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1. 发明申请

US20120100625A1 Method and Assembly for Determining the Temperature of a Test Sensor 有权
标题翻译：用于确定测试传感器温度的方法和组件
公开(公告)号：US20120100625A1
公开(公告)日：2012-04-26
申请号：US13339533
申请日：2011-12-29
申请人： Jeffrey D. Blais , Steve Sun , Bern Harrison , Narasinha C. Parasnis , Serban F. Peteu , Tony Nguyen , Paul Ripley , Xin Wang , Igor Gofman
发明人： Jeffrey D. Blais , Steve Sun , Bern Harrison , Narasinha C. Parasnis , Serban F. Peteu , Tony Nguyen , Paul Ripley , Xin Wang , Igor Gofman
IPC分类号： G01N25/20 , G01N21/00
CPC分类号： A61B5/14532 , A61B5/1455 , A61B5/1486 , A61B2560/0242 , A61B2560/0252 , G01N21/78 , G01N21/8483 , G01N27/3274
摘要： An assembly determines an analyte concentration in a sample of body fluid. The assembly includes a test sensor having a fluid-receiving area for receiving a sample of body fluid, where the fluid-receiving area contains a reagent that produces a measurable reaction with an analyte in the sample. The assembly also includes a meter having a port or opening configured to receive the test sensor; a measurement system configured to determine a measurement of the reaction between the reagent and the analyte; and a temperature-measuring system configured to determine a measurement of the test-sensor temperature when the test sensor is received into the opening. The meter determines a concentration of the analyte in the sample according to the measurement of the reaction and the measurement of the test-sensor temperature.
摘要翻译：组件确定体液样品中的分析物浓度。组件包括具有用于接收体液样本的流体接收区域的测试传感器，其中流体接收区域包含与样品中的分析物产生可测量反应的试剂。组件还包括具有端口或开口的表，该端口或开口被配置为接收测试传感器; 测量系统，被配置为确定所述试剂和所述分析物之间的反应的测量; 以及温度测量系统，被配置为当测试传感器被接收到开口中时确定测试传感器温度的测量。根据反应的测量和测试传感器温度的测量，仪表确定样品中分析物的浓度。

2. 发明授权

US08313951B2 Method and assembly for determining the temperature of a test sensor 有权
公开(公告)号：US08313951B2
公开(公告)日：2012-11-20
申请号：US13339533
申请日：2011-12-29
申请人： Jeffrey D. Blais , Steve Sun , Bern Harrison , Narasinha C. Parasnis , Serban F. Peteu , Tony Nguyen , Paul Ripley , Xin Wang , Igor Gofman
发明人： Jeffrey D. Blais , Steve Sun , Bern Harrison , Narasinha C. Parasnis , Serban F. Peteu , Tony Nguyen , Paul Ripley , Xin Wang , Igor Gofman
IPC分类号： G01N25/20 , G01N21/00
CPC分类号： A61B5/14532 , A61B5/1455 , A61B5/1486 , A61B2560/0242 , A61B2560/0252 , G01N21/78 , G01N21/8483 , G01N27/3274
摘要： An assembly determines an analyte concentration in a sample of body fluid. The assembly includes a test sensor having a fluid-receiving area for receiving a sample of body fluid, where the fluid-receiving area contains a reagent that produces a measurable reaction with an analyte in the sample. The assembly also includes a meter having a port or opening configured to receive the test sensor; a measurement system configured to determine a measurement of the reaction between the reagent and the analyte; and a temperature-measuring system configured to determine a measurement of the test-sensor temperature when the test sensor is received into the opening. The meter determines a concentration of the analyte in the sample according to the measurement of the reaction and the measurement of the test-sensor temperature.

3. 发明申请

US20090098657A1 METHOD AND ASSEMBLY FOR DETERMINING THE TEMPERATURE OF A TEST SENSOR 有权
标题翻译：用于确定测试传感器温度的方法和装置
公开(公告)号：US20090098657A1
公开(公告)日：2009-04-16
申请号：US12252348
申请日：2008-10-15
申请人： Jeffrey D. Blais , Steve Sun , Bern Harrison , Narasinha C. Parasnis , Serban F. Peteu , Tony Nguyen , Paul Ripley , Xin Wang , Igor Gofman
发明人： Jeffrey D. Blais , Steve Sun , Bern Harrison , Narasinha C. Parasnis , Serban F. Peteu , Tony Nguyen , Paul Ripley , Xin Wang , Igor Gofman
IPC分类号： G01N25/00 , G01N21/01
CPC分类号： A61B5/14532 , A61B5/1455 , A61B5/1486 , A61B2560/0242 , A61B2560/0252 , G01N21/78 , G01N21/8483 , G01N27/3274
摘要： An assembly determines an analyte concentration in a sample of body fluid. The assembly includes a test sensor having a fluid-receiving area for receiving a sample of body fluid, where the fluid-receiving area contains a reagent that produces a measurable reaction with an analyte in the sample. The assembly also includes a meter having a port or opening configured to receive the test sensor; a measurement system configured to determine a measurement of the reaction between the reagent and the analyte; and a temperature-measuring system configured to determine a measurement of the test-sensor temperature when the test sensor is received into the opening. The meter determines a concentration of the analyte in the sample according to the measurement of the reaction and the measurement of the test-sensor temperature.
摘要翻译：组件确定体液样品中的分析物浓度。组件包括具有用于接收体液样本的流体接收区域的测试传感器，其中流体接收区域包含与样品中的分析物产生可测量反应的试剂。组件还包括具有端口或开口的表，该端口或开口被配置为接收测试传感器; 测量系统，被配置为确定所述试剂和所述分析物之间的反应的测量; 以及温度测量系统，被配置为当测试传感器被接收到开口中时确定测试传感器温度的测量。根据反应的测量和测试传感器温度的测量，仪表确定样品中分析物的浓度。

4. 发明授权

US07482381B2 Artificial muscle hydrogel blends reversibly electroactuated near neutral pH, implantable actuating devices, and methods using the same 失效
标题翻译：人造肌水凝胶在中性pH附近可逆地电活化，可植入的致动装置，以及使用其的方法
公开(公告)号：US07482381B2
公开(公告)日：2009-01-27
申请号：US10803985
申请日：2004-03-19
申请人： Sylvia Daunert , Serban F. Peteu , Leonidas G. Bachas , Marc J. Madou , Elissavet Moschou
发明人： Sylvia Daunert , Serban F. Peteu , Leonidas G. Bachas , Marc J. Madou , Elissavet Moschou
IPC分类号： A61K47/30 , A61K47/00 , A61K9/14 , A61F13/00
CPC分类号： A61K9/0051 , A61K9/0024
摘要： A novel artificial muscle material and miniature valves and micropumps made therefrom are provided. The artificial muscle material bends reversibly when electroactuated by applying low voltage, in a wide pH range, even at that of physiological pH, and works without contact with electrodes. Miniature valves made from the artificial material are successfully triggered for the fluid release in a wide pH range, even at that of physiological pH. Novel fluid release devices were manufactured using this artificial muscle, and methods using the same were provided, including an implantable device optimized for trans-scleral drug delivery.
摘要翻译：提供了一种新颖的人造肌肉材料和由其制成的微型阀和微型泵。人造肌肉材料通过在宽pH值范围内施加低电压进行电致动作，甚至在生理pH值范围内可逆地弯曲，并且不与电极接触。即使在生理pH范围内，人造材料制成的微型阀也可在较宽的pH范围内成功地触发流体释放。使用该人造肌肉制造新的流体释放装置，并提供使用该人造肌肉的方法，包括针对经巩膜药物递送优化的可植入装置。

5. 发明授权

US08105841B2 Method and assembly for determining the temperature of a test sensor 有权
标题翻译：用于确定测试传感器温度的方法和组件
公开(公告)号：US08105841B2
公开(公告)日：2012-01-31
申请号：US12252348
申请日：2008-10-15
申请人： Jeffrey D. Blais , Steve Sun , Bern Harrison , Narasinha C. Parasnis , Serban F. Peteu , Tony Nguyen , Paul Ripley , Xin Wang , Igor Gofman
发明人： Jeffrey D. Blais , Steve Sun , Bern Harrison , Narasinha C. Parasnis , Serban F. Peteu , Tony Nguyen , Paul Ripley , Xin Wang , Igor Gofman
IPC分类号： G01N25/20
CPC分类号： A61B5/14532 , A61B5/1455 , A61B5/1486 , A61B2560/0242 , A61B2560/0252 , G01N21/78 , G01N21/8483 , G01N27/3274
摘要： An assembly determines an analyte concentration in a sample of body fluid. The assembly includes a test sensor having a fluid-receiving area for receiving a sample of body fluid, where the fluid-receiving area contains a reagent that produces a measurable reaction with an analyte in the sample. The assembly also includes a meter having a port or opening configured to receive the test sensor; a measurement system configured to determine a measurement of the reaction between the reagent and the analyte; and a temperature-measuring system configured to determine a measurement of the test-sensor temperature when the test sensor is received into the opening. The meter determines a concentration of the analyte in the sample according to the measurement of the reaction and the measurement of the test-sensor temperature.
摘要翻译：组件确定体液样品中的分析物浓度。组件包括具有用于接收体液样本的流体接收区域的测试传感器，其中流体接收区域包含与样品中的分析物产生可测量反应的试剂。组件还包括具有端口或开口的表，该端口或开口被配置为接收测试传感器; 测量系统，被配置为确定所述试剂和所述分析物之间的反应的测量; 以及温度测量系统，被配置为当测试传感器被接收到开口中时确定测试传感器温度的测量。根据反应的测量和测试传感器温度的测量，仪表确定样品中分析物的浓度。

6. 发明授权

US5611900A Microbiosensor used in-situ 失效
标题翻译：微生物传感器原位使用
公开(公告)号：US5611900A
公开(公告)日：1997-03-18
申请号：US504687
申请日：1995-07-20
申请人： R. Mark Worden , David Emerson , Serban F. Peteu
发明人： R. Mark Worden , David Emerson , Serban F. Peteu
IPC分类号： C12Q1/00 , G01N27/26
CPC分类号： C12Q1/001 , Y10S435/817
摘要： The present invention is a novel, ultra-small tip, internal referenced, amperometric microbiosensor that uses an immobilized biological interface to measure the concentration of an analyte in a specimen. It consists of a casing that narrows to an aperture having a diameter at the tip no greater than 4 .mu.m; enclosed within the casing a reference electrode and a working electrode both immersed in electrolyte; within the aperture, an inner polymer film, an immobilized biological interface layer, and an outer specimen-compatible, non-virulent polymer film. Another important feature of the present invention is that the microbiosensor can readily be encased in a durable protective sheath. The microbiosensor is especially useful in situ for specimens that cannot be mixed, such as in situ compounds in unmixed fluid, or semi-solid specimens. The microbiosensor provides 90% response time less than 5 seconds and typically about 1 second, less than 5% change in output current due to changes in the stirring rate, and the ability to measure in viscous, semi-solid or porous-solid specimens with a spatial resolution as small as 30 .mu.m.
摘要翻译：本发明是一种新颖的超小尖端，内部参考的电流型微生物传感器，其使用固定化的生物界面来测量样品中分析物的浓度。它由一个缩小到尖端直径不大于4μm的孔的壳体组成; 封装在壳体内，参考电极和工作电极均浸入电解质中; 在孔内，内聚合物膜，固定的生物界面层和外标本相容的非毒性聚合物膜。本发明的另一个重要特征是微生物传感器可以容易地被包裹在耐用的保护鞘中。微生物传感器对于不能混合的样品，例如在未混合流体中的原位化合物或半固体样品，对于原位特别有用。微生物传感器提供90％的响应时间，小于5秒，通常约1秒，由于搅拌速率的变化，输出电流的变化小于5％，并且在粘性，半固体或多孔固体样品中测量的能力空间分辨率低至30亩。

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