专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US10101299B2 Magnetic sensor based quantitative binding kinetics analysis 有权
公开(公告)号：US10101299B2
公开(公告)日：2018-10-16
申请号：US13046368
申请日：2011-03-11
申请人： Shan X. Wang , Richard S. Gaster , Liang Xu , Shu-Jen Han , Robert Wilson
发明人： Shan X. Wang , Richard S. Gaster , Liang Xu , Shu-Jen Han , Robert Wilson
IPC分类号： G01N27/00 , G01N27/74 , G01N33/557
摘要： Methods for quantitatively determining a binding kinetic parameter of a molecular binding interaction are provided. Aspects of embodiments of the methods include: producing a magnetic sensor device including a magnetic sensor in contact with an assay mixture including a magnetically labeled molecule to produce a detectable molecular binding interaction; obtaining a real-time signal from the magnetic sensor; and quantitatively determining a binding kinetics parameter of the molecular binding interaction from the real-time signal. Also provided are systems and kits configured for use in the methods.

2. 发明授权

US09153547B2 Integrated inductor structure and method of fabrication 有权
标题翻译：集成电感器结构及其制造方法
公开(公告)号：US09153547B2
公开(公告)日：2015-10-06
申请号：US12428430
申请日：2009-04-22
申请人： Ankur Mohan Crawford , Henning Braunisch , Rajendran Nair , Gilroy Vandentop , Shan X. Wang
发明人： Ankur Mohan Crawford , Henning Braunisch , Rajendran Nair , Gilroy Vandentop , Shan X. Wang
IPC分类号： H01F5/00 , H01F27/28 , H01L27/08 , H01F7/06 , H01L23/64 , H01F17/00 , H01F41/04 , H01L23/498 , H01L49/02 , H05K1/03 , H05K1/16 , H05K3/46
CPC分类号： H01L23/645 , H01F17/0033 , H01F41/046 , H01L23/49822 , H01L28/10 , H01L2224/16 , H01L2224/16235 , H01L2924/00011 , H01L2924/00014 , H01L2924/01077 , H01L2924/01078 , H01L2924/15311 , H01L2924/15312 , H01L2924/3011 , H05K1/0373 , H05K1/165 , H05K3/4644 , H05K2201/086 , H05K2201/09563 , H01L2224/0401
摘要： An inductor structure comprised of a magnetic section and a single turn solenoid. The single turn solenoid to contain within a portion of the magnetic section and circumscribed by the magnetic section.
摘要翻译：一个电感结构由一个磁性部分和一个单一的旋转螺线管组成。单转螺线管包含在磁性部分的一部分内并由磁性部分限定。

3. 发明授权

US08481336B2 Magnetic separation device for cell sorting and analysis 有权
标题翻译：用于细胞分选和分析的磁选机
公开(公告)号：US08481336B2
公开(公告)日：2013-07-09
申请号：US12807625
申请日：2010-09-09
申请人： Christopher M. Earhart , Shan X. Wang , Robert J. Wilson
发明人： Christopher M. Earhart , Shan X. Wang , Robert J. Wilson
IPC分类号： G01N33/553 , B01D63/00
CPC分类号： C12N13/00 , G01N33/54333 , G01N33/56966 , G01N33/57488
摘要： A magnetic sifter is adapted for manipulation of biological cells by providing a greater pore density at the edge of the sifter than at the center. Application of an external magnetic field to the sifter causes high magnetic fields and field gradients at the sifter pores. These conditions are suitable for capturing magnetically tagged or labeled cells at the sifter pores. Altering the external magnetic field can provide controlled capture and/or release of magnetically labeled cells from the sifter pores. The purpose of having a greater pore density at the periphery of the sifter than at the center is to provide improved flow rate uniformity through the sifter. Such flow rate uniformity is advantageous for cell quantification.
摘要翻译：磁选机适用于通过在筛子的边缘处提供比在中心处更大的孔密度来操纵生物细胞。在筛子上施加外部磁场会在筛分孔产生高磁场和场梯度。这些条件适用于在筛子孔处捕获磁标记或标记的细胞。改变外部磁场可以提供来自筛子孔的磁性标记细胞的受控捕获和/或释放。在筛子周边具有比中心更大的孔密度的目的是通过筛子提供改善的流速均匀性。这样的流速均匀性对于细胞定量是有利的。

4. 发明申请

US20100231203A1 Temperature and drift compensation in magnetoresistive sensors 有权
标题翻译：磁阻传感器的温度和漂移补偿
公开(公告)号：US20100231203A1
公开(公告)日：2010-09-16
申请号：US12661158
申请日：2010-03-10
申请人： Drew A. Hall , Richard Gaster , Sebastian J. Osterfeld , Shan X. Wang
发明人： Drew A. Hall , Richard Gaster , Sebastian J. Osterfeld , Shan X. Wang
IPC分类号： G01R35/00 , G01R33/18
CPC分类号： G01R33/1269 , B82Y25/00 , G01R33/09 , G01R33/093
摘要： Double modulation of a magnetoresistive sensor entails modulating both an excitation (e.g., voltage or current) applied to the sensor and a tickling magnetic field applied to the sensor. The excitation and magnetic field are modulated at different frequencies fc and ff, respectively. As a result of the double modulation, the sensor output spectrum includes a carrier tone (CT) at frequency fc and side tones (STs) at frequencies fc±ff. A baseline relation between CT amplitude and ST amplitude is determined (e.g., by measuring CT and ST amplitude while drift occurs in the absence of a sample). During sensor operation, raw ST measurements are corrected using corresponding raw CT measurements to provide corrected ST measurements as the sensor output.
摘要翻译：磁阻传感器的双重调制需要调制施加到传感器的激励（例如，电压或电流）以及施加到传感器的挠曲磁场。励磁和磁场分别以不同频率fc和ff进行调制。作为双调制的结果，传感器输出频谱包括频率为fc的载波音（CT）和频率fc±ff的侧音（ST）。确定CT幅度和ST幅度之间的基线关系（例如，通过测量CT和ST振幅，而在不存在样本的情况下发生漂移）。在传感器操作期间，使用相应的原始CT测量来校正原始ST测量值，以提供校正的ST测量作为传感器输出。

5. 发明申请

US20090201113A1 INTEGRATED INDUCTOR STRUCTURE AND METHOD OF FABRICATION 有权
标题翻译：综合电感结构与制造方法
公开(公告)号：US20090201113A1
公开(公告)日：2009-08-13
申请号：US12428430
申请日：2009-04-22
申请人： Ankur Mohan Crawford , Henning Braunisch , Rajendran Nair , Gilroy Vandentop , Shan X. Wang
发明人： Ankur Mohan Crawford , Henning Braunisch , Rajendran Nair , Gilroy Vandentop , Shan X. Wang
IPC分类号： H01F21/02 , H01F17/04
CPC分类号： H01L23/645 , H01F17/0033 , H01F41/046 , H01L23/49822 , H01L28/10 , H01L2224/16 , H01L2224/16235 , H01L2924/00011 , H01L2924/00014 , H01L2924/01077 , H01L2924/01078 , H01L2924/15311 , H01L2924/15312 , H01L2924/3011 , H05K1/0373 , H05K1/165 , H05K3/4644 , H05K2201/086 , H05K2201/09563 , H01L2224/0401
摘要： An inductor structure comprised of a magnetic section and a single turn solenoid. The single turn solenoid to contain within a portion of the magnetic section and circumscribed by the magnetic section.
摘要翻译：一个电感结构，由一个磁性部分和一个单一的旋转螺线管组成。单转螺线管包含在磁性部分的一部分内并由磁性部分限定。

6. 发明申请

US20080168863A1 DUMBBELL-LIKE NANOPARTICLES AND A PROCESS OF FORMING THE SAME 失效
标题翻译：类似纳米粒子的纳米颗粒及其形成方法
公开(公告)号：US20080168863A1
公开(公告)日：2008-07-17
申请号：US11830870
申请日：2007-07-31
申请人： Shouheng Sun , Heng Yu , Shan X. Wang
发明人： Shouheng Sun , Heng Yu , Shan X. Wang
IPC分类号： B22F9/16
CPC分类号： C01G1/00 , B22F1/0022 , B22F1/0096 , B22F2999/00 , B82Y25/00 , B82Y30/00 , C01B17/20 , C01B19/007 , C01P2002/72 , C01P2002/84 , C01P2004/04 , C01P2004/30 , C01P2004/64 , C01P2004/80 , C01P2006/42 , C09C3/063 , H01F1/0054 , Y10S977/835 , B22F1/0018
摘要： Dumbbell-shaped or flower-shaped nanoparticles and a process of forming the same, wherein the process comprises forming a mixture of a nanoparticle with a precursor in a first solvent, wherein the nanoparticle comprises a hydrophobic outer coating; heating the mixture; cooling the mixture to room temperature; modifying the hydrophobic outer coating into a hydrophilic outer coating; precipitating a solid product from the mixture, and dispersing the product in a second solvent. The nanoparticles comprise any of a semiconducting, magnetic, and noble metallic material, wherein the nanoparticles comprise a first portion comprising any of PbSe, PbS, CdSe, CdS, ZnS, Au, Ag, Pd, and Pt, and wherein the precursor comprises any of a cationic, neutral or particulate Au, Ag, Pd, Pt, or transition metal (Fe, Co, Ni) precursors of Fe(CO)5, Co(CO)8, Ni(CO)4 or their analogues. The first and second solvents comprise any of alkanes, arenes, ethers, nitrites, ketones, and chlorinated hydrocarbons.
摘要翻译：哑铃形或花形纳米颗粒及其形成方法，其中所述方法包括在第一溶剂中形成纳米颗粒与前体的混合物，其中所述纳米颗粒包含疏水外涂层; 加热混合物; 将混合物冷却至室温; 将疏水性外涂层改性为亲水性外涂层; 从混合物中沉淀出固体产物，并将产物分散在第二溶剂中。纳米颗粒包括半导体，磁性和贵金属材料中的任何一种，其中纳米颗粒包括包含PbSe，PbS，CdSe，CdS，ZnS，Au，Ag，Pd和Pt中的任何一种的第一部分，并且其中前体包含任何的阳离子，中性或微粒Au，Ag，Pd，Pt或过渡金属（Fe，Co，Ni）前体Fe（CO）5，Co（CO）（CO）4或它们的类似物。第一和第二溶剂包括任何烷烃，芳烃，醚，亚硝酸盐，酮和氯代烃。

7. 发明授权

US07288134B2 Dumbbell-like nanoparticles and a process of forming the same 失效
标题翻译：哑铃状纳米颗粒及其形成方法
公开(公告)号：US07288134B2
公开(公告)日：2007-10-30
申请号：US10938897
申请日：2004-09-10
申请人： Shouheng Sun , Heng Yu , Shan X. Wang
发明人： Shouheng Sun , Heng Yu , Shan X. Wang
IPC分类号： B22F1/02
CPC分类号： C01G1/00 , B22F1/0022 , B22F1/0096 , B22F2999/00 , B82Y25/00 , B82Y30/00 , C01B17/20 , C01B19/007 , C01P2002/72 , C01P2002/84 , C01P2004/04 , C01P2004/30 , C01P2004/64 , C01P2004/80 , C01P2006/42 , C09C3/063 , H01F1/0054 , Y10S977/835 , B22F1/0018
摘要： Dumbbell-shaped or flower-shaped nanoparticles and a process of forming the same, wherein the process comprises forming a mixture of a nanoparticle with a precursor in a first solvent, wherein the nanoparticle comprises a hydrophobic outer coating; heating the mixture; cooling the mixture to room temperature; modifying the hydrophobic outer coating into a hydrophilic outer coating; precipitating a solid product from the mixture, and dispersing the product in a second solvent. The nanoparticles comprise any of a semiconducting, magnetic, and noble metallic material, wherein the nanoparticles comprise a first portion comprising any of PbSe, PbS, CdSe, CdS, ZnS, Au, Ag, Pd, and Pt, and wherein the precursor comprises any of a cationic, neutral or particulate Au, Ag, Pd, Pt, or transition metal (Fe, Co, Ni) precursors of Fe(CO)5, Co(CO)8, Ni(CO)4 or their analogues. The first and second solvents comprise any of alkanes, arenes, ethers, nitrites, ketones, and chlorinated hydrocarbons.
摘要翻译：哑铃形或花形纳米颗粒及其形成方法，其中所述方法包括在第一溶剂中形成纳米颗粒与前体的混合物，其中所述纳米颗粒包含疏水性外涂层; 加热混合物; 将混合物冷却至室温; 将疏水性外涂层改性为亲水性外涂层; 从混合物中沉淀出固体产物，并将产物分散在第二溶剂中。纳米颗粒包括半导体，磁性和贵金属材料中的任何一种，其中纳米颗粒包括包含PbSe，PbS，CdSe，CdS，ZnS，Au，Ag，Pd和Pt中的任何一种的第一部分，并且其中前体包含任何的阳离子，中性或微粒Au，Ag，Pd，Pt或过渡金属（Fe，Co，Ni）前体Fe（CO）5，Co（CO）（CO）4或它们的类似物。第一和第二溶剂包括任何烷烃，芳烃，醚，亚硝酸盐，酮和氯代烃。

8. 发明授权

US09863939B2 Analyte detection with magnetic sensors 有权
公开(公告)号：US09863939B2
公开(公告)日：2018-01-09
申请号：US12234506
申请日：2008-09-19
申请人： Shan X. Wang , Sebastian J. Osterfeld , Heng Yu , Nader Pourmand , Robert L. White
发明人： Shan X. Wang , Sebastian J. Osterfeld , Heng Yu , Nader Pourmand , Robert L. White
IPC分类号： G01N33/00 , G01N33/543 , G01N27/00
CPC分类号： G01N33/54326 , Y10T436/143333
摘要： Methods for analyte detection with magnetic sensors are provided. Aspects of the methods include producing a magnetic sensor device having a magnetically labeled analyte from a sample, such as a serum sample, bound to a surface of a magnetic sensor thereof; and obtaining a signal, e.g., a real-time signal, from the magnetic sensor to determine whether the analyte is present in the sample. Also provided are devices, systems and kits that find use in practicing the methods of the invention. The methods, devices, systems and kits of the invention find use in a variety of different applications, including detection of biomarkers, such as disease markers.

9. 发明授权

US08722017B2 Fluorescent magnetic nanoprobes, methods of making, and methods of use 有权
公开(公告)号：US08722017B2
公开(公告)日：2014-05-13
申请号：US12460007
申请日：2009-07-10
申请人： Aihua Fu , Shan X. Wang , Sanjiv Sam Gambhir
发明人： Aihua Fu , Shan X. Wang , Sanjiv Sam Gambhir
IPC分类号： A61B5/055
CPC分类号： A61K49/1848 , A61K9/5094 , A61K49/0002 , A61K49/0032 , A61K49/0045 , A61K49/005 , A61K49/0093 , A61K49/1833 , A61K49/1866 , A61K51/1244 , B82Y5/00 , B82Y15/00 , G01N33/5434 , G01N33/582 , G01N33/587
摘要： Embodiments of the present disclosure provide for nanoprobes, methods of imaging, methods of imaging a target, methods of making nanoprobes, and the like.

10. 发明申请

US20110250464A1 Directly fabricated nanoparticles for Raman scattering 失效
标题翻译：用于拉曼散射的直接纳米颗粒
公开(公告)号：US20110250464A1
公开(公告)日：2011-10-13
申请号：US13066248
申请日：2011-04-08
申请人： Robert J. Wilson , Jung-Sub Wi , Shan X. Wang , Edward S. Barnard , Mark L. Brongersma , Mary Tang
发明人： Robert J. Wilson , Jung-Sub Wi , Shan X. Wang , Edward S. Barnard , Mark L. Brongersma , Mary Tang
IPC分类号： B22F1/00
CPC分类号： B22F1/0018 , B22F7/08 , B22F2001/0037 , B82Y30/00
摘要： A Raman-active nanoparticle is provided that includes a dish-shape plasmonically active metal base, and a plasmonically active metal pillar disposed on the plasmonically active metal base, where the plasmonically active metal pillar is disposed within the dish-shape plasmonically active metal base and normal to a bottom of the dish-shape plasmonically active metal base, where a circular gap is disposed between the dish-shape plasmonically active metal pillar and inner walls of the dish-shape plasmonically active metal base. In one embodiment a Raman-active nanoparticle is provided that includes a dish-shape base having a dielectric material, an electrically conductive layer disposed on the inner surface of the dish-shape base, and an electrically conductive pillar disposed on the conductive layer, and within the dish-shape and perpendicular to a bottom of the dish-shape base, where a circular gap is disposed between the conductive pillar and inner walls of the dish-shape base.
摘要翻译：提供了一种拉曼活性纳米颗粒，其包括盘状等离子体活性金属碱和设置在等离子体活性金属基体上的等离子体活性金属柱，其中等离子体活性金属柱设置在盘状等离子体活性金属基质内，垂直于盘形等离子体活性金属基底的底部，其中盘形等离子体活性金属柱和盘形等离子体活性金属基底的内壁之间设置有圆形间隙。在一个实施方案中，提供了拉曼活性纳米颗粒，其包括具有介电材料的盘形基底，设置在盘形基底的内表面上的导电层和设置在导电层上的导电柱，以及在碟形基底中的垂直于盘形基底的底部，其中圆形间隙设置在盘形基底的导电柱和内壁之间。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式