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1. 发明申请

US20090232852A1 USE OF OUTER MEMBRANE PROTEIN A (OMPA) IN TREATMENT/PREVENTION/DIAGNOSIS OF INFECTIONS CAUSED BY KLEBSIELLA PNEUMONIAE AND OTHER GRAM-NEGATIVE BACTERIA 有权
标题翻译：使用外膜蛋白A（OMPA）治疗/预防/诊断由克氏杆菌肺炎和其他灰质细菌引起的感染
公开(公告)号：US20090232852A1
公开(公告)日：2009-09-17
申请号：US12359205
申请日：2009-01-23
申请人： Yi-Yuan Yang , Hsueh-Hsia Wu , Sy-Jye Leu , Neng-Yao Shih , I-Jen Huang , Ching-Yu Lin , Wen-Shyang Hsieh , Ko-Jiunn Liu , Shih-Yi Huang , Yueh-Lun Lee , Chi-Hsin Lee , Yuan-Soon Ho , Shih-Lan Hsu
发明人： Yi-Yuan Yang , Hsueh-Hsia Wu , Sy-Jye Leu , Neng-Yao Shih , I-Jen Huang , Ching-Yu Lin , Wen-Shyang Hsieh , Ko-Jiunn Liu , Shih-Yi Huang , Yueh-Lun Lee , Chi-Hsin Lee , Yuan-Soon Ho , Shih-Lan Hsu
IPC分类号： A61K39/108 , A61K38/16 , A61K39/02 , G01N33/569 , A61K39/112
CPC分类号： G01N33/56916 , A61K38/164 , A61K39/025 , G01N2469/10 , Y02A50/474 , Y02A50/482 , Y02A50/484
摘要： The present invention provides a method for the treatment and/or prevention of bacterial infection caused by klebsiella pneumoniae and other gram-negative bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation in a mammal.
摘要翻译：本发明提供了一种通过施用有效量的外膜蛋白A（OmpA）来治疗和/或预防哺乳动物中枢神经系统和/或外周血循环中由肺炎克雷伯杆菌和其它革兰氏阴性细菌引起的细菌感染的方法）或其衍生物。还提供了一种用于接种哺乳动物以在中枢神经系统和/或外周血循环中产生由肠杆菌科家族引起的细菌感染的抗体的方法，以及检测或诊断由中枢神经系统中肠杆菌科家族引起的细菌感染的方法和/或哺乳动物的外周血循环。

2. 发明授权

US07364758B2 Pharmaceutical use of Graptopetalum and related plants 有权
标题翻译： Graptopetalum及相关植物的药用
公开(公告)号：US07364758B2
公开(公告)日：2008-04-29
申请号：US10931791
申请日：2004-08-31
申请人： Shih-Lan Hsu
发明人： Shih-Lan Hsu
IPC分类号： A01N65/00 , A61K36/00
CPC分类号： A61K36/41 , Y10S514/838 , Y10S514/893 , Y10S514/894
摘要： The present invention relates to compositions comprising Graptopetalum and uses thereof Graptopetalum can protect animals from liver diseases and medical conditions, such as inflammation, steatosis, and fibrosis. In particular, Graptopetalum inhibits proliferation of activated hepatic stellate cells, which play a pivotal role in liver fibrosis. Graptopetalum also has anti-fibrosis activities as well as inhibits proliferation of lung fibroblasts. Therefore, in addition to being a prophylactic and therapeutic agent for the liver, Graptopetalum is useful against fibrosis or inflammation of tissues or organs other than the liver, in particular lung, kidney, and bladder. Other plants in the family of Crassulaceae, particularly Echeveria, have similar effects as Graptopetalum.
摘要翻译：本发明涉及包含Graptopetalum的组合物及其用途Graptopetalum可以保护动物免受肝脏疾病和医学病症如炎症，脂肪变性和纤维化。特别是，Graptopetalum抑制活化肝星状细胞的增殖，其在肝纤维化中起关键作用。 Graptopetalum还具有抗纤维化活性以及抑制肺成纤维细胞的增殖。因此，Graptopetalum除了作为肝脏的预防和治疗剂之外，还可用于除了肝脏，特别是肺，肾和膀胱以外的组织或器官的纤维化或炎症。十字花科的其他植物，尤其是Echeveria，具有与Graptopetalum类似的作用。

3. 发明授权

US08361441B2 Detection and therapy of bacterial infection caused by Enterobacteriaceae 有权
标题翻译：检测和治疗由肠杆菌科引起的细菌感染
公开(公告)号：US08361441B2
公开(公告)日：2013-01-29
申请号：US12569363
申请日：2009-09-29
申请人： Yi-Yuan Yang , Hsueh-Hsia Wu , Sy-Jye Leu , Neng-Yao Shih , I-Jen Huang , Wen-Shyang Hsieh , Ko-Jiunn Liu , Shih-Yi Huang , Yung-Luen Shih , Chi-Hsin Lee , Yuan-Soon Ho , Shih-Lan Hsu
发明人： Yi-Yuan Yang , Hsueh-Hsia Wu , Sy-Jye Leu , Neng-Yao Shih , I-Jen Huang , Wen-Shyang Hsieh , Ko-Jiunn Liu , Shih-Yi Huang , Yung-Luen Shih , Chi-Hsin Lee , Yuan-Soon Ho , Shih-Lan Hsu
IPC分类号： A61K49/00 , A61K39/02 , A61K39/112
CPC分类号： A61K38/164 , C07K16/1232 , C07K2317/11 , C07K2317/23 , C07K2317/76 , G01N33/56916 , G01N33/6893 , G01N2800/26
摘要： The present invention provides a method for the treatment and/or prevention of bacterial infection caused by Enterobacteriaceae bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation in a mammal. An antibody and a kit on the basis of the vaccinating method and detecting/diagnosing method are also provided.
摘要翻译：本发明提供了一种通过将有效量的外膜蛋白A（OmpA）或其衍生物施用于哺乳动物的中枢神经系统和/或外周血循环中由肠杆菌科细菌引起的细菌感染的治疗和/或预防方法哺乳动物。还提供了一种用于接种哺乳动物以在中枢神经系统和/或外周血循环中产生由肠杆菌科家族引起的细菌感染的抗体的方法，以及检测或诊断由中枢神经系统中肠杆菌科家族引起的细菌感染的方法和/或哺乳动物的外周血循环。还提供了基于疫苗接种方法和检测/诊断方法的抗体和试剂盒。

4. 发明授权

US07972785B2 Biomarkers for liver fibrotic injury 有权
标题翻译：肝纤维化损伤的生物标志物
公开(公告)号：US07972785B2
公开(公告)日：2011-07-05
申请号：US11656389
申请日：2007-01-23
申请人： Hui-Chu Hsieh , Tzu-Ling Tseng , Li-Jen Su , Chi-Ying Huang , Shih-Lan Hsu
发明人： Hui-Chu Hsieh , Tzu-Ling Tseng , Li-Jen Su , Chi-Ying Huang , Shih-Lan Hsu
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/158 , G01N33/5023 , G01N2800/085
摘要： The present invention provides a method for detecting liver fibrotic injury, including fibrosis and/or cirrhosis, by assaying biological samples for differential expression of at least one gene encoding a protein chosen from SEQ ID NO: 1-SEQ ID NO: 63 and human orthologs thereof, wherein differential expression of at least one gene suggests the presence of liver fibrosis or cirrhosis. The invention also provides a kit containing nucleic acid probes or antibodies for detecting liver fibrosis and/or cirrhosis by assaying the differential expression of proteins encoded by SEQ ID NO: 1-SEQ ID NO: 63 and human orthologs thereof.
摘要翻译：本发明提供一种检测肝纤维化损伤（包括纤维化和/或肝硬化）的方法，通过测定生物样品来鉴别至少一种编码选自SEQ ID NO：1-SEQ ID NO：63的蛋白质的基因和人直向同源物其中至少一个基因的差异表达表明存在肝纤维化或肝硬化。本发明还提供了一种试剂盒，其包含通过测定由SEQ ID NO：1-SEQ ID NO：63编码的蛋白质的差异表达及其人类直向同源物来检测肝纤维化和/或肝硬化的核酸探针或抗体。

5. 发明申请

US20070184476A1 Biomarkers for liver fibrotic injury 有权
标题翻译：肝纤维化损伤的生物标志物
公开(公告)号：US20070184476A1
公开(公告)日：2007-08-09
申请号：US11656389
申请日：2007-01-23
申请人： Hui-Chu Hsieh , Tzu-Ling Tseng , Li-Jen Su , Chi-Ying Huang , Shih-Lan Hsu
发明人： Hui-Chu Hsieh , Tzu-Ling Tseng , Li-Jen Su , Chi-Ying Huang , Shih-Lan Hsu
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/158 , G01N33/5023 , G01N2800/085
摘要： The present invention provides a method for detecting liver fibrotic injury, including fibrosis and/or cirrhosis, by assaying biological samples for differential expression of at least one gene encoding a protein chosen from SEQ ID NO: 1-SEQ ID NO: 63 and human orthologs thereof, wherein differential expression of at least one gene suggests the presence of liver fibrosis or cirrhosis. The invention also provides a kit containing nucleic acid probes or antibodies for detecting liver fibrosis and/or cirrhosis by assaying the differential expression of proteins encoded by SEQ ID NO: 1-SEQ ID NO: 63 and human orthologs thereof.
摘要翻译：本发明提供一种检测肝纤维化损伤（包括纤维化和/或肝硬化）的方法，通过测定生物样品来鉴别至少一种编码选自SEQ ID NO：1-SEQ ID NO：63的蛋白质的基因和人直向同源物其中至少一个基因的差异表达表明存在肝纤维化或肝硬化。本发明还提供了一种试剂盒，其包含通过测定由SEQ ID NO：1-SEQ ID NO：63编码的蛋白质的差异表达及其人类直向同源物来检测肝纤维化和/或肝硬化的核酸探针或抗体。

6. 发明授权

US07807139B2 Use of outer membrane protein A (OMPA) in treatment/prevention/diagnosis of infections caused by Klebsiella pneumoniae and other gram-negative bacteria 有权
标题翻译：使用外膜蛋白A（OMPA）治疗/预防/诊断由肺炎克雷伯杆菌和其他革兰氏阴性细菌引起的感染
公开(公告)号：US07807139B2
公开(公告)日：2010-10-05
申请号：US12359205
申请日：2009-01-23
申请人： Yi-Yuan Yang , Hsueh-Hsia Wu , Sy-Jye Leu , Neng-Yao Shih , I-Jen Huang , Ching-Yu Lin , Wen-Shyang Hsieh , Ko-Jiunn Liu , Shih-Yi Huang , Yueh-Lun Lee , Chi-Hsin Lee , Yuan-Soon Ho , Shih-Lan Hsu
发明人： Yi-Yuan Yang , Hsueh-Hsia Wu , Sy-Jye Leu , Neng-Yao Shih , I-Jen Huang , Ching-Yu Lin , Wen-Shyang Hsieh , Ko-Jiunn Liu , Shih-Yi Huang , Yueh-Lun Lee , Chi-Hsin Lee , Yuan-Soon Ho , Shih-Lan Hsu
IPC分类号： A61K49/00 , A61K39/00 , A61K39/108
CPC分类号： G01N33/56916 , A61K38/164 , A61K39/025 , G01N2469/10 , Y02A50/474 , Y02A50/482 , Y02A50/484
摘要： The present invention provides a method for the treatment and/or prevention of bacterial infection caused by Klebsiella pneumoniae and other gram-negative bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation in a mammal.
摘要翻译：本发明提供一种通过施用有效量的外膜蛋白A（OmpA）来治疗和/或预防哺乳动物的中枢神经系统和/或外周血循环中由肺炎克雷伯杆菌和其它革兰氏阴性细菌引起的细菌感染的方法）或其衍生物。还提供了一种用于接种哺乳动物以在中枢神经系统和/或外周血循环中产生由肠杆菌科家族引起的细菌感染的抗体的方法，以及检测或诊断由中枢神经系统中肠杆菌科家族引起的细菌感染的方法和/或哺乳动物的外周血循环。

7. 发明授权

US07588776B2 Pharmaceutical use of water-soluble fraction of Graptopetalum 有权
$Pharmaceutical use of water-soluble fraction of Graptopetalum$
标题翻译：药用石菖蒲水溶性成分
公开(公告)号：US07588776B2
公开(公告)日：2009-09-15
申请号：US12038132
申请日：2008-02-27
申请人： Shih-Lan Hsu
发明人： Shih-Lan Hsu
IPC分类号： A01N65/00 , A61K36/00
CPC分类号： A61K36/41 , Y10S514/838 , Y10S514/893 , Y10S514/894
摘要： A pharmaceutical composition containing a water-soluble fraction of Graptopetalum and its use in treating a liver disease or condition, such as inflammation, steatosis, and fibrosis.
摘要翻译：含有Graptopetalum的水溶性级分的药物组合物及其在治疗肝脏疾病或病症如炎症，脂肪变性和纤维化中的用途。

8. 发明申请

US20100087373A1 DETECTION AND THERAPY OF BACTERIAL INFECTION CAUSED BY ENTEROBACTERIACEAE 有权
标题翻译：肠杆菌引起的细菌感染的检测和治疗
公开(公告)号：US20100087373A1
公开(公告)日：2010-04-08
申请号：US12569363
申请日：2009-09-29
申请人： Yi-Yuan Yang , Hsueh-Hsia Wu , Sy-Jye Leu , Neng-Yao Shih , I-Jen Huang , Ching-Yu Lin , Wen-Shyang Hsieh , Ko-Jiunn Liu , Shih-Yi Huang , Yung-Luen Shih , Chi-Hsin Lee , Yuan-Soon Ho , Shih-Lan Hsu
发明人： Yi-Yuan Yang , Hsueh-Hsia Wu , Sy-Jye Leu , Neng-Yao Shih , I-Jen Huang , Ching-Yu Lin , Wen-Shyang Hsieh , Ko-Jiunn Liu , Shih-Yi Huang , Yung-Luen Shih , Chi-Hsin Lee , Yuan-Soon Ho , Shih-Lan Hsu
IPC分类号： A61K38/16 , A61K39/02 , C07K16/12 , G01N33/53
CPC分类号： A61K38/164 , C07K16/1232 , C07K2317/11 , C07K2317/23 , C07K2317/76 , G01N33/56916 , G01N33/6893 , G01N2800/26
摘要： The present invention provides a method for the treatment and/or prevention of bacterial infection caused by Enterobacteriaceae bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation in a mammal. An antibody and a kit on the basis of the vaccinating method and detecting/diagnosing method are also provided.
摘要翻译：本发明提供了一种通过将有效量的外膜蛋白A（OmpA）或其衍生物施用于哺乳动物的中枢神经系统和/或外周血循环中由肠杆菌科细菌引起的细菌感染的治疗和/或预防方法哺乳动物。还提供了一种用于接种哺乳动物以在中枢神经系统和/或外周血循环中产生由肠杆菌科家族引起的细菌感染的抗体的方法，以及检测或诊断由中枢神经系统中肠杆菌科家族引起的细菌感染的方法和/或哺乳动物的外周血循环。还提供了基于疫苗接种方法和检测/诊断方法的抗体和试剂盒。

9. 发明申请

US20080160112A1 PHARMACEUTICAL USE OF WATER-SOLUBLE FRACTION OF GRAPTOPETALUM 有权
标题翻译：水溶性纤维素分解的药物使用
公开(公告)号：US20080160112A1
公开(公告)日：2008-07-03
申请号：US12038132
申请日：2008-02-27
申请人： Shih-Lan Hsu
发明人： Shih-Lan Hsu
IPC分类号： A61K36/41 , A61P1/16 , A61P31/12
CPC分类号： A61K36/41 , Y10S514/838 , Y10S514/893 , Y10S514/894
摘要： The present invention relates to a pharmaceutical composition containing a water-soluble fraction of Graptopetalum and its use in treating a liver disease or condition, such as inflammation, steatosis, and fibrosis.
摘要翻译：本发明涉及含有Graptopetalum的水溶性级分的药物组合物及其在治疗肝脏疾病或病症如炎症，脂肪变性和纤维化中的用途。

10. 发明申请

US20060045925A1 Pharmaceutical use of Graptopetalum and related plants 有权
标题翻译： Graptopetalum及相关植物的药用
公开(公告)号：US20060045925A1
公开(公告)日：2006-03-02
申请号：US10931791
申请日：2004-08-31
申请人： Shih-Lan Hsu
发明人： Shih-Lan Hsu
IPC分类号： A61K36/754
CPC分类号： A61K36/41 , Y10S514/838 , Y10S514/893 , Y10S514/894
摘要： The present invention relates to compositions comprising Graptopetalum and uses thereof Graptopetalum can protect animals from liver diseases and medical conditions, such as inflammation, steatosis, and fibrosis. In particular, Graptopetalum inhibits proliferation of activated hepatic stellate cells, which play a pivotal role in liver fibrosis. Graptopetalum also has anti-fibrosis activities as well as inhibits proliferation of lung fibroblasts. Therefore, in addition to being a prophylactic and therapeutic agent for the liver, Graptopetalum is useful against fibrosis or inflammation of tissues or organs other than the liver, in particular lung, kidney, and bladder. Other plants in the family of Crassulaceae, particularly Echeveria, have similar effects as Graptopetalum.
摘要翻译：本发明涉及包含Graptopetalum的组合物及其用途Graptopetalum可以保护动物免受肝脏疾病和医学病症如炎症，脂肪变性和纤维化。特别是，Graptopetalum抑制活化肝星状细胞的增殖，其在肝纤维化中起关键作用。 Graptopetalum还具有抗纤维化活性以及抑制肺成纤维细胞的增殖。因此，Graptopetalum除了作为肝脏的预防和治疗剂之外，还可用于除了肝脏，特别是肺，肾和膀胱以外的组织或器官的纤维化或炎症。十字花科的其他植物，尤其是Echeveria，具有与Graptopetalum类似的作用。

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