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1. 发明申请

US20110023155A1 NOVEL DNA FRAGMENT AND USE THEREOF 有权
标题翻译：新型DNA片段及其用途
公开(公告)号：US20110023155A1
公开(公告)日：2011-01-27
申请号：US12865996
申请日：2009-02-04
申请人： Satoshi Hirohata , Yoshifumi Ninomiya , Shozo Kusachi , Faruk Hatipoglu Omer
发明人： Satoshi Hirohata , Yoshifumi Ninomiya , Shozo Kusachi , Faruk Hatipoglu Omer
IPC分类号： A61K31/7052 , C07H21/04 , C12N15/63 , A01K67/027 , A61P9/10
CPC分类号： C12N15/85 , A61K48/0058 , C12N9/6489 , C12N2830/00 , C12N2830/002 , G01N2800/324
摘要： The invention relates to a DNA consisting of the nucleotide sequence shown in SEQ ID NO: 1, or a nucleotide sequence the same or substantially the same as a partial nucleotide sequence thereof containing at least one HRE consensus sequence, which transiently has a transcription promoting activity in a vascular endothelial cell-specific manner in a hypoxic state, or a vector containing a promoter containing the DNA, and the like. The prophylaxis and/or treatment, as well as diagnosis, of acute ischemic diseases are enabled by connecting a prophylactic and/or therapeutic gene or a reporter gene to the downstream of the vector and administering same to mammals.
摘要翻译：本发明涉及由SEQ ID NO：1所示的核苷酸序列组成的DNA，或与含有至少一个HRE共有序列的部分核苷酸序列相同或基本相同的核苷酸序列，其瞬时具有转录促进活性在缺氧状态下以血管内皮细胞特异性方式，或含有含有该DNA的启动子的载体等。通过将预防和/或治疗基因或报告基因连接到载体的下游并将其施用于哺乳动物来实现急性缺血性疾病的预防和/或治疗以及诊断。

2. 发明授权

US08865669B2 DNA fragment and use thereof 有权
标题翻译： DNA片段及其用途
公开(公告)号：US08865669B2
公开(公告)日：2014-10-21
申请号：US12865996
申请日：2009-02-04
申请人： Satoshi Hirohata , Yoshifumi Ninomiya , Shozo Kusachi , Faruk Hatipoglu Omer
发明人： Satoshi Hirohata , Yoshifumi Ninomiya , Shozo Kusachi , Faruk Hatipoglu Omer
IPC分类号： A01N43/04 , C12N15/00 , C07H21/02 , C07H21/04 , C12N15/85 , C12N9/64 , A61K48/00
CPC分类号： C12N15/85 , A61K48/0058 , C12N9/6489 , C12N2830/00 , C12N2830/002 , G01N2800/324
摘要： The invention relates to a DNA consisting of the nucleotide sequence shown in SEQ ID NO: 1, or a nucleotide sequence the same or substantially the same as a partial nucleotide sequence thereof containing at least one HRE consensus sequence, which transiently has a transcription promoting activity in a vascular endothelial cell-specific manner in a hypoxic state, or a vector containing a promoter containing the DNA, and the like. The prophylaxis and/or treatment, as well as diagnosis, of acute ischemic diseases are enabled by connecting a prophylactic and/or therapeutic gene or a reporter gene to the downstream of the vector and administering same to mammals.
摘要翻译：本发明涉及由SEQ ID NO：1所示的核苷酸序列组成的DNA，或与含有至少一个HRE共有序列的部分核苷酸序列相同或基本相同的核苷酸序列，其瞬时具有转录促进活性在缺氧状态下以血管内皮细胞特异性方式，或含有含有该DNA的启动子的载体等。通过将预防和/或治疗基因或报告基因连接到载体的下游并将其施用于哺乳动物来实现急性缺血性疾病的预防和/或治疗以及诊断。

3. 发明授权

US06391610B1 Nucleic acids encoding zinc metalloproteases 有权
标题翻译：编码锌金属蛋白酶的核酸
公开(公告)号：US06391610B1
公开(公告)日：2002-05-21
申请号：US09369364
申请日：1999-08-06
申请人： Suneel S. Apte , Tiina L. Hurskainen , Satoshi Hirohata
发明人： Suneel S. Apte , Tiina L. Hurskainen , Satoshi Hirohata
IPC分类号： C12N964
CPC分类号： C12N9/6489
摘要： Isolated mammalian proteins having disintegrin-like and metalloprotease domains with thrombospondin type I motifs, i.e., ADAMTS proteins, are provided. The proteins are ADAMTS-5, ADAMTS-6, ADAMTS-7, ADAMTS-8, ADAMTS-9 and ADAMTS-10, collectively referred to as “ADAMTS-N”. The present invention also provides isolated polynucleotides which encode an ADAMTS-N protein or a variant thereof, polynucleotide sequences complementary to such polynucleotides, vectors containing such polynucleotides, and host cells transformed or transfected with such vectors. The present invention also relates to antibodies which are immunospecific for one or more of the ADAMTS-N proteins. The present invention also relates to a protein referred to hereinafter as ADAMTS-R1 (ADAM-TS Related protein-1) and the polynucleotides which encode such protein.
摘要翻译：提供了具有血小板反应蛋白I型基序（即ADAMTS蛋白）的具有去整合素样和金属蛋白酶结构域的分离的哺乳动物蛋白质。蛋白质是ADAMTS-5，ADAMTS-6，ADAMTS-7，ADAMTS-8，ADAMTS-9和ADAMTS-10，统称为“ADAMTS-N”。本发明还提供编码ADAMTS-N蛋白或其变体的分离的多核苷酸，与这种多核苷酸互补的多核苷酸序列，含有这种多核苷酸的载体，以及用这些载体转化或转染的宿主细胞。本发明还涉及对一种或多种ADAMTS-N蛋白质具有免疫特异性的抗体。本发明还涉及下文称为ADAMTS-R1（ADAM-TS相关蛋白-1）的蛋白质和编码该蛋白质的多核苷酸。

4. 发明授权

US5583543A Pen input processing apparatus 失效
标题翻译：笔输入处理装置
公开(公告)号：US5583543A
公开(公告)日：1996-12-10
申请号：US143786
申请日：1993-11-01
申请人： Masamitsu Takahashi , Yukihiro Shibata , Aki Miake , Hiroshi Okuno , Hiroshi Nishida , Yutaka Nakamura , Hiroyuki Shigematsu , Satoshi Hirohata
发明人： Masamitsu Takahashi , Yukihiro Shibata , Aki Miake , Hiroshi Okuno , Hiroshi Nishida , Yutaka Nakamura , Hiroyuki Shigematsu , Satoshi Hirohata
IPC分类号： G06F3/038 , G06F3/0481 , G06F3/0488 , G06F17/24 , G06K9/22 , G09G5/00
CPC分类号： G06F3/038 , G06F17/24 , G06F3/0481 , G06F3/04883 , G06K9/00429
摘要： A pen input processing apparatus in accordance with the present invention has a text editing section for displaying on a screen a window through which a character is handwritten only by handwriting on the screen a line drawing indicative of inputting of character by handwriting. The text editing section has a function wherein the name of gesture command corresponding to a line drawing and the character to be edited are displayed by the screen when each line drawing is handwritten with respect to the screen. The pen input processing apparatus has a gesture command judging section for recognizing the gesture command in accordance with a trace coordinate of the line drawing. When the gesture command is recognized and specified, the recognition of the gesture command is informed by a sound. Only one line drawing is assigned to the same editing instructions for one character and a plurality of characters as editing objects. The present apparatus is arranged so as to ignore a minute moving of an inputting pen, thereby making it easy to perform specifying operation of a graphic on the screen for example.
摘要翻译：根据本发明的笔输入处理装置具有文本编辑部分，用于在屏幕上显示仅通过手写在屏幕上手写字符的窗口，该画面指示通过手写输入字符的线条图。文本编辑部分具有这样的功能，其中当画面相对于画面被手写时，屏幕显示与线条画面对应的手势命令的名称和要被编辑的角色的功能。笔输入处理装置具有用于根据线条图的轨迹坐标来识别手势命令的手势命令判断部。当识别和指定手势命令时，通过声音通知手势命令的识别。对于一个字符和多个字符作为编辑对象，仅将一个线条图分配给相同的编辑指令。本装置被布置为忽略输入笔的微小移动，从而使得可以容易地在屏幕上执行图形的指定操作。

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