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1. 发明申请

WO2012174243A8 D -SERINE FOR THE TREATMENT OF VISUAL SYSTEM DISORDERS 审中-公开
标题翻译：用于治疗视力系统疾病的D -
公开(公告)号：WO2012174243A8
公开(公告)日：2013-02-07
申请号：PCT/US2012042466
申请日：2012-06-14
申请人： ALLERGAN INC , LI YONG-XIN , FOSTER ALAN C , STAUBLI URSULA , DONELLO JOHN E , ALCANTARA MIGUEL
发明人： LI YONG-XIN , FOSTER ALAN C , STAUBLI URSULA , DONELLO JOHN E , ALCANTARA MIGUEL
IPC分类号： A61K31/198 , A61K31/4015 , A61K31/42 , A61P27/02
CPC分类号： A61K31/198 , A61K31/4015 , A61K31/42
摘要： The present invention relates to therapeutic methods using pharmaceutical compositions comprising one or a combination of co-agonists at the N-methyl-D- aspartate receptor for the treatment of visual system disorders.
摘要翻译：本发明涉及使用药物组合物的治疗方法，所述药物组合物包含N-甲基-D-天冬氨酸受体中的一种或多种共激动剂的组合，用于治疗视觉系统疾病。

2. 发明申请

WO2012166533A1 D-SERINE TRANSPORTER INHIBITORS AS PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF VISUAL SYSTEM DISORDERS 审中-公开
标题翻译： D-丝氨酸转运蛋白抑制剂作为治疗视力系统疾病的药物组合物
公开(公告)号：WO2012166533A1
公开(公告)日：2012-12-06
申请号：PCT/US2012/039396
申请日：2012-05-24
申请人： ALLERGAN, INC. , FOSTER, Alan C. , LI, Yong-Xin , STAUBLI, Ursula , VISWANATH, Veena , LUHRS, Lauren
发明人： FOSTER, Alan C. , LI, Yong-Xin , STAUBLI, Ursula , VISWANATH, Veena , LUHRS, Lauren
IPC分类号： A61K31/196 , A61K31/198 , A61K31/401 , A61K45/06
CPC分类号： A61K31/197 , A61K31/196 , A61K31/198 , A61K31/216 , A61K31/401 , A61K31/405 , A61K45/06 , A61K2300/00
摘要： The present invention relates to pharmaceutical compositions comprising D-serine transporter inhibitors and therapeutic methods using such pharmaceutical compositions in methods for the treatment of visual system disorders and the enhancement of the visual function.
摘要翻译：本发明涉及包含D-丝氨酸转运蛋白抑制剂的药物组合物和使用这种药物组合物在治疗视觉系统障碍和增强视觉功能的方法中的治疗方法。

3. 发明申请

WO2011009061A1 COMPOSITIONS COMPRISING A CHOLINESTERASE INHIBITOR FOR TREATING COGNITIVE DISORDERS 审中-公开
标题翻译：包含用于治疗认知障碍的胆碱酯酶抑制剂的组合物
公开(公告)号：WO2011009061A1
公开(公告)日：2011-01-20
申请号：PCT/US2010/042308
申请日：2010-07-16
申请人： ALLERGAN, INC. , STAUBLI, Ursula V. , DONELLO, John E.
发明人： STAUBLI, Ursula V. , DONELLO, John E.
IPC分类号： A61K31/40 , A61K31/4025 , A61K31/4409 , A61K31/4427 , A61K31/4523 , A61K31/4709 , A61P25/00 , A61P25/28 , A61P25/16 , A61K45/06
CPC分类号： A61K45/06 , A61K31/40 , A61K31/4025 , A61K31/4409 , A61K31/4427 , A61K31/4523 , A61K31/4709 , A61K2300/00
摘要： Disclosed herein is a pharmaceutical composition comprising a cholinesterase inhibitor and compound of the following formula: The composition is effective for treating cognitive disorders, and methods of treating such disorders using the composition are also disclosed.
摘要翻译：本文公开了包含胆碱酯酶抑制剂和下式化合物的药物组合物：该组合物对于治疗认知障碍是有效的，并且还公开了使用该组合物治疗这种病症的方法。

4. 发明申请

WO2005072345A3 ENHANCEMENT OF AMPAKINE-INDUCED FACILITATION OF SYNAPTIC RESPONSES BY CHOLINESTERASE INHIBITORS 审中-公开
公开(公告)号：WO2005072345A3
公开(公告)日：2005-08-11
申请号：PCT/US2005/002372
申请日：2005-01-26
申请人： CORTEX PHARMACEUTICALS INC. , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , STAUBLI, Ursula , LYNCH, Gary , ZHONG, Sheng , COLGIN, Laura
发明人： STAUBLI, Ursula , LYNCH, Gary , ZHONG, Sheng , COLGIN, Laura
IPC分类号： A61K31/445
摘要： The present invention relates to a method for enhancing the physiological and therapeutic effects of an AMPA receptor potentiator in an animal by co-administration of an acetylcholinesterase inhibitor with the potentiator. Also disclosed is a method for treating a cognitive disorder in an animal by co-administration of an AMPA receptor potentiator and an acetylcholinesterase inhibitor. In addition, a composition comprising an effective amount of an AMPA receptor potentiator and an effective amount of an acetylcholinesterase inhibitor is also disclosed.

5. 发明申请

WO2013116186A1 BRIMONIDINE FOR TREATING VISUAL DISORDERS MEDIATED BY CENTRAL VISUAL PROJECTIONS FROM THE EYE 审中-公开
标题翻译：用于治疗眼睛中央视觉投射介导的视觉障碍的甘露辛
公开(公告)号：WO2013116186A1
公开(公告)日：2013-08-08
申请号：PCT/US2013/023548
申请日：2013-01-29
申请人： ALLERGAN, INC. , STAUBLI, Ursula , FOSTER, Alan, C. , GIL, Daniel, W. , DONELLO, John, E
发明人： STAUBLI, Ursula , FOSTER, Alan, C. , GIL, Daniel, W. , DONELLO, John, E
IPC分类号： A61K31/00 , A61K31/498 , A61P25/00
CPC分类号： A61K31/498
摘要： The present invention relates to a method for treating visual disorders mediated by lateral geniculate nucleus, superior colliculus and the visual cortex by administering to a patient in need of such treatment, compounds acting at the alpha 2 adrenergic receptor.
摘要翻译：本发明涉及通过向需要这种治疗的患者施用在α2肾上腺素能受体上起作用的化合物来治疗外侧膝状核，上丘和视皮质介导的视觉障碍的方法。

6. 发明申请

WO2011130411A1 COMPOSITIONS AND METHODS FOR TREATING VISUAL DISORDERS 审中-公开
标题翻译：用于治疗视力障碍的组合物和方法
公开(公告)号：WO2011130411A1
公开(公告)日：2011-10-20
申请号：PCT/US2011/032325
申请日：2011-04-13
申请人： ALLERGAN, INC. , STAUBLI, Ursula V. , LI, Yong-Xin , FOSTER, Alan C.
发明人： STAUBLI, Ursula V. , LI, Yong-Xin , FOSTER, Alan C.
IPC分类号： A61K31/53 , A61P27/02
CPC分类号： A61K31/517 , A61K9/0048 , A61K31/454 , A61K31/536 , A61K31/5415
摘要： Disclosed are methods of treating disorders of the eye by administering to a patient in need of such treatment a compound represented by formula (I), Wherein R1 and R2 are independently hydrogen, alkyl, substituted alkyl, cycloalkyl, alkynyl, substituted alkynyl, cyano, alkoxy, carboxamido, substituted carboxamido, and if R1 and R2 are alkyl, R1 and R2 may be joined with a bond or --(CH 2 ) m -- to produce a cycloalkyl, R3 and R4 are independently hydrogen, alkyl, hydroxyl, alkoxy, cyano, fluoro, and if R3 and R4 are alkyl, R3 and R4 may be joined with a bond or --(CH 2 ) m -- to produce a cycloalkyl, Q may be absent, hydrogen, alkyl, cycloalkyl, cycloalkenyl, alkoxy, substituted alkoxy, substituted thio, cyano, thionitrile, sulfonamide, substituted sulfonamide, substituted sulfonyl, aromatic, substituted aromatic, heteroaromatic, substituted heteroaromatic, or bicycloheteroaromatic, R5 is hydrogen, alkyl, cycloalkyl, or when R6 is also alkyl, together with R6 may form a heterocydoalkyl ring, R6 may be hydrogen, alkyl, substituted alkyl, or --OR7, R7 is alkyl or, when R5 is alkyl, together with R5 forms a 5-, 6-, or 7-membered ring, L may be --Ο--, -S-, -N= or absent, Z may be carbon or nitrogen or absent, m is 1, 2 or 3, n is 0, 1 or 2, and when n is 0, Q may be directly bonded to Z, or a pharmaceutically acceptable addition salt of an acid or base thereof.
摘要翻译：公开了通过向需要这种治疗的患者施用由式（I）表示的化合物，其中R1和R2独立地为氢，烷基，取代的烷基，环烷基，炔基，取代的炔基，氰基，烷氧基，甲酰胺基，取代的甲酰氨基，如果R 1和R 2是烷基，则R 1和R 2可以与键或 - （CH 2）m - 连接以产生环烷基，R 3和R 4独立地是氢，烷基，羟基，烷氧基，氰基，氟，并且如果R 3和R 4是烷基，则R 3和R 4可以与键或 - （CH 2）m - 连接以产生环烷基，Q可以不存在，氢，烷基，环烷基，环烯基，烷氧基取代的烷氧基，取代的硫代，氰基，亚氨基，磺酰胺，取代的磺酰胺，取代的磺酰基，芳族的，取代的芳族的，杂芳族的，取代的杂芳族或双环芳烃，R 5是氢，烷基，环烷基，或者当R6也是烷基时，可以形成杂环烷基环， R 6可以是氢，烷基，取代的烷基或-OR 7，R 7是烷基，或者当R 5是烷基时，与R 5一起形成5-，6-或7-元环，L可以是-β- ，-S-，-N =或不存在，Z可以是碳或氮或不存在，m是1,2或3，n是0,1或2，当n是0时，Q可以直接键合到Z，或其药学上可接受的酸或碱的加成盐。

7. 发明申请

WO2005072345A2 ENHANCEMENT OF AMPAKINE-INDUCED FACILITATION OF SYNAPTIC RESPONSES BY CHOLINESTERASE INHIBITORS 审中-公开
标题翻译：胆碱酯酶抑制剂增强AMPAKINE对突触反应的促进作用
公开(公告)号：WO2005072345A2
公开(公告)日：2005-08-11
申请号：PCT/US2005002372
申请日：2005-01-26
申请人： CORTEX PHARMA INC , UNIV CALIFORNIA , STAUBLI URSULA , LYNCH GARY , ZHONG SHENG , COLGIN LAURA
发明人： STAUBLI URSULA , LYNCH GARY , ZHONG SHENG , COLGIN LAURA
IPC分类号： A61K31/445
CPC分类号： A61K31/445
摘要： The present invention relates to a method for enhancing the physiological and therapeutic effects of an AMPA receptor potentiator in an animal by co-administration of an acetylcholinesterase inhibitor with the potentiator. Also disclosed is a method for treating a cognitive disorder in an animal by co-administration of an AMPA receptor potentiator and an acetylcholinesterase inhibitor. In addition, a composition comprising an effective amount of an AMPA receptor potentiator and an effective amount of an acetylcholinesterase inhibitor is also disclosed.
摘要翻译：本发明涉及通过共同施用乙酰胆碱酯酶抑制剂和增效剂来增强动物中AMPA受体增强剂的生理和治疗效果的方法。还公开了通过共同施用AMPA受体增强剂和乙酰胆碱酯酶抑制剂来治疗动物认知障碍的方法。此外，还公开了包含有效量的AMPA受体增强剂和有效量的乙酰胆碱酯酶抑制剂的组合物。

8. 发明申请

WO2013016073A1 ALPHA-2 ADRENERGIC MODULATORS FOR TREATING VISUAL DISORDERS MEDIATED BY CENTRAL VISUAL PROJECTIONS FROM THE EYE 审中-公开
标题翻译：用于治疗视力障碍的ALPHA-2 ADRENERGIC调制器由眼睛的中央视觉投射介导
公开(公告)号：WO2013016073A1
公开(公告)日：2013-01-31
申请号：PCT/US2012/047064
申请日：2012-07-17
申请人： ALLERGAN, INC. , STAUBLI, Ursula V. , FOSTER, Alan C. , GIL, Daniel W. , DONELLO, John E.
发明人： STAUBLI, Ursula V. , FOSTER, Alan C. , GIL, Daniel W. , DONELLO, John E.
IPC分类号： A61K31/4174 , A61K31/4184 , A61P25/00
CPC分类号： A61K31/4174 , A61K31/4184
摘要： The present invention relates to a method for treating visual disorders mediated by lateral geniculate nucleus, superior colliculus and the visual cortex by administering to a patient in need of such treatment, compounds acting at the alpha 2 adrenergic receptors.
摘要翻译：本发明涉及通过向需要这种治疗的患者施用在α2肾上腺素能受体上起作用的化合物来治疗由外侧膝状核，上丘和视皮层介导的视觉障碍的方法。

9. 发明申请

WO2012174243A1 D -SERINE FOR THE TREATMENT OF VISUAL SYSTEM DISORDERS 审中-公开
标题翻译：用于治疗视力系统疾病的D -
公开(公告)号：WO2012174243A1
公开(公告)日：2012-12-20
申请号：PCT/US2012/042466
申请日：2012-06-14
申请人： ALLERGAN, INC. , LI, Yong-Xin , FOSTER, Alan, C. , STAUBLI, Ursula , DONELLO, John E. , ALCANTARA, Miguel
发明人： FOSTER, Alan, C. , STAUBLI, Ursula , DONELLO, John E. , ALCANTARA, Miguel
IPC分类号： A61K31/198 , A61K31/4015 , A61K31/42 , A61P27/02
CPC分类号： A61K31/198 , A61K31/4015 , A61K31/42
摘要： The present invention relates to therapeutic methods using pharmaceutical compositions comprising one or a combination of co-agonists at the N-methyl-D- aspartate receptor for the treatment of visual system disorders.
摘要翻译：本发明涉及使用药物组合物的治疗方法，所述药物组合物包含N-甲基-D-天冬氨酸受体中的一种或多种共激动剂的组合，用于治疗视觉系统疾病。

10. 发明申请

WO2012166544A1 D-SERINE TRANSPORTER INHIBITORS AS PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS 审中-公开
标题翻译： D-丝氨酸转运蛋白抑制剂作为治疗中枢神经系统疾病的药物组合物
公开(公告)号：WO2012166544A1
公开(公告)日：2012-12-06
申请号：PCT/US2012/039428
申请日：2012-05-24
申请人： ALLERGAN, INC. , FOSTER, Alan C. , LI, Yong-Xin , STAUBLI, Ursula , VISWANATH, Veena , LUHRS, Lauren
发明人： FOSTER, Alan C. , LI, Yong-Xin , STAUBLI, Ursula , VISWANATH, Veena , LUHRS, Lauren
IPC分类号： A61K31/196 , A61K31/198 , A61K31/401 , A61P25/00
CPC分类号： A61K31/197 , A61K31/196 , A61K31/198 , A61K31/216 , A61K31/401 , A61K31/405 , A61K45/06 , A61K2300/00
摘要： The present invention relates to pharmaceutical compositions comprising D-serine transporter inhibitors and therapeutic methods using such pharmaceutical compositions in methods for the treatment of central nervous system disorders.
摘要翻译：本发明涉及包含D-丝氨酸转运蛋白抑制剂的药物组合物以及在治疗中枢神经系统疾病的方法中使用这种药物组合物的治疗方法。

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