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1. 发明专利

JP2009077838A Instrument for forming valve leaflet and its component 有权
标题翻译：用于形成阀门叶片及其组件的仪器
公开(公告)号：JP2009077838A
公开(公告)日：2009-04-16
申请号：JP2007248327
申请日：2007-09-26
申请人： Shigeyuki Ozaki , 崎重之尾
发明人： OZAKI SHIGEYUKI
IPC分类号： A61F2/76 , A61F2/24 , A61L27/00
CPC分类号： A61F2/2415
摘要： PROBLEM TO BE SOLVED: To faciliate determination of the shape and the size of a valve leaflet when restoring the aortic valve or the like using a valve leaflet formed from biological membrane of oneself. SOLUTION: An instrument for forming a valve leaflet is provided, which includes valve leaflet sizers (2) for determining the size of a valve leaflet appropriate for the size of the valve of the heart and a template (3) for drawing a line of the shape of a valve leaflet on an artificial membrane or a biological membrane in accordance with the measured valve leaflet size. In the valve leaflet sizers (2), a plurality of sizer blocks (G 1 -G 8 ) having arc surfaces (24) and formed by cutting columns (22) of various diameters at an angle corresponding to the central angle of the commissure are attached to the distal ends of handles (21) respectively. The template (3) has drawing sections (31) each having an almost semicircular valve leaflet base forming section (33) and a coaptation zone forming section (34) continued from the valve leaflet base forming section. The diameter of each valve leaflet base forming section is the sum of a margin (w) and the nominal diameter (D 1 -D 8 ) of a sizer block (G 1 -G 8 ) having an arc section (24) whose both ends fit the commissures on both sides. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：使用由自己的生物膜形成的瓣叶片恢复主动脉瓣等时，确定瓣叶的形状和尺寸。提供了一种用于形成瓣膜小叶的仪器，其包括用于确定适合于心脏瓣膜尺寸的瓣膜小叶尺寸的瓣膜小叶分离器（2）和用于绘制根据测量的瓣叶大小在人造膜或生物膜上的瓣膜形状的线。在瓣膜分片器（2）中，具有弧形表面（24）并由切割柱（22）形成的多个分切器块（G -G 8 ）以对应于连合中心角的角度的各种直径分别附接到把手（21）的远端。模板（3）具有分别具有大致半圆形的小叶基部形成部（33）和从阀瓣形成部连续的接合区形成部（34）的拉拔部（31）。每个瓣膜基底形成部分的直径是筛分块的边缘（w）和标称直径（D 1 -D 8 ）之和（G < 具有弧形部分（24）的两端均配合在一起的SB> 1 -G 8 。版权所有（C）2009，JPO＆INPIT

2. 发明申请

US20210386548A1 VALVE CUSP SIZER 有权
公开(公告)号：US20210386548A1
公开(公告)日：2021-12-16
申请号：US17287599
申请日：2019-10-11
申请人： Shigeyuki OZAKI
发明人： Shigeyuki OZAKI
IPC分类号： A61F2/24 , A61F2/76
摘要： A valve cusp sizer includes a back surface brought into contact with a living body, and a hole that is formed on the top surface at a distance from the center in a left-right direction toward one side in the left-right direction and into which a support rod is inserted.

3. 发明申请

US20060212074A1 Method of removing cell 有权
标题翻译：去除细胞的方法
公开(公告)号：US20060212074A1
公开(公告)日：2006-09-21
申请号：US10556400
申请日：2004-05-12
申请人： Mitsuo Umezu , Kiyotaka Iwasaki , Shigeyuki Ozaki , Yuji Morimoto , Osamu Endo
发明人： Mitsuo Umezu , Kiyotaka Iwasaki , Shigeyuki Ozaki , Yuji Morimoto , Osamu Endo
IPC分类号： A61N1/39 , A01N1/02
CPC分类号： A61K35/34 , A61F2/2415 , Y10S623/901
摘要： In the transplant of a living organism tissue, such as a heart valve, taken from an animal, etc. into a human body, a cell removing solution for removing original cells from the living organism tissue is provided with flow approximately equal to the bloodstream of transplant recipient living body, and the living organism tissue is placed in the flow so as to effect immersion of the living organism tissue in the cell removing solution. In the immersion, it is preferred that the living organism tissue placed in the cell removing solution, while being rotated, be irradiated with microwave. As a result, original cells can be removed from the living organism tissue uniformly and reliably, so that the biocompatibility of living organism tissue after transplant can be enhanced.
摘要翻译：在将从动物等取出的生物体组织如心脏瓣膜等移植到人体内时，从生物体组织中除去原始细胞的细胞去除溶液具有大约等于移植受体活体，并将活体组织置于流中，以使活体组织浸入细胞去除溶液中。在浸渍中，优选将放置在细胞去除溶液中的活体组织在旋转的同时用微波照射。结果，原始细胞可以均匀可靠地从生物体组织中去除，从而可以提高移植后活体组织的生物相容性。

4. 发明授权

US09414920B2 Instrument of patterning cusp for cardiac valve reconstruction and component thereof 有权
标题翻译：用于心脏瓣膜重建的图案化尖瓣仪及其部件
公开(公告)号：US09414920B2
公开(公告)日：2016-08-16
申请号：US14070706
申请日：2013-11-04
申请人： Shigeyuki Ozaki
发明人： Shigeyuki Ozaki
IPC分类号： A61B17/00 , A61F2/24
CPC分类号： A61F2/2415 , A61F2/2445 , A61F2/2496
摘要： In a case of repairing an aortic valve by forming a valve cusp with a biomembrane, the shape and the size of a valve cusp can be determined easily. An instrument including a valve cusp sizer for measuring the size of the valve cusp and a template for scribing lines for the shape of a valve cusp conforming to the measured size of the valve cusp, in which the valve cusp sizer has a plurality of differently-sized sizer blocks attached to each of the top ends of grip members respectively and each sizer block has an arcuate surface formed by cutting each of differently-sized circular cylinders at an angle conforming to the central angle for the commissure portions and, the template is formed with a scribing portion including a substantially semi-circular valve cusp base forming portion.
摘要翻译：在通过用生物膜形成阀尖来修复主动脉瓣的情况下，可以容易地确定阀尖的形状和尺寸。一种包括用于测量阀尖的尺寸的阀尖调整器的仪器和用于根据所测量的阀尖的尺寸对阀尖形状进行划线的模板，其中阀尖调整器具有多个不同的方式，并且每个分级器块具有通过以与合金部分的中心角度相符的角度切割每个不同尺寸的圆柱体而形成的弓形表面，并且形成模板具有包括基本上半圆形的阀尖头基部形成部分的划线部分。

5. 发明公开

US20240164764A1 RETRACTOR AND HOLDER 审中-公开
公开(公告)号：US20240164764A1
公开(公告)日：2024-05-23
申请号：US18283351
申请日：2022-03-15
申请人： Shigeyuki OZAKI
发明人： Shigeyuki OZAKI
IPC分类号： A61B17/02 , A61B17/00 , A61B17/04 , A61B17/22
CPC分类号： A61B17/0218 , A61B2017/00473 , A61B2017/00783 , A61B2017/0414 , A61B2017/0464 , A61B2017/22082
摘要： A retractor includes plural holes penetrating from a front surface to a back surface of the retractor. The retractor is inserted into an aorta. When one end side of a thread that penetrates from the front surface to the back surface through one of the holes and penetrates from an inside to an outside of the aorta, and the other end side of the thread that penetrates from the front surface to the back surface through a hole of the plural holes different from the hole through which the one end side penetrates and penetrates from the inside to the outside of the aorta are pulled, the aorta is widened in a radial direction.

6. 发明授权

US08043854B2 Method of decellularizing tissues 有权
标题翻译：脱细胞组织方法
公开(公告)号：US08043854B2
公开(公告)日：2011-10-25
申请号：US10556400
申请日：2004-05-12
申请人： Mitsuo Umezu , Kiyotaka Iwasaki , Shigeyuki Ozaki , Yuji Morimoto , Osamu Endo
发明人： Mitsuo Umezu , Kiyotaka Iwasaki , Shigeyuki Ozaki , Yuji Morimoto , Osamu Endo
IPC分类号： A01N1/00
CPC分类号： A61K35/34 , A61F2/2415 , Y10S623/901
摘要： In the transplant of a living organism tissue, such as a heart valve, taken from an animal, etc. into a human body, a cell removing solution for removing original cells from the living organism tissue is provided with flow approximately equal to the bloodstream of transplant recipient living body, and the living organism tissue is placed in the flow so as to effect immersion of the living organism tissue in the cell removing solution. In the immersion, it is preferred that the living organism tissue placed in the cell removing solution, while being rotated, be irradiated with microwave. As a result, original cells can be removed from the living organism tissue uniformly and reliably, so that the biocompatibility of living organism tissue after transplant can be enhanced.
摘要翻译：在将从动物等取出的生物体组织如心脏瓣膜等移植到人体内时，从生物体组织中除去原始细胞的细胞去除溶液具有大约等于移植受体活体，并将活体组织置于流中，以使活体组织浸入细胞去除溶液中。在浸渍中，优选将放置在细胞去除溶液中的活体组织在旋转的同时用微波照射。结果，原始细胞可以均匀可靠地从生物体组织中去除，从而可以提高移植后活体组织的生物相容性。

7. 发明申请

US20140058504A1 INSTRUMENT OF PATTERNING CUSP FOR CARDIAC VALVE RECONSTRUCTION AND COMPONENT THEREOF 有权
标题翻译：用于心脏瓣膜重建的方法的仪器及其组件
公开(公告)号：US20140058504A1
公开(公告)日：2014-02-27
申请号：US14070706
申请日：2013-11-04
申请人： Shigeyuki OZAKI
发明人： Shigeyuki OZAKI
IPC分类号： A61F2/24
CPC分类号： A61F2/2415 , A61F2/2445 , A61F2/2496
摘要： In a case of repairing an aortic valve by forming a valve cusp with a biomembrane, the shape and the size of a valve cusp can be determined easily. An instrument including a valve cusp sizer for measuring the size of the valve cusp and a template for scribing lines for the shape of a valve cusp conforming to the measured size of the valve cusp, in which the valve cusp sizer has a plurality of differently-sized sizer blocks attached to each of the top ends of grip members respectively and each sizer block has an arcuate surface formed by cutting each of differently-sized circular cylinders at an angle conforming to the central angle for the commissure portions and, the template is formed with a scribing portion including a substantially semi-circular valve cusp base forming portion.
摘要翻译：在通过用生物膜形成阀尖来修复主动脉瓣的情况下，可以容易地确定阀尖的形状和尺寸。一种包括用于测量阀尖的尺寸的阀尖调整器的仪器和用于根据所测量的阀尖的尺寸对阀尖形状进行划线的模板，其中阀尖调整器具有多个不同的方式，并且每个分级器块具有通过以与合金部分的中心角度相符的角度切割每个不同尺寸的圆柱体而形成的弓形表面，并且形成模板具有包括基本上半圆形的阀尖头基部形成部分的划线部分。

8. 发明申请

US20110251598A1 INSTRUMENT OF PATTERNING CUSP FOR CARDIAC VALVE RECONSTRUCTION AND COMPONENT THEREOF 审中-公开
标题翻译：用于心脏瓣膜重建的方法的仪器及其组件
公开(公告)号：US20110251598A1
公开(公告)日：2011-10-13
申请号：US12758844
申请日：2010-04-13
申请人： Shigeyuki OZAKI
发明人： Shigeyuki OZAKI
IPC分类号： A61B17/00
CPC分类号： A61F2/2415 , A61F2/2445 , A61F2/2496
摘要： In a case of repairing an aortic valve, etc. by forming a valve cusp with a biomembrane or the like, the shape and the size of a valve cusp can be determined easily.An instrument including a valve cusp sizer 2 for measuring the sizer of the valve cusp and a template 3 for scribing lines for the shape of a valve cusp conforming to the measured size of the valve cusp, in which the valve cusp sizer 2 has a plurality of differently-sized sizer blocks (G1 to G8) attached to each of the top ends of grip members 21 respectively and each sizer block has an arcuate surface 24 formed by cutting each of differently-sized circular cylinders 22 at an angle conforming to the central angle for the commissure portions and,the template 3 is formed with a scribing portion 31 including a substantially semi-circular valve cusp base forming portion 33 having a diameter as a sum of a nominal diameter (D1 to D8) defined for the diameter of a circular cylinder constituting the arcuate surface of a sizer block (G1 to G8) whose arcuate surface 24 conforms at both ends thereof to both of the commissure portions and an allowance for stitching margin (W), and a coaptation zone forming portion 34 in contiguous with the valve cusp base forming portion.
摘要翻译：在通过用生物膜等形成阀尖来修复主动脉瓣等的情况下，可以容易地确定阀尖的形状和尺寸。一种仪器，其包括用于测量阀尖的尺寸调节器的阀瓣尖分度器2和用于根据所测量的阀尖的尺寸对阀尖形状进行划线的模板3，其中，阀尖调整器2具有多个分别安装在抓握构件21的每个顶端上的不同尺寸的尺寸调节器块（G1至G8），并且每个分级器块具有通过以与中心相对应的角度切割不同尺寸的圆柱体22而形成的弓形表面24 合模部分的角度，并且模板3形成有划线部分31，划线部分31包括基本上为半圆形的阀尖部基部形成部分33，其直径为为直径的直径定义的公称直径（D1至D8）之和圆形圆柱体构成其弓形表面24在其两端与两个接合部分一致的尺寸调节器块（G1至G8）的弧形表面，以及缝合余量（W）的允许值，以及接合zo 形成部分34与阀尖头基部形成部分邻接。

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