L77/06C08L2666/20
    • A particle composition comprising a graft copolymer formed from a biocompatible polymer and a plurality of polyamine moieties, wherein the polyamine moieties are bound to the biocompatible polymer, and a combinatorial delivery polymer comprising a plurality of particles that comprises a graft copolymer of formed from a biocompatible polymer and a plurality of polyamine moieties, wherein the polyamine moieties are bound to the biocompatible polymer, a plurality of nucleic acids electrostatically loaded onto the particles, a plurality of chemokine molecules, and a biodegradable polymer network, in which the loaded particles and chemokine molecules may be entrapped, are disclosed. Also disclosed is a method for treating a subject comprising administering a therapeutically effective dose of a pharmaceutical composition, the pharmaceutical composition comprising a particle composition that comprises a graft copolymer formed from a biocompatible polymer and a plurality of polyamine moieties, wherein the polyamine moieties are bound to the biocompatible polymer.
    • 一种颗粒组合物,其包含由生物相容性聚合物和多个多胺部分形成的接枝共聚物,其中所述多胺部分与所述生物相容性聚合物结合,以及包含多个颗粒的组合递送聚合物,所述组合递送聚合物包含由生物相容性 聚合物和多个多胺部分,其中多胺部分结合生物相容性聚合物,静电负载到颗粒上的多个核酸,多个趋化因子分子和可生物降解的聚合物网络,其中负载的颗粒和趋化因子分子 可能被截留,被披露。 还公开了治疗受试者的方法,包括施用治疗有效剂量的药物组合物,所述药物组合物包含颗粒组合物,所述颗粒组合物包含由生物相容性聚合物和多个多胺部分形成的接枝共聚物,其中多胺部分结合 生物相容性聚合物。
    • 9. 发明申请
    • Polyamine modified particles
    • 多胺改性颗粒
    • US20090110719A1
    • 2009-04-30
    • US11145589
    • 2005-06-06
    • Krishnendu RoySudhir Pai Kasturi
    • Krishnendu RoySudhir Pai Kasturi
    • A61K9/127C07H5/06A61K31/7088A61K38/17A61K9/10A61K9/14A61K38/02
    • A61K9/0019A61K9/06A61K9/1647A61K9/1652A61K31/7088A61K38/195A61K47/59A61K47/61A61K48/0041A61K2039/53C08J3/12C08J2300/16C08L77/02C08L77/06C08L2666/20
    • A particle composition comprising a graft copolymer formed from a biocompatible polymer and a plurality of polyamine moieties, wherein the polyamine moieties are bound to the biocompatible polymer, and a combinatorial delivery polymer comprising a plurality of particles that comprises a graft copolymer formed from a biocompatible polymer and a plurality of polyamine moieties, wherein the polyamine moieties are bound to the biocompatible polymer, a plurality of nucleic acids electrostatically loaded onto the particles, a plurality of chemokine molecules, and a biodegradable polymer network, in which the loaded particles and chemokine molecules may be entrapped, are disclosed. Also disclosed is a method for treating a subject comprising administering a therapeutically effective dose of a pharmaceutical composition, the pharmaceutical composition comprising a particle composition that comprises a graft copolymer formed from a biocompatible polymer and a plurality of polyamine moieties, wherein the polyamine moieties are bound to the biocompatible polymer.
    • 一种包含由生物相容性聚合物和多个多胺部分形成的接枝共聚物的颗粒组合物,其中多胺部分结合生物相容性聚合物,以及包含多个颗粒的组合递送聚合物,所述组合递送聚合物包含由生物相容性聚合物形成的接枝共聚物 和多个多胺部分,其中多胺部分结合生物相容性聚合物,静电负载到颗粒上的多个核酸,多个趋化因子分子和可生物降解的聚合物网络,其中负载的颗粒和趋化因子分子可以 被包埋,被披露。 还公开了治疗受试者的方法,包括施用治疗有效剂量的药物组合物,所述药物组合物包含颗粒组合物,所述颗粒组合物包含由生物相容性聚合物和多个多胺部分形成的接枝共聚物,其中多胺部分结合 生物相容性聚合物。