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1. 发明申请

WO2005072345A2 ENHANCEMENT OF AMPAKINE-INDUCED FACILITATION OF SYNAPTIC RESPONSES BY CHOLINESTERASE INHIBITORS 审中-公开
标题翻译：胆碱酯酶抑制剂增强AMPAKINE对突触反应的促进作用
公开(公告)号：WO2005072345A2
公开(公告)日：2005-08-11
申请号：PCT/US2005002372
申请日：2005-01-26
申请人： CORTEX PHARMA INC , UNIV CALIFORNIA , STAUBLI URSULA , LYNCH GARY , ZHONG SHENG , COLGIN LAURA
发明人： STAUBLI URSULA , LYNCH GARY , ZHONG SHENG , COLGIN LAURA
IPC分类号： A61K31/445
CPC分类号： A61K31/445
摘要： The present invention relates to a method for enhancing the physiological and therapeutic effects of an AMPA receptor potentiator in an animal by co-administration of an acetylcholinesterase inhibitor with the potentiator. Also disclosed is a method for treating a cognitive disorder in an animal by co-administration of an AMPA receptor potentiator and an acetylcholinesterase inhibitor. In addition, a composition comprising an effective amount of an AMPA receptor potentiator and an effective amount of an acetylcholinesterase inhibitor is also disclosed.
摘要翻译：本发明涉及通过共同施用乙酰胆碱酯酶抑制剂和增效剂来增强动物中AMPA受体增强剂的生理和治疗效果的方法。还公开了通过共同施用AMPA受体增强剂和乙酰胆碱酯酶抑制剂来治疗动物认知障碍的方法。此外，还公开了包含有效量的AMPA受体增强剂和有效量的乙酰胆碱酯酶抑制剂的组合物。

2. 发明专利

AU2005208871B2 Enhancement of ampakine-induced facilitation of synaptic responses by cholinesterase inhibitors 未知
公开(公告)号：AU2005208871B2
公开(公告)日：2010-04-01
申请号：AU2005208871
申请日：2005-01-26
申请人： CORTEX PHARMA INC , UNIV CALIFORNIA
发明人： ZHONG SHENG , STAUBLI URSULA , COLGIN LAURA , LYNCH GARY
IPC分类号： A61K31/445
摘要： The present invention relates to a method for enhancing the physiological and therapeutic effects of an AMPA receptor potentiator in an animal by co-administration of an acetylcholinesterase inhibitor with the potentiator. Also disclosed is a method for treating a cognitive disorder in an animal by co-administration of an AMPA receptor potentiator and an acetylcholinesterase inhibitor. In addition, a composition comprising an effective amount of an AMPA receptor potentiator and an effective amount of an acetylcholinesterase inhibitor is also disclosed.

3. 发明专利

AT556710T 未知
公开(公告)号：AT556710T
公开(公告)日：2012-05-15
申请号：AT05712023
申请日：2005-01-26
申请人： CORTEX PHARMA INC , UNIV CALIFORNIA
发明人： STAUBLI URSULA , LYNCH GARY , ZHONG SHENG , COLGIN LAURA
IPC分类号： A61K31/445 , A61K31/40 , A61K31/4525 , A61K45/06
摘要： The present invention relates to a method for enhancing the physiological and therapeutic effects of an AMPA receptor potentiator in an animal by co-administration of an acetylcholinesterase inhibitor with the potentiator. Also disclosed is a method for treating a cognitive disorder in an animal by co-administration of an AMPA receptor potentiator and an acetylcholinesterase inhibitor. In addition, a composition comprising an effective amount of an AMPA receptor potentiator and an effective amount of an acetylcholinesterase inhibitor is also disclosed.

4. 发明专利

CA2554600A1 ENHANCEMENT OF AMPAKINE-INDUCED FACILITATION OF SYNAPTIC RESPONSES BY CHOLINESTERASE INHIBITORS 未知
公开(公告)号：CA2554600A1
公开(公告)日：2005-08-11
申请号：CA2554600
申请日：2005-01-26
申请人： CORTEX PHARMA INC , UNIV CALIFORNIA
发明人： STAUBLI URSULA , LYNCH GARY , COLGIN LAURA , ZHONG SHENG
IPC分类号： A61K31/445
摘要： The present invention relates to a method for enhancing the physiological an d therapeutic effects of an AMPA receptor potentiator in an animal by co- administration of an acetylcholinesterase inhibitor with the potentiator. Al so disclosed is a method for treating a cognitive disorder in an animal by co- administration of an AMPA receptor potentiator and an acetylcholinesterase inhibitor. In addition, a composition comprising an effective amount of an AMPA receptor potentiator and an effective amount of an acetylcholinesterase inhibitor is also disclosed.

5. 发明专利

AU2005208871A1 Enhancement of ampakine-induced facilitation of synaptic responses by cholinesterase inhibitors 未知
公开(公告)号：AU2005208871A1
公开(公告)日：2005-08-11
申请号：AU2005208871
申请日：2005-01-26
申请人： CORTEX PHARMA INC , UNIV CALIFORNIA
发明人： ZHONG SHENG , STAUBLI URSULA , COLGIN LAURA , LYNCH GARY
IPC分类号： A61K31/445
摘要： The present invention relates to a method for enhancing the physiological and therapeutic effects of an AMPA receptor potentiator in an animal by co-administration of an acetylcholinesterase inhibitor with the potentiator. Also disclosed is a method for treating a cognitive disorder in an animal by co-administration of an AMPA receptor potentiator and an acetylcholinesterase inhibitor. In addition, a composition comprising an effective amount of an AMPA receptor potentiator and an effective amount of an acetylcholinesterase inhibitor is also disclosed.

6. 发明公开

EP1715863A4 ENHANCEMENT OF AMPAKINE-INDUCED FACILITATION OF SYNAPTIC RESPONSES BY CHOLINESTERASE INHIBITORS 有权
标题翻译：改善突触反应BY AMPAKINE诱导方便胆碱酯酶抑制剂
公开(公告)号：EP1715863A4
公开(公告)日：2009-03-25
申请号：EP05712023
申请日：2005-01-26
申请人： CORTEX PHARMA INC , UNIV CALIFORNIA
发明人： STAUBLI URSULA , LYNCH GARY , ZHONG SHENG , COLGIN LAURA
IPC分类号： A61K31/445
CPC分类号： A61K31/445

7. 发明公开

EP3198063A4 RNA STITCH SEQUENCING: AN ASSAY FOR DIRECT MAPPING OF RNA : RNA INTERACTIONS IN CELLS 审中-公开
公开(公告)号：EP3198063A4
公开(公告)日：2018-05-02
申请号：EP15845347
申请日：2015-09-18
申请人： UNIV CALIFORNIA
发明人： ZHONG SHENG , NGUYEN TRI CONG
IPC分类号： C40B30/04 , C07H21/02 , C12Q1/68
CPC分类号： C12Q1/6809 , C12Q2521/501 , C12Q2523/101
摘要： Methods and compositions for generating chimeric RNAs comprising RNAs which interact with one another in a cell are provided. In some embodiments, the chimeric RNAs can be used to identify at least 100, at least 500, at least 1000 or more than 1000 RNA-RNA interactions in the cell.

8. 发明公开

EP3198037A4 SINGLE MOLECULE RNA DETECTION 审中-公开
公开(公告)号：EP3198037A4
公开(公告)日：2018-03-21
申请号：EP15843589
申请日：2015-09-18
申请人： UNIV CALIFORNIA
发明人： ZHONG SHENG , BIASE FERNANDO
IPC分类号： C12Q1/6841 , C12Q1/682
CPC分类号： C12Q1/6841 , C12Q1/682 , C12Q1/6825 , C12Q2537/143 , C12Q2563/143 , C12Q2543/10 , C12Q2563/107 , C12Q2563/149
摘要： Quantification of RNAs is one of the most essential tools to characterize cells. This tool is widely used in disease diagnosis, pharmacogenomics, and drug development. Single cell RNA fluorescent in situ hybridization (smRNA-FISH) revolutionized RNA detection and quantification by detecting every single RNA molecule of a gene. However, this technology is incapable of assaying relatively short RNAs, and it suffers from high cost and low throughput. Here, we describe a technology that simultaneously overcomes the three drawbacks using conventional instrumentation. This QD-smRNA-FISH technology uses hybridization of quantum dot-labeled DNA oligonucleotides to the RNA molecules for visualization and counting. Quantum dots (QDs) have been assumed inapplicable to counting individual RNA molecules, due to the well-known blinking problem (display intermittency) (Medintz I L, Uyeda H T, Goldman E R, Mattoussi H (2005) Quantum dot bioconjugates for imaging, labelling and sensing. Nat Mater 4: 435-446). This problem has been circumvented by this new experimental design. In some embodiments described herein, the methods assemble several QDs to every target RNA molecule and leverage the complementation of the QDs to achieve an overall non-intermittent signal on each target molecule. We validated QD-smRNA-FISH by comparing its signals with those of standard smRNA-FISH. We successfully applied QD-smRNA-FISH to test the interaction of two RNAs, a task that cannot be accomplished with standard smRNA-FISH. The QD-smRNA-FISH method offers a highly accurate method for single RNA molecule detection and counting under standard fluorescent microscopes, and enables analysis of relatively short RNAs (

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