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1. 发明申请

WO2004100761A2 SYSTEM AND METHOD FOR THERAPY AND DIAGNOSIS COMPRISING IN COMBINATION NON-MECHANICAL AND MECHANICAL DISTRIBUTORS FOR DISTRIBUTION OF RADIATION 审中-公开
标题翻译：用于组合非机械和机械分配器的用于分布辐射的治疗和诊断的系统和方法
公开(公告)号：WO2004100761A2
公开(公告)日：2004-11-25
申请号：PCT/SE2004000758
申请日：2004-05-14
申请人： SPECTRACURE AB , JOHANSSON ANN , ANDERSSON ENGELS STEFAN , JOHANSSON THOMAS , PAALSSON SARA , SOTO THOMPSON MARCELO , SVANBERG KATARINA , SVANBERG SUNE
发明人： JOHANSSON ANN , ANDERSSON ENGELS STEFAN , JOHANSSON THOMAS , PAALSSON SARA , SOTO THOMPSON MARCELO , SVANBERG KATARINA , SVANBERG SUNE
IPC分类号： A61B5/00 , A61B17/00 , A61B18/20 , A61N5/06 , A61B
CPC分类号： A61N5/0601 , A61B5/0071 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B2017/00057 , A61B2018/208 , A61N5/062 , A61N2005/0612 , A61N2005/0629
摘要： A system and method for therapy and diagnosis of a human or animal. At least one coupling element for coupling of radiation couples radiation from at least a first radiation source to a tumour site and/or from said second radiation source to said site and/or from said site to a detector. The coupling elements are combinations of at least one translatory distributor, at least one rotary distributor, and at least one operation mode selector means for directing either said therapeutic radiation or said diagnostic radiation to said site through said at least one first radiation conductor. The system may be used for interactive interstitial photodynamic tumour therapy. The system and method according to the invention combines the advantages of purely mechanical and purely non-mechanical solutions in a new and synergetic way.
摘要翻译：用于人或动物的治疗和诊断的系统和方法。用于耦合辐射的至少一个耦合元件将来自至少第一辐射源的辐射耦合到肿瘤部位和/或从所述第二辐射源到所述部位和/或从所述部位耦合到检测器。耦合元件是至少一个平移分配器，至少一个旋转分配器和至少一个操作模式选择器装置的组合，用于通过所述至少一个第一辐射导体将所述治疗辐射或所述诊断辐射引导到所述部位。该系统可用于交互式间质性光动力肿瘤治疗。根据本发明的系统和方法以新的和协同的方式结合了纯机械和纯非机械解决方案的优点。

2. 发明专利

AT467439T 未知
公开(公告)号：AT467439T
公开(公告)日：2010-05-15
申请号：AT07802631
申请日：2007-08-15
申请人： SPECTRACURE AB
发明人： SVANBERG SUNE , AXELSSON JOHAN , SWARTLING JOHANNES , JOHANSSON ANN , ANDERSSON-ENGELS STEFAN
IPC分类号： A61N5/06
摘要： A method and system for controlling and adjusting light in interstitial photodynamic light therapy (IPDT) in a subject is disclosed. More particularly, a method for controlling the light in interstitial tumor photodynamic light therapy is described using a calculation method for determination of status of tissue during the PDT treatment. The status is used in a feedback loop to control the continued PDT treatment. Methods are disclosed that constitute pre-treatment and realtime dosimetry modules for IPDT on the whole prostate glandular tissue. The method includes reconstruction of the target geometry, optimization of source fiber positions within this geometry, monitoring of the light attenuation during the treatment procedure and updating individual fiber irradiation times to take into account any variation in tissue light transmission. A control device that is arranged to restrict delivery of therapeutic light treatment at least temporary in dependence of at least one attribute of one of photodynamic treatment parameters. In comparison to no treatment feedback, a significant undertreatment of the patient as well as damage to healthy organs at risk are avoided.

4. 发明专利

SE0301411L 未知
公开(公告)号：SE0301411L
公开(公告)日：2005-01-13
申请号：SE0301411
申请日：2003-05-14
申请人： SPECTRACURE AB
发明人： JOHANSSON ANN , ENGELS STEFAN ANDERSSON , JOHANSSON THOMAS , PAALSSON SARA , THOMPSON MARCELO SOTO , SVANBERG KATARINA , SVANBERG SUNE
IPC分类号： A61B20060101 , A61B5/00 , A61N5/06

5. 发明专利

AT547043T 未知
公开(公告)号：AT547043T
公开(公告)日：2012-03-15
申请号：AT04733227
申请日：2004-05-14
申请人： SPECTRACURE AB
发明人： JOHANSSON ANN , ANDERSSON ENGELS STEFAN , JOHANSSON THOMAS , PALSSON SARA , SOTO THOMPSON MARCELO , SVANBERG KATARINA , SVANBERG SUNE
IPC分类号： A61B5/00 , A61B17/00 , A61B18/20 , A61N5/06

6. 发明专利

AU2004238183C1 System and method for therapy and diagnosis comprising in combination non-mechanical and mechanical distributors for distribution of radiation 未知
公开(公告)号：AU2004238183C1
公开(公告)日：2010-09-09
申请号：AU2004238183
申请日：2004-05-14
申请人： SPECTRACURE AB
发明人： SVANBERG SUNE , ENGELS STEFAN ANDERSSON , PALSSON SARA , THOMPSON MARCELO SOTO , SVANBERG KATARINA , JOHANSSON ANN , JOHANSSON THOMAS
IPC分类号： A61B5/00 , A61B17/00 , A61B18/20 , A61N5/06
摘要： A system and method for therapy and diagnosis of a human or animal. At least one coupling element for coupling of radiation couples radiation from at least a first radiation source to a tumor site and/or from said second radiation source to said site and/or from said site to a detector. The coupling elements are combinations of at least one translatory distributor, at least one rotary distributor, and at least one operation mode selector means for directing either said therapeutic radiation or said diagnostic radiation to said site through said at least one first radiation conductor. The system may be used for interactive interstitial photodynamic tumor therapy. The system and method according to the invention combines the advantages of purely mechanical and purely non-mechanical solutions in a new and synergetic way.

7. 发明专利

ES2346262T3 SISTEMA Y METODO PARA CONTROLAR Y AJUSTAR PARAMETROS DE TERAPIA LUMINOSA FOTODINAMICA INTERSTICIAL. 未知
公开(公告)号：ES2346262T3
公开(公告)日：2010-10-13
申请号：ES07802631
申请日：2007-08-15
申请人： SPECTRACURE AB
发明人： SVANBERG SUNE , AXELSSON JOHAN , SWARTLING JOHANNES , JOHANSSON ANN , ANDERSSON-ENGELS STEFAN
IPC分类号： A61N5/06
摘要： Un sistema para proporcionar una terapia fotodinámica intersticial sobre el tejido en un cuerpo, comprendiendo dicho sistema: al menos una fibra óptica (105) para suministrar una luz terapéutica a dicho tejido para la interacción con un agente fotosensibilizador en dicho tejido, en donde dicha fibra óptica está diseñada para ser insertada intersticialmente dentro de dicho tejido con una región extrema distal del mismo; un dispositivo para evaluar al menos un parámetro de tratamiento fotodinámico de dicha terapia fotodinámica intersticial en dicha región extrema distal de dicha fibra óptica un dispositivo para modificar características de dicha luz terapéutica de dicha terapia fotodinámica intersticial en respuesta a la evaluación de dicho parámetro de tratamiento fotodinámico; y un dispositivo de control que está dispuesto para restringir dicho suministro de tratamiento de luz terapéutica que depende temporalmente de al menos un atributo de uno de dichos parámetros de tratamiento fotodinámico, en donde dicho dispositivo de control es un dispositivo de umbral y dicho atributo es al menos un valor de umbral de un valor (P) de uno de dichos parámetros de tratamiento fotodinámico, en donde dicho al menos un valor de umbral comprende un primer umbral (th1), un segundo umbral (th2), y un tercer umbral (th3), en el que dicho tercer umbral (th3) es más bajo que dicho segundo umbral (th2) y dicho segundo umbral es más bajo que dicho primer umbral (th1); y en donde dicho primer umbral (th1), dicho segundo umbral (th2), y dicho tercer umbral (th3) son dinámicamente ajustables durante dicha terapia fotodinámica intersticial.

8. 发明专利

DE602007006520D1 SYSTEM UND VERFAHREN ZUR KONTROLLE UND EINSTELLUNG VON INTERSTITIELLEN PHOTODYNAMISCHEN LICHTTHERAPIE-PARAMETERN 未知
公开(公告)号：DE602007006520D1
公开(公告)日：2010-06-24
申请号：DE602007006520
申请日：2007-08-15
申请人： SPECTRACURE AB
发明人： SVANBERG SUNE , AXELSSON JOHAN , SWARTLING JOHANNES , JOHANSSON ANN , ANDERSSON-ENGELS STEFAN
IPC分类号： A61N5/06

9. 发明专利

CA2694471A1 SYSTEM AND METHOD FOR CONTROLLING AND ADJUSTING INTERSTITIAL PHOTODYNAMIC LIGHT THERAPY PARAMETERS 未知
公开(公告)号：CA2694471A1
公开(公告)日：2008-02-21
申请号：CA2694471
申请日：2007-08-15
申请人： SPECTRACURE AB
发明人： SVANBERG SUNE , AXELSSON JOHAN , SWARTLING JOHANNES , JOHANSSON ANN , ANDERSSON-ENGELS STEFAN
IPC分类号： A61N5/06
摘要： A method and system for controlling and adjusting light in interstitial photodynamic light therapy (IPDT) in a subject is disclosed. More particularly, a method for controlling the light in interstitial tumor photodynamic light therapy is described using a calculation method for determination of status of tissue during the PDT treatment. The status is used in a feedback loop to control the continued PDT treatment. Methods are disclosed that constitute pre-treatment and realtime dosimetry modules for IPDT on the whole prostate glandular tissue. The method includes reconstruction of the target geometry, optimization of source fiber positions within this geometry, monitoring of the light attenuation during the treatment procedure and updating individual fiber irradiation times to take into account any variation in tissue light transmission. A control device that is arranged to restrict delivery of therapeutic light treatment at least temporary in dependence of at least one attribute of one of photodynamic treatment parameters. In comparison to no treatment feedback, a significant undertreatment of the patient as well as damage to healthy organs at risk are avoided.

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