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1. 发明授权

US07118767B2 Pharmaceutical composition for increasing the production of nitric oxide and IFN-γ, and process for preparation thereof 失效
标题翻译：用于增加一氧化氮和IFN-γ生产的药物组合物及其制备方法
公开(公告)号：US07118767B2
公开(公告)日：2006-10-10
申请号：US10206023
申请日：2002-07-26
申请人： Hyung-Min Kim , HyungJa You , Sang-Bong Seo
发明人： Hyung-Min Kim , HyungJa You , Sang-Bong Seo
IPC分类号： A61K35/78
CPC分类号： A61K36/03 , A61K36/076 , A61K36/254 , A61K36/28 , A61K36/288 , A61K36/346 , A61K36/355 , A61K36/484 , A61K36/882 , A61K36/8994 , A61K2300/00
摘要： The present invention relates to a pharmaceutical composition comprising an extract of the mixture of Coicis Semen, Chicorium intibus, Acanthopanax sessiliflorus SEEM, Lonicerae flos, Platycodi radix, Poria, laminariae Thallus, Taraxaci herba, Acori graminei Rhizoma and Glycyrrhia uralaensis FISCH or dry power of the extract for increasing nitric oxide (NO) and INF-γ production and a process for preparation thereof.
摘要翻译：本发明涉及一种药物组合物，其包含茜素精液，内，蚕，刺五加SEEM，金银花，扁柏，茯苓，茯苓，蒲公英，枸杞和甘草的混合物的提取物，用于增加一氧化氮（NO）和INF-γ生产的提取物及其制备方法。

2. 发明授权

US06995137B2 Water-soluble natural film and its preparing method 失效
标题翻译：水溶性天然膜及其制备方法
公开(公告)号：US06995137B2
公开(公告)日：2006-02-07
申请号：US10730920
申请日：2003-12-10
申请人： Hyung Ja You , Sang Bong Seo
发明人： Hyung Ja You , Sang Bong Seo
IPC分类号： A61K38/16 , A61K31/70
CPC分类号： C08L5/08 , A61K8/0208 , A61K8/736 , A61K9/006 , A61K36/03 , A61K36/04 , A61K36/28 , A61K47/36 , A61Q19/00 , C08B37/003 , A61K2300/00
摘要： The present invention relates to water-soluble natural film and its preparing method. More particularly, the present invention relates to water-soluble natural film manufactured by dissolving as an active ingredient a water-soluble chitosan prepared in such a manner that chitin/chitosan decomposed with lysozyme is rinsed with ethanol, subjected to electric adjustment and sonication in a saline solution and to ion-exchange to obtain water-soluble β-glucosamine fibrin followed by nano-sized coating the β-glucosamine fibrin with immunoglobulin (γ-globulin), and seaweeds and functional ingredients in distilled water and gelatinating. The water-soluble natural film according to the present invention, unlike the conventional film containing chitosan, comprises, at a predetermined content ratio, chitosan with improved water solubility and immunity, seaweeds and functional ingredients. Therefore, it imparts elasticity to matrix of a film to enable film molding with convenience and renders more compatibility to human body due to natural materials as its active ingredients, eliciting more favorable feeling when taken in. In particular, the film composition itself is processed to form a film with a desired thickness and size or is coated on a conventional biodegradable resin film, being applicable to a film in preparing an oral cleaning agent with immediate effect and a food packaging material.
摘要翻译：本发明涉及水溶性天然膜及其制备方法。更具体地说，本发明涉及通过将以溶菌酶分解的壳多糖/壳聚糖用乙醇冲洗的水溶性壳聚糖作为活性成分溶解而制造的水溶性天然膜，用乙醇冲洗，进行电调节和超声处理盐水溶液和离子交换以获得水溶性β-葡糖胺纤维蛋白，然后用免疫球蛋白（γ-球蛋白）纳米尺寸涂布β-葡糖胺纤维蛋白，并将海藻和功能成分在蒸馏水中凝胶化。根据本发明的水溶性天然膜与常规含有壳聚糖的膜不同，含有预定含量的具有改善的水溶性和免疫性，海藻和功能成分的壳聚糖。因此，由于天然材料作为活性成分，因此赋予膜的基质赋予弹性，能够方便地进行成膜，并且由于天然材料的活性成分而使人体更容易相容，因此在摄取时引起更好的感觉。特别地，将膜组合物本身加工成形成具有所需厚度和尺寸的膜，或涂覆在常规的可生物降解树脂膜上，适用于制备立即口服清洁剂的膜和食品包装材料。

3. 发明授权

US07511023B2 Anticancer drug-chitosan complex forming self-aggregates and preparation method thereof 失效
标题翻译：形成自聚集体的抗癌药物 - 壳聚糖复合物及其制备方法
公开(公告)号：US07511023B2
公开(公告)日：2009-03-31
申请号：US10473629
申请日：2002-08-14
申请人： Ick Chan Kwon , In-San Kim , Seo Young Jeong , Hesson Chung , Yong Woo Cho , Yoen Ju Son , Chong Rae Park , Sang Bong Seo
发明人： Ick Chan Kwon , In-San Kim , Seo Young Jeong , Hesson Chung , Yong Woo Cho , Yoen Ju Son , Chong Rae Park , Sang Bong Seo
IPC分类号： A01N43/04 , A61K31/70
CPC分类号： A61K31/704 , A61K47/61 , A61K47/6907
摘要： The present invention relates to an anticancer drug-chitosan complex forming self-aggregates and the preparation method thereof. More precisely, the present invention relates to the anticancer drug-chitosan complex forming self-aggregates in aqueous media composed of a hydrophobic anticancer agent and a hydrophilic chitosan, and the preparation method thereof. The anticancer drug-chitosan complex of the present invention not only works selectively against target tumor tissue but also continues to release the medicine over a long period of time. Besides, the anticancer drug-chitosan complex could have greater amount of drug by adding the anticancer drug into self-aggregates, which is generally limited by chemical bond. Therefore, the anticancer drug-chitosan complex of the present invention can be effectively used for the cancer chemotherapy.
摘要翻译：本发明涉及形成自聚集体的抗癌药物 - 壳聚糖复合物及其制备方法。更准确地说，本发明涉及在由疏水性抗癌剂和亲水性壳聚糖组成的水性介质中形成自聚集体的抗癌药物 - 壳聚糖复合物及其制备方法。本发明的抗癌药物 - 壳聚糖复合物不仅对目标肿瘤组织有选择性的作用，而且还能够长时间地释放药物。此外，抗癌药物 - 壳聚糖复合物可以通过将抗癌药物加入自聚集体中而具有更大量的药物，其通常受化学键的限制。因此，本发明的抗癌药物 - 壳聚糖复合物可以有效地用于癌症化疗。

4. 发明授权

US06521268B2 Antibacterial and anti-inflammatory compositions with Inula helenium L. extract and water soluble chitosan 失效
标题翻译：具有Inula helenium L.提取物和水溶性壳聚糖的抗菌和抗炎组合物
公开(公告)号：US06521268B2
公开(公告)日：2003-02-18
申请号：US09866738
申请日：2001-05-30
申请人： Hyung Ja You , Sang Bong Seo , Chan Seok Seo
发明人： Hyung Ja You , Sang Bong Seo , Chan Seok Seo
IPC分类号： A61K3578
CPC分类号： A61K31/722 , A61K36/28 , A61K2300/00
摘要： The present invention relates to a natural cell control carrier, more specifically to a natural cell control carrier containing water-soluble chitosan (HFP) and elecampane (Inula Helenium L.) extract, which solves problems of conventional synthesized antibacterial agents and provides various superior properties, improved antibacterial activity and anti-inflammatory effect with a broad antibacterial spectrum, so that it can be used for food, cosmetics and medicine.
摘要翻译：本发明涉及一种天然细胞对照载体，更具体地涉及含有水溶性壳聚糖（HFP）和电生理（Inula Helenium L.）提取物的天然细胞对照载体，其解决常规合成抗菌剂的问题并提供各种优异的性质提高抗菌活性和抗炎作用，具有广泛的抗菌谱，使其可用于食品，化妆品和医药。

5. 发明申请

US20080008755A1 PHARMACEUTICAL FORMULATION OF CHOLANIC ACID-CHITOSAN COMPLEX INCORPORATED WITH HYDROPHOBIC ANTICANCER DRUGS AND PREPARATION METHOD THEREOF 审中-公开
标题翻译：用疏水性药物制剂混合制备丙酰胆碱复合物的药物制剂及其制备方法
公开(公告)号：US20080008755A1
公开(公告)日：2008-01-10
申请号：US11777705
申请日：2007-07-13
申请人： Ick Chan Kwon , Seo Young Jeong , In-san Kim , Hesson Chung , Sang Bong Seo , Jae Hyung Park , Seunglee Kwon , Kwangmyung Kim , Jong-ho Kim
发明人： Ick Chan Kwon , Seo Young Jeong , In-san Kim , Hesson Chung , Sang Bong Seo , Jae Hyung Park , Seunglee Kwon , Kwangmyung Kim , Jong-ho Kim
IPC分类号： A61K9/24 , A61K31/7072 , A61K31/704 , A61K31/407 , A61K31/337 , C08B37/08 , A61K33/24
CPC分类号： A61K31/337 , A61K9/0019 , A61K9/5123 , A61K9/5161 , A61K47/61
摘要： Disclosed are a pharmaceutical formulation characterized in that hydrophobic anticancer drugs are incorporated into a cholanic acid-chitosan complex and a preparation method thereof, and more particularly, the cholanic acid-chitosan complex composing of hydrophobic cholanic acid and hydrophilic chitosan forms self-aggregates in an aquatic environment. The pharmaceutical formulation characterized in that hydrophobic anticancer drugs are incorporated into a cholanic acid-chitosan complex, wherein the cholanic acid-chitosan complex forms self-aggregates, prolongs the drug release period, enhances the selectivity of the complex for tumor tissue, and greatly increases drug loading content when a drug is incorporated into the self-aggregates, compared to chemical bonding, which limits drug incorporation. Thus, the pharmaceutical formulation of the present invention is useful for anticancer chemotherapy.
摘要翻译：公开了一种药物制剂，其特征在于将疏水性抗癌药物并入胆酸 - 壳聚糖复合物及其制备方法中，更具体地说，由疏水性胆酸和亲水性壳聚糖组成的胆酸 - 壳聚糖复合物形成自聚集体水生环境。药物制剂的特征在于将疏水性抗癌药物掺入胆酸 - 壳聚糖复合物中，其中胆酸 - 壳聚糖复合物形成自聚集体，延长药物释放时间，提高复合物对肿瘤组织的选择性，并大大增加当药物掺入自聚集体中时，药物加载含量与化学键合相比，这限制了药物并入。因此，本发明的药物制剂可用于抗癌化疗。

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