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1. 发明授权

US08361441B2 Detection and therapy of bacterial infection caused by Enterobacteriaceae 有权
标题翻译：检测和治疗由肠杆菌科引起的细菌感染
公开(公告)号：US08361441B2
公开(公告)日：2013-01-29
申请号：US12569363
申请日：2009-09-29
申请人： Yi-Yuan Yang , Hsueh-Hsia Wu , Sy-Jye Leu , Neng-Yao Shih , I-Jen Huang , Wen-Shyang Hsieh , Ko-Jiunn Liu , Shih-Yi Huang , Yung-Luen Shih , Chi-Hsin Lee , Yuan-Soon Ho , Shih-Lan Hsu
发明人： Yi-Yuan Yang , Hsueh-Hsia Wu , Sy-Jye Leu , Neng-Yao Shih , I-Jen Huang , Wen-Shyang Hsieh , Ko-Jiunn Liu , Shih-Yi Huang , Yung-Luen Shih , Chi-Hsin Lee , Yuan-Soon Ho , Shih-Lan Hsu
IPC分类号： A61K49/00 , A61K39/02 , A61K39/112
CPC分类号： A61K38/164 , C07K16/1232 , C07K2317/11 , C07K2317/23 , C07K2317/76 , G01N33/56916 , G01N33/6893 , G01N2800/26
摘要： The present invention provides a method for the treatment and/or prevention of bacterial infection caused by Enterobacteriaceae bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation in a mammal. An antibody and a kit on the basis of the vaccinating method and detecting/diagnosing method are also provided.
摘要翻译：本发明提供了一种通过将有效量的外膜蛋白A（OmpA）或其衍生物施用于哺乳动物的中枢神经系统和/或外周血循环中由肠杆菌科细菌引起的细菌感染的治疗和/或预防方法哺乳动物。还提供了一种用于接种哺乳动物以在中枢神经系统和/或外周血循环中产生由肠杆菌科家族引起的细菌感染的抗体的方法，以及检测或诊断由中枢神经系统中肠杆菌科家族引起的细菌感染的方法和/或哺乳动物的外周血循环。还提供了基于疫苗接种方法和检测/诊断方法的抗体和试剂盒。

2. 发明申请

US20110127921A1 Light-emitting Diode (LED) Current Balance Circuit 有权
标题翻译：发光二极管（LED）电流平衡电路
公开(公告)号：US20110127921A1
公开(公告)日：2011-06-02
申请号：US12954958
申请日：2010-11-29
申请人： Li-Wei Lin , Chen-Chiang LEE , Chi-Hsin LEE , Yuan-Po HUANG , Wen-Ming LIN
发明人： Li-Wei Lin , Chen-Chiang LEE , Chi-Hsin LEE , Yuan-Po HUANG , Wen-Ming LIN
IPC分类号： H05B37/02
CPC分类号： H05B33/0827 , H05B33/0887
摘要： A light-emitting diode (LED) current balance circuit includes a reference current generator, a current mirror and a voltage compensation circuit. The reference current generator provides a reference current robust against disturbance in a supply voltage applied to the reference current generator. The current mirror generates, according to the reference current, sink currents to bias lightbars and employs a structure to reduce the influence of unmatched transistors on the sink currents so as to stabilize and clamp currents through the lightbar. The voltage compensation circuit detects the voltages across the lightbars to compensate the lightbars having various forward voltages so as to ensure the turn-on of all lightbars and effectively balance the currents through the lightbars. Therefore, the invention employs simpler circuit architecture and not need a specific-purpose LED controller so as to be cheaper and more competitive.
摘要翻译：发光二极管（LED）电流平衡电路包括参考电流发生器，电流镜和电压补偿电路。参考电流发生器提供了对施加到参考电流发生器的电源电压中的干扰的参考电流。电流镜根据参考电流产生吸收电流以偏置光棒并且采用结构来减少不匹配的晶体管对吸收电流的影响，以便稳定和钳制通过光棒的电流。电压补偿电路检测光束两端的电压，以补偿具有各种正向电压的光棒，以确保所有光条的导通，并有效平衡通过光棒的电流。因此，本发明采用更简单的电路架构，并且不需要特定目的的LED控制器，以便更便宜和更具竞争力。

3. 发明授权

US08525436B2 Light-emitting diode (LED) current balance circuit 有权
标题翻译：发光二极管（LED）电流平衡电路
公开(公告)号：US08525436B2
公开(公告)日：2013-09-03
申请号：US12954958
申请日：2010-11-29
申请人： Li-Wei Lin , Chen-Chiang Lee , Chi-Hsin Lee , Yuan-Po Huang , Wen-Ming Lin
发明人： Li-Wei Lin , Chen-Chiang Lee , Chi-Hsin Lee , Yuan-Po Huang , Wen-Ming Lin
IPC分类号： H05B37/02
CPC分类号： H05B33/0827 , H05B33/0887
摘要： A light-emitting diode (LED) current balance circuit includes a reference current generator, a current mirror and a voltage compensation circuit. The reference current generator provides a reference current robust against disturbance in a supply voltage applied to the reference current generator. The current mirror generates, according to the reference current, sink currents to bias lightbars and employs a structure to reduce the influence of unmatched transistors on the sink currents to stabilize and clamp currents through the lightbar. The voltage compensation circuit detects the voltages across the lightbars to compensate the lightbars having various forward voltages to ensure the turn-on of all lightbars and to effectively balance the currents through the lightbars. Therefore, a simpler circuit architecture is employed which does not need a specific-purpose LED controller to be cheaper and more competitive.
摘要翻译：发光二极管（LED）电流平衡电路包括参考电流发生器，电流镜和电压补偿电路。参考电流发生器提供了对施加到参考电流发生器的电源电压中的干扰的参考电流。电流镜根据参考电流产生吸收电流以偏置光棒并且采用结构来减少不匹配的晶体管对吸收电流的影响，以稳定和钳制通过光棒的电流。电压补偿电路检测光束两端的电压，以补偿具有各种正向电压的光棒，以确保所有光条的导通，并有效平衡通过光棒的电流。因此，采用更简单的电路结构，其不需要特定目的的LED控制器以便更便宜和更具竞争力。

4. 发明申请

US20110148314A1 Serial-Type Light-Emitting Diode (LED) Device 有权
标题翻译：串联型发光二极管（LED）装置
公开(公告)号：US20110148314A1
公开(公告)日：2011-06-23
申请号：US12974074
申请日：2010-12-21
申请人： Li-Wei Lin , Chen-Chiang Lee , Chi-Hsin Lee
发明人： Li-Wei Lin , Chen-Chiang Lee , Chi-Hsin Lee
IPC分类号： H05B37/02
CPC分类号： H05B33/0827
摘要： A serial-type LED device includes p light source units and a dimming circuit. Each light source unit includes a first and a second terminals, m light strings and m current balance units. Each light string includes LEDs coupled in series to have a first terminal coupled to the first terminal of a corresponding light source unit and a second terminal coupled to the second terminal of the corresponding light source unit through a corresponding current balance unit. The first terminal of the first light source unit is coupled to a second DC voltage, and the second terminal of the i-th light source unit is coupled to the first terminal of the (i+1)-th light source unit, where m and p are integers greater than or equal to 2 and i is any integer from 1 to (p−1). The dimming circuit coupled to the second terminal of the p-th light source unit controls the second DC voltage according to a current outputted from the p-th light source unit.
摘要翻译：串联型LED器件包括p个光源单元和一个调光电路。每个光源单元包括第一和第二端子，m个光线和m个电流平衡单元。每个灯串包括串联耦合的LED以具有耦合到相应光源单元的第一端的第一端和通过相应的电流平衡单元耦合到相应光源单元的第二端的第二端。第一光源单元的第一端子耦合到第二DC电压，并且第i个光源单元的第二端子耦合到第（i + 1）个光源单元的第一端子，其中m p是大于或等于2的整数，i是从1到（p-1）的任何整数。耦合到第p个光源单元的第二端的调光电路根据从第p个光源单元输出的电流来控制第二直流电压。

5. 发明授权

US07608247B2 Use of outer membrane protein a in treatment/prevention/diagnosis of bacterial infection in central nervous system and/or peripheral blood circulation 有权
标题翻译：使用外膜蛋白a治疗/预防/诊断中枢神经系统和/或外周血液循环中的细菌感染
公开(公告)号：US07608247B2
公开(公告)日：2009-10-27
申请号：US12046165
申请日：2008-03-11
申请人： Yi-Yuan Yang , Hsueh-Hsia Wu , Sy-Jye Leu , I-Jen Huang , Neng-Yao Shih , Ko-Jiunn Liu , Mei-Ru Chen , Wen-Shyang Hsieh , Chi-Hsin Lee
发明人： Yi-Yuan Yang , Hsueh-Hsia Wu , Sy-Jye Leu , I-Jen Huang , Neng-Yao Shih , Ko-Jiunn Liu , Mei-Ru Chen , Wen-Shyang Hsieh , Chi-Hsin Lee
IPC分类号： A61K49/00 , A61K39/108 , A61K39/02
CPC分类号： G01N33/6893 , A61K38/164 , G01N2800/26 , Y02A50/474 , Y02A50/482
摘要： The present invention provides a method for the treatment and/or prevention of bacterial infection in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided is an antibody binding to OmpA that can assay OmpA levels in a biological sample and detect or diagnose bacterial infection in central nervous system and/or peripheral blood circulation.
摘要翻译：本发明提供了一种通过向哺乳动物施用有效量的外膜蛋白A（OmpA）或其衍生物来治疗和/或预防哺乳动物的中枢神经系统和/或外周血液循环中的细菌感染的方法。还提供了结合OmpA的抗体，其可以测定生物样品中的OmpA水平并检测或诊断中枢神经系统和/或外周血液循环中的细菌感染。

6. 发明申请

US20090232852A1 USE OF OUTER MEMBRANE PROTEIN A (OMPA) IN TREATMENT/PREVENTION/DIAGNOSIS OF INFECTIONS CAUSED BY KLEBSIELLA PNEUMONIAE AND OTHER GRAM-NEGATIVE BACTERIA 有权
标题翻译：使用外膜蛋白A（OMPA）治疗/预防/诊断由克氏杆菌肺炎和其他灰质细菌引起的感染
公开(公告)号：US20090232852A1
公开(公告)日：2009-09-17
申请号：US12359205
申请日：2009-01-23
申请人： Yi-Yuan Yang , Hsueh-Hsia Wu , Sy-Jye Leu , Neng-Yao Shih , I-Jen Huang , Ching-Yu Lin , Wen-Shyang Hsieh , Ko-Jiunn Liu , Shih-Yi Huang , Yueh-Lun Lee , Chi-Hsin Lee , Yuan-Soon Ho , Shih-Lan Hsu
发明人： Yi-Yuan Yang , Hsueh-Hsia Wu , Sy-Jye Leu , Neng-Yao Shih , I-Jen Huang , Ching-Yu Lin , Wen-Shyang Hsieh , Ko-Jiunn Liu , Shih-Yi Huang , Yueh-Lun Lee , Chi-Hsin Lee , Yuan-Soon Ho , Shih-Lan Hsu
IPC分类号： A61K39/108 , A61K38/16 , A61K39/02 , G01N33/569 , A61K39/112
CPC分类号： G01N33/56916 , A61K38/164 , A61K39/025 , G01N2469/10 , Y02A50/474 , Y02A50/482 , Y02A50/484
摘要： The present invention provides a method for the treatment and/or prevention of bacterial infection caused by klebsiella pneumoniae and other gram-negative bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation in a mammal.
摘要翻译：本发明提供了一种通过施用有效量的外膜蛋白A（OmpA）来治疗和/或预防哺乳动物中枢神经系统和/或外周血循环中由肺炎克雷伯杆菌和其它革兰氏阴性细菌引起的细菌感染的方法）或其衍生物。还提供了一种用于接种哺乳动物以在中枢神经系统和/或外周血循环中产生由肠杆菌科家族引起的细菌感染的抗体的方法，以及检测或诊断由中枢神经系统中肠杆菌科家族引起的细菌感染的方法和/或哺乳动物的外周血循环。

7. 发明授权

US07807139B2 Use of outer membrane protein A (OMPA) in treatment/prevention/diagnosis of infections caused by Klebsiella pneumoniae and other gram-negative bacteria 有权
标题翻译：使用外膜蛋白A（OMPA）治疗/预防/诊断由肺炎克雷伯杆菌和其他革兰氏阴性细菌引起的感染
公开(公告)号：US07807139B2
公开(公告)日：2010-10-05
申请号：US12359205
申请日：2009-01-23
申请人： Yi-Yuan Yang , Hsueh-Hsia Wu , Sy-Jye Leu , Neng-Yao Shih , I-Jen Huang , Ching-Yu Lin , Wen-Shyang Hsieh , Ko-Jiunn Liu , Shih-Yi Huang , Yueh-Lun Lee , Chi-Hsin Lee , Yuan-Soon Ho , Shih-Lan Hsu
发明人： Yi-Yuan Yang , Hsueh-Hsia Wu , Sy-Jye Leu , Neng-Yao Shih , I-Jen Huang , Ching-Yu Lin , Wen-Shyang Hsieh , Ko-Jiunn Liu , Shih-Yi Huang , Yueh-Lun Lee , Chi-Hsin Lee , Yuan-Soon Ho , Shih-Lan Hsu
IPC分类号： A61K49/00 , A61K39/00 , A61K39/108
CPC分类号： G01N33/56916 , A61K38/164 , A61K39/025 , G01N2469/10 , Y02A50/474 , Y02A50/482 , Y02A50/484
摘要： The present invention provides a method for the treatment and/or prevention of bacterial infection caused by Klebsiella pneumoniae and other gram-negative bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation in a mammal.
摘要翻译：本发明提供一种通过施用有效量的外膜蛋白A（OmpA）来治疗和/或预防哺乳动物的中枢神经系统和/或外周血循环中由肺炎克雷伯杆菌和其它革兰氏阴性细菌引起的细菌感染的方法）或其衍生物。还提供了一种用于接种哺乳动物以在中枢神经系统和/或外周血循环中产生由肠杆菌科家族引起的细菌感染的抗体的方法，以及检测或诊断由中枢神经系统中肠杆菌科家族引起的细菌感染的方法和/或哺乳动物的外周血循环。

8. 发明授权

US08610368B2 Serial-type light-emitting diode (LED) device 有权
标题翻译：串联式发光二极管（LED）装置
公开(公告)号：US08610368B2
公开(公告)日：2013-12-17
申请号：US12974074
申请日：2010-12-21
申请人： Li-Wei Lin , Chen-Chiang Lee , Chi-Hsin Lee
发明人： Li-Wei Lin , Chen-Chiang Lee , Chi-Hsin Lee
IPC分类号： G05F1/00
CPC分类号： H05B33/0827
摘要： A serial-type LED device includes p light source units and a dimming circuit. Each light source unit includes first and second terminals, m light strings and m current balance units. Each light string includes LEDs coupled in series to have a first terminal coupled to the first terminal of a corresponding light source unit and a second terminal coupled to the second terminal of the corresponding light source unit through a corresponding current balance unit. The first terminal of the first light source unit is coupled to a second DC voltage, and the second terminal of the i-th light source unit is coupled to the first terminal of the (i+1)-th light source unit, where m and p are integers greater than or equal to 2, and i is any integer from 1 to (p−1). The dimming circuit coupled to the second terminal of the p-th light source unit controls the second DC voltage according to a current outputted from the p-th light source unit.
摘要翻译：串联型LED器件包括p个光源单元和一个调光电路。每个光源单元包括第一和第二端子，m个光线和m个电流平衡单元。每个灯串包括串联耦合的LED以具有耦合到相应光源单元的第一端的第一端和通过相应的电流平衡单元耦合到相应光源单元的第二端的第二端。第一光源单元的第一端子耦合到第二DC电压，并且第i个光源单元的第二端子耦合到第（i + 1）个光源单元的第一端子，其中m p是大于或等于2的整数，i是从1到（p-1）的整数。耦合到第p个光源单元的第二端的调光电路根据从第p个光源单元输出的电流来控制第二直流电压。

9. 发明授权

US08525774B2 Light-emitting diode (LED) driving circuit 有权
标题翻译：发光二极管（LED）驱动电路
公开(公告)号：US08525774B2
公开(公告)日：2013-09-03
申请号：US12913837
申请日：2010-10-28
申请人： Li-Wei Lin , Chen-Chiang Lee , Chi-Hsin Lee , Wen-Ming Lin , Chun-Chi Liao , Yuan-Po Huang
发明人： Li-Wei Lin , Chen-Chiang Lee , Chi-Hsin Lee , Wen-Ming Lin , Chun-Chi Liao , Yuan-Po Huang
IPC分类号： G09G3/36 , G09G3/10
CPC分类号： H05B33/0887 , H05B33/0815 , H05B33/0818 , H05B33/0827
摘要： A light-emitting diode (LED) driving circuit for driving a plurality of first lightbars and a plurality of second lightbars includes a first current mirror, a second current mirror and a control circuit. The first current mirror, if enabled, balances current among the first lightbars. The second current mirror, if enabled, balances current among the second lightbars. During a first period, the control circuit disables the second current mirror and adjusts the duration of enabling the first current mirror according to a dimming signal. During a second period, the control circuit disables the first current mirror and adjusts the duration of enabling the second current mirror according to the dimming signal. Therefore, only first or second lightbars are driven in each period.
摘要翻译：用于驱动多个第一光条和多个第二光棒的发光二极管（LED）驱动电路包括第一电流镜，第二电流镜和控制电路。第一个当前的镜像，如果启用，平衡第一个光条之间的电流。第二个电流镜如果启用，则平衡第二个光条之间的电流。在第一时段期间，控制电路禁用第二电流镜，并且根据调光信号调节启用第一电流镜的持续时间。在第二时段期间，控制电路禁用第一电流镜并根据调光信号调节启用第二电流镜的持续时间。因此，在每个周期内仅驱动第一或第二个光条。

10. 发明申请

US20110096055A1 Light-emitting Diode (LED) Driving Circuit 有权
标题翻译：发光二极管（LED）驱动电路
公开(公告)号：US20110096055A1
公开(公告)日：2011-04-28
申请号：US12913837
申请日：2010-10-28
申请人： Li-Wei Lin , Chen-Chiang Lee , Chi-Hsin Lee , Wen-Ming Lin , Chun-Chi Liao , Yuan-Po Huang
发明人： Li-Wei Lin , Chen-Chiang Lee , Chi-Hsin Lee , Wen-Ming Lin , Chun-Chi Liao , Yuan-Po Huang
IPC分类号： G06F3/038
CPC分类号： H05B33/0887 , H05B33/0815 , H05B33/0818 , H05B33/0827
摘要： A light-emitting diode (LED) driving circuit for driving a plurality of first lightbars and a plurality of second lightbars includes a first current mirror, a second current mirror and a control circuit. The first current mirror, if enabled, balances current among the first lightbars. The second current mirror, if enabled, balances current among the second lightbars. During a first period, the control circuit disables the second current mirror and adjusts the duration of enabling the first current mirror according to a dimming signal. During a second period, the control circuit disables the first current mirror and adjusts the duration of enabling the second current mirror according to the dimming signal. Therefore, only first or second lightbars are driven in each period.
摘要翻译：用于驱动多个第一光条和多个第二光棒的发光二极管（LED）驱动电路包括第一电流镜，第二电流镜和控制电路。第一个当前的镜像，如果启用，平衡第一个光条之间的电流。第二个电流镜如果启用，则平衡第二个光条之间的电流。在第一时段期间，控制电路禁用第二电流镜，并且根据调光信号调节启用第一电流镜的持续时间。在第二时段期间，控制电路禁用第一电流镜并根据调光信号调节启用第二电流镜的持续时间。因此，在每个周期内仅驱动第一或第二个光条。

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