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1. 发明专利

IL240717A Novel insulin analog and use thereof 未知
公开(公告)号：IL240717A
公开(公告)日：2020-05-31
申请号：IL24071715
申请日：2015-08-20
申请人： SUNG HEE HONG , DAE JIN KIM , YONG HO HUH , SUNG YOUB JUNG , SE CHANG KWON , KIM SEUNG SU , HANMI PHARM IND CO LTD , SANG YOUN HWANG , IN YOUNG CHOI , MYUNG HYUN JANG , HYUN UK KIM , JIN YOUNG KIM
发明人： SUNG HEE HONG , DAE JIN KIM , YONG HO HUH , SUNG YOUB JUNG , SE CHANG KWON , KIM SEUNG SU , SANG YOUN HWANG , IN YOUNG CHOI , MYUNG HYUN JANG , HYUN UK KIM , JIN YOUNG KIM
IPC分类号： A61K47/68 , A61K47/60
摘要： The present invention relates to an insulin analog that has a reduced insulin titer and a reduced insulin receptor binding affinity compared to the native form for the purpose of increasing the blood half-life of insulin, a conjugate prepared by linking the insulin analog and a carrier, a long-acting formulation including the conjugate, and a method for preparing the conjugate.

2. 发明专利

IL240717D0 Novel insulin analog and use thereof 未知
公开(公告)号：IL240717D0
公开(公告)日：2015-10-29
申请号：IL24071715
申请日：2015-08-20
申请人： SUNG HEE HONG , DAE JIN KIM , YONG HO HUH , SUNG YOUB JUNG , SE CHANG KWON , KIM SEUNG SU , HANMI PHARM IND CO LTD , SANG YOUN HWANG , IN YOUNG CHOI , MYUNG HYUN JANG , HYUN UK KIM , JIN YOUNG KIM
发明人： SUNG HEE HONG , DAE JIN KIM , YONG HO HUH , SUNG YOUB JUNG , SE CHANG KWON , KIM SEUNG SU , SANG YOUN HWANG , IN YOUNG CHOI , MYUNG HYUN JANG , HYUN UK KIM , JIN YOUNG KIM
IPC分类号： C07K20060101
摘要： The present invention relates to an insulin analog that has a reduced insulin titer and a reduced insulin receptor binding affinity compared to the native form for the purpose of increasing the blood half-life of insulin, a conjugate prepared by linking the insulin analog and a carrier, a long-acting formulation including the conjugate, and a method for preparing the conjugate.

3. 发明专利

IL298298A Liquid formulation of long-acting conjugate of glp-2 未知
公开(公告)号：IL298298A
公开(公告)日：2023-01-01
申请号：IL29829822
申请日：2022-11-16
申请人： HANMI PHARM CO LTD , SUNG HEE HONG , KIM SANG YUN , KIM MIN YOUNG , BAE SUNG MIN
发明人： SUNG HEE HONG , KIM SANG YUN , KIM MIN YOUNG , BAE SUNG MIN
IPC分类号： A61K38/00 , A61K38/26 , A61K47/12 , A61K47/18 , A61K47/20 , A61K47/22 , A61K47/26 , A61K47/64
摘要： The present invention relates to a liquid formulation of a long-acting conjugate of glucagon-like peptide-2 (GLP-2), and a method for producing same.

4. 发明专利

IL224225A Liquid formulation of long-acting human growth hormone conjugate 未知
公开(公告)号：IL224225A
公开(公告)日：2018-07-31
申请号：IL22422513
申请日：2013-01-14
申请人： HANMI SCIENCE CO LTD , SE CHANG KWON , SUNG MIN BAE , SUNG HEE HONG , BYUNG SUN LEE , DEA SEONG IM , JEA MIN LEE
发明人： SE CHANG KWON , SUNG MIN BAE , SUNG HEE HONG , BYUNG SUN LEE , DEA SEONG IM , JEA MIN LEE
IPC分类号： A61K20060101
摘要： Disclosed is a liquid formulation of long-acting human growth hormone (hGH) conjugate, free of albumin, which can guarantee the stability of the long-acting hGH conjugate when stored over a long period of time, wherein the long-acting human growth hormone conjugate includes a human growth hormone linked to an immunoglobulin Fc region, and has a prolonged in vivo stability compared to the native form. The liquid formulation of hGH conjugate including a pH 5.0˜6.0 buffer, a sugar alcohol, a salt and a non-ionic surfactant is free of human serum albumin and other hazardous factors which are potentially contaminated with viruses, and can provide excellent storage stability customized for a long-acting hGH conjugate composed of an hGH polypeptide and an immunoglobulin Fc region which has higher molecular weight and in vivo durability, compared to the native.

5. 发明授权

US08877734B2 Seleny-methyluracil compounds, radiosensitizer and pharmaceutical composition using them 有权
标题翻译：硒 - 甲基尿嘧啶化合物，放射增敏剂和使用它们的药物组合物
公开(公告)号：US08877734B2
公开(公告)日：2014-11-04
申请号：US13878711
申请日：2010-12-23
申请人： In Seok Hong , Sung Hee Hong , Marc M. Greenberg
发明人： In Seok Hong , Sung Hee Hong , Marc M. Greenberg
IPC分类号： A61K31/70 , A61K31/505 , C07H19/00 , C07D239/02 , A61K41/00 , C07H19/073 , C07H19/06
CPC分类号： A61K41/0038 , C07H19/06 , C07H19/073
摘要： Provided are novel selenyl-methyluracil compounds and a pharmaceutical composition for enhancing the effect of radiation treatment. The composition contains at least one compound selected from the group consisting of the selenyl-methyluracil compounds or pharmaceutically acceptable salts thereof, as an active ingredient.
摘要翻译：提供新颖的烯酰基 - 甲基尿嘧啶化合物和用于增强放射治疗效果的药物组合物。所述组合物含有选自由以下组成的组的至少一种化合物作为活性成分，所述化合物或其药学上可接受的盐为其药学上可接受的盐。

6. 发明申请

US20130127704A1 SPATIAL TOUCH APPARATUS USING SINGLE INFRARED CAMERA 审中-公开
标题翻译：使用单一红外摄像机的空间触控装置
公开(公告)号：US20130127704A1
公开(公告)日：2013-05-23
申请号：US13527256
申请日：2012-06-19
申请人： Kwang Mo JUNG , Sung Hee HONG , Byoung Ha PARK , Young Choong PARK , Kwang Soon CHOI , Yang Keun AHN
发明人： Kwang Mo JUNG , Sung Hee HONG , Byoung Ha PARK , Young Choong PARK , Kwang Soon CHOI , Yang Keun AHN
IPC分类号： G09G5/00 , H04N5/33
CPC分类号： G06F3/017 , G06F3/005 , G06F3/042 , G06F2203/04101
摘要： The present disclosure relates to a spatial touch apparatus using a single infrared camera. More particularly, it relates to a spatial touch apparatus to implement a virtual touch screen in a free space by using an infrared light emitting diode (LED) array and a single infrared camera and to calculate X-axis and Z-axis coordinates of the infrared screen touched by a user indication object. Therefore, the present invention will provide tangible and interactive user interfaces to users and can implement more various user interfaces (UI) than a conventional 2D touch apparatus.
摘要翻译：本公开涉及使用单个红外相机的空间触摸装置。更具体地说，本发明涉及一种通过使用红外发光二极管（LED）阵列和单个红外相机在自由空间中实现虚拟触摸屏并且计算红外线的X轴和Z轴坐标的空间触摸装置。屏幕由用户指示对象触摸。因此，本发明将为用户提供有形和交互的用户界面，并且可以实现比常规2D触摸设备更多的各种用户界面（UI）。

7. 发明授权

US07139155B2 Head drum assembly of a tape recorder having a resilient body to preload bearings thereof 失效
标题翻译：具有弹性体的磁带录音机的磁头鼓组件，以预加载其轴承
公开(公告)号：US07139155B2
公开(公告)日：2006-11-21
申请号：US10679389
申请日：2003-10-07
申请人： Seung-Woo Lee , Sung-Hee Hong , Tae-Gil Kang , Do-Young Choi , Chung-Hum Baik
发明人： Seung-Woo Lee , Sung-Hee Hong , Tae-Gil Kang , Do-Young Choi , Chung-Hum Baik
IPC分类号： G11B5/52
CPC分类号： G11B5/537 , G11B5/105
摘要： A head drum assembly of a tape recorder in which an inner race and an outer race of an upper bearing are press-fitted onto a shaft and a rotary drum, respectively, thereby applying a preload. A resilient body, such as a compressed coil spring, is disposed between a lower bearing disposed between the rotary drum and the shaft and a stationary drum. The resilient body upwardly presses the inner race of the lower bearing, thereby applying a preload. Accordingly, the head drum assembly of the tape recorder provides enhanced assembling efficiency and reduced manufacturing costs.
摘要翻译：一种磁带记录器的磁头鼓组件，其中内座圈和上轴承的外座圈分别压配到轴和旋转鼓上，从而施加预载。诸如压缩螺旋弹簧的弹性体设置在设置在旋转滚筒和轴之间的下轴承和固定滚筒之间。弹性体向上按压下轴承的内圈，从而施加预载。因此，磁带记录器的磁头鼓组件提高了组装效率并降低了制造成本。

8. 发明授权

US06369991B1 Head drum apparatus 失效
标题翻译：头鼓设备
公开(公告)号：US06369991B1
公开(公告)日：2002-04-09
申请号：US09456517
申请日：1999-12-08
申请人： Do-Young Choi , Young-Ho Cho , Hyeong-Seok Choi , Chung-Hum Baik , Jun-Young Kim , Seung-Woo Lee , Sung-Hee Hong
发明人： Do-Young Choi , Young-Ho Cho , Hyeong-Seok Choi , Chung-Hum Baik , Jun-Young Kim , Seung-Woo Lee , Sung-Hee Hong
IPC分类号： G11B552
CPC分类号： G11B5/531
摘要： A head drum apparatus including a lower drum; a stationary shaft pressed and fitted into a center hole of the lower drum; an upper drum rotatably coupled to the stationary shaft via at least one bearing; a rotor magnet secured via a plate to the upper drum; a boss fixed to the top portion of the stationary shaft by a set-screw; a PCB mounted to the boss such that it is opposite to the rotor magnet, the PCB having a pulse generator (“PG”) pattern, a frequency generator (“FG”) pattern, connection patterns and jump patterns formed on one surface thereof, the PG pattern and the FG pattern being connected to the respective connection patterns via the respective jump patterns; and motor stator coils mounted to the PCB, whereby the structure of the motor becomes simpler, the number of the components and the manufacturing steps are reduced, the manufacturing efficiency is enhanced and the productivity thereof is increased.
摘要翻译：一种头鼓装置，包括下鼓; 固定轴被压配合到下鼓的中心孔中; 上鼓，其经由至少一个轴承可旋转地联接到所述固定轴; 通过板固定到上鼓的转子磁体; 通过固定螺钉固定到固定轴的顶部的凸台; PCB安装到凸台以使其与转子磁体相对，PCB具有脉冲发生器（“PG”）图案，频率发生器（“FG”）图案，在其一个表面上形成的连接图案和跳跃图案， PG图案和FG图案经由各自的跳跃图案连接到各个连接图案; 以及安装在PCB上的电动机定子线圈，由此电动机的结构变得更简单，部件数量和制造步骤减少，制造效率提高，生产率提高。

9. 发明授权

US09636420B2 Polypeptide complex comprising non-peptidyl polymer having three functional ends 有权
公开(公告)号：US09636420B2
公开(公告)日：2017-05-02
申请号：US13055406
申请日：2009-07-23
申请人： Dae Hae Song , Jae Hee Shin , Mi Ji Lee , Sung Hee Hong , Se Chang Kwon , Gwan Sun Lee
发明人： Dae Hae Song , Jae Hee Shin , Mi Ji Lee , Sung Hee Hong , Se Chang Kwon , Gwan Sun Lee
IPC分类号： A61K47/48 , C07K14/62 , C07K14/505 , C07K14/52 , C07K14/56 , C07K14/61 , C07K14/475 , C07K19/00 , A61K38/28 , C07K14/59
CPC分类号： A61K47/48715 , A61K47/60 , A61K47/6811 , A61K47/6889 , C07K14/59 , C07K19/00 , C07K2319/31
摘要： Disclosed is a protein complex, comprising a physiologically active polypeptide, a dimeric protein and a non-peptidyl polymer having three functional ends (3-arm), with the linkage of both the physiologically active polypeptide and the dimeric protein to the 3-arm non-peptidyl polymer via respective covalent bonds. The protein complex guarantees the long acting activity and biostability of a physiologically active polypeptide. Having the ability to maintain the bioactivity of physiologically active polypeptides or peptides highly and to significantly improve the serum half life of the polypeptides or peptides, the protein complex can be applied to the development of sustained release formulations of various physiologically active polypeptide drugs. Also, it utilizes raw materials including the physiologically active polypeptides without significant loss, thereby increasing the production yield. Further, it can be easily purified.

10. 发明授权

US09421244B2 Long-acting interferon beta formulation comprising an immunoglobulin fragment 有权
标题翻译：包含免疫球蛋白片段的长效干扰素β制剂
公开(公告)号：US09421244B2
公开(公告)日：2016-08-23
申请号：US13638821
申请日：2011-04-04
申请人： Dae Jin Kim , Min Young Kim , Jin Sun Kim , Sung Hee Hong , Sung Youb Jung , Se Chang Kwon
发明人： Dae Jin Kim , Min Young Kim , Jin Sun Kim , Sung Hee Hong , Sung Youb Jung , Se Chang Kwon
IPC分类号： A61K38/21 , A61K47/48 , C07K14/565 , C07K19/00
CPC分类号： A61K38/215 , A61K47/68 , A61K47/6813 , A61K47/6835 , C07K14/565 , C07K19/00 , C07K2317/52 , C07K2317/732 , C07K2317/734 , C07K2319/30
摘要： The present invention relates to a long-acting interferon beta formulation having improved in vivo duration and stability, comprising an interferon beta conjugate that is prepared by covalently linking interferon beta with an immunoglobulin Fc region via a non-peptidyl polymer, and a preparation method thereof. The long-acting interferon beta formulation of the present invention maintains in vivo activity of interferon beta at a relatively high level and remarkably increases the serum half-life thereof, thereby being used for various diseases, for which interferon is efficacious.
摘要翻译：本发明涉及具有改善的体内持续时间和稳定性的长效型干扰素β制剂，其包含通过非肽基聚合物共价连接干扰素β与免疫球蛋白Fc区制备的干扰素β偶联物及其制备方法。本发明的长效干扰素β配方维持干扰素β的体内活性在相当高的水平，并显着提高其血清半衰期，从而被用于干扰素有效的各种疾病。

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