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1. 发明公开

EP0588994A1 FLUORESCENCE DIAGNOSTICS OF CANCER USING $g(d)-AMINO LEVULINIC ACID 失效
标题翻译：肿瘤杂志荧光诊断USING -G（D）氨基乙酰丙酸。
公开(公告)号：EP0588994A1
公开(公告)日：1994-03-30
申请号：EP93901458.0
申请日：1992-12-18
申请人： SVANBERG, Sune , SVANBERG, Katarina , BERG, Roger , JOHANSSON, Jonas
发明人： SVANBERG, Sune , SVANBERG, Katarina , BERG, Roger , JOHANSSON, Jonas
IPC分类号： A61B5 , A61K31 , A61K49
CPC分类号： A61K49/0021 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0091 , A61B5/4312 , A61K31/195
摘要： On décrit un procédé de détection de tumeurs malignes à l'aide de l'acide levulique delta-amino (hydrochlorure) comme marqueur de tumeur. Le tissu est exposé à l'agent soit par injection intraveineuse ou par application d'un onguent sur les tumeurs superficielles. Après une temporisation adéquate, la fluorescence est induite dans le tissu à l'aide d'une source d'excitation, par exemple, un laser. Le cancer apparaît ensuite avec une forte pointe de fluorescence spécifique à 635 nm. En divisant cette intensité de pointe rouge par l'intensité de l'autofluorescence bleue-verte du tissu, on obtient une démarcation améliorée ainsi qu'une insensibilité aux variations de nombreux paramètres expérimentaux.

2. 发明申请

WO2004100761A3 SYSTEM AND METHOD FOR THERAPY AND DIAGNOSIS COMPRISING IN COMBINATION NON-MECHANICAL AND MECHANICAL DISTRIBUTORS FOR DISTRIBUTION OF RADIATION 审中-公开
公开(公告)号：WO2004100761A3
公开(公告)日：2004-11-25
申请号：PCT/SE2004/000758
申请日：2004-05-14
申请人： SPECTRACURE AB , JOHANSSON, Ann , ANDERSSON ENGELS, Stefan , JOHANSSON, Thomas , PÅLSSON, Sara , SOTO THOMPSON, Marcelo , SVANBERG, Katarina , SVANBERG, Sune
发明人： JOHANSSON, Ann , ANDERSSON ENGELS, Stefan , JOHANSSON, Thomas , PÅLSSON, Sara , SOTO THOMPSON, Marcelo , SVANBERG, Katarina , SVANBERG, Sune
IPC分类号： A61B5/00
摘要： A system and method for therapy and diagnosis of a human or animal. At least one coupling element for coupling of radiation couples radiation from at least a first radiation source to a tumour site and/or from said second radiation source to said site and/or from said site to a detector. The coupling elements are combinations of at least one translatory distributor, at least one rotary distributor, and at least one operation mode selector means for directing either said therapeutic radiation or said diagnostic radiation to said site through said at least one first radiation conductor. The system may be used for interactive interstitial photodynamic tumour therapy. The system and method according to the invention combines the advantages of purely mechanical and purely non-mechanical solutions in a new and synergetic way.

3. 发明申请

WO2003041575A1 THERAPY AND DIAGNOSIS SYSTEM AND METHOD WITH DISTRIBUTOR FOR DISTRIBUTION OF RADIATION 审中-公开
标题翻译：治疗和诊断系统及其分配方法用于分布辐射
公开(公告)号：WO2003041575A1
公开(公告)日：2003-05-22
申请号：PCT/SE2002/002050
申请日：2002-11-11
申请人： SVANBERG, Sune , ANDERSSON-ENGELS, Stefan , SVANBERG, Katarina
发明人： SVANBERG, Sune , ANDERSSON-ENGELS, Stefan , SVANBERG, Katarina
IPC分类号： A61B5/00
CPC分类号： A61N5/062 , A61B5/1455 , A61N5/0601 , A61N2005/0612 , A61N2005/063 , G02B6/3504 , G02B6/3556 , G02B6/4298
摘要： A system and method for interactive, interstitial photodynamic and/or photothermal tumour therapy, said system comprising a distributor (1) for distribution of radiation from at least one radiation source (9a, 9b) to a reaction site (8), or from the reaction site (8) to at least one radiation sensor (12). A plurality of first radiation conductors (6, 6') are arranged for conduction of radiation to and from the reaction site (8) and a plurality of second radiation conductors (7, 7a, 7a', 7b) are arranged for emitting radiation from the radiation source (9a, 9b) and/or conduction of radiation to the radiation sensor (12). The distributor comprises two plane discs (3, 4), mounted abutting each other, one being fixed and the other turnable relative the first, each disc having holes arranged equally separated on a circle line; the number of holes in the turnable disc being a multiple of the number of holes in the fixed disc. One end of the first radiation conductors (6, 6’) are fixed in the holes of the fixed disc (3) and one end of the second radiation conductors (7, 7a, 7a’, 7b) are fixed in the holes of the turnable disc.
摘要翻译：一种用于交互式，间质光动力学和/或光热治疗肿瘤治疗的系统和方法，所述系统包括用于将辐射从至少一个辐射源（9a，9b）分配到反应部位（8）的分布器（1）反应部位（8）到至少一个辐射传感器（12）。布置多个第一辐射导体（6,6'）用于将辐射传导到反应部位（8）和从反应部位（8）传导辐射，并且布置多个第二辐射导体（7,7a，7a'，7b）以发射辐射辐射源（9a，9b）和/或辐射传导到辐射传感器（12）。分配器包括两个彼此邻接的平面盘（3,4），一个是固定的，另一个可相对于第一个旋转，每个盘具有在圆线上等距分布的孔; 可转动盘中的孔数是固定盘中孔数的倍数。第一辐射导体（6,6'）的一端固定在固定盘（3）的孔中，第二辐射导体（7,7a，7a'，7b）的一端固定在固定盘可转盘

4. 发明申请

WO2002103859A2 LASER SYSTEM FOR TREATMENT AND DIAGNOSIS 审中-公开
标题翻译：激光治疗和诊断系统
公开(公告)号：WO2002103859A2
公开(公告)日：2002-12-27
申请号：PCT/DK2002/000405
申请日：2002-06-14
申请人： FORSKNINGSCENTER RISØ , ANDERSEN, Peter, E. , PETERSEN, Paul, Michael , ANDERSEN, Eva, Samsøe , SVANBERG, Sune , SVANBERG, Katarina , ANDERSSON-ENGELS, Stefan
发明人： ANDERSEN, Peter, E. , PETERSEN, Paul, Michael , ANDERSEN, Eva, Samsøe , SVANBERG, Sune , SVANBERG, Katarina , ANDERSSON-ENGELS, Stefan
IPC分类号： H01S
CPC分类号： A61B18/22 , A61B2017/00057 , H01S5/005 , H01S5/2036 , H01S5/4012 , H01S5/4062
摘要： The present invention relates to a system and a method for emitting laser light to biological tissue, wherein in high power lasers are modulated in order to provide an output beam consisting of high temporal and/or spatial coherence and at the same time is capable of delivering an output beam having a high power when being delivered through fibres having a core diameter of less than 400 µm. The method and system may in particular be used for photodynamic treatment (PDT) and/or thermal treatment. In a preferred embodiment the system and method also includes a monitoring system for the effect actually delivered to the biological tissue. Furthermore, the invention relates to a method of treatment using the system, as well as a method for diagnosing using the system.
摘要翻译：本发明涉及一种用于向生物组织发射激光的系统和方法，其中在高功率激光器中进行调制，以便提供由高时间和/或空间相干性组成的输出光束，并且同时能够传送当通过具有小于400μm的芯直径的纤维递送时具有高功率的输出光束。该方法和系统可特别用于光动力处理（PDT）和/或热处理。在优选实施例中，系统和方法还包括用于实际递送到生物组织的效果的监测系统。此外，本发明涉及使用该系统的治疗方法以及使用该系统进行诊断的方法。

5. 发明申请

WO1993013403A1 FLUORESCENCE DIAGNOSTICS OF CANCER USING 'delta'-AMINO LEVULINIC ACID 审中-公开
标题翻译：使用δ-氨基酸的癌症的荧光诊断
公开(公告)号：WO1993013403A1
公开(公告)日：1993-07-08
申请号：PCT/SE1992000879
申请日：1992-12-18
申请人： SVANBERG, Sune , SVANBERG, Katarina , BERG, Roger , JOHANSSON, Jonas
IPC分类号： G01N21/64
CPC分类号： A61K49/0021 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0091 , A61B5/4312 , A61K31/195
摘要： A procedure for the detection of malignant tumours using the agent delta -amino levulinic acid (hydrochloride) as a tumour marker is described. The tissue is exposed to the agent either by intravenous injection or by application of an unguent over superficial tumours. After a suitable time delay fluorescence is induced in the tissue using an excitation source, e.g. a laser. Cancer then emerges with a strong and specific fluorescence peak at 635 nm. By dividing this red peak intensity by the intensity of the blue-green autofluorescence from the tissue an improved demarcation is obtained and also immunity to variations in many experimental parameters.
摘要翻译：描述了使用试剂δ-氨基乙酰丙酸（盐酸盐）作为肿瘤标志物检测恶性肿瘤的方法。组织通过静脉注射或通过施用无菌的超浅表肿瘤而暴露于药剂。在合适的时间延迟之后，使用激发源，例如，在组织中诱导荧光。雷射。然后，癌症在635nm处出现强烈而特异的荧光峰。通过将该红色峰强度除以来自组织的蓝绿色自发荧光的强度，获得了改善的分界，并且还获得许多实验参数的变化的免疫性。

6. 发明申请

WO2002103859A3 LASER SYSTEM FOR TREATMENT AND DIAGNOSIS 审中-公开
公开(公告)号：WO2002103859A3
公开(公告)日：2002-12-27
申请号：PCT/DK2002/000405
申请日：2002-06-14
申请人： FORSKNINGSCENTER RISØ , ANDERSEN, Peter, E. , PETERSEN, Paul, Michael , ANDERSEN, Eva, Samsøe , SVANBERG, Sune , SVANBERG, Katarina , ANDERSSON-ENGELS, Stefan
发明人： ANDERSEN, Peter, E. , PETERSEN, Paul, Michael , ANDERSEN, Eva, Samsøe , SVANBERG, Sune , SVANBERG, Katarina , ANDERSSON-ENGELS, Stefan
IPC分类号： A61N5/067
摘要： The present invention relates to a system and a method for emitting laser light to biological tissue, wherein in high power lasers are modulated in order to provide an output beam consisting of high temporal and/or spatial coherence and at the same time is capable of delivering an output beam having a high power when being delivered through fibres having a core diameter of less than 400 µm. The method and system may in particular be used for photodynamic treatment (PDT) and/or thermal treatment. In a preferred embodiment the system and method also includes a monitoring system for the effect actually delivered to the biological tissue. Furthermore, the invention relates to a method of treatment using the system, as well as a method for diagnosing using the system.

7. 发明申请

WO2006121408A1 A DEVICE, SYSTEM AND METHOD FOR DETERMINING THE EFFECT OF PHOTODYNAMIC OR PHOTOTHERMAL TUMOR THERAPY 审中-公开
标题翻译：用于确定光热或热光肿瘤治疗效果的装置，系统和方法
公开(公告)号：WO2006121408A1
公开(公告)日：2006-11-16
申请号：PCT/SE2006/050121
申请日：2006-05-12
申请人： SPECTRACURE AB , SVANBERG, Sune , SVANBERG, Katarina
发明人： SVANBERG, Sune , SVANBERG, Katarina
IPC分类号： A61B5/026 , A61N5/06
CPC分类号： A61B5/0261 , A61B2017/00057 , A61N5/0601 , A61N5/062 , A61N2005/063
摘要： A device and method for determining the effect of therapy in a tumour tissue of a human or a mammal under interstitial photodynamic or photothermal therapy by analyzing a liquid flow in a tissue of a human or a mammal. A first fibre is interstitially inserted in a first position of said tissue and connected to a light source, and a second fibre is interstitially inserted in a second position of said tissue for receiving light emitted from the first fibre. A detector is arranged for receiving the light from said second fibre for producing an output signal. An analysator receives the output signal from the detector and determines if there is a frequency component in the frequency area below about 1 MHz in the output signal, which is indicative of blood cell movement in the tissue. If the frequency component is below a threshold value, it is determined that there is no blood flow. In photothermal therapy, no blood flow is interpreted as the fact that the blood has coagulated and the therapy may be finalized. In photodynamic tumour therapy, changes in blood flow may be used to evaluate the treatment progression.
摘要翻译：用于通过分析人或哺乳动物的组织中的液体流量来确定在间质性光动力学或光热疗法下对人或哺乳动物的肿瘤组织中的治疗效果的装置和方法。第一纤维间隙地插入所述组织的第一位置并连接到光源，并且第二纤维间隙插入所述组织的第二位置，用于接收从第一纤维发射的光。检测器被布置成用于接收来自所述第二光纤的光以产生输出信号。分析器接收来自检测器的输出信号，并且确定在输出信号中低于约1MHz的频率区域中是否存在频率分量，其表示组织中的血细胞运动。如果频率分量低于阈值，则确定不存在血流。在光热治疗中，没有血流量被解释为血液已经凝结并且可以完成治疗的事实。在光动力学肿瘤治疗中，血流量的变化可用于评估治疗进展。

8. 发明申请

WO2006112789A1 HUMAN CAVITY GAS MEASUREMENT DEVICE AND METHOD 审中-公开
标题翻译：人类气体测量装置和方法
公开(公告)号：WO2006112789A1
公开(公告)日：2006-10-26
申请号：PCT/SE2006/050077
申请日：2006-04-18
申请人： GASPOROX AB , SVANBERG, Sune , PERSSON, Linda , SVANBERG, Katarina
发明人： SVANBERG, Sune , PERSSON, Linda , SVANBERG, Katarina
IPC分类号： A61B5/00 , G01N21/49
CPC分类号： A61B5/411 , A61B5/08 , A61B5/082 , A61B5/1455 , A61B5/1459 , A61B5/6814 , A61B5/6817 , G01N21/3504 , G01N21/359 , G01N21/49
摘要： A device and method for gas measurements in body cavities are provided. These may be any body cavity containing a free gas, where there is an interest in detecting and/or measuring the concentration of said free gas by means of a non-invasive or minimally invasive method. According to an exemplary embodiment measurement of free oxygen in cranium cavities is performed by scattering media absorption spectroscopy, and in particular variations of such oxygen. This is particularly useful for diagnostic purposes based on the measurements, for instance for detecting sinusitis or the like.
摘要翻译：提供了一种用于体腔内气体测量的装置和方法。这些可以是包含游离气体的任何体腔，其中有兴趣通过非侵入性或微创方法检测和/或测量所述游离气体的浓度。根据示例性实施例，通过散射介质吸收光谱法，特别是这种氧的变化来进行颅腔中游离氧的测量。这对于基于测量的诊断目的尤其有用，例如用于检测鼻窦炎等。

9. 发明申请

WO2004100761A2 SYSTEM AND METHOD FOR THERAPY AND DIAGNOSIS COMPRISING IN COMBINATION NON-MECHANICAL AND MECHANICAL DISTRIBUTORS FOR DISTRIBUTION OF RADIATION 审中-公开
标题翻译：用于组合非机械和机械分配器的用于分布辐射的治疗和诊断的系统和方法
公开(公告)号：WO2004100761A2
公开(公告)日：2004-11-25
申请号：PCT/SE2004000758
申请日：2004-05-14
申请人： SPECTRACURE AB , JOHANSSON ANN , ANDERSSON ENGELS STEFAN , JOHANSSON THOMAS , PAALSSON SARA , SOTO THOMPSON MARCELO , SVANBERG KATARINA , SVANBERG SUNE
发明人： JOHANSSON ANN , ANDERSSON ENGELS STEFAN , JOHANSSON THOMAS , PAALSSON SARA , SOTO THOMPSON MARCELO , SVANBERG KATARINA , SVANBERG SUNE
IPC分类号： A61B5/00 , A61B17/00 , A61B18/20 , A61N5/06 , A61B
CPC分类号： A61N5/0601 , A61B5/0071 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B2017/00057 , A61B2018/208 , A61N5/062 , A61N2005/0612 , A61N2005/0629
摘要： A system and method for therapy and diagnosis of a human or animal. At least one coupling element for coupling of radiation couples radiation from at least a first radiation source to a tumour site and/or from said second radiation source to said site and/or from said site to a detector. The coupling elements are combinations of at least one translatory distributor, at least one rotary distributor, and at least one operation mode selector means for directing either said therapeutic radiation or said diagnostic radiation to said site through said at least one first radiation conductor. The system may be used for interactive interstitial photodynamic tumour therapy. The system and method according to the invention combines the advantages of purely mechanical and purely non-mechanical solutions in a new and synergetic way.
摘要翻译：用于人或动物的治疗和诊断的系统和方法。用于耦合辐射的至少一个耦合元件将来自至少第一辐射源的辐射耦合到肿瘤部位和/或从所述第二辐射源到所述部位和/或从所述部位耦合到检测器。耦合元件是至少一个平移分配器，至少一个旋转分配器和至少一个操作模式选择器装置的组合，用于通过所述至少一个第一辐射导体将所述治疗辐射或所述诊断辐射引导到所述部位。该系统可用于交互式间质性光动力肿瘤治疗。根据本发明的系统和方法以新的和协同的方式结合了纯机械和纯非机械解决方案的优点。

10. 发明申请

WO1990010219A1 IMPROVEMENTS IN DIAGNOSIS BY MEANS OF FLUORESCENT LIGHT EMISSION FROM TISSUE 审中-公开
标题翻译：通过组织荧光灯排出的诊断改进
公开(公告)号：WO1990010219A1
公开(公告)日：1990-09-07
申请号：PCT/SE1990000118
申请日：1990-02-21
申请人： ANDERSSON-ENGELS, Stefan , JOHANSSON, Jonas , STENRAM, Unne , SVANBERG, Katarina , SVANBERG, Sune
IPC分类号： G01N21/64
CPC分类号： G01N21/6408 , G01N21/6456 , G01N2021/3177 , G01N2021/6421
摘要： A sample (1) is irradiated by a pulse from a laser (2), creating fluorescence radiation, which is brought, in imaging relation or otherwise, to a detector (6) sensing from the same sample (1) in a plurality of spectral intervals (6A-6D), for obtaining intensity values. The radiation may be sensed in imaging relation, creating a multiplicity of said pluralities. The spectral intervals may be wavelength defined by passband filters (5A-5D) or time interval defined time spectral intervals controlled by a computer (7), which makes a numerical evaluation comprising a division. The tissue character may then be evaluated from the evaluation.

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