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1. 发明申请

US20090110719A1 Polyamine modified particles 有权
标题翻译：多胺改性颗粒
公开(公告)号：US20090110719A1
公开(公告)日：2009-04-30
申请号：US11145589
申请日：2005-06-06
申请人： Krishnendu Roy , Sudhir Pai Kasturi
发明人： Krishnendu Roy , Sudhir Pai Kasturi
IPC分类号： A61K9/127 , C07H5/06 , A61K31/7088 , A61K38/17 , A61K9/10 , A61K9/14 , A61K38/02
CPC分类号： A61K9/0019 , A61K9/06 , A61K9/1647 , A61K9/1652 , A61K31/7088 , A61K38/195 , A61K47/59 , A61K47/61 , A61K48/0041 , A61K2039/53 , C08J3/12 , C08J2300/16 , C08L77/02 , C08L77/06 , C08L2666/20
摘要： A particle composition comprising a graft copolymer formed from a biocompatible polymer and a plurality of polyamine moieties, wherein the polyamine moieties are bound to the biocompatible polymer, and a combinatorial delivery polymer comprising a plurality of particles that comprises a graft copolymer formed from a biocompatible polymer and a plurality of polyamine moieties, wherein the polyamine moieties are bound to the biocompatible polymer, a plurality of nucleic acids electrostatically loaded onto the particles, a plurality of chemokine molecules, and a biodegradable polymer network, in which the loaded particles and chemokine molecules may be entrapped, are disclosed. Also disclosed is a method for treating a subject comprising administering a therapeutically effective dose of a pharmaceutical composition, the pharmaceutical composition comprising a particle composition that comprises a graft copolymer formed from a biocompatible polymer and a plurality of polyamine moieties, wherein the polyamine moieties are bound to the biocompatible polymer.
摘要翻译：一种包含由生物相容性聚合物和多个多胺部分形成的接枝共聚物的颗粒组合物，其中多胺部分结合生物相容性聚合物，以及包含多个颗粒的组合递送聚合物，所述组合递送聚合物包含由生物相容性聚合物形成的接枝共聚物和多个多胺部分，其中多胺部分结合生物相容性聚合物，静电负载到颗粒上的多个核酸，多个趋化因子分子和可生物降解的聚合物网络，其中负载的颗粒和趋化因子分子可以被包埋，被披露。还公开了治疗受试者的方法，包括施用治疗有效剂量的药物组合物，所述药物组合物包含颗粒组合物，所述颗粒组合物包含由生物相容性聚合物和多个多胺部分形成的接枝共聚物，其中多胺部分结合生物相容性聚合物。

2. 发明授权

US08399025B2 Polyamine modified particles 有权
标题翻译：多胺改性颗粒
公开(公告)号：US08399025B2
公开(公告)日：2013-03-19
申请号：US11145589
申请日：2005-06-06
申请人： Krishnendu Roy , Sudhir Pai Kasturi
发明人： Krishnendu Roy , Sudhir Pai Kasturi
IPC分类号： A61K51/00
CPC分类号： A61K9/0019 , A61K9/06 , A61K9/1647 , A61K9/1652 , A61K31/7088 , A61K38/195 , A61K47/59 , A61K47/61 , A61K48/0041 , A61K2039/53 , C08J3/12 , C08J2300/16 , C08L77/02 , C08L77/06 , C08L2666/20
摘要： A particle composition comprising a graft copolymer formed from a biocompatible polymer and a plurality of polyamine moieties, wherein the polyamine moieties are bound to the biocompatible polymer, and a combinatorial delivery polymer comprising a plurality of particles that comprises a graft copolymer of formed from a biocompatible polymer and a plurality of polyamine moieties, wherein the polyamine moieties are bound to the biocompatible polymer, a plurality of nucleic acids electrostatically loaded onto the particles, a plurality of chemokine molecules, and a biodegradable polymer network, in which the loaded particles and chemokine molecules may be entrapped, are disclosed. Also disclosed is a method for treating a subject comprising administering a therapeutically effective dose of a pharmaceutical composition, the pharmaceutical composition comprising a particle composition that comprises a graft copolymer formed from a biocompatible polymer and a plurality of polyamine moieties, wherein the polyamine moieties are bound to the biocompatible polymer.
摘要翻译：一种颗粒组合物，其包含由生物相容性聚合物和多个多胺部分形成的接枝共聚物，其中所述多胺部分与所述生物相容性聚合物结合，以及包含多个颗粒的组合递送聚合物，所述组合递送聚合物包含由生物相容性聚合物和多个多胺部分，其中多胺部分结合生物相容性聚合物，静电负载到颗粒上的多个核酸，多个趋化因子分子和可生物降解的聚合物网络，其中负载的颗粒和趋化因子分子可能被截留，被披露。还公开了治疗受试者的方法，包括施用治疗有效剂量的药物组合物，所述药物组合物包含颗粒组合物，所述颗粒组合物包含由生物相容性聚合物和多个多胺部分形成的接枝共聚物，其中多胺部分结合生物相容性聚合物。

3. 发明授权

US06475995B1 Oral delivery of nucleic acid vaccines by particulate complexes 有权
标题翻译：通过颗粒复合物口服递送核酸疫苗
公开(公告)号：US06475995B1
公开(公告)日：2002-11-05
申请号：US09232167
申请日：1999-01-15
申请人： Krishnendu Roy , Shau-Ku Huang , Hugh Sampson , Kam W. Leong
发明人： Krishnendu Roy , Shau-Ku Huang , Hugh Sampson , Kam W. Leong
IPC分类号： A61K4800
CPC分类号： B82Y5/00 , A61K39/35 , A61K47/6939 , A61K2039/53 , A61K2039/542 , Y10S977/916 , Y10S977/918
摘要： Nanoparticle coacervates of nucleic acids and polycations serve as effective vaccines when administered orally. They can induce immunity to a variety of disease causing agents and raise a protective response to allergens.
摘要翻译：当口服给药时，核酸和聚阳离子的纳米颗粒凝聚层作为有效疫苗。它们可以诱导对各种疾病引发剂的免疫，并对变应原产生保护性反应。

4. 发明申请

US20070014752A1 Surface functionalization of polymeric materials 审中-公开
标题翻译：聚合物材料的表面官能化
公开(公告)号：US20070014752A1
公开(公告)日：2007-01-18
申请号：US11483019
申请日：2006-07-07
申请人： Krishnendu Roy , Laxminariyan Raja
发明人： Krishnendu Roy , Laxminariyan Raja
IPC分类号： A61K31/74
CPC分类号： C08J7/123 , A61K47/6927 , C08J3/128 , C08J2367/04
摘要： The present invention relates to methods for functionalizing a surface, comprising exposing a surface of a polymeric material to an atmospheric pressure glow plasma discharge, wherein exposure to the plasma discharge functionalizes the surface of the polymeric material. The present invention further provides for methods for functionalizing a polymeric material, wherein the functionalized surface has conjugated thereto bioactive agents. The present invention is also directed to compositions comprising a functionalized surface with attached bioactive agents.
摘要翻译：本发明涉及使表面官能化的方法，包括将聚合材料的表面暴露于大气压辉光等离子体放电，其中暴露于等离子体放电功能化了聚合物材料的表面。本发明还提供用于官能化聚合物材料的方法，其中官能化表面与其结合生物活性剂。本发明还涉及包含具有连接的生物活性剂的官能化表面的组合物。

5. 发明申请

US20110262493A1 MULTI-LAYERED HYDROGEL CONSTRUCTS AND ASSOCIATED METHODS 有权
标题翻译：多层水文结构及相关方法
公开(公告)号：US20110262493A1
公开(公告)日：2011-10-27
申请号：US13093606
申请日：2011-04-25
申请人： Krishnendu Roy , Lonnissa Nguyen
发明人： Krishnendu Roy , Lonnissa Nguyen
IPC分类号： A61K9/00 , A61L33/04 , A61P19/04 , A61K35/12 , A61K35/28
CPC分类号： C12N5/0655 , A61L27/227 , A61L27/3839 , A61L27/52 , A61L2430/06 , C12N2513/00 , C12N2533/30 , C12N2533/70 , C12N2533/80
摘要： Multi-layered hydrogel constructs comprising: a first layer comprising a first polymerizable material, hyaluronic acid and a plurality of cells; a second layer comprising a second polymerizable material, chondroitin sulfate and a plurality of cells; and a third layer comprising a third polymerizable material, chondroitin sulfate, a matrix metalloprotease sensitive peptide, and a plurality of cells are provided. Associated methods are also provided.
摘要翻译：多层水凝胶构建体，其包含：第一层，其包含第一可聚合材料，透明质酸和多个细胞; 第二层，其包含第二可聚合材料，硫酸软骨素和多个细胞; 并且提供包含第三可聚合材料，硫酸软骨素，基质金属蛋白酶敏感肽和多个细胞的第三层。还提供了相关的方法。

6. 发明授权

US5972707A Gene delivery system 失效
标题翻译：基因传递系统
公开(公告)号：US5972707A
公开(公告)日：1999-10-26
申请号：US890599
申请日：1997-07-09
申请人： Krishnendu Roy , Hai-Quan Mao , Vu L. Truong , Thomas August , Kam W. Leong
发明人： Krishnendu Roy , Hai-Quan Mao , Vu L. Truong , Thomas August , Kam W. Leong
IPC分类号： C12N15/09 , A61K9/16 , A61K9/51 , A61K47/48 , A61K48/00 , C12N15/88 , C12N15/00
CPC分类号： A61K9/5161 , A61K47/4823 , A61K47/48238 , A61K47/48292 , A61K47/48561 , A61K47/48876 , A61K9/167 , A61K9/5169 , A61K9/5192 , B82Y5/00 , C12N15/88 , A61K48/00 , Y10S977/808 , Y10S977/906 , Y10S977/915 , Y10S977/916 , Y10S977/92
摘要： A gene delivery system is made of enzymatically degradable polymeric cation and nucleic acid (DNA or RNA) nanospheres optionally with a linking moiety or a targeting ligand attached to the surface. The delivery system can be made by a simple method of coacervation. Targeting ligands can be attached to the nanosphere directly or via a linking moiety. The linkage design allows the attachment of any molecule onto the nanosphere surface including antibodies, cell adhesion molecules, hormones and other cell-specific ligands.
摘要翻译：基因递送系统由可酶降解的聚合阳离子和核酸（DNA或RNA）纳米球制成，任选地具有连接部分或连接到表面的靶向配体。输送系统可以通过简单的凝聚方法制成。靶向配体可以直接或通过连接部分连接到纳米球。连接设计允许将任何分子附着到纳米球表面，包括抗体，细胞粘附分子，激素和其他细胞特异性配体。

7. 发明申请

US20070031505A1 Methods for fabricating nano and microparticles for drug delivery 有权
标题翻译：用于制备用于药物递送的纳米和微粒的方法
公开(公告)号：US20070031505A1
公开(公告)日：2007-02-08
申请号：US11418885
申请日：2006-05-05
申请人： Krishnendu Roy , Li Shi , Luz Glangchai
发明人： Krishnendu Roy , Li Shi , Luz Glangchai
IPC分类号： A61K9/50 , A61K9/16
CPC分类号： A61K9/5146 , A61K41/0042 , B82Y5/00 , B82Y10/00 , B82Y30/00 , B82Y40/00 , G03F7/0002
摘要： The present invention generally relates to stimuli-responsive drug carriers and methods for making. More specifically, the present invention relates to stimuli-responsive lidded particles that respond to a physiological stimulus and dissolve at a target site inside the body thereby releasing therapeutic agents. The present invention further relates to solid, drug-loaded particles that are made from biodegradable polymers. The present invention further relates to methods for fabricating lidded particles and particles for drug delivery.
摘要翻译：本发明一般涉及刺激响应性药物载体和制备方法。更具体地，本发明涉及响应于生理刺激并溶解在体内目标部位的刺激响应的带盖的颗粒，从而释放治疗剂。本发明还涉及由可生物降解的聚合物制成的固体，药物负载的颗粒。本发明还涉及用于制造用于药物递送的带盖颗粒和颗粒的方法。

8. 发明授权

US09180102B2 Methods for fabricating nano and microparticles for drug delivery 有权
标题翻译：用于制备用于药物递送的纳米和微粒的方法
公开(公告)号：US09180102B2
公开(公告)日：2015-11-10
申请号：US11418885
申请日：2006-05-05
申请人： Krishnendu Roy , Li Shi , Luz Cristal S. Glangchai
发明人： Krishnendu Roy , Li Shi , Luz Cristal S. Glangchai
IPC分类号： A61K9/50 , A61K9/16 , A61K9/51 , A61K41/00 , B82Y5/00 , B82Y10/00 , B82Y30/00 , B82Y40/00 , G03F7/00
CPC分类号： A61K9/5146 , A61K41/0042 , B82Y5/00 , B82Y10/00 , B82Y30/00 , B82Y40/00 , G03F7/0002
摘要： The present invention generally relates to stimuli-responsive drug carriers and methods for making. More specifically, the present invention relates to stimuli-responsive lidded particles that respond to a physiological stimulus and dissolve at a target site inside the body thereby releasing therapeutic agents. The present invention further relates to solid, drug-loaded particles that are made from biodegradable polymers. The present invention further relates to methods for fabricating lidded particles and particles for drug delivery.
摘要翻译：本发明一般涉及刺激响应性药物载体和制备方法。更具体地，本发明涉及响应于生理刺激并溶解在体内目标部位的刺激响应的带盖的颗粒，从而释放治疗剂。本发明还涉及由可生物降解的聚合物制成的固体，药物负载的颗粒。本发明还涉及用于制造用于药物递送的带盖颗粒和颗粒的方法。

9. 发明授权

US09096830B2 Multi-layered hydrogel constructs and associated methods 有权
标题翻译：多层水凝胶结构及相关方法
公开(公告)号：US09096830B2
公开(公告)日：2015-08-04
申请号：US13093606
申请日：2011-04-25
申请人： Krishnendu Roy , Lonnissa Nguyen
发明人： Krishnendu Roy , Lonnissa Nguyen
IPC分类号： A01N63/00 , C12N5/077 , A61L27/22 , A61L27/38 , A61L27/52
CPC分类号： C12N5/0655 , A61L27/227 , A61L27/3839 , A61L27/52 , A61L2430/06 , C12N2513/00 , C12N2533/30 , C12N2533/70 , C12N2533/80
摘要： Multi-layered hydrogel constructs comprising: a first layer comprising a first polymerizable material, hyaluronic acid and a plurality of cells; a second layer comprising a second polymerizable material, chondroitin sulfate and a plurality of cells; and a third layer comprising a third polymerizable material, chondroitin sulfate, a matrix metalloprotease sensitive peptide, and a plurality of cells are provided. Associated methods are also provided.
摘要翻译：多层水凝胶构建体，其包含：第一层，其包含第一可聚合材料，透明质酸和多个细胞; 第二层，其包含第二可聚合材料，硫酸软骨素和多个细胞; 并且提供包含第三可聚合材料，硫酸软骨素，基质金属蛋白酶敏感肽和多个细胞的第三层。还提供了相关的方法。

10. 发明申请

US20110206617A1 MODIFIED POLYSACCHARIDES FOR DRUG AND CONTRAST AGENT DELIVERY 审中-公开
标题翻译：用于药物和对照药物递送的改性多糖
公开(公告)号：US20110206617A1
公开(公告)日：2011-08-25
申请号：US13032280
申请日：2011-02-22
申请人： Krishnendu Roy , Bilal Ghosn , Rebecca Richards-Kortum , Anne van de Ven-Moloney
发明人： Krishnendu Roy , Bilal Ghosn , Rebecca Richards-Kortum , Anne van de Ven-Moloney
IPC分类号： A61K49/00 , A61K47/36 , A61K39/395 , C08B37/08 , A61P43/00 , A61P35/00 , B82Y5/00
CPC分类号： A61K49/0043 , A61K9/0034 , A61K9/5146 , A61K31/722 , A61K39/395 , A61K45/06 , A61K49/0065 , C08B37/003 , A61K2300/00
摘要： According to one embodiment, the disclosure provides a delivery formulation including a chitosan in which the primary amines are partially modified with 4-imidazole acetic acid monohydrochloride and a therapeutic or imaging material. According to another embodiment, the disclosure provides a method for delivering a material to an epithelial or mucosal tissue comprising increasing the permeability of an epithelial or mucosal tissue by applying to said tissue a delivery formulation including a chitosan in which the primary amines are partially modified with 4-imidazole acetic acid monochlorohydride and a therapeutic or imaging material.
摘要翻译：根据一个实施方案，本公开提供了包含壳聚糖的递送制剂，其中伯胺用4-咪唑乙酸单盐酸盐和治疗或成像材料部分地修饰。根据另一个实施方案，本公开提供了一种将材料递送至上皮或粘膜组织的方法，包括通过向所述组织施用包含壳聚糖的递送制剂来增加上皮或粘膜组织的渗透性，其中所述伯胺部分地用 4-咪唑乙酸一氯化氢和治疗或成像材料。

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