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    • 1. 发明授权
    • REM sleep augmentation with extra-ocular light
    • REM睡眠增强与眼外光
    • US06669627B1
    • 2003-12-30
    • US09937324
    • 2001-09-20
    • Scott S. CampbellPatricia J. Murphy
    • Scott S. CampbellPatricia J. Murphy
    • A61M2100
    • A61N5/0618A61N2005/0662
    • The invention provides for exposing an extraocular (i.e., non-ocular) region of a human to light during sleep which enhances REM sleep. Also provided are devices to carry out the methods. Key timing parameters ensure effective REM enhancement without adversely impacting a subject's circadian clock. The invention provides for improving cognitive function and performance in healthy individuals, and in individuals suffering from a disease or disorder in which mental status is compromised. One embodiment of the invention (100) includes a fiber optics pad (160) attached to a power source, and lamp housing (120) by a fiber optics cable (140).
    • 本发明提供了在睡眠期间将人的眼睛(即,非眼睛)区域暴露于光,从而增强REM睡眠。 还提供了执行方法的设备。 关键时间参数确保有效的REM增强,而不会对受试者的昼夜节律钟产生不利影响。 本发明提供了改善健康个体以及患有精神状态受损的疾病或病症的个体的认知功能和表现。 本发明的一个实施例(100)包括通过光纤电缆(140)连接到电源的光纤垫(160)和灯壳体(120)。
    • 3. 发明授权
    • Non-ocular circadian clock resetting in humans
    • 非人眼昼夜节律时钟复位
    • US6135117A
    • 2000-10-24
    • US74455
    • 1998-05-07
    • Scott S. CampbellPatricia J. Murphy
    • Scott S. CampbellPatricia J. Murphy
    • A61N5/06A61B19/00
    • A61N5/0618A61N2005/0652
    • A method for resetting the phase of the human circadian clock and for enhancing alertness and performance in humans. The method involves the application of non-solar photic stimulation, in the range of 15 to 150,000 lux, to any non-ocular region of the human body during wakefulness or during sleep. Preferably, the photic stimulation has a wavelength within the visible spectrum (.about.400-750 nm). The method can be used to both delay and advance the circadian clock according to a phase response curve (PRC). The method may also be used for acute/immediate enhancement of alertness and performance. The method is applicable to alleviation of problems associated with "jet-lag", shift work sleep disturbance, and other sleep disturbances involving misalignment of circadian rhythms. The method provides a novel technique for shifting the phase of the circadian clock, and enhancing alertness and performance, using existing, or newly-developed devices.
    • 一种重建人类生物钟的相位并提高人类警觉性和表现的方法。 该方法涉及在觉醒期间或睡眠期间将15至15万勒克司的非太阳光照刺激应用于人体的任何非眼部区域。 优选地,光刺激具有可见光谱内的波长(DIFFERENCE 400-750nm)。 该方法可用于根据相位响应曲线(PRC)延迟和推进昼夜节律钟。 该方法还可用于急性/立即增强警觉性和性能。 该方法适用于缓解与“昼间滞后”相关的问题,改变工作睡眠障碍以及其他涉及昼夜节律调整的睡眠障碍。 该方法提供了一种用于移动昼夜节律钟的相位并利用现有或新开发的装置来增强警觉性和性能的新颖技术。