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    • 4. 发明授权
    • Gene therapy for lysosomal storage diseases
    • 溶酶体贮积病基因治疗
    • US08796236B2
    • 2014-08-05
    • US12631336
    • 2009-12-04
    • James DodgeSeng Cheng
    • James DodgeSeng Cheng
    • A61K48/00A01N63/00
    • A61K48/0075A61K38/47C12N15/86C12N2750/14143C12Y302/01045
    • This disclosure provides methods and compositions for treating lysosomal storage diseases in a subject. In one aspect of the invention, a transgene product is delivered to a subject by administering a recombinant neurotrophic viral vector containing the transgene to the brain. The viral vector delivers the transgene to a region of the brain which is susceptible to infection by the virus and which expresses the encoded recombinant viral gene product. Also provided are compositions for delivery of a transgene product to a subject by administering a recombinant neurotrophic viral vector containing the transgene to the subject's brain. The transgene product may be any that is deficient in a lysosomal storage disease.
    • 本公开提供了用于治疗受试者中溶酶体贮积病的方法和组合物。 在本发明的一个方面,通过将含有转基因的重组神经营养病毒载体给予脑,将转基因产物递送至受试者。 病毒载体将转基因递送到易受病毒感染并表达编码的重组病毒基因产物的脑区域。 还提供了通过将含有转基因的重组神经营养病毒载体给予受试者的脑,将转基因产物递送给受试者的组合物。 转基因产物可以是溶酶体贮积病中缺乏的任何一种。
    • 7. 发明授权
    • Method and system for enabling recovery of data stored in a computer network; a method and a system for recovering data stored in a computer network
    • 用于恢复存储在计算机网络中的数据的方法和系统; 用于恢复存储在计算机网络中的数据的方法和系统
    • US07234079B2
    • 2007-06-19
    • US10618170
    • 2003-07-11
    • Heng Seng ChengLek Heng NgohZheng Yuan
    • Heng Seng ChengLek Heng NgohZheng Yuan
    • G06F11/00
    • H04L1/0041G06F11/2007H04L1/0045H04L1/0072H04L2001/0095
    • A method for enabling recovery of data stored in a computer network, the computer network comprises a plurality of computer nodes, the method comprising the steps of generating a set of redundancy data based on a predetermined relationship between a first set of data and a second set of data, injecting the first set of data, the second set of data and the set of redundancy data into separate looping paths of the computer network, wherein a looping path is a path along a plurality of computer nodes in which data is transported, and the looping paths are defined in separate communication channels between the computer nodes and pass through at least one common node of the computer network, such that the redundancy data and the second set of data can be used to reconstruct the first set of data based on the predetermined relationship between the first and second set of data when the first set of data is lost, thereby enabling the recovery of data stored in the computer network.
    • 一种能够恢复存储在计算机网络中的数据的方法,所述计算机网络包括多个计算机节点,所述方法包括以下步骤:基于第一组数据和第二组之间的预定关系生成一组冗余数据 将第一组数据,第二组数据和冗余数据集合注入到计算机网络的分离的循环路径中,其中循环路径是沿数据传送的多个计算机节点的路径,以及 循环路径在计算机节点之间的分开的通信信道中定义并且通过计算机网络的至少一个公共节点,使得冗余数据和第二组数据可以用于基于 当第一组数据丢失时,第一组数据和第二组数据之间的预定关系,从而能够恢复存储在计算机网络中的数据。